CROSS REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. application Ser. No. 17/716,816 filed Apr. 8, 2022, allowed, which is a divisional of U.S. application Ser. No. 17/239,484 filed Apr. 23, 2021, allowed, which claims priority to and the benefit of U.S. Provisional Patent Application No. 63/141,926, filed on Jan. 26, 2021, and U.S. Provisional Patent Application No. 63/105,834, filed on Oct. 26, 2020, the entire contents of which are incorporated by reference herein for all purposes.
SEQUENCE LISTING The instant application contains a Sequence Listing which will be submitted via Patent Center and is hereby incorporated by reference in its entirety. Said XML copy, created on Aug. 29, 2023, is named ANB-203D2_SL.xml and is 845,305 bytes in size.
BACKGROUND Cancer continues to present a significant clinical burdSen despite the substantial research efforts and scientific advances in cancer therapies. Blood and bone marrow cancers are frequently diagnosed cancer types, including multiple myelomas, leukemia, and lymphomas. Current treatment options for these cancers are not effective for all patients and/or can have substantial adverse side effects. Other types of cancer also remain challenging to treat using existing therapeutic options. Cancer immunotherapies are a promising solution because they can be highly specific, allowing for increased therapeutic effectiveness and the mitigation of side effects.
Genetically engineered immune cell therapy is a growing field with promising applications for the treatment of diseases including, but not limited to, cancer. Through the alteration of coding and/or non-coding genomic regions, researchers are identifying transgenes and insertion sites within cells that facilitate, for example, enhanced cell function, arrest cell growth, induced cell death, and tumor size/volume reduction. The identification of safe harbor sites (SHS) has improved outcomes of genome-engineering therapies. Well known SHS include the AAVS1 adeno-associated virus insertion site on chromosome 19, the human homolog of the murine Rosa26 locus, and the CCR5 chemokine receptor gene—the absence of which confers HIV resistance. (See, for example, Pellenz et al., 2018, the relevant disclosures of which are herein incorporated by reference). However, there is still a need for improved guidelines for gene editing therapies and additional SHS to address challenges such as poor knock-in (KI) efficiency, insertional oncogenesis, unstable and/or anomalous expression of transgenes and/or adjacent genes, etc.
SUMMARY The present disclosure is directed, inter alia, to safe harbor loci that exhibit high knock-in efficiency and stable expression of their transgenes. These safe harbor loci can be used to alter T cells for immunotherapy. These safe harbor loci are useful for the treatment of various diseases, including cancer.
In one aspect, the present disclosure provides an engineered cell, comprising at least one sequence encoding a transgene, wherein the at least one sequence is inserted within a safe harbor locus, the safe harbor locus is at any one or more of the sgRNA target loci provided in Table 4; and wherein expression of the at least one sequence encoding the transgene is operatively linked to an endogenous promoter. In another aspect, the present disclosure provides an engineered cell, comprising at least one sequence encoding a transgene, wherein the at least one sequence is inserted within a safe harbor locus, the safe harbor locus is at any one or more of the sgRNA target loci provided in Table 4; and wherein expression of the at least one sequence encoding the transgene is operatively linked to an exogenous promoter.
In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.
In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93.
In some embodiments, the exogenous promoter is an EF1a promoter. In some embodiments, the engineered cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor. In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR).
In another aspect, the present disclosure provides a composition comprising the engineered cell as described herein and a pharmaceutical excipient.
In another aspect, the present disclosure provides a guide ribonucleic acids (gRNA) for editing a cell at a safe harbor locus, wherein gRNA comprises any one of the sgRNA sequences in Table 4.
In some embodiments, the gRNA comprises any one of SEQ ID NOS:1-120. In some embodiments, the gRNA comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor.
In another aspect, the present disclosure provides a method of editing a cell having chromosomal DNA, comprising inserting at least one sequence encoding a transgene within a safe harbor locus in the chromosomal DNA of the cell, wherein the safe harbor locus is any one or more of the sgRNA target loci provided in Table 4.
In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.
In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93.
In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR). In some embodiments, the at least one sequence comprises an exogenous promoter and the exogenous promoter is operably linked to the transgene. In some embodiments, the exogenous promoter is an EF1a promoter. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell progenitor. In some embodiments, the at least one sequence is inserted using a homology-directed repair. In some embodiments, the at least one sequence is inserted using a homology independent targeted insertion. In some embodiments, the at least one sequence is inserted using one or more guide ribonucleic acids (gRNAs) and one or more Cas9 endonucleases.
In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 1-120. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102.
In another aspect, the present disclosure provides a method of editing a T cell, comprising contacting a T cell with one or more guide ribonucleic acids (gRNAs), at least one sequence encoding a transgene, and one or more Cas9 endonucleases, wherein the one or more gRNAs and Cas9 endonucleases facilitate the insertion of the at least one sequence into chromosomal DNA within a safe harbor locus, wherein the safe harbor locus is selected from any one or more of the sgRNA target loci in Table 4.
In some embodiments, the one or more gRNAs comprises a sequence selected from any one of the sgRNA sequences in Table 4. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 1-120. In some embodiments, the one or more gRNAs comprises any one of SEQ ID NOS: 91-96 and 100-105. In some embodiments, the gRNA comprises SEQ ID NO:94 or SEQ ID NO:102. In some embodiments, the gRNA comprises SEQ ID NO:94. In some embodiments, the gRNA comprises SEQ ID NO:102.
In some embodiments, the target locus is selected from: chr10:33130000-33140000, chr10:72290000-72300000, chr11:128340000-128350000, chr11:65425000-65427000 (NEAT1), chr15:92830000-92840000, chr16:11220000-11230000, chr2:87460000-87470000, chr3:186510000-186520000, chr3:59450000-59460000, chr8:127980000-128000000, and chr9:7970000-7980000. In some embodiments, the target locus is selected from: chr10:72290000-72300000, chr11:128340000-128350000, chr15:92830000-92840000, and chr16:11220000-11230000. In some embodiments, the target locus is chr11:128340000-128350000. In some embodiments, the target locus is chr15:92830000-92840000. In some embodiments, the target locus is a gene selected from: APRT, B2M, CAPNS1, CBLB, CD2, CD3E, CD3G, CD5, EDF1, FTL, PTEN, PTPN2, PTPN6, PTPRC, PTPRCAP, RPS23, RTRAF, SERF2, SLC38A1, SMAD2, SOCS1, SRP14, SRSF9, SUB1, TET2, TIGIT, TRAC, and TRIM28.
In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS88, GS89, GS90, GS91, GS92, GS93, GS94, GS95, GS96, GS97, GS98, GS99, GS100, GS101, GS102, GS103, GS104, GS105, GS106, GS107, GS108, GS109, GS110, GS111, GS112, GS113, GS114, GS115, GS116, GS117, GS118, GS119, GS120. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, GS93, GS94, GS95, GS96, GS100, GS101, GS102, GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS103, GS104, and GS105. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS94, GS95, and GS96. In some embodiments, the safe harbor locus is the GS94 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS100, GS101, and GS102. In some embodiments, the safe harbor locus is the GS102 integration site in Table 4. In some embodiments, the safe harbor locus is selected from any one of the integration sites in Table 4 designated: GS91, GS92, and GS93
In another aspect, the present disclosure provides an ex vivo method of obtaining an engineered cell or population thereof, comprising (a) obtaining a cell; and (b) genetically modifying the cell by inserting at least one sequence encoding a transgene within a safe harbor locus, wherein the safe harbor locus is selected from any one of the sgRNA target loci in Table 4.
In some embodiments, obtaining the cell comprises: (i) collecting a tissue sample from a subject, (ii) isolating the cells from the tissue samples, and (iii) culturing the cells in vitro. In some embodiments, the tissue sample is a blood sample. In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell precursor. In some embodiments, the at least one sequence is inserted using a homology-directed repair. In some embodiments, the at least one sequence is inserted using a homology independent targeted insertion.
In some embodiments, the genetically modifying in step (b) comprises contacting the cell with one or more guide ribonucleic acids (gRNAs), the at least one sequence, and one or more Cas9 endonucleases, wherein the one or more gRNAs and Cas9 endonucleases facilitate the insertion of the at least one sequence into chromosomal DNA within the safe harbor locus. In some embodiments, the one or more gRNAs comprises a sequence selected from any one of the sgRNA sequences in Table 4.
In some embodiments, the transgene encodes a recombinant protein, optionally a therapeutic agent. In some embodiments, the transgene encodes a chimeric antigen receptor (CAR). In some embodiments, the at least one sequence comprises an exogenous promoter and the exogenous promoter is operably linked to the transgene. In some embodiments, the exogenous promoter is an EF1a promoter.
In yet another aspect, the present disclosure provides a method of treating a subject having or at risk of having a disease, comprising administering to the subject an effective amount of an engineered cell as described herein, a population thereof, or a composition as described herein. In some embodiments, the cell, the population thereof, or the composition is administered to the subject by infusion.
In yet another aspect, the present disclosure provides a method of treating a subject having or at risk of having a disease, comprising (a) conducting any one of the methods described supra; and (b) administering to the subject an effective amount of a composition comprising the cell or a population thereof. In some embodiments, the composition is administered to the subject by infusion. In some embodiments, the disease is cancer. In some embodiments, the disease is blood cancer.
In another aspect, the present disclosure provides a method of identifying a safe harbor locus, comprising: (a) identifying genes or non-coding regions in a chromosome that are above a threshold level for expression across developmental cell states and/or a threshold level for accessibility of chromatin; (b) generating a linear model that correlates the gene or non-coding region from step (a) with knock-in (KI) efficiency and estimates the KI efficiency of any gene or coding region on the chromosome; and (c) selecting the safe harbor locus based on threshold parameters; wherein the safe harbor locus is selected for insertion of at least one sequence encoding a transgene within a cell.
In some embodiments, the threshold parameters include one or more of: stable expression of a transgene, knockout of the gene confers benefit to the function of the cell, no known function within the cell, stable transgene expression in vitro with or without CD3/CD28 stimulation, negligible off-target cleavage as detected by iGuide-Seq or CRISPR-Seq, less off-target cleavage relative to other loci as detected by iGuide-Seq or CRISPR-Seq, negligible transgene-independent cytotoxicity, negligible transgene-independent cytokine expression, negligible transgene-independent chimeric antigen receptor expression, negligible deregulation or silencing of nearby genes, and positioned outside of a cancer-related gene. In some embodiments, the stable expression of a transgene at the safe harbor locus is less than or equal to 2-fold expression change over the course of at least 1, 2, 3, 4, 5, 6, or 7 days, and wherein expression change is measured by mean fluorescence intensity of a reporter gene encoded by the at least one sequence. In some embodiments, the accessibility of chromatin is measured using an assay for transposase-accessible chromatin using sequencing (ATAC-seq). In some embodiments, the level of expression across developmental cell states is measured using RNA sequencing (RNA-seq).
In some embodiments, the cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or T cell precursor. In some embodiments, the linear model has a coefficient of determination (R2 value) of at least 30%.
In yet another aspect, the present disclosure provides an engineered cell, composition, gRNA or method as described herein, wherein insertion within the safe harbor locus increase cell cytotoxicity of diseased cells.
In yet another aspect, the present disclosure provides an engineered cell, composition, gRNA or method as described herein, wherein knock-in efficiency at the safe harbor locus is increased relative to other locations along the chromosome.
BRIEF DESCRIPTION OF THE DRAWINGS These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, and accompanying drawings, where:
FIG. 1 includes a schematic depicting the methodology used to identify safe harbor loci in the present disclosure, in some embodiments.
FIGS. 2A-2C include schematic depicting 3 top safe harbor loci known in the art: AAVS1 (FIG. 2A), CCR5 (FIG. 2B), and Rosa26 (FIG. 2C). The figures were retrieved from Sadelain, M., et al. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58, the relevant disclosures of which are herein incorporated by reference in their entirety.
FIG. 3 includes a schematic outlining the data provided in Roth, T. L., et al. 2019. Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561, the relevant disclosures of which are herein incorporated by reference in their entirety.
FIGS. 4A-4B include heatmaps with samples clustered based on activation status and cell type, generated with processed RNA-seq data. FIG. 4A includes a heatmap of samples generated with processed RNA-seq data. FIG. 4B includes a heatmap sample generated with processed RNA-seq data, showing the clustering of ˜20 k genes.
FIGS. 5A-5B include plots generated using processed RNA-seq data. FIG. 5A includes a plot showing direct correlation between transcript expression data from Roth, T. L., et al. 2019 and transcript expression data generated by the inventors of the present disclosure. FIG. 5B includes a heatmap showing clusters of the top 10% expressed genes.
FIG. 6 includes a heatmap of samples generated with processed ATAC-seq data.
FIGS. 7A-7B includes plots depicting the signal enrichment at transcription start sites (TSS) (FIG. 7A) and peak size distribution (FIG. 7B), generated with processed ATAC-seq data for coding regions.
FIG. 8 includes a plot depicting the open chromatin regions around the TRAC locus.
FIG. 9 includes a plot depicting KI (knock-in) efficiency for coding regions/genes with GFP as a reporter.
FIG. 10 includes a plot depicting KI efficiency for coding regions/genes with tNGFR as a reporter.
FIG. 11 includes plots showing scaled KI efficiency for 90 genes vs d2 (day-2) RNA-seq data, d4 (day-4) RNA-seq data and ATAC-seq data, utilized for the predictive linear model.
FIG. 12 includes a plot showing chromatin accessibility for a top candidate non-coding region, measured using ATAQ sequencing.
FIG. 13A includes plots showing the cell counts for GFP controls used for the evaluation of candidate KI loci. FIG. 13B includes pmax (GFP_high) readings for GFP controls used for the evaluation of candidate KI loci.
FIG. 14A includes plots showing the maximum episomal GFP expression (GFP_high) readings for non-targeting controls. FIG. 14B includes the cell count for non-targeting controls from donors 1, 2, and 3.
FIG. 15 includes the cell count and maximum GFP expression (GFP_high) readings for WT controls.
FIG. 16 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA5, which targets a B2M safe harbor locus, and the construct expression was driven by an endogenous promoter.
FIG. 17 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA5, which targets a B2M safe harbor locus, and the construct expression was driven by an EF1a promoter.
FIG. 18 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA79 to target a TRAC safe harbor locus, and the construct expression was driven by an endogenous promoter.
FIG. 19 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA79, which targets a TRAC safe harbor locus, and the construct expression was driven by an exogenous promoter.
FIG. 20 includes plots showing TCR (T cell receptor) vs. GFP among all donors and time points when using sgRNA79, and the construct is driven by an endogenous promoter.
FIG. 21 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA79 and the construct is driven by an exogenous promoter.
FIG. 22 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA83, which targets a TRAC safe harbor locus, and the construct expression was driven by an endogenous promoter.
FIG. 23 includes plots showing the cell count and maximum GFP expression (GFP_high) readings when using sgRNA83, which targets a TRAC safe harbor locus, and the construct expression was driven by an exogenous promoter.
FIG. 24 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA83 and the construct is driven by an endogenous promoter.
FIG. 25 includes plots showing TCR vs. GFP among all donors and time points when using sgRNA83 and the construct is driven by an exogenous promoter.
FIG. 26 includes plots illustrating potential sources of variation (e.g., edge effects and electroporation errors) observed between replicates and donors.
FIG. 27 includes plots illustrating potential sources of variation observed between replicates and donors, e.g., relating to inherent differences between donors.
FIG. 28 includes plots illustrating potential sources of variation observed between replicates and donors, e.g., relating to gating errors.
FIG. 29 includes plots showing the GFP mean fluorescence intensity (GFP MFI) and KI efficiency for top KI loci evaluated with endogenous promoters.
FIG. 30 includes plots showing the GFP mean fluorescence intensity (GFP MFI) and KI efficiency for top KI loci evaluated with the EF1a promoter.
FIGS. 31A-31C include plots showing all the significant KI loci (top KI loci) as evaluated with endogenous and EF1a promoters. FIG. 31A includes a plot showing that the expression from the EF1a promoter was approximately 10 times higher than expression from an endogenous promoter. FIG. 31B shows the top KI loci ranked by GFP MFI at week 3. FIG. 31C shows the top integration loci ranked by GFP MFI (at weeks 3 and 4; donors 1-3).
FIG. 32A includes a plot showing some target loci and their measured transgene expression levels. FIG. 32B includes plots showing the transgene (Prime Receptor (PrimeR)) and TCR expression for the control and insertion at GS94, GS102 and TRAC loci.
FIG. 33A includes a plot showing the PrimeR levels measured for the indicated integration sites. FIG. 33B includes a schematic showing the GS94 integration site on Chromosome 11.
FIG. 34A includes plots showing CAR induction and primeR expression of engineered T cells after 48 hours of coculturing with K562-CD19 cells. FIG. 34B includes plots showing the cytotoxity and cytokine secretion levels for engineered T cells 48 hours of coculturing with K562-CD19/MSLN cells.
FIG. 35A includes a schematic showing the experimental overview for evaluating the effect of integration site on cytotoxicity. FIG. 35B includes plots showing the measured cytotoxicity for engineered T cells cocultured for 48 hours with the K562 CD19+/MSLN+ or K562 CD19−/MSLN+ cells.
FIG. 36A includes a schematic showing the experimental overview for evaluating the effect of integration site on cytokine secretion. FIG. 36B includes plots showing the measured cytokine levels for engineered T cells cocultured for 48 hours with K562 CD19+/MSLN+ cells.
FIG. 37 includes a schematic showing the in vitro experiment conducted to determin the effect of integration site on primeR-independent CAR expression. “Flow” refers to flow cytometry and “restim” refers to repetitive CD3/CD28 stimulation of the engineered T cells. “EP” refers to electroporation.
FIGS. 38A and 38B include plots showing the stability of PrimeR expression over time when using the indicated integration sites. “Flow” refers to flow cytometry and “restim” refers to repetitive CD3/CD28 stimualation of the engineered T cells. “EP” refers to electroporation. In FIG. 38B, the PrimeR expression is normalized to the expression from using the TRAC integration site.
FIG. 39A includes a schematic showing the iGuide-Seq assay technique. FIG. 39B includes a plot showing the on-target efficiency, using iGuide Seq assay, for the indicated integration sites. FIG. 39C includes schematics from the iGuide-Seq analysis showing that GS94 had no reproducible putatitve off-targets across two donors FIG. 39C discloses SEQ ID NOS 312-322, 312-313, and 323-331, respectively, in order of appearance.
FIG. 40 includes a schematic showing the iGuide-Seq workflow and data.
FIG. 41 includes a plot showing rhAmp-seg™ analysis of putative off-target sites identified by iGUIDE-seq and Elevation prediction.
FIG. 42 includes plots showing RNA-seq analysis of cells with GS94, GS102 and TRAC knock-in of CD19/MSLN circuits. Scatterplot of gene expression in cells with integration at the GS94 locus (y-axis) vs cells with integration at either the TRAC or the GS102 locus (x-axis) in two donors. The yellow dots correspond to ETS1 and FLI1. In blue are the genes that were found to be differentially expressed using edgeR (fold-change >0, FDR-corrected p-value <0.01, average counts-per-million across compared conditions at least 2).
FIG. 43 includes plots showing the absence of cytokine-independent growth in cells with CD19/MSLN circuit KI at GS94.
DETAILED DESCRIPTION The present disclosure provides safe harbor loci and methods for identifying safe harbor loci that exhibit high integration efficiency (e.g., high knock-in (KI) efficiency), high and constant levels of transgene expression, and such benefits independent of T cell activation/differentiation state. In some embodiments, the safe harbor loci also exhibit minimal to no disruption to T cell function and/or capacity for product manufacturing. In some embodiments, these loci are useful for effective and safe integration and expression of transgenes in T cells (e.g. in CAR T therapies). In some embodiments, the methods described herein can be used for the identification of safe harbor loci for insertion of transgenes in other types of cells.
FIG. 1 illustrates the overall approach that the inventors of the present disclosure used to identify safe harbor loci. In some embodiments, the present disclosure provides a method comprising the identification of genes within a genome and non-coding regions with sustained expression in a treatment cell (e.g. T cell) and using a predictive model of KI efficiency as a function of T cell chromatic state and computational analysis to predict candidate integration sites. The method further comprises evaluating the candidate integration sites for actual KI efficiency, sustained levels of transgene expression of a transgene, and minimal disruption to the treatment cell phenotype (e.g., T cell function and/or capacity for treatment product expansion and manufacturing). In some embodiments, the safe harbor loci allow for integration of a transgene driven by an endogenous promoter. In some embodiments, the safe harbor loci allow for integration of a transgene driven by an exogenous promoter (e.g. EF1a promoter).
To facilitate an understanding of the present disclosure, a number of terms and phrases are defined below. Unless otherwise defined herein, scientific and technical terms used in this application shall have the meanings that are commonly understood by those of ordinary skill in the art. Generally, nomenclature used in connection with, and techniques of pharmacology, cell and tissue culture, molecular biology, cell and cancer biology, neurobiology, neurochemistry, virology, immunology, microbiology, genetics and protein and nucleic acid chemistry, described herein, are those well-known and commonly used in the art. In case of conflict, the present specification, including definitions, will control.
Unless otherwise defined, all terms of art, notations and other scientific terminology used herein are intended to have the meanings commonly understood by those of skill in the art. In some cases, terms with commonly understood meanings are defined herein for clarity and/or for ready reference, and the inclusion of such definitions herein should not necessarily be construed to represent a difference over what is generally understood in the art. The techniques and procedures described or referenced herein are generally well understood and commonly employed using conventional methodologies by those skilled in the art, such as, for example, the widely utilized molecular cloning methodologies described in Sambrook et al., Molecular Cloning: A Laboratory Manual 4th ed. (2012) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. As appropriate, procedures involving the use of commercially available kits and reagents are generally carried out in accordance with manufacturer-defined protocols and conditions unless otherwise noted.
As used herein, the singular forms “a,” “an,” and “the” include the plural referents unless the context clearly indicates otherwise. The terms “include,” “such as,” and the like are intended to convey inclusion without limitation, unless otherwise specifically indicated.
As used herein, the term “comprising” also specifically includes embodiments “consisting of” and “consisting essentially of” the recited elements, unless specifically indicated otherwise.
The term “about” indicates and encompasses an indicated value and a range above and below that value. In certain embodiments, the term “about” indicates the designated value ±10%, ±5%, or ±1%. In certain embodiments, where applicable, the term “about” indicates the designated value(s) ±one standard deviation of that value(s).
As used herein, the term “gene” refers to the basic unit of heredity, consisting of a segment of DNA arranged along a chromosome, which codes for a specific protein or segment of protein. A gene typically includes a promoter, a 5′ untranslated region, one or more coding sequences (exons), optionally introns, a 3′ untranslated region. The gene may further comprise a terminator, enhancers and/or silencers.
As used herein, the term “locus” refers to a specific, fixed physical location on a chromosome where a gene or genetic marker is located.
As used herein, the term “target locus” refers to a locus on a chromosome within which a safe harbor locus can be used for the insertion of a sequence. A target locus can consist of multiple potential safe harbor loci (integration sites). Examples of target loci are provided in Table 4, as sgRNA target loci. The notation used for the sgRNA target loci in Table 4 refers to the genomic region of the target locus, defined by the chromosome of the target locus and the coordinate range for that target locus. For example, chr10:33130000-33140000 refers to a target locus on Chr10 (chromosome 10) starting from coordinate 33130000 and ending with coordinate 33140000.
The term “safe harbor locus” refers to a locus at which genes or genetic elements can be incorporated without disruption to expression or regulation of adjacent genes. These safe harbor loci are also referred to as safe harbor sites (SHS). As used herein, a safe harbor locus refers to an “integration site” or “knock-in site” at which a sequence encoding a transgene, as defined herein, can be inserted. In some embodiments the insertion occurs with replacement of a sequence that is located at the integration site. In some embodiments, the insertion occurs without replacement of a sequence at the integration site. Examples of integration sites contemplated are provided in Table 4.
As used herein, the term “insert” refers to a nucleotide sequence that is integrated (inserted) at a safe harbor site. The insert can be used to refer to the genes or genetic elements that are incorporated at the safe harbor site using, for example, homology-directed repair (HDR) CRISPR/Cas9 genome-editing or other methods for inserting nucleotide sequences into a genomic region known to those of ordinary skill in the art.
The “CRISPR/Cas” system refers to a widespread class of bacterial systems for defense against foreign nucleic acid. CRISPR/Cas systems are found in a wide range of eubacterial and archaeal organisms. CRISPR/Cas systems include type I, II, and III sub-types. Wild-type type II CRISPR/Cas systems utilize an RNA-mediated nuclease, Cas9 in complex with guide and activating RNA to recognize and cleave foreign nucleic acid. Guide RNAs having the activity of both a guide RNA and an activating RNA are also known in the art. In some cases, such dual activity guide RNAs are referred to as a small guide RNA (sgRNA).
Cas9 homologs are found in a wide variety of eubacteria, including, but not limited to bacteria of the following taxonomic groups: Actinobacteria, Aquificae, Bacteroidetes-Chlorobi, Chlamydiae-Verrucomicrobia, Chlroflexi, Cyanobacteria, Firmicutes, Proteobacteria, Spirochaetes, and Thermotogae. An exemplary Cas9 protein is the Streptococcus pyogenes Cas9 protein. Additional Cas9 proteins and homologs thereof are described in, e.g., Chylinksi, et al., RNA Biol. 2013 May 1; 10(5): 726-737; Nat. Rev. Microbiol. 2011 June; 9(6): 467-477; Hou, et al., Proc Natl Acad Sci USA. 2013 Sep. 24; 110(39):15644-9; Sampson et al., Nature. 2013 May 9; 497(7448):254-7; and Jinek, et al., Science. 2012 Aug. 17; 337(6096):816-21. The Cas9 nuclease domain can be optimized for efficient activity or enhanced stability in the host cell.
As used herein, the term “Cas9” refers to an RNA-mediated nuclease (e.g., of bacterial or archeal orgin, or derived therefrom). Exemplary RNA-mediated nuclases include the foregoing Cas9 proteins and homologs thereof, and include but are not limited to, CPF1 (See, e.g., Zetsche et al., Cell, Volume 163, Issue 3, p 759-771, 22 Oct. 2015). Similarly, as used herein, the term “Cas9 ribonucleoprotein” complex and the like refers to a complex between the Cas9 protein, and a crRNA (e.g., guide RNA or small guide RNA), the Cas9 protein and a trans-activating crRNA (tracrRNA), the Cas9 protein and a small guide RNA, or a combination thereof (e.g., a complex containing the Cas9 protein, a tracrRNA, and a crRNA guide RNA).
As used herein, the terms “T lymphocyte” and “T cell” are used interchangeably and refer to cells that have completed maturation in the thymus, and identify certain foreign antigens in the body. The terms also refer to the major leukocyte types that have various roles in the immune system, including activation and deactivation of other immune cells. The T cell can be any T cell such as a cultured T cell, e.g., a primary T cell, or a T cell derived from a cultured T cell line, e.g., a Jurkat, SupT1, etc., or a T cell obtained from a mammal. The T cell can be a CD3+ cell. The T cell can be any type of T cell, CD4+/CD8+ double positive T cells, CD4+ helper T cells (e.g. Th1 and Th2 cells), CD8+ T cells (e.g. cytotoxic T cells), peripheral Including but not limited to blood mononuclear cells (PBMC), peripheral blood leukocytes (PBL), tumor infiltrating lymphocytes (TIL), memory T cells, naive T cells, regulatory T cells, γδ T cells, etc. It can be any T cell at any stage of development. Additional types of helper T cells include Th3 (Treg) cells, Th17 cells, Th9 cells, or Tfh cells. Additional types of memory T cells include cells such as central memory T cells (Tcm cells), effector memory T cells (Tem cells and TEMRA cells). A T cell can also refer to a genetically modified T cell, such as a T cell that has been modified to express a T cell receptor (TCR) or a chimeric antigen receptor (CAR). T cells can also be differentiated from stem cells or progenitor cells.
“CD4+ T cells” refers to a subset of T cells that express CD4 on their surface and are associated with a cellular immune response. CD4+ T cells are characterized by a post-stimulation secretion profile that can include secretion of cytokines such as IFN-γ, TNF-α, IL-2, IL-4 and IL-10. “CD4” is a 55 kD glycoprotein originally defined as a differentiation antigen on T lymphocytes, but was also found on other cells including monocytes/macrophages. The CD4 antigen is a member of the immunoglobulin superfamily and has been implicated as an associative recognition element in MHC (major histocompatibility complex) class II restricted immune responses. On T lymphocytes, the CD4 antigen defines a helper/inducer subset.
“CD8+ T cells” refers to a subset of T cells that express CD8 on their surface, are MHC class I restricted, and function as cytotoxic T cells. The “CD8” molecule is a differentiation antigen present on thymocytes, as well as on cytotoxic and suppressor T lymphocytes. The CD8 antigen is a member of the immunoglobulin superfamily and is an associative recognition element in major histocompatibility complex class I restriction interactions.
As used herein, the term “ex vivo” generally includes experiments or measurements made in or on living tissue, preferably in an artificial environment outside the organism, preferably with minimal differences from natural conditions.
As used herein, the term “construct” refers to a complex of molecules, including macromolecules or polynucleotides.
As used herein, the term “integration” refers to the process of stably inserting one or more nucleotides of a construct into the cell genome, i.e., covalently linking to a nucleic acid sequence in the chromosomal DNA of the cell. It may also refer to nucleotide deletions at a site of integration. Where there is a deletion at the insertion site, “integration” may further include substitution of the endogenous sequence or nucleotide deleted with one or more inserted nucleotides.
As used herein, the term “exogenous” refers to a molecule or activity that has been introduced into a host cell and is not native to that cell. The molecule can be introduced, for example, by introduction of the encoding nucleic acid into host genetic material, such as by integration into a host chromosome, or as non-chromosomal genetic material, such as a plasmid. Thus, the term, when used in connection with expression of an encoding nucleic acid, refers to the introduction of the encoding nucleic acid into a cell in an expressible form. The term “endogenous” refers to a molecule or activity that is present in a host cell under natural, unedited conditions. Similarly, the term, when used in connection with expression of the encoding nucleic acid, refers to expression of the encoding nucleic acid that is contained within the cell and not introduced exogenously.
As used herein, a “polynucleotide donor construct” refers to a nucleotide sequence (e.g. DNA sequence) that is genetically inserted into a polynucleotide and is exogenous to that polynucleotide. The polynucleotide donor construct is transcribed into RNA and optionally translated into a polypeptide. The polynucleotide donor construct can include prokaryotic sequences, cDNA from eukaryotic mRNA, genomic DNA sequences from eukaryotic (e.g., mammalian) DNA, and synthetic DNA sequences. For example, the polynucleotide donor construct can be a miRNA, shRNA, natural polypeptide (i.e., a naturally occurring polypeptide) or fragment thereof or a variant polypeptide (e.g. a natural polypeptide having less than 100% sequence identity with the natural polypeptide) or fragments thereof.
As used herein, the term “transgene” refers to a polynucleotide that has been transferred naturally, or by any of a number of genetic engineering techniques from one organism to another. It is optionally translated into a polypeptide. It is optionally translated into a recombinant protein. A “recombinant protein” is a protein encoded by a gene—recombinant DNA—that has been cloned in a system that supports expression of the gene and translation of messenger RNA (see expression system). The recombinant protein can be a therapeutic agent, e.g. a protein that treats a disease or disorder disclosed herein. As used, transgene can refer to a polynucleotide that encodes a polypeptide. A transgene can also refer to a non-encoding sequence, such as, but not limited to shRNAs, miRNAs, and miRs.
The terms “protein,” “polypeptide,” and “peptide” are used herein interchangeably.
As used herein, the term “operably linked” refers to the binding of a nucleic acid sequence to a single nucleic acid fragment such that one function is affected by the other. For example, if a promoter is capable of affecting the expression of a coding sequence or functional RNA (i.e., the coding sequence or functional RNA is under transcriptional control by the promoter), the promoter is operably linked thereto. Coding sequences can be operably linked to control sequences in both sense and antisense orientation.
As used herein, the term “developmental cell states” refers to, for example, states when the cell is inactive, actively expressing, differentiating, senescent, etc. developmental cell state may also refer to a cell in a precursor state (e.g., a T cell precursor).
As used, the term “encoding” refers to a sequence of nucleic acids which codes for a protein or polypeptide of interest. The nucleic acid sequence may be either a molecule of DNA or RNA. In preferred embodiments, the molecule is a DNA molecule. In other preferred embodiments, the molecule is a RNA molecule. When present as a RNA molecule, it will comprise sequences which direct the ribosomes of the host cell to start translation (e.g., a start codon, ATG) and direct the ribosomes to end translation (e.g., a stop codon). Between the start codon and stop codon is an open reading frame (ORF). Such terms are known to one of ordinary skill in the art.
The term “inserting” refers to a manipulation of a nucleotide sequence to introduce a non-native sequence. This is done, for example, via the use of restriction enzymes and ligases whereby the DNA sequence of interest, usually encoding the gene of interest, can be incorporated into another nucleic acid molecule by digesting both molecules with appropriate restriction enzymes in order to create compatible overlaps and then using a ligase to join the molecules together. One skilled in the art is very familiar with such manipulations and examples may be found in Sambrook et al. (Sambrook, Fritsch, & Maniatis, “Molecular Cloning: A Laboratory Manual”, 2nd ed., Cold Spring Harbor Laboratory, 1989), which is hereby incorporated by reference in its entirety including any drawings, figures and tables.
As used herein, the term “subject” refers to a mammalian subject. Exemplary subjects include humans, monkeys, dogs, cats, mice, rats, cows, horses, camels, goats, rabbits, pigs and sheep. In certain embodiments, the subject is a human. In some embodiments the subject has a disease or condition that can be treated with an engineered cell provided herein or population thereof. In some aspects, the disease or condition is a cancer.
As used herein, the term “promoter” refers to a nucleotide sequence (e.g. DNA sequence) capable of controlling the expression of a coding sequence or functional RNA. The promoter sequence consists of proximal and more distal upstream elements, the latter elements often referred to as enhancers. A promoter can be derived from natural genes in its entirety, can be composed of different elements from different promoters found in nature, and/or may comprise synthetic DNA segments. A promoter, as contemplated herein, can be endogenous to the cell of interest or exogenous to the cell of interest. It is appreciated by those skilled in the art that different promoters can induce gene expression in different tissue or cell types, or at different developmental stages, or in response to different environmental conditions. As is known in the art, a promoter can be selected according to the strength of the promoter and/or the conditions under which the promoter is active, e.g., constitutive promoter, strong promoter, weak promoter, inducible/repressible promoter, tissue specific Or developmentally regulated promoters, cell cycle-dependent promoters, and the like.
A promoter can be an inducible promoter (e.g., a heat shock promoter, tetracycline-regulated promoter, steroid-regulated promoter, metal-regulated promoter, estrogen receptor-regulated promoter, etc.). The promoter can be a constitutive promoter (e.g., CMV promoter, UBC promoter). In some embodiments, the promoter can be a spatially restricted and/or temporally restricted promoter (e.g., a tissue specific promoter, a cell type specific promoter, etc.). See for example U.S. application Ser. No. 15/715,068, the disclosures of which are herein incorporated by reference in their entirety.
Gene editing, as contemplated herein, may involve a gene (or nucleotide sequence) knock-in or knock-out. As used herein, the term “knock-in” refers to an addition of a DNA sequence, or fragment thereof into a genome. Such DNA sequences to be knocked-in may include an entire gene or genes, may include regulatory sequences associated with a gene or any portion or fragment of the foregoing. For example, a polynucleotide donor construct encoding a recombinant protein may be inserted into the genome of a cell carrying a mutant gene. In some embodiments, a knock-in strategy involves substitution of an existing sequence with the provided sequence, e.g., substitution of a mutant allele with a wild-type copy. On the other hand, the term “knock-out” refers to the elimination of a gene or the expression of a gene. For example, a gene can be knocked out by either a deletion or an addition of a nucleotide sequence that leads to a disruption of the reading frame. As another example, a gene may be knocked out by replacing a part of the gene with an irrelevant (e.g., non-coding) sequence.
As used herein, the term “non-homologous end joining” or NHEJ refers to a cellular process in which cut or nicked ends of a DNA strand are directly ligated without the need for a homologous template nucleic acid. NHEJ can lead to the addition, the deletion, substitution, or a combination thereof, of one or more nucleotides at the repair site.
As used herein, the term “homology directed repair” or HDR refers to a cellular process in which cut or nicked ends of a DNA strand are repaired by polymerization from a homologous template nucleic acid. Thus, the original sequence is replaced with the sequence of the template. The homologous template nucleic acid can be provided by homologous sequences elsewhere in the genome (sister chromatids, homologous chromosomes, or repeated regions on the same or different chromosomes). Alternatively, an exogenous template nucleic acid can be introduced to obtain a specific HDR-induced change of the sequence at the target site. In this way, specific mutations can be introduced at the cut site.
The terms “vector” and “plasmid” are used interchangeably and as used herein refer to polynucleotide vehicles useful to introduce genetic material into a cell. Vectors can be linear or circular. Vectors can integrate into a target genome of a host cell or replicate independently in a host cell. Vectors can comprise, for example, an origin of replication, a multicloning site, and/or a selectable marker. An expression vector typically comprises an expression cassette. Vectors and plasmids include, but are not limited to, integrating vectors, prokaryotic plasmids, eukaryotic plasmids, plant synthetic chromosomes, episomes, viral vectors, cosmids, and artificial chromosomes.
As used herein the term “expression cassette” is a polynucleotide construct, generated recombinantly or synthetically, comprising regulatory sequences operably linked to a selected polynucleotide to facilitate expression of the selected polynucleotide in a host cell. For example, the regulatory sequences can facilitate transcription of the selected polynucleotide in a host cell, or transcription and translation of the selected polynucleotide in a host cell. An expression cassette can, for example, be integrated in the genome of a host cell or be present in an expression vector.
As used herein, the phrase “subject in need thereof” refers to a subject that exhibits and/or is diagnosed with one or more symptoms or signs of a disease or disorder as described herein.
A “chemotherapeutic agent” refers to a chemical compound useful in the treatment of cancer. Chemotherapeutic agents include “anti-hormonal agents” or “endocrine therapeutics” which act to regulate, reduce, block, or inhibit the effects of hormones that can promote the growth of cancer.
The term “composition” refers to a mixture that contains, e.g., an engineered cell or protein contemplated herein. In some embodiments, the composition may contain additional components, such as adjuvants, stabilizers, excipients, and the like. The term “composition” or “pharmaceutical composition” refers to a preparation which is in such form as to permit the biological activity of an active ingredient contained therein to be effective in treating a subject, and which contains no additional components which are unacceptably toxic to the subject in the amounts provided in the pharmaceutical composition.
As used herein, the term “effective amount” refers to the amount of a compound (e.g., a compositions described herein, cells described herein) sufficient to effect beneficial or desired results. An effective amount can be administered in one or more administrations, applications or dosages and is not intended to be limited to a particular formulation or administration route. As used herein, the term “treating” includes any effect, e.g., lessening, reducing, modulating, ameliorating or eliminating, that results in the improvement of the condition, disease, disorder, and the like, or ameliorating a symptom thereof.
The terms “modulate” and “modulation” refer to reducing or inhibiting or, alternatively, activating or increasing, a recited variable.
The terms “increase” and “activate” refer to an increase of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 50-fold, 100-fold, or greater in a recited variable.
The terms “reduce” and “inhibit” refer to a decrease of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 2-fold, 3-fold, 4-fold, 5-fold, 10-fold, 20-fold, 100-fold, or greater in a recited variable.
1. Safe Harbor Loci
Gene editing therapies include, for example, viral vector integration and site specific integration. Site-specific integration is a promising alternative to random integration of viral vectors, as it mitigates the risks of insertional mutagenesis or insertional oncogenesis (Kolb et al. Trends Biotechnol. 2005 23:399-406; Porteus et al. Nat Biotechnol. 2005 23:967-973; Paques et al. Curr Gen Ther. 2007 7:49-66). However, site specific integration continues to face challenges such as poor knock-in efficiency, risk of insertional oncogenesis, unstable and/or anomalous expression of adjacent genes or the transgene, low accessibility (e.g. within kB of adjacent genes), etc. These challenges can be addressed, in part, through the identification and use of safe harbor loci or safe harbor sites (SHS), which are sites in which genes or genetic elements can be incorporated without disruption to expression or regulation of adjacent genes.
The most widely used of the putative human safe harbor sites is the AAVS1 site on chromosome 19q, which was initially identified as a site for recurrent adenoassociated virus insertion. Other potential SHS have been identified on the basis of homology, with sites first identified in other species (e.g., the human homolog of the permissive murine Rosa26 locus) or among the growing number of human genes that appear non-essential under some circumstances. One putative SHS of this type is the CCR5 chemokine receptor gene, which, when disrupted, confers resistance to human immunodeficiency virus infection. Additional potential genomic SHS have been identified in human and other cell types on the basis of viral integration site mapping or gene-trap analyses, as was the original murine Rosa26 locus. The three top SHS, AAVS1, CCR5, and Rosa26, are in close proximity to many protein coding genes and regulatory elements. (See FIG. 2 from Sadelain, M., et al. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58, the relevant disclosures of which are herein incorporated by reference in their entirety).
The AAVS1 (also known as the PPP 1R12C locus) on human chromosome 19 is a known SHS for hosting transgenes (e.g. DNA transgenes) with expected function. It is at position 19q13.42. It has an open chromatin structure and is transcription-competent. The canonical SHS locus for AAVS1 is chr19: 55,625,241-55,629,351. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference. An exemplary AAVS1 target gRNA and target sequence are provided below:
AAVS1-gRNA sequence:
(SEQ ID NO: 121)
ggggccactagggacaggatGTTTTAGAGCTAGAA
ATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAAC
TTGAAAAAGTGGCACCGAGTCGGTGCTTTTTTT
AAVS1 target sequence:
(SEQ ID NO: 122)
ggggccactagggacaggat
CCR5, which is located on chromosome 3 at position 3p21.31, encodes the major co-receptor for HIV-1. Disruption at this site in the CCR5 gene has been beneficial in HIV/AIDS therapy and prompted the development of zinc-finger nucleases that target its third exon. The canonical SHS locus for CCR5 is chr3: 46,414,443-46,414,942. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.
The mouse Rosa26 locus is particularly useful for genetic modification as it can be targeted with high efficiency and is expressed in most cell types tested. Irion et al. 2007 (“Identification and targeting of the ROSA26 locus in human embryonic stem cells.” Nature biotechnology 25.12 (2007): 1477-1482, the relevant disclosure of which are herein incorporated by reference) identified the human homolog, human ROSA26, in chromosome 3 (position 3p25.3). The canonical SHS locus for human Rosa26 (hRosa26) is chr3: 9,415,082-9,414,043. See Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.
Additional examples of safe harbor sites are provided in Pellenz et al. “New Human Chromosomal Sites with “Safe Harbor” Potential for Targeted Transgene Insertion.” Human gene therapy vol. 30,7 (2019): 814-828, the relevant disclosures of which are herein incorporated by reference.
The present disclosure is directed to methods for identifying safe harbor loci with benefits including, but not limited to, high knock-in efficiency and high expression of transgene. An example of applications of the presently disclosed methods is the identification of safe harbor loci for insertion of transgenes (e.g., chimeric antigen receptors (CAR)) into T-cells. In some embodiments, the safe harbor loci of the present disclosure are useful for the insertion of a sequence encoding a transgene. In some embodiments, the safe harbor sites allow for high transgene expression (sufficient to allow for transgene functionality or treatment of a disease of interest) and stable expression of the transgene over several days, weeks or months. In some embodiments, knockout of the gene at the safe harbor locus confers benefit to the function of the cell, or the gene at the safe harbor locus has no known function within the cell. In some embodiments the safe harbor locus results in stable transgene expression in vitro with or without CD3/CD28 stimulation, negligible off-target cleavage as detected by iGuide-Seq or CRISPR-Seq, less off-target cleavage relative to other loci as detected by iGuide-Seq or CRISPR-Seq, negligible transgene-independent cytotoxicity, negligible transgene-independent cytokine expression, negligible transgene-independent chimeric antigen receptor expression, negligible deregulation or silencing of nearby genes, and positioned outside of a cancer-related gene.
As used, a “nearby gene” can refer to a gene that is within about 100 kB, about 125 kB, about 150 kB, about 175 kB, about 200 kB, about 225 kB, about 250 kB, about 275 kB, about 300 kB, about 325 kB, about 350 kB, about 375 kB, about 400 kB, about 425 kB, about 450 kB, about 475 kB, about 500 kB, about 525 kB, about 550 kB away from the safe harbor locus (integration site).
In some embodiments, the present disclosure contemplates inserts that comprise one or more transgenes. The transgene can encode a therapeutic protein, an antibody, a peptide, a suicide gene, an apoptosis gene or any other gene of interest. The safe harbor loci identified using the method described herein allow for transgene integration that results in, for example, enhanced therapeutic properties. These enhanced therapeutic properties, as used herein, refer to an enhanced therapeutic property of a cell when compared to a typical immune cell of the same normal cell type. For example, an NK cell having “enhanced therapeutic properties” has an enhanced, improved, and/or increased treatment outcome when compared to a typical, unmodified and/or naturally occurring NK cell. The therapeutic properties of immune cells can include, but are not limited to, cell transplantation, transport, homing, viability, self-renewal, persistence, immune response control and regulation, survival, and cytotoxicity. The therapeutic properties of immune cells are also manifested by: antigen-targeted receptor expression; HLA presentation or lack thereof; tolerance to the intratumoral microenvironment; induction of bystander immune cells and immune regulation; improved target specificity with reduction; resistance to treatments such as chemotherapy.
As used herein, the term “insert size” refers to the length of the nucleotide sequence being integrated (inserted) at the safe harbor site. In some embodiments, the insert size comprises at least about 100, 200, 300, 400 or 500 basepairs. In some embodiments, the insert size comprises about 500 nucleotides or basepairs. In some embodiments, the insert size comprises up to 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 kbp (kilo basepairs) or the sizes in between. In some embodiments, the insert size is greater than 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 kbp or the sizes in between. In some embodiments, the insert size is within the range of 3-15 kbp or is any number in that range. In some embodiments, the insert size is within the range of 1.5-8.3 kbp or is any number in that range. In some embodiments, the insert size is within the range of 1.5-15 kbp or is any number in that range. In some embodiments, the insert size is within the range of 0.5-20 kbp or is any number in that range. In some embodiments, the insert size is 0.5-10, 0.6-10, 0.7-10, 0.8-10, 0.9-10, 1-10, 2-10, 3-10, 4-10, 5-10, 6-10, 7-10, 8-10, 9-10 kbp. In some embodiments, the insert size is 0.5-11, 0.6-11, 0.7-11, 0.8-11, 0.9-11, 1-11, 2-11, 3-11, 4-11, 5-11, 6-11, 7-11, 8-11, 9-11, or 10-11 kbp. In some embodiments, the insert size is 0.5-12, 0.6-12, 0.7-12, 0.8-12, 0.9-12, 1-12, 2-12, 3-12, 4-12, 5-12, 6-12, 7-12, 8-12, 9-12, 10-12, or 11-12 kbp. In some embodiments, the insert size is 0.5-13, 0.6-13, 0.7-13, 0.8-13, 0.9-13, 1-13, 2-13, 3-13, 4-13, 5-13, 6-13, 7-13, 8-13, 9-13, 10-13, 11-13, or 12-13 kbp. In some embodiments, the insert size is 0.5-14, 0.6-14, 0.7-14, 0.8-14, 0.9-14, 1-14, 2-14, 3-14, 4-14, 5-14, 6-14, 7-14, 8-14, 9-14, 10-14, 11-14, 12-14 or 13-14 kbp. In some embodiments, the insert size is 0.5-15, 0.6-15, 0.7-15, 0.8-15, 0.9-15, 2-15, 3-15, 4-15, 5-15, 6-15, 7-15, 8-15, 9-15, 10-15, 11-15, 12-15, 13-15, or 14-15 kbp. In some embodiments, the insert size is 0.5-16, 0.6-16, 0.7-16, 0.8-16, 0.9-16, 1-16, 2-16, 3-16, 4-16, 5-16, 6-16, 7-16, 8-16, 9-16, 10-16, 11-16, 12-16, 13-16, 14-16 or 15-16 kbp. In some embodiments, the insert size is 0.5-17, 0.6-17, 0.7-17, 0.8-17, 0.9-17, 1-17, 2-17, 3-17, 4-17, 5-17, 6-17, 7-17, 8-17, 9-17, 10-17, 11-17, 12-17, 13-17, or 14-17, 15-17 or 16-17 kbp. In some embodiments, the insert size is 0.5-18, 0.6-18, 0.7-18, 0.8-18, 0.9-18, 1-18, 2-18, 3-18, 4-18, 5-18, 6-18, 7-18, 8-18, 9-18, 10-18, 11-18, 12-18, 13-18, 14-18, 15-18, 16-18 or 17-18 kbp. In some embodiments, the insert size is 0.5-19, 0.6-19, 0.7-19, 0.8-19, 0.9-19, 1-19, 2-19, 3-19, 4-19, 5-19, 6-19, 7-19, 8-19, 9-19, 10-19, 11-19, 12-19, 13-19, 14-0.7-20, 19, 15-19, 16-19, 17-19, or 18-19 kbp. In some embodiments, the insert size is 0.5-20, 0.6-20, 0.7-20, 0.8-20, 0.9-20, 1-20, 2-20, 3-20, 4-20, 5-20, 6-20, 7-20, 8-20, 9-20, 10-20, 11-20, 12-20, 13-20, 14-20, 15-20, 16-20, 17-20, 18-20, or 19-20 kbp.
The inserts of the present disclosure refer to nucleic acid molecules or polynucleotide inserted at a safe harbor site. In some embodiments, the nucleotide sequence is a DNA molecule, e.g., genomic DNA, or comprises deoxy-ribonucleotides. In some embodiments, the insert comprises a smaller fragment of DNA, such as a plastid DNA, mitochondrial DNA, or DNA isolated in the form of a plasmid, a fosmid, a cosmid, a bacterial artificial chromosome (BAC), a yeast artificial chromosome (YAC), and/or any other sub-genome segment of DNA. In some embodiments, the insert is an RNA molecule or comprises ribonucleotides. The nucleotides in the insert are contemplated as naturally occurring nucleotides, non-naturally occurring, and modified nucleotides. Nucleotides may be modified chemically or biochemically, or may contain non-natural or derivatized nucleotide bases, as will be readily appreciated by those of skill in the art. Such modifications include, for example, labels, methylation, substitution of one or more of the naturally occurring nucleotides with an analog, internucleotide modifications. The polynucleotides can be in any topological conformation, including single-stranded, double-stranded, partially duplexed, triplexed, hairpinned, circular conformations, and other three-dimension conformations contemplated in the art.
The inserts can have coding and/or non-coding regions. The insert can comprises a non-coding sequence (e.g., control elements, e.g., a promoter sequence). In some embodiments, the insert encodes transcription factors. In some embodiments, the insert encodes an antigen binding receptors such as single receptors, T-cell receptors (TCRs), syn-notch, CARs, mAbs, etc. In some embodiments, the inserts are RNAi molecules, including, but not limited to, miRNAs, siRNA, shRNAs, etc. In some embodiments, the insert is a human sequence. In some embodiments, the insert is chimeric. In some embodiments, the insert is a multi-gene/multi-module therapeutic cassette. A multi-gene/multi-module therapeutic cassette referst to an insert or cassette having one or more than one receptor (e.g., synthetic receptors), other exogenous protein coding sequences, non-coding RNAs, transcriptional regulatory elements, and/or insulator sequences, etc.
Various cell types are contemplated as having the safe harbor sites in the present disclosure. A cell comprising a safe harbor site and/or a cell comprising an insert at a safe harbor site as described in the present disclosure can be referred to as an engineered cell. The cells can include, but are not limited to, eukaryotic cells, prokaryotic cells, animal cells, plant cells, fungal cells and the like. Optionally, the cell is a mammalian cell, for example, a human cell. In some embodiments, that engineered cell is a stem cell, a human cell, a primary cell, an hematopoietic cell, an adaptive immune cell, an innate immune cell, a T cell or a T cell progenitor. Non-limiting examples of immune cells that are contemplated in the present disclosure include T cell, B cell, natural killer (NK) cell, NKT/iNKT cell, macrophage, myeloid cell, and dendritic cells. Non-limiting examples of stem cells that are contemplated in the present disclosure include pluripotent stem cells (PSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), embryo-derived embryonic stem cells obtained by nuclear transfer (ntES; nuclear transfer ES), male germline stem cells (GS cells), embryonic germ cells (EG cells), hematopoietic stem/progenitor stem cells (HSPCs), somatic stem cells (adult stem cells), hemangioblasts, neural stem cells, mesenchymal stem cells and stem cells of other cells (including osteocyte, chondrocyte, myocyte, cardiac myocyte, neuron, tendon cell, adipocyte, pancreocyte, hepatocyte, nephrocyte and follicle cells and so on). In some embodiments, the engineered cells is a T cell, NK cells, iPSC, and HSPC. In some embodiments, the engineered cells used in the present disclosure are human cell lines grown in vitro (e.g. deliberately immortalized cell lines, cancer cell lines, etc.).
The methods for integrating the inserts at the safe harbor sites can be viral or non-viral delivery techniques.
In some embodiments, the nucleic acid sequence is inserted into the genome of the engineered cell by introducing a vector, for example, a viral vector, comprising the nucleic acid. Examples of viral vectors include, but are not limited to, adeno-associated viral (AAV) vectors, retroviral vectors or lentiviral vectors. In some embodiments, the lentiviral vector is an integrase-deficient lentiviral vector.
In some embodiments, the nucleic acid sequence is inserted into the genome of the T cell via non-viral delivery. In non-viral delivery methods, the nucleic acid can be naked DNA, or in a non-viral plasmid or vector. Non-viral delivery techniques can be site-specific integration techniques, as described herein or known to those of ordinary skill in the art. Examples of site-specific techniques for integration into the safe harbor loci include, without limitation, homology-dependent engineering using nucleases and homology independent targeted insertion using Cas9.
In some embodiments, the insert is integrated at a safe harbor site by introducing into the engineered cell, (a) a targeted nuclease that cleaves a target region in the safe harbor site to create the insertion site; and (b) the nucleic acid sequence (insert), wherein the insert is incorporated at the insertion site by, e.g., HDR. Examples of non-viral delivery techniques that can be used in the methods of the present disclosure are provided in U.S. application Ser. Nos. 16/568,116 and 16/622,843, the relevant disclosures of which are herein incorporated by reference in their entirety.
2. CAR T Cell Therapy
Chimeric antigen receptor (CAR) T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor for use in immunotherapy. Chimeric antigen receptors are receptor proteins that have been engineered to confer T cells with the ability to target a specific protein. The genetic modification of lymphocytes (e.g. T cells) by incorporation of, for example, CARs, and administration of the engineered cells to a subject is an example of “adoptive cell therapy”. As used herein, the term “adoptive cell therapy” refers to cell-based immunotherapy for transfusion of autologous or allogeneic lymphocytes, referred to as T cells or B cells. In this CAR therapy approach, cells are expanded and cultured ex vivo and genetically modified, prior to transfusion.
The expression of CARs allows the engineered T-cells to target and bind specific proteins, for example, tumor antigens. In CAR therapy, T-cells are harvested from a subject—they can be autologous T-cells from the subject own blood or from a donor that will not be receiving the CAR therapy. Once isolated, the T-cells are genetically modified with a CAR, expanded ex vivo, and administered to the subject (i.e. patient) by, e.g. infusion.
The CARs may be introduced into the T-cells using, for example, a viral technique (e.g., retroviral integration) or site-specific technique. With site specific integration of the transgenes (e.g. CARs), the transgenes may be targeted to a safe harbor locus. Examples of site-specific techniques for integration into the safe harbor loci include, without limitation, homology-dependent engineering using nucleases and homology independent targeted insertion using Cas9.
The engineered CAR T cells have applications to immune-oncology. The CAR, for example, can be selected to target a specific tumor antigen. Examples of cancers that can be effectively targeted using CAR T cells are blood cancers. In some embodiments, CAR T cell therapy can be used to treat solid tumors.
3. Gene Editing
The terms “gene editing” or “genome editing”, as used herein, refer to a type of genetic manipulation in which DNA is inserted, replaced, or removed from the genome using artificially manipulated nucleases or “molecular scissors”. It is a useful tool for elucidating the function and effect of sequence-specific genes or proteins or altering cell behavior (e.g. for therapeutic purposes).
Currently available genome editing tools include zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALENs) to incorporate genes at safe harbor loci (e.g. the adeno-associated virus integration site 1 (AAVS1) safe harbor locus). The DICE (dual integrase cassette exchange) system utilizing phiC31 integrase and Bxb1 integrase is a tool for target integration. Additionally, clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) techniques can be used for targeted gene insertion.
Site specific gene editing approaches can include homology dependent mechanisms or homology independent mechanisms.
All methods known in the art for targeted insertion of gene sequences are contemplated in the methods described herein to insert constructs at safe harbor loci.
4. Crispr-Cas Gene Editing
One effective example of gene editing is the Crisp-Cas approach (e.g. Crispr-Cas9). This approach incorporates the use of a guide polynucleotide (e.g. guide ribonucleic acid or gRNA) and a cas endonuclease (e.g. Cas9 endonuclease).
As used herein, a polypeptide referred to as a “Cas endonuclease” or having “Cas endonuclease activity” refers to a CRISPR-related (Cas) polypeptide encoded by a Cas gene, wherein a Cas polypeptide is a target DNA sequence that can be cleaved when operably linked to one or more guide polynucleotides (see, e.g., U.S. Pat. No. 8,697,359). Also included in this definition are variants of Cas endonuclease that retain guide polynucleotide-dependent endonuclease activity. The Cas endonuclease used in the donor DNA insertion method detailed herein is an endonuclease that introduces double-strand breaks into DNA at the target site (e.g., within the target locus or at the safe harbor site).
As used herein, the term “guide polynucleotide” relates to a polynucleotide sequence capable of complexing with a Cas endonuclease and allowing the Cas endonuclease to recognize and cleave a DNA target site. The guide polynucleotide can be a single molecule or a double molecule. The guide polynucleotide sequence can be an RNA sequence, a DNA sequence, or a combination thereof (RNA-DNA combination sequence). A guide polynucleotide comprising only ribonucleic acid is also referred to as “guide RNA”. In some embodiments, a polynucleotide donor construct is inserted at a safe harbor locus using a guide RNA (gRNA) in combination with a cas endonuclease (e.g. Cas9 endonuclease).
The guide polynucleotide includes a first nucleotide sequence domain (also referred to as a variable targeting domain or VT domain) that is complementary to a nucleotide sequence in the target DNA, and a second nucleotide that interacts with a Cas endonuclease polypeptide. It can be a double molecule (also referred to as a double-stranded guide polynucleotide) comprising a sequence domain (referred to as a Cas endonuclease recognition domain or CER domain). The CER domain of this double molecule guide polynucleotide comprises two separate molecules that hybridize along the complementary region. The two separate molecules can be RNA sequences, DNA sequences and/or RNA-DNA combination sequences.
Genome editing using CRISPR-Cas approaches relies on the repair of site-specific DNA double-strand breaks (DSBs) induced by the RNA-guided Cas endonuclease (e.g. Cas 9 endonuclease). Homology-directed repair (HDR) of these DSBs enables precise editing of the genome by introducing defined genomic changes, including base substitutions, sequence insertions, and deletions. Conventional HDR-based CRISPR/Cas9 genome-editing involves transfecting cells with Cas9, gRNA and donor DNA containing homologous arms matching the genomic locus of interest.
HITI (homology independent targeted insertion) uses a non-homologous end joining (NHEJ)-based homology-independent strategy and the method can be more efficient than HDR. Guide RNAs (gRNAs) target the insertion site. For HITI, donor plasmids lack homology arms and DSB repair does not occur through the HDR pathway. The donor polynucleotide construct can be engineered to include Cas9 cleavage site(s) flanking the gene or sequence to be inserted. This results in Cas9 cleavage at both the donor plasmid and the genomic target sequence. Both target and donor have blunt ends and the linearized donor DNA plasmid is used by the NHEJ pathway resulting integration into the genomic DSB site. (See, for example, Suzuki, K., et al. (2016). In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature, 540(7631), 144-149, the relevant disclosures of which are herein incorporated in their entirety).
Methods for conducing gene editing using CRISPR-Cas approaches are known to those of ordinary skill in the art. (See, for example, U.S. application Ser. No. 16/312,676, U.S. Ser. No. 15/303,722, and U.S. Ser. No. 15/628,533, the disclosures of which are herein incorporated by reference in their entirety). Additionally, uses of endonucleases for inserting transgenes into safe harbor loci are described, for example, in U.S. application Ser. No. 13/036,343, the disclosures of which are herein incorporated by reference in their entirety.
The guide RNAs and/or mRNA (or DNA) encoding an endonuclease can be chemically linked to one or more moieties or conjugates that enhance the activity, cellular distribution, or cellular uptake of the oligonucleotide. Non-limiting examples of such moieties include lipid moieties such as a cholesterol moiety, cholic acid, a thioether, a thiocholesterol, an aliphatic chain (e.g., dodecandiol or undecyl residues), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate, a polyamine or a polyethylene glycol chain, adamantane acetic acid, a palmityl moiety and an octadecylamine or hexylamino-carbonyl-t oxycholesterol moiety. See for example U.S. application Ser. No. 15/715,068, the disclosures of which are herein incorporated by reference in their entirety.
5. Therapeutic Applications
For therapeutic applications, the engineered cells, populations thereof, or compositions thereof are administered to a subject, generally a mammal, generally a human, in an effective amount.
The engineered cells may be administered to a subject by infusion (e.g., continuous infusion over a period of time) or other modes of administration known to those of ordinary skill in the art.
The engineered cells provided herein can be administered as part of a pharmaceutical compositions. In some embodiments, the present disclosure provides compositions comprising a guide RNA of the present disclosure. The pharmaceutical composition may comprise one or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, and one of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference in its entirety.
The engineered cells provided herein not only find use in gene therapy but also in non-pharmaceutical uses such as, e.g., production of animal models and production of recombinant cell lines expressing a protein of interest.
The engineered cells of the present disclosure can be any cell, generally a mammalian cell, generally a human cell that has been modified by integrating a transgene at a safe harbor locus described herein. In some embodiments, the engineered cells are immune cells. In some embodiments, the engineered cells are lymphocytes. In some embodiments, the engineered cells are T cells or T cell precursors.
The engineered cells, compositions and methods of the present disclosure are useful for therapeutic applications such as CAR T cell therapy and TCR T cell therapy. In some embodiments, the insertion of a sequence encoding a transgene within a safe harbor locus maintains the TCR expression relative to instances when there is no insertion and enables transgene expression while maintaining TCR function.
Various diseases treated using the engineered cells, populations thereof, or compositions thereof are provided herein. Non-limiting examples of such diseases include alopecia areata, autoimmune hemolytic anemia, autoimmune hepatitis, cancer, dermatomyositis, diabetes (type 1), certain juvenile idiopathic arthritis, glomerulonephritis, Graves' disease, Guillain Valley Syndrome, idiopathic thrombocytopenic purpura, myasthenia gravis, certain myocarditis, multiple sclerosis, pemphigus/pemphigoid, pernicious anemia, polyarteritis nodosa, polymyositis, primary bile With cirrhosis, psoriasis, rheumatoid arthritis, scleroderma/systemic sclerosis, Sjogren's syndrome, systemic lupus erythematosus, certain thyroiditis, certain uveitis, vitiligo, multiple vasculitis (Wegener)); autoimmune disorders including, but not limited to, granulomatosis; hematopoietic tumors including but not limited to acute and chronic leukemia, lymphoma, multiple myeloma and myelodysplastic syndrome; tumors of the prostate, breast, lung, colon, uterus, skin, liver, bone, pancreas, ovary, testis, bladder, kidney, head, neck, stomach, cervix, rectum, larynx, or esophagus solid tumors; HIV (human immunodeficiency virus) related disorders, RSV (respiratory syncytial virus) related disorders; EBV (Epstein-Barr virus) related disorders; CMV (cytomegalovirus) related disorders; and infectious diseases including, but not limited to, adenovirus-related disorders and BK polyomavirus-related disorders.
Cancers that can be treated with the engineered cells (e.g., CAR T-cells) of the present disclosure, populations thereof, or compositions thereof include blood cancers. In some embodiments, the cancer treated using the engineered cells (e.g., CAR T-cells) described herein, populations thereof, or compositions thereof is a hematologic malignancy or leukemia. In some embodiments, the engineered cells (e.g., CAR T-cells) described herein, populations thereof, or compositions thereof are used for the treatment of acute lymphoblastic leukemia (ALL) or diffuse large B-cell lymphoma (DLBCL). In some embodiments, the cancer is acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), myelodysplasia, myelodysplastic syndromes, acute T-lymphoblastic leukemia, or acute promyelocytic leukemia, chronic myelomonocytic leukemia, or myeloid blast crisis of chronic myeloid leukemia. Examples of cancers treatable using the engineered cells (e.g., CAR T-cells) described herein include, without limitation, breast cancer, ovarian cancer, esophageal cancer, bladder or gastric cancer, salivary duct carcinoma, salivary duct carcinomas, adenocarcinoma of the lung or aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma. In some other embodiments, the cancer is brain cancer, breast cancer, cervical cancer, colon cancer, colorectal cancer, endometrial cancer, esophageal cancer, leukemia, lung cancer, liver cancer, melanoma, ovarian cancer, pancreatic cancer, rectal cancer, renal cancer, stomach cancer, testicular cancer, or uterine cancer. In yet other embodiments, the cancer is a squamous cell carcinoma, adenocarcinoma, small cell carcinoma, melanoma, neuroblastoma, sarcoma (e.g., an angiosarcoma or chondrosarcoma), larynx cancer, parotid cancer, biliary tract cancer, thyroid cancer, acral lentiginous melanoma, actinic keratoses, acute lymphocytic leukemia, acute myeloid leukemia, adenoid cystic carcinoma, adenomas, adenosarcoma, adenosquamous carcinoma, anal canal cancer, anal cancer, anorectum cancer, astrocytic tumor, bartholin gland carcinoma, basal cell carcinoma, biliary cancer, bone cancer, bone marrow cancer, bronchial cancer, bronchial gland carcinoma, carcinoid, cholangiocarcinoma, chondrosarcoma, choroid plexus papilloma/carcinoma, chronic lymphocytic leukemia, chronic myeloid leukemia, clear cell carcinoma, connective tissue cancer, cystadenoma, digestive system cancer, duodenum cancer, endocrine system cancer, endodermal sinus tumor, endometrial hyperplasia, endometrial stromal sarcoma, endometrioid adenocarcinoma, endothelial cell cancer, ependymal cancer, epithelial cell cancer, Ewing's sarcoma, eye and orbit cancer, female genital cancer, focal nodular hyperplasia, gallbladder cancer, gastric antrum cancer, gastric fundus cancer, gastrinoma, glioblastoma, glucagonoma, heart cancer, hemangioblastomas, hemangioendothelioma, hemangiomas, hepatic adenoma, hepatic adenomatosis, hepatobiliary cancer, hepatocellular carcinoma, Hodgkin's disease, ileum cancer, insulinoma, intraepithelial neoplasia, interepithelial squamous cell neoplasia, intrahepatic bile duct cancer, invasive squamous cell carcinoma, jejunum cancer, joint cancer, Kaposi's sarcoma, pelvic cancer, large cell carcinoma, large intestine cancer, leiomyosarcoma, lentigo maligna melanomas, lymphoma, male genital cancer, malignant melanoma, malignant mesothelial tumors, medulloblastoma, medulloepithelioma, meningeal cancer, mesothelial cancer, metastatic carcinoma, mouth cancer, mucoepidermoid carcinoma, multiple myeloma, muscle cancer, nasal tract cancer, nervous system cancer, neuroepithelial adenocarcinoma nodular melanoma, non-epithelial skin cancer, non-Hodgkin's lymphoma, oat cell carcinoma, oligodendroglial cancer, oral cavity cancer, osteosarcoma, papillary serous adenocarcinoma, penile cancer, pharynx cancer, pituitary tumors, plasmacytoma, pseudosarcoma, pulmonary blastoma, rectal cancer, renal cell carcinoma, respiratory system cancer, retinoblastoma, rhabdomyosarcoma, sarcoma, serous carcinoma, sinus cancer, skin cancer, small cell carcinoma, small intestine cancer, smooth muscle cancer, soft tissue cancer, somatostatin-secreting tumor, spine cancer, squamous cell carcinoma, striated muscle cancer, submesothelial cancer, superficial spreading melanoma, T cell leukemia, tongue cancer, undifferentiated carcinoma, ureter cancer, urethra cancer, urinary bladder cancer, urinary system cancer, uterine cervix cancer, uterine corpus cancer, uveal melanoma, vaginal cancer, verrucous carcinoma, VIPoma, vulva cancer, well-differentiated carcinoma, or Wilms tumor.
In some embodiments, the present disclosure provides methods of treating a subject in need of treatment by administering to the subject a composition comprising any of the engineered cells described herein. As used, the terms “treat,” “treatment,” and the like refer generally to obtaining a desired pharmacological and/or physiological effect. That effect is preventive in terms of complete or partial prevention of the disease and/or therapeutic in terms of partial or complete cure of the disease and/or adverse effects resulting from the disease. The term “treatment”, as used herein, encompasses any treatment of a disease in a subject (e.g., mammal, e.g., human). Treatment may also refer to the administration of the engineered cells provided herein to a subject that is susceptible to the disease but has not yet been diagnosed as suffering from it, including preventing the disease from occurring; inhibiting disease progression; or reducing the disease (i.e., causing a regression of the disease). Further, treatment may stabilize or reduce undesirable clinical symptoms in subjects (e.g., patients). The cells provided herein populations thereof, or compositions thereof may be administered before, during or after the occurrence of the disease or injury.
In certain embodiments, the subject has a disease, condition, and/or injury that can be treated and/or ameliorated by cell therapy. In some embodiments, the subject in need of cell therapy is a subject having an injury, disease, or condition, thereby causing cell therapy (e.g., therapy in which cellular material is administered to the subject). However, it is contemplated that it is possible to treat, ameliorate and/or reduce the severity of at least one symptom associated with the injury, disease or condition. In certain embodiments, a subject in need of cell therapy includes, but is not limited to, a bone marrow transplant or stem cell transplant candidate, a subject who has received chemotherapy or radiation therapy, a hyperproliferative disease or cancer (e.g., a hematopoietic system), a subject having or at risk of developing a hyperproliferative disease or cancer), a subject having or at risk of developing a tumor (e.g., solid tumor), viral infection or virus. It is also intended to encompass subjects suffering from or at risk of suffering from a disease associated with an infection.
In some embodiments, the present disclosure provides a composition of the present disclosure along with instructions for use. The instructions for use can be present in the kits as a package insert, in the labeling of the container of the kit or components thereof, or can be in digital form (e.g. on a CD-ROM, via a link on the internet). A kit can include one or more of a genome-targeting nucleic acid, a polynucleotide encoding a genome-targeting nucleic acid, a site-directed polypeptide, and/or a polynucleotide encoding a site-directed polypeptide. Additional components within the kits are also contemplated, for example, buffer (such as reconstituting buffer, stabilizing buffer, diluting buffer), and/or one or more control vectors.
6. Combination Therapies
In some embodiments, an engineered cells of the present disclosure or composition thereof is administered with at least one additional therapeutic agent. Any suitable additional therapeutic agent may be administered with an engineered cell provided herein, populations thereof, or compositions thereof. In some aspects, the additional therapeutic agent is selected from radiation, an ophthalmologic agent, a cytotoxic agent, a chemotherapeutic agent, a cytostatic agent, an anti-hormonal agent, an immunostimulatory agent, an anti-angiogenic agent, and combinations thereof.
In some embodiments, an engineered cell of the present disclosure or composition thereof is administered with a steroid. The administration of a steroid can prevent or mitigate the risk of a subject receiving the engineered cell(s) or composition thereof having an autoimmune reaction.
The additional therapeutic agent may be administered by any suitable means. In some embodiments, the engineered cells described herein, populations thereof, or compositions thereof and the additional therapeutic agent is administered in the same pharmaceutical composition, e.g. by infusion. In some embodiments, the engineered cells described herein and additional therapeutic agent are included in different pharmaceutical compositions.
The pharmaceutical composition may comprise one or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, and one of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference in its entirety.
Various modes of administering the additional therapeutic agents are contemplated herein. In some embodiments, the additional therapeutic agent is administered by any suitable mode of administration. Generally, modes of administration include, without limitation, intravitreal, subretinal, suprachoroidal, intraarterial, intradermal, intramuscular, intraperitoneal, intravenous, nasal, parenteral, topical, pulmonary, and subcutaneous routes.
In embodiments where the engineered cells provided herein and the additional therapeutic agent are included in different pharmaceutical compositions, administration of the engineered cells provided herein can occur prior to, simultaneously, and/or following, administration of the additional therapeutic agent.
EXAMPLES The following are examples of methods and compositions of the invention. It is understood that various other embodiments may be practiced, given the general description provided herein.
Below are examples of specific embodiments for carrying out the present invention. The examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperatures, etc.), but some experimental error and deviation should, of course, be allowed for.
The practice of the present invention will employ, unless otherwise indicated, conventional methods of protein chemistry, biochemistry, recombinant DNA techniques and pharmacology, within the skill of the art. Such techniques are explained fully in the literature. See, e.g., T. E. Creighton, Proteins: Structures and Molecular Properties (W.H. Freeman and Company, 1993); A. L. Lehninger, Biochemistry (Worth Publishers, Inc., current addition); Sambrook, et al., Molecular Cloning: A Laboratory Manual (2nd Edition, 1989); Methods In Enzymology (S. Colowick and N. Kaplan eds., Academic Press, Inc.); Remington's Pharmaceutical Sciences, 18th Edition (Easton, Pennsylvania: Mack Publishing Company, 1990).
Example 1: Identification of Knock-In Loci in Coding Regions The objective of the experiments in this set of examples was to identify T-cell knock-in (KI) loci in coding regions outside of the T Cell Receptor Alpha Constant (TRAC) locus. To select candidate loci, the criteria and requirements shown in Table 1 were used.
TABLE 1
Criteria used for identification of candidate knock-in loci
within coding regions
Detailed Datasets Considered for
Criteria Requirements identification of loci
KI High expression at Knock in efficiency
efficiency d2 (day 2) data on ~90 genes
Similar expression derived from
dynamics as TRAC Roth, T. L., et al. 2019.
(stable expression (Rapid discovery of synthetic
upon activation) DNA sequences to rewrite endogenous
Accessible T cell circuits. bioRxiv, 604561.)
chromatin Bulk RNA-seq data at do, d2, d3 and d4:
gRNA editing (i) publicly available data;
efficiency (ii) data derived from Roth,
T. L., et al. 2019.
(Rapid discovery of synthetic
DNA sequences to rewrite
endogenous T cell circuits.
bioRxiv, 604561.); and
(iii) internally generated data
Bulk ATAC-seq data
at do, d2, d3 and d4:
(i) data derived from Roth,
T. L., et al. 2019.
(Rapid discovery of
synthetic DNA sequences
to rewrite endogenous T cell
circuits. bioRxiv, 604561.); and
(ii) internally generated data
Safety Does not affect T cell screening data
proliferation, Achilles' project on cancer cell lines data
cytolytic activity or Annotated oncogenes and tumor
signaling of T cells suppressors from TCGA
Annotated functions in immune cells
Be careful with
tumor suppressors
and oncogenes
Generally, the requirements for candidate KI loci within the coding regions was that the coding gene is not essential for T cell function or the knock-out of that gene would be beneficial to chimeric antigen receptor therapy (CAR T) functions.
As shown in Table 1, some of the data utilized, for comparison purposes, to identify candidate KI loci was sourced, in part, from Roth, T. L., et al. 2019 (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561), the relevant disclosures of which are herein incorporated by reference in their entirety. A summary of data in the Roth, T. L. et al. paper is shown in FIG. 3.
FIG. 4A and FIG. 4B show the processed RNA-seq data, showing that samples cluster based on activation status and by cell type. Donor 4 (AKI4) was identified as an outlier, as it clustered differently than the others, and was removed from remaining analysis. The transcript expression data from RNA-seq experiments on the 90 genes cited in the Roth, T. L. et al. paper was correlated to transcript expression data in Roth, T. L. et al. paper. (See FIG. 5A and FIG. 5B).
FIG. 6 shows the process ATAC-seq data, which focused on the 10 kb area around the transcription start site (TSS). Again, donor 4 (AK14) was identified as an outlier, based on expression profile in both CD4 and CD8 cells, and was removed from remaining analysis. The results of the remaining ATAC-seq analysis are shown in FIGS. 7A-8. The data in FIG. 7A for TSS enrichment scores also indicated that all libraries were high quality. The data on open chromatin regions around the TRAC locus revealed the highest signal near exon 3 rather than exon 1 (FIG. 8).
Determination of Knock-In Efficiency: The K1 efficiency results (obtained using the model described infra) based on the 5 donors, 2 gRNA, and 2 replicates/gRNAs from the Roth, T. L. et al. paper are shown in FIG. 9 and FIG. 10.
A linear model was built to estimate KI efficiency of approximately 90 genes using RNA-seq and ATAC-seq data. The linear model captured 33% of the variation in the data (i.e. R2=0.33). FIG. 11 shows KI efficiency versus day 2 (d2) RNA-seq data, day 4 (d4) RNA seq data, and d2 ATAC data. The linear model was applied to remaining candidate genes to estimate their KI efficiency.
The candidate coding loci were selected by first ranking all genes in the pooled data sets by predicted KI efficiency, using RNA-seq expression data from d2 (day 2). Candidate coding loci were required to be stably expressed during T cell activation (e.g., <=2-fold expression change relative to day 0 (d0). The candidate loci also had to be accessible based on ATAC-seq data. Using that selection process/requirements, 16 well-characterized coding genes (with known functions) were selected as candidate genes. The knockout of these 16 would confer a benefit to the function of CART cells (e.g. B2M, CD5, SMAD2, PTPRC, CD3E). An additional 12 coding genes with high predicted KI efficiency and no apparent essential function (inert coding genes) were selected as candidate genes. (See Table 2).
TABLE 2
KI Candidate Loci selected
Genes with Known Functions Inert Coding Genes
B2M (~70%) CD2 SUB1
CD3E (~50%) SMAD2 EDF1
PTPRC (~50%) SLC38A1 CAPNS1
CD3G (~30%) TIGIT SRP14
SOCS1 PTPN2 RTRAF APRT
Tested in Roth, T.L. et al CBLB PTPRCAP
paper (reported editing PTEN SRSF9
efficiency from Roth, PTPN6 FTL
T.L. et al paper) CD5 TRIM28
TET2 SERF2
TRAC RPS23
Example 2: Identification of Knock-In Loci in Gene Deserts The criteria for selection of candidate loci in non-coding regions or gene deserts is summarized in Table 3.
TABLE 3
Criteria used for identification of candidate knock-in loci within
non-coding regions
Datasets Considered for
Criteria Detailed Requirements identification of loci
KI Accessible chromatin Bulk ATAC-seq data
efficiency at d0, d2, d3 and d4:
(i) data derived from
Roth, T. L., et al. 2019.
(Rapid discovery of synthetic
DNA sequences to rewrite
endogenous T cell circuits.
bioRxiv, 604561.); and
(ii) internally generated data
Safety >10 kb from cancer-related Ensembl genes
genes or TADS Annotated oncogenes and tumor
>10 kb from any suppressors from TCGA
miRNA/functional small Annotated enhancers
RNAs from Encode and papers
>10 kb from any 5' gene
end
>10 kb from any regulatory
regions (ultra-conserved
elements, enhancers)
To select candidate regions within the non-coding regions, the inventors here started by looking in highly accessible regions of the genome (10 kb windows). The most accessible region overlapped with (i) annotated protein coding genes (>50% accessible regions), (ii) pseudogenes and noncoding RNAs (˜20% accessible regions), and (iii) enhancer/regulatory regions (˜20% accessible regions). The candidate genes were required to be <10 kb from the coding regions. A few regions that overlapped with long intergenic noncoding RNAs (lincRNAs) but did not have apparent function in T cells were also considered.
Examples of other criteria that have been used in the art for selection of SHS are described, for example in Pellenz, S., et al. (2019). New human chromosomal sites with “safe harbor” potential for targeted transgene insertion. Human gene therapy, 30(7), 814-828, the relevant disclosures of which are herein incorporated by reference in their entirety.
FIG. 12 is a plot showing the normalized ATAQ SEQ data for a top candidate non-coding region.
Using the above-described selection process/requirement, 11 candidate regions in gene deserts were selected. In total, there were 39 KI candidate loci, including those in coding and non-coding regions that would be evaluated as safe harbor loci (predicted loci).
Example 3: Experimental Evaluation of Predicted Loci Materials
-
- 120 sgRNAs were ordered from Synthego, 3 sgRNAs per region, and editing efficiency was assessed by next generation sequencings (NGS).
- 87 targeted coding genes
- 33 targeted gene deserts
- 189 constructs were synthesized by Genscript
- Homology arm: 450 bp each
- eGFP was used as the reporter
- Vector backbone: pUC57-Kan backbone
- 78 with endogenous promoters
- 111 with EF1a-HTLV promoter
- Constructs were sequence verified by Genscript and majority were internally verified by sequencing. The sgRNA sequences are provided in Table 4 and the construct sequences are provided in Table 5.
Methods
To evaluate the effectiveness of the predicted loci, the following were used:
-
- (87 endogenous constructs+120 exogenous construct)*2=414 wells+Controls=460
- 3 donors, 2 replicates at 3 time points: wk 1 (d6=day 6), wk 3 (d21=day 21) and wk 4 (d28=day 28)
- Controls
- DNA-only (no ribonucleoprotein (RNP)): episomal expression (n=8)
- DNA+non-targeting guides+RNP: to check if DNA delivery is more efficient with RNP (n=8)
pMax GFP was measured to check if transfection is ok (n=3).
WT cells with no electroporation
WT cells with electroporation
Controls were spread out across plates.
Cells were electroporated without RNP/HDR to check if cell counting makes sense.
2 more donors were added and changed to 3 replicates at 1 time point: wk 1 (d6)
FACS panel: GFP, TCR, Zombie
Washed every 3 wells.
The secondary data collected included: RNA-seq data: at d0, d2, and d4 (to determine stable expression) and ATAC-seq data: at d2 (to identify activated cells). The methods used for conducting the RNA-seq and ATAC-seq experiments are in Roth, T. L., et al. 2019. (Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561), which is herein incorporated by reference in its entirety.
Automated gating was performed on FACS data, using .fcs files. For constructs with endogenous promoters, all 5 donors and all 3 time points were used. For constructs with EF1a promoter, used 3 donors (donors 1-3) and 2 time points (wk 3 and wk 4).
To summarize data, wells with a % K1 efficiency (% GFP_high cells)<=10% (likely a gating error, experimental error or minimal integration) were removed. Loci were then ranked by median expression among donors and median % K1 efficiency among donors.
Loci significance was calculated using robust rank aggregation, which was the methodology used for consistent ranking of loci among donors and time points. Methods for conducting robust rank aggregation are known in the art. (See, for example, Kolde, R., et al. (2012). Robust rank aggregation for gene list integration and meta-analysis. Bioinformatics (Oxford, England), 28(4), 573-580, the disclosure of which is herein incorporated by reference in its entirety).
Results
The results from the analysis of controls and experimental groups is shown in FIGS. 13A-25.
The results of the pmax_GFP control experiments revealed that donor 5 had significantly higher cell count than other donors. Generally, the GFP_high readings decreased over time, as expected. (FIGS. 13A and 13B).
Experiments to analyze non-targeting controls for changes in episomal GFP expression, revealed that episomal GFP expression decreased to less than 0.05 over time. (FIGS. 14A and 14B) Some of the outliers were attributed to gating errors, which were most severe in donor 3. WT control experiments also exhibited <0.05 GFP_high readings, as expected (FIG. 15).
As shown in FIG. 16 and FIG. 17, there was a more consistent trend among donors when using sgRNAS to target the B2M safe harbor locus.
A comparison of GFP expression trends between sgRNA79 and sgRNA83 for TRAC insertion and expression with an endogenous reporter revealed that donor 2 trends were different between sgRNA79 and sgRNA83, while donor 4 trends were the same (FIG. 18 and FIG. 22). Some potential reasons for the observed variation between replicates and donors include:
-
- (1) manual handling of a large number of plates (e.g., FIG. 26):
- Edge effects
- Electroporation errors
- (2) Inherent differences among donors (e.g., FIG. 27):
- There were consistent differences with certain wells throughput the assay (spanning multiple weeks)
- There were variable cell numbers between donors
- (3) Gating errors (e.g. FIG. 28):
- 1 peak vs >2 peaks in GFP signals
Example 4: Ranking Loci by Expression and KI Efficiency The loci were ranked based on mean florescence intensity (MFI) of reporter gene, GFP, and KI efficiency.
FIG. 29 shows GFP MFI and KI efficiency for all significant loci having endogenous promoters. The B2M locus reported the highest GFP MFI. The TRAC locus was among the top 10 MFI. The highest GFP MFI readings were reported in week 1 and reduced slightly in weeks 3 and 4. The results also showed most top loci have more than 1 sgRNA. With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. Overall, KI efficiency showed greater variation among donors than GFP MFI.
FIG. 30 shows GFP MFI and KI efficiency for all significant loci having exogenous promoters (e.g. EF1a promoters). The TRAC locus reported the highest GFP MFI. There was comparable expression between weeks 3 and 4. The results also showed most top loci have more than 1 sgRNA. With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. Overall, KI efficiency showed less variation when driven by the exogenous promoters than when driven by endogenous promoters.
FIGS. 31A, 31B, and 31C show GFP MFI and KI efficiency for all significant loci having endogenous and exogenous (e.g., EF1a) promoters. The results showed that expression driven by EF1a promoters is about 10× higher than endogenous promoters (FIG. 31A). With regard to KI efficiency, the SOCS1 locus reported the highest KI efficiency. At weeks 3 and 4, KI efficiency was higher when driven by the exogenous promoters than when driven by endogenous promoters.
Example 5: Evaluation of TCR Expression in Candidate Noncoding Sites This experiment was conducted to identify target loci and integration sites that enable high transgene expression without disrupting the TCR. Some gene deserts (e.g. gene deserts 2, 3, 5, and 6) were identified as having high transgene expression (FIG. 32A).
To evaluate and identify preferred knock-in sites, TCR expression was measured following circuit cassette knock in of PrimeR (Prime Receptor (Myc)). Myc denotes an N-terminal Myc epitope tag to facilate detection of surface expressed primer receptor. Briefly, CD3-CD28 Dynabead-activated T cells were electroporated with sgRNA/Cas9 RNPs targeting the indicated sites (see FIGS. 32B and 33A), as well as HDRTs with homology arms directing HDR-mediated integration into the indicated sites. At day 6 post-electroporation, cells were stained with anti-TCRalpha/beta and anti-myc antibodies and analyzed on an Attune NxT flow cytometer. As shown in FIG. 32B, the TCR expression was maintained at GS94 and GS102 candidate integration (knock-in) sites. Only ⅔ of the cells that had circuit cassette knock in of PrimeR at GS79 (TRAC) locus maintained TCR expression. These results indicated that the GS94 and GS102 sites showed better potential for TCR stimulation.
The percentage of cells showing effective knock-in (based on measurements of PrimeR) was 36%±4% when using the GS94 integration site, as compared to 32%±5% when using the TRAC integration site. These results revealed integration sites, including GS94, that supported reproducibly high circuit cassette knockin rates. See FIG. 33A.
Example 6: Evaluation of GS94 Circuit Expression and Function GS94 is a candidate integration site located on chromosome 11's distal q arm. It is within 180-350 kb of the promoters for ETS1 and FLI1 (FIG. 33B), however that is considered low-risk for integration vector gene therapy. The circuit expression and function potential of the GS94 gene was evaluated.
T cells underwent circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site. The cells were cocultured with K562 C19 cells for 48 hours and then the PrimeR induced CAR MFI was compared to the PrimeR MFI.
Briefly, T cells generated as described in the Example above were cocultured with K562 CD19+/MSLN− cells at day 7 post-electroporation. MSLN (mesothelin) is a gene that is overexpressed in human pancreatic cancer. Cells were then stained with anti-FLAG antibody 48 h post initiation of coculture and analyzed on an Attune NxT flow cytometer. The results revealed that GS94 yields superior CAR induction with high prime R expression following the 48-hour coculture with the K562 C19 cells. See FIG. 34A. GS94 resulted in prime antigen-dependent CAR expression that was approximately two-fold higher than the expression in several other candidate integration sites as well as the TRAC integration site. Additionally, on average, the prime receptor surface expression level was no less than 50% of expression level when using the TRAC integration site.
Cytotoxicity and Cytokine Secretion To evaluate the effect of the candidate integration site on cytotoxicity and cytokine secretion, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site were cocultured with K562 C19/MSLN cells for 48 hours. MSLN is a gene that is overexpressed in human pancreatic cancer. The cells were treated at a 1:1 effector:target cell ratio (1:1 E:T)). Briefly, T cells generated as described above were cocultured with K562 CD19+/MSLN+ cells at day 7 post-electroporation. 48 h post initiation of coculture, supernatants were collected and analyzed via Luminex® for cytokine levels. The cytokines measure were IL-2, INFg, and TNF. Cytotoxicity was analyzed by measuring luciferase activity of remaining target cells after 48 h. Each of the data points in FIG. 34B represent two replicates and the lines represent the range of cytotoxicity for the replicates. As shown in FIG. 34B, the GS94 integration sites resulted in superior cycotoxic ability and cytokine secretion following the 48-hour coculture with K562 C19/MSLN cells.
Prime-Independent Cytotoxicity To compare the effect of the candidate integration site on cytotoxicity versus prime-independent cytotoxicity, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site were cocultured with K562 CD19+/MSLN+ cells or K562 CD19−/MSLN+ cells (“K562 MSLN”) at day 7 post-electroporation for 48 hours. 0.3, 1.0, and 3.0 E:T cell ratios were tested. See FIG. 35A and FIG. 35B. At 48 h post initiation of coculture, cytotoxicity was analyzed by measuring luciferase activity of remaining target cells As shown in FIG. 35B, the GS94 integration site resulted in equivalent cytotoxic potential to the TRAC integration site and there was no prime-independent cytotoxicity.
Prime-Independent Cytokine Section To compare the effect of the candidate integration site on cytoxicity versus prime-independent cytotoxicity, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site and GS94 integration site, generated as described above, were cocultured with K562 CD19+/MSLN+ cells. A group that had target cells only (E:T=0; Targets only) was compared to a group with an E:T cell ratio of 1. Following the 48 h coculture with the K562 CD19+/MSLN+ cells, supernatant was collected and analyzed via Luminex® for cytokine levels to measure secretion of IL-2, INFg and TNF cytokines. See FIG. 36A and FIG. 36B. As shown in FIG. 36B, the GS94 integration site resulted in equivalent cytokine secretion to the TRAC integration site and there was no prime-independent secretion of IL-2, INFg or TNF.
Prime-Independent CAR Expression To evaluate the effect of the candidate integration site on prime-independent CAR expression, T cells that had undergone circuit cassette integration with PrimeR at GS79 (TRAC) integration site, GS94 integration site, and GS102 integration site were cultured in vitro for 32 days. The cells were treated with repetitive CD3/CD28 stimulation at days 5, 12, 19 and 28 of the experiment. On Day 16, the cells were evaluated for CAR expression using a flow cytometry assay. As shown in FIG. 37, T cell activation through TCR did not result in prime R-independent CAR expression from circuit cassette integration at the candidate integration sites.
T cells generated as described above were cultured in 96-well plates, with T cell growth medium being exchanged every 2 days. At days 5, 12, 19 and 28, T cells were stimulated with 1:1 CD3/CD28 Dynabeads. Cells were analyzed for PrimeR expression by myc epitope tag staining, and for CAR expression by FLAG epitope tag staining at the indicated time points. Flow analysis was performed on an Attune NxT flow cytometer.
Example 7: Evaluating Stability of Prime Receptor Expression Over Several Weeks To evaluate the effect of the candidate integration sites on stable (sustained) expression of PrimeR, T cells that had undergone circuit cassette integration with PrimeR at the integration sites indicated in FIG. 38 were cultured in vitro for 32 days. Briefly, T cells generated as described above were cultured in 96-well plates, with T cell growth medium being exchanged every 2 days. At days 5, 12, 19 and 28, T cells were stimulated with 1:1 CD3/CD28 Dynabeads repetitive stimulation. Flow cytometry assays were run on days 16 and 32 using an Attune NxT flow cytometer. The cells were analyzed for PrimeR expression by myc epitope tag staining. As shown in FIGS. 38A and 38B, the GS94 integration site resulted in stable PrimeR expression over at least a 4-week period.
Example 8: Evaluation of On-Target Editing Efficiency To evaluate the on-target editing efficiency of candidate knock-in sites, iGUIDE-Seq assay was used. The methods used for conducting the iGUIDE-Seq assay are illustrated in FIG. 39A and provided in Nobles et al., Genome Biology (2019), which is hereby incorporated by reference in its entirety. As shown in FIG. 39B, the GS94 integration site had the highest on-target editing efficiency of the evaluated candidate integration sites. As shown in FIG. 39C, GS94 resulted in no putative off-target editing as observed with two donors.
Example 9: Evaluation of GS94 Knock-In Methods Elevation prediction: Computational predictions of potential off-target sites from (gs94) were performed using Elevation-search (algorithm described in Listgarten et al. 2018. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs. Nat Biomed Engr 2, 37-48; software obtained from github.com/Microsoft/Elevation). All sites identified by Elevation-search were subjected to analysis using rhAmp-seg™.
rhAmpSeg™: 49 candidate off-target sites for GS94 identified by iGUIDE or the Elevation prediction algorithm and the GS94 target site were characterized by rhAmpSeg™ (Integrated DNA Technologies, Inc.). This targeted amplification enables NGS-based quantification of the editing occurring at numerous sites simultaneously. Genomic DNA from T cells from at least 2 donors that had been treated singly with each of the following 7 guides: GS84, GS94, GS95, GS96, GS102, GS108, and GS138 was isolated with the GenFind® V3 DNA purification system (Beckman Coulter). Two separate rhAmpSeg™ amplification pools were used to cover the 50 loci, the procedure was performed as recommended by Integrated DNA Technologies for each of the samples. The rhAmpSeg™ libraries were sequenced on a MiniSeg™ with a Mid Output Kit (300-cycles) (Illumina). The CRISPResso2 algorithm (github.com/pinellolab/CRISPResso2) was used to determine the percentage of insertions and deletions at each of the amplified loci. Statistical significance (FDR-adjusted p-value≤0.001) using a chi-squared test was only observed at the GS94 site.
RNA-seq: To evaluate changes induced by GS94 integration at the transcriptional level, a CD19/MSLN circuit was integrated at the GS79 (TRAC), GS94, and GS102 integration sites. On day 6 post-integration, 1e6 edited cells were sorted using a BD FACSAria based on transgene expression. RNA was isolated from sorted T cells with the RNeasy kit (Qiagen). Purified RNA was converted into an NGS library using the TruSeq™ RNA Library Prep Kit v2 (Illumina). Libraries were sequenced on either the NovaSeq™ 6000 or NextSeq™ 550 instruments (Illumina). The STAR 2.7.3a aligner (Dobin A. et al. Bioinformatics. 2013. 29:15-21) was used to align the RNA-seq data against the reference human GRCh38 transcriptome and to obtain gene-level read counts. edgeR (Robinson M D et al. Bioinformatics. 2010. 26: 139-140) was used to compute differential expression, combining data across both donors. The only genes within 300 Kb of the GS94 site, ETS1 and FLI1, were not differentially expressed in cells with integration at the GS94 integration site compared to cells with integration at any of the other two loci. At an FDR-adjusted p-value cutoff of 0.01, the number of differentially expressed genes was minimal (<100 genes genome-wide).
Cytokine-independent growth assay: To evaluate the safety of the primary T cells with GS94 locus KI, cytokine-independent growth assay was performed to evaluate the potential for oncogenic transformation. Briefly, primary human T cells that had undergone CD19/MSLN circuit cassette integration at GS94 locus were thawed and recovered overnight. 1×106 cells were then seeded in one well of a 24 well-GRex plate, culturing for 5 days in the medium with or without cytokines. Cell number and viability were recorded at days 0, 3 and 5. As a positive control, 1×106 Jurkat cells were cultured in the medium without cytokines in parallel. As shown in FIG. 43, while GS94 KI T cells maintained good viability and total cell count when cultured with cytokine, the viability of GS94 KI T cells drastically decreased over the course of 5 days when cultured without cytokine and there was no viable cell left on day 5. The positive control Jurkat cells maintained good viability and expansion without cytokine throughout the assay. Taken together, this data shows that GS94 edited primary human T cells still depend on exogenous cytokine for growth, survival and expansion, therefore, there is no concern for cellular transformation.
Results The specificity of CRISPR reagents (e.g. SpCas9 complexed with sgRNA) targeting candidate loci including GS94 was evaluated by iGUIDE-seq (FIG. 40). GS94-targeting CRISPR RNP showed the highest percentage of iGUIDE-seq oligo cassette trapping events of all candidates evaluated, and the control sgRNA sequences from the iGUIDE-seq paper showed similar specificities to what was reported in the original publication, suggesting that the assay performed as expected.
Putative off-target sites were taken from the iGUIDE-seq output, which already suggested that the putative sites were spurious. Additional target sites were predicted by a computational approach (Elevation software package). rhAmp-seg™ was used to prepare high-throughput sequencing libraries for each of the putative off-target sites, and the method was applied to DNA samples from T cells electroporated with CRISPR RNPs targeting the candidate target sites. The resulting NGS data were processed with CRISPResso2 software, and the frequency of insertions and deletions (indels) was taken as indication of CRISPR cleavage activity, as is common in the field. T cells electroporated with GS94-targeting CRISPR RNP showed no greater frequency of indels at the set of putative off-target sites than T cells treated with CRISPR RNP targeting other sites, consistent with the GS94-targeting CRISPR RNP having no consequential or detectable off-target activity, and therefore being the most specific out of the set evaluated (FIG. 41).
Potential effects of transgene integration at the GS94 site on the regulation of the T cell transcriptome were evaluated by knocking in a large cassette to the site, growing T cells for several days, sorting cells expressing the transgene within the cassette, and then collecting RNA from the cells. RNA-seq libraries were prepared and sequenced, and analysis of the resulting Illumina sequencing data revealed no biologically or statistically significant differences in expression of any genes within 300 kb of the GS94 site in cells with integrations at GS94 compared to cells with integration at TRAC or the GS102 sites (FIG. 42). Furthermore, other gene expression differences that reached statistical significance were minimal in number and in effect size, consistent with them being noise in the comparison.
To assess whether transgene integration at GS94 could confer a transformed phenotype, cells with integrations at the GS94 site were cultured with and without cytokines in vitro. Cells remained alive and viable with cytokine addition, but died without cytokine supplementation and lost their viability (FIG. 43). The positive control Jurkat cells remained viable and proliferated. Overall, this indicates that integration of a transgene at GS94 does not confer capacity for cytokine-independent growth, which is a hallmark of T cell transformation.
Example 10: In Vivo Insertion of a CAR Expressing Cassette In vivo efficacy of T cells with a transgene cassette expressing a CAR recognizing a tumor antigen, or a CAR recognizing a tumor antigen under control of a priming receptor recognizing an antigen in the anatomical vicinity of the tumor, is assessed against human tumor cells such as K562 engineered to express the CAR antigen or to express antigens recognized by both the priming receptor and the CAR. Tumor cells (e.g. 1e6) are subcutaneously injected into the flank of NSG mice (Jackson Laboratories). Tumor growth is assessed by dimensional measurement by calipers every 2-4 days. When the tumor volume reaches ˜100 cubic mm, mice are intravenously injected with 5e6 T cells with a CAR or prime-CAR circuit cassette integrated at a specific site by CRISPR-mediated insertion, or with T cells engineered with CRISPR RNP alone, or with PBS alone as a sham injection. Tumor growth is monitored and mice are euthanized when tumor volume reaches 2000 cubic mm. Peripheral blood is bled from mice through a retro-orbital procedure, and flow cytometry and/or ddPCR is used to observe engineered T cell expansion over time. At time of sacrifice, spleen, blood, tumor and/or other tissue is analyzed via flow cytometry, ddPCR, and/or immunohistochemistry for the presence of engineered T cells. The results demonstrate that T cells engineered with cassette integration at one of the defined genomic loci lead to tumor regression and clearance in injected mice as compared to T cells without cassette integration, and that engineered T cells are detectable in the peripheral blood and tissues of injected mice.
REFERENCES
- Eyquem, J., Mansilla-Soto, J., Giavridis, T., van der Stegen, S. J Hamieh, M., Cunanan, K. M., . . . & Sadelain, M. (2017). Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature, 543(7643), 113-117.
- Sadelain, M., Papapetrou, E. P., & Bushman, F. D. (2012). Safe harbours for the integration of new DNA in the human genome. Nature reviews Cancer, 12(1), 51-58.
- Irion, S., Luche, H., Gadue, P., Fehling, H. J., Kennedy, M., & Keller, G. (2007). Identification and targeting of the ROSA26 locus in human embryonic stem cells. Nature biotechnology, 25(12), 1477-1482.
- Pellenz, S., Phelps, M., Tang, W., Hovde, B. T., Sinit, R. B., Fu, W., . . . & Monnat Jr, R. J. (2019). New human chromosomal sites with “safe harbor” potential for targeted transgene insertion. Human gene therapy, 30(7), 814-828.
- Roth, T. L., Li, P. J., Nies, J. F., Yu, R., Nguyen, M. L., Lee, Y., . . . & Nguyen, D. N. (2019). Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits. bioRxiv, 604561.
TABLE 4
SGRNA SEQUENCES USED FOR EVALUATION OF PREDICTED LOCI
Median (%
Modified),
sgRNA_ summarized
start_ sgRNA Integra- from 2
sgRNA coor Target tion donors, 2
ID sgRNA Sequence GRCH38 Loci Site primersets
sgRNA_ GCACCTGAATACCACGCCTG chr16: APRT APRT 79.28
1 (SEQ ID NO: 1) 88811818
sgRNA_ CGCCTGCGATGTAGTCGATG chr16: APRT APRT 78.60
2 (SEQ ID NO: 2) 88811551
sgRNA_ CAGGACGGGCGAGATGTCCC chr16: APRT APRT 85.25
3 (SEQ ID NO: 3) 88811640
sgRNA_ CTGAATCTTTGGAGTACCTG chr15: B2M B2M 78.51
4 (SEQ ID NO: 4) 44715425
sgRNA_ GGCCACGGAGCGAGACATCT chr15: B2M B2M 94.75
5 (SEQ ID NO: 5) 44711550
sgRNA_ AAGTCAACTTCAATGTCGGA chr15: B2M B2M 70.97
6 (SEQ ID NO: 6) 44715515
sgRNA_ GCTTGGAGGCCTGATCAGCG chr19: CAPNS1 CAPNS1 89.34
7 (SEQ ID NO: 7) 36141111
sgRNA_ CTTATCTCTTCGCAGCGAGG chr19: CAPNS1 CAPNS1 91.09
8 (SEQ ID NO: 8) 36142301
sgRNA_ CACACATTACTCCAACATTG chr19: CAPNS1 CAPNS1 71.98
9 (SEQ ID NO: 9) 36142676
sgRNA_ TTCCGCAAAATAGAGCCCCA chr3: CBLB CBLB 91.55
10 (SEQ ID NO: 10) 105746019
sgRNA_ TGCACAGAACTATCGTACCA chr3: CBLB CBLB 91.43
11 (SEQ ID NO: 11) 105751622
sgRNA_ GCAATAAGACTCTTTAAAGA chr3: CBLB CBLB 76.18
12 (SEQ ID NO: 12) 105853470
sgRNA_ CAAAGAGATTACGAATGCCT chr1: CD2 CD2 89.80
13 (SEQ ID NO: 13) 116754658
sgRNA_ CAAGGCACCCCAGGTTTCCA chr1: CD2 CD2 92.70
14 (SEQ ID NO: 14) 116754663
sgRNA_ TTACGAATGCCTTGGAAACC chr1: CD2 CD2 92.82
15 (SEQ ID NO: 15) 116754666
sgRNA_ CAGAGACGCATCTGACCCTC chr11: CD3E CD3E 90.96
16 (SEQ ID NO: 16) 118315540
sgRNA_ CATGCAGTTCTCACACACTG chr11: CD3E CD3E 87.47
17 (SEQ ID NO: 17) 118313715
sgRNA_ GTGTGAGAACTGCATGGAGA chr11: CD3E CD3E 86.65
18 (SEQ ID NO: 18) 118313715
sgRNA_ TCTCATTTCAGGAAACCACT chr11: CD3G CD3G 87.24
19 (SEQ ID NO: 19) 118349748
sgRNA_ AGTCATACACCTTAACCAAG chr11: CD3G CD3G 87.99
20 (SEQ ID NO: 20) 118349754
sgRNA_ TTCAAGGAAACCAGTTGAGG chr11: CD3G CD3G 86.55
21 (SEQ ID NO: 21) 118352458
sgRNA_ GAGCCTTGCCTGGAAATCTG chr11: CD5 CD5 84.03
22 (SEQ ID NO: 22) 61118177
sgRNA_ AAGCGTCAAAAGTCTGCCAG chr11: CD5 CD5 89.19
23 (SEQ ID NO: 23) 61118324
sgRNA_ CGTTCCAACTCGAAGTGCCA chr11: CD5 CD5 83.11
24 (SEQ ID NO: 24) 61118121
sgRNA_ GAGCGACTGGGACACGGTGA chr9: EDF1 EDF1 88.84
25 (SEQ ID NO: 25) 136866246
sgRNA_ GCTGCGCAAGAAGGGCCCTA chr9: EDF1 EDF1 91.04
26 (SEQ ID NO: 26) 136866211
sgRNA_ TTGTTCTGGCCAGCAGCCCC chr9: EDF1 EDF1 85.98
27 (SEQ ID NO: 27) 136863433
sgRNA_ CTTCCAGAGCCACATCATCG chr19: FTL FTL 93.10
28 (SEQ ID NO: 28) 48965791
sgRNA_ GGGACTCACCAGAGAGAGGT chr19: FTL FTL 88.86
29 (SEQ ID NO: 29) 48965601
sgRNA_ CGGTCGAAATAGAAGCCCTA chr19: FTL FTL 93.14
30 (SEQ ID NO: 30) 48965770
sgRNA_ AAAAGGATATTGTGCAACTG chr10: PTEN PTEN 92.37
31 (SEQ ID NO: 31) 87933015
sgRNA_ TGTGCATATTTATTACATCG chr10: PTEN PTEN 90.64
32 (SEQ ID NO: 32) 87933183
sgRNA_ TTTGTGAAGATCTTGACCAA chr10: PTEN PTEN 85.36
33 (SEQ ID NO: 33) 87933087
sgRNA_ TGTCATGCTGAACCGCATTG chr18: PTPN2 PTPN2 87.94
34 (SEQ ID NO: 34) 12830972
sgRNA_ CCACTCTATGAGGATAGTCA chr18: PTPN2 PTPN2 92.45
35 (SEQ ID NO: 35) 12859219
sgRNA_ TTGACATAGAAGAGGCACAA chr18: PTPN2 PTPN2 93.96
36 (SEQ ID NO: 36) 12836828
sgRNA_ GAGTACTACACTCAGCAGCA chr12: PTPN6 PTPN6 89.61
37 (SEQ ID NO: 37) 6952098
sgRNA_ TCACGCACAAGAAACGTCCA chr12: PTPN6 PTPN6 82.74
38 (SEQ ID NO: 38) 6954872
sgRNA_ AGGTCTCGGTGAAACCACCT chr12: PTPN6 PTPN6 91.27
39 (SEQ ID NO: 39) 6951610
sgRNA_ AGCATTATCCAAAGAGTCCG chr1: PTPRC PTPRC 88.88
40 (SEQ ID NO: 40) 198696873
sgRNA_ ATATTAATTCTTACCAGTGG chr1: PTPRC PTPRC 88.95
41 (SEQ ID NO: 41) 198692370
sgRNA_ AGCTTTAAATCAAGGTTCAT chr1: PTPRC PTPRC 96.89
42 (SEQ ID NO: 42) 198756176
sgRNA_ ATCCCGAGCCCTAAGGTGCA chr11: PTPRCAP PTPRCA 84.08
43 (SEQ ID NO: 43) 67436325 P
sgRNA_ GGCAGCGCGGAGGACAGCGT chr11: PTPRCAP PTPRCA 97.74
44 (SEQ ID NO: 44) 67436285 P
sgRNA_ CTCAGGGGGCTACTACCACC chr11: PTPRCAP PTPRCA 91.50
45 (SEQ ID NO: 45) 67436170 P
sgRNA_ GTCACCGACGAGACCAGAAG chr5: RPS23 RPS23 79.40
46 (SEQ ID NO: 46) 82277810
sgRNA_ GTCGTGGACTTCGTACTGCT chr5: RPS23 RPS23 83.07
47 (SEQ ID NO: 47) 82277843
sgRNA_ TAATTTTTAGGCAAGTGTCG chr5: RPS23 RPS23 61.94
48 (SEQ ID NO: 48) 82277860
sgRNA_ TTAGCTGTTAGACTTGAATA chr14: RTRAF RTRAF 85.50
49 (SEQ ID NO: 49) 51993810
sgRNA_ CGAGAGCCGTCAACTTGCGT chr14: RTRAF RTRAF 85.64
50 (SEQ ID NO: 50) 51989652
sgRNA_ CGGCTTCAACTGCAAAGGTG chr14: RTRAF RTRAF 88.77
51 (SEQ ID NO: 51) 51989700
sgRNA_ TATGAAAAAGCAGAGCGACT chr15: SERF2 SERF2 89.61
52 (SEQ ID NO: 52) 43793025
sgRNA_ TCTGGCGGGCGAGCTCACGC chr15: SERF2 SERF2 86.73
53 (SEQ ID NO: 53) 43792989
sgRNA_ CTCACGCTGGTTACCGCCTA chr15: SERF2 SERF2 80.57
54 (SEQ ID NO: 54) 43792977
sgRNA_ AAAGATTACGAACTTCCCTG chr12: SLC38A1 SLC38A1 92.24
55 (SEQ ID NO: 55) 46207559
sgRNA_ GTTAAAAACAGACATGCCTA chr12: SLC38A1 SLC38A1 91.51
56 (SEQ ID NO: 56) 46229232
sgRNA_ ATGCCTAAGGAGGTTGTACC chr12: SLC38A1 SLC38A1 79.48
57 (SEQ ID NO: 57) 46229246
sgRNA_ CTCCAGGTATCCCATCGAAA chr18: SMAD2 SMAD2 79.53
58 (SEQ ID NO: 58) 47869418
sgRNA_ CACCAAATACGATAGATCAG chr18: SMAD2 SMAD2 86.61
59 (SEQ ID NO: 59) 47870532
sgRNA_ TGGCGGCGTGAATGGCAAGA chr18: SMAD2 SMAD2 82.91
60 (SEQ ID NO: 60) 47896729
sgRNA_ TAGGATGGTAGCACACAACC chr16: SOCS1 SOCS1 92.25
61 (SEQ ID NO: 61) 11255478
sgRNA_ CAGCAGCAGAGCCCCGACGG chr16: SOCS1 SOCS1 83.79
62 (SEQ ID NO: 62) 11255432
sgRNA_ CGGCGTGCGAACGGAATGTG chr16: SOCS1 SOCS1 84.24
63 (SEQ ID NO: 63) 11255296
sgRNA_ TATAGACGCTGCCCGACGTC chr15: SRP14 SRP14 95.12
64 (SEQ ID NO: 64) 40038895
sgRNA_ TCCAAAGAAGGGTACTGTGG chr15: SRP14 SRP14 92.14
65 (SEQ ID NO: 65) 40038368
sgRNA_ ACAGTACCCTTCTTTGGAAT chr15: SRP14 SRP14 65.82
66 (SEQ ID NO: 66) 40038358
sgRNA_ GCGACGGGCGCATCTACGTG chr12: SRSF9 SRSF9 83.68
67 (SEQ ID NO: 67) 120469572
sgRNA_ CCCGACCTCCATAAGTCCTG chr12: SRSF9 SRSF9 92.56
68 (SEQ ID NO: 68) 120465700
sgRNA_ GGGGTCCTCGAAGCGCACGA chr12: SRSF9 SRSF9 89.94
69 (SEQ ID NO: 69) 120469426
sgRNA_ TGCTCTGTTTAGAAGATGAC chr5: SUB1 SUB1 79.36
70 (SEQ ID NO: 70) 32591641
sgRNA_ ATATTCTTTTCTAGTTAAAG chr5: SUB1 SUB1 70.93
71 (SEQ ID NO: 71) 32591566
sgRNA_ CCTGTAAAGAAACAAAAGAC chr5: SUB1 SUB1 93.66
72 (SEQ ID NO: 72) 32591614
sgRNA_ TGGAGAAAGACGTAACTTCG chr4: TET2 TET2 83.53
73 (SEQ ID NO: 73) 105234315
sgRNA_ TCTGCCCTGAGGTATGCGAT chr4: TET2 TET2 90.97
74 (SEQ ID NO: 74) 105234747
sgRNA_ ATTCCGCTTGGTGAAAACGA chr4: TET2 TET2 89.62
75 (SEQ ID NO: 75) 105235656
sgRNA_ CAGGCACAATAGAAACAACG chr3: TIGIT TIGIT 92.65
76 (SEQ ID NO: 76) 114295571
sgRNA_ CCATTTGTAATGCTGACTTG chr3: TIGIT TIGIT 60.75
77 (SEQ ID NO: 77) 114295700
sgRNA_ CTGGGTCACTTGTGCCGTGG chr3: TIGIT TIGIT 87.99
78 (SEQ ID NO: 78) 114295634
sgRNA_ GTCAGGGTTCTGGATATCTG chr14: TRAC TRAC 98.20
79 (SEQ ID NO: 79) 22547508
sgRNA_ TGGATTTAGAGTCTCTCAGC chr14: TRAC TRAC 88.15
80 (SEQ ID NO: 80) 22547541
sgRNA_ CTGCGGCTGTGGTCCAGCTG chr14: TRAC TRAC 94.77
81 (SEQ ID NO: 81) 22550661
sgRNA_ ACAAAACTGTGCTAGACATG chr14: TRAC TRAC 87.86
82 (SEQ ID NO: 82) 22547658
sgRNA_ TTCTTCCCCAGCCCAGGTAA chr14: TRAC TRAC 89.85
83 (SEQ ID NO: 83) 22547778
sgRNA_ CGTCATGAGCAGATTAAACC chr14: TRAC TRAC 95.81
84 (SEQ ID NO: 84) 22550625
sgRNA_ GAGAGCGCCTGCGACCCGAG chr19: TRIM28 TRIM28 89.44
85 (SEQ ID NO: 85) 58544980
sgRNA_ CCAGCGGGTGAAGTACACCA chr19: TRIM28 TRIM28 94.79
86 (SEQ ID NO: 86) 58544869
sgRNA_ GGAGCGCTTTTCGCCGCCAG chr19: TRIM28 TRIM28 91.81
87 (SEQ ID NO: 87) 58544839
sgRNA_ TGAGGCCTGGACCTTATGCA chr10: chr10: desert_ 69.44
88 (SEQ ID NO: 88) 33134193 33130000- 1
33140000 (GS88)
sgRNA_ CCTGGTGGAGTGAACCATGA chr10: chr10: desert_ 95.25
89 (SEQ ID NO: 89) 33132917 33130000- 1
33140000 (GS89)
sgRNA_ CAAGCACTTAGGTTCCCCTG chr10: chr10: desert_ 91.13
90 (SEQ ID NO: 90) 33134633 33130000- 1
33140000 (GS90)
sgRNA_ GGTCTCCCTACAATTCAGCG chr10: chr10: desert_ 92.02
91 (SEQ ID NO: 91) 72294568 72290000- 2
72300000 (GS91)
sgRNA_ CACAGCGCGTGACTGCAATG chr10: chr10: desert_ 90.22
92 (SEQ ID NO: 92) 72298268 72290000- 2
72300000 (GS92)
sgRNA_ TCTGGGGCACCAATTCTAGG chr10: chr10: desert_ 86.35
93 (SEQ ID NO: 93) 72292786 72290000- 2
72300000 (GS93)
sgRNA_ GAGCCATGCTTGGCTTACGA chr11: chr11: desert_ 91.24
94 (SEQ ID NO: 94) 128342576 128340000- 3
128350000 (GS94)
sgRNA_ GTACAAGTACTTATCTCATG chr11: chr11: desert_ 89.02
95 (SEQ ID NO: 95) 128343592 128340000- 3
128350000 (GS95)
sgRNA_ GAGATAACAACATAACAACA chr11: chr11: desert_ 96.47
96 (SEQ ID NO: 96) 128347170 128340000- 3
128350000 (GS96)
sgRNA_ CATATTCCATAGTCTTTGGG chr11: chr11: desert_ 88.54
97 (SEQ ID NO: 97) 65425000 65425000- 4
65427000 (GS97)
(NEAT1)
sgRNA_ CTGCCCCTTAGCAACTTAGG chr11: chr11: desert_ 92.76
98 (SEQ ID NO: 98) 65425507 65425000- 4
65427000 (GS98)
(NEAT1)
sgRNA_ TGTTTAAAAATATGTTGACA chr11: chr11: desert_ 90.76
99 (SEQ ID NO: 99) 65426264 65425000- 4
65427000 (GS99)
(NEAT1)
sgRNA_ CCAGGAATGGAAACTCACGC chr15: chr15: desert_ 87.84
100 (SEQ ID NO: 100) 92830315 92830000- 5
92840000 (GS100)
sgRNA_ GAGGCCGCTGAATTAACCCG chr15: chr15: desert_ 85.32
101 (SEQ ID NO: 101) 92831850 92830000- 5
92840000 (GS101)
sgRNA_ ATACACGCACACTTGCAGAA chr15: chr15: desert_ 99.92
102 (SEQ ID NO: 102) 92831131 92830000- 5
92840000 (GS102)
sgRNA_ GAGCAGACAGAAACCCAGGG chr16: chr16: desert_ 87.92
103 (SEQ ID NO: 103) 11225670 11220000- 6
11230000 (GS103)
sgRNA_ TGAGTCTCCAAACAGAACAG chr16: chr16: desert_ 88.53
104 (SEQ ID NO: 104) 11226284 11220000- 6
11230000 (GS104)
sgRNA_ TAATATCACTGACTTCACGG chr16: chr16: desert_ 87.65
105 (SEQ ID NO: 105) 11225029 11220000- 6
11230000 (GS105)
sgRNA_ TACACACAATGTAAGCAGCA chr2: chr2: desert_ 71.79
106 (SEQ ID NO: 106) 87467461 87460000- 7
87470000 (GS106)
sgRNA_ GGGAGCTCAATTCGAAACCA chr2: chr2: desert_ 65.89
107 (SEQ ID NO: 107) 87468809 87460000- 7
87470000 (GS107)
sgRNA_ TTGGACAGGTGAGACAGTCG chr2: chr2: desert_ 72.64
108 (SEQ ID NO: 108) 87467001 87460000- 7
87470000 (GS108)
sgRNA_ AAGCTCACTCAGATAGTGTG chr3: chr3: desert_ 76.89
109 (SEQ ID NO: 109) 186511316 186510000- 8
186520000 (GS109)
sgRNA_ CAGGAGAACCACCTTACACG chr3: chr3: desert_ 86.31
110 (SEQ ID NO: 110) 186515260 186510000- 8
186520000 (GS110)
sgRNA_ GGACAGACCCTGATTCACAA chr3: chr3: desert_ 85.47
111 (SEQ ID NO: 111) 186519655 186510000- 8
186520000 (GS111)
sgRNA_ ACATGGCAGTCTATGAACAG chr3: chr3: desert_ 87.77
112 (SEQ ID NO: 112) 59451154 59450000- 9
59460000 (GS112)
sgRNA_ CCTATAGAGAGTACTACTTG chr3: chr3: desert_ 79.33
113 (SEQ ID NO: 113) 59456416 59450000- 9
59460000 (GS113)
sgRNA_ CCAACCGGGTCTTCATTACG chr3: chr3: desert_ 92.21
114 (SEQ ID NO: 114) 59457029 59450000- 9
59460000 (GS114)
sgRNA_ TCAAGCGTAGAGTTCCGAGT chr8: chr8: desert_ 93.07
115 (SEQ ID NO: 115) 127993006 127980000- 10
128000000 (GS115)
sgRNA_ TCATGCAATTATGGACCCAG chr8: chr8: desert_ 89.40
116 (SEQ ID NO: 116) 127994663 127980000- 10
128000000 (GS116)
sgRNA_ CGGGAAAGTGACTGGCCATG chr8: chr8: desert_ 87.45
117 (SEQ ID NO: 117) 127996766 127980000- 10
128000000 (GS117)
sgRNA_ TGAGATTGAAATCAAATCGG chr9: chr9: desert_ 84.84
118 (SEQ ID NO: 118) 7974159 7970000- 11
7980000 (GS118)
sgRNA_ TATGCAATATTCATCACGCG chr9: chr9: desert_ 85.44
119 (SEQ ID NO: 119) 7977914 7970000- 11
7980000 (GS119)
sgRNA_ AATGTGTTAAATCAAATGCA chr9: chr9: desert_ 83.48
120 (SEQ ID NO: 120) 7976895 7970000- 11
7980000 (GS120)
TABLE 5
CONSTRUCTS USED FOR EVALUATION OF PREDICTED LOCI
Construct name Sequence Length
pARBI-903: ATCTCGGCCAATAAAGGAGAAAGGGCGCGGCCCGTACGCGCGCCAGGTGC 1806
APRT_1_ GTGGGCGAGACCAGCTCACGCCCCTCCTCCAGCCGCCAAGGCCCCGGCCC
Endogenous_1 ACAGCTGCCTGGCTGCAGTCAGAAGCGTAGCCCGAGACAAGGAAGGGCGC
CTTGACTCGCACTTTTGTCCGGTTCGAACGTTCTGctcagtggtgcgtgg
aatgcgagcgcgtcttaaaatcgatggcgcctaggagtccatgaaatacg
gTACAGGCTTCCGGCGACGGATGCCCCGCCCCTCACCCACGCTCCGCCCT
CCGGGGATGCCCCACCCCTCGTGGCGGTCCCGCCCGTCCCCGCGCAGGCG
CGCTCGGGCTGCCGCTGGCTCTTCGCACGCGGCCATGGCCGACTCCGAGC
TGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCCACCCCA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGCGTGGTATTCAGGTGCACGCACAGGCCGCCCTCGTGGCGCCC
CGACCTGCGGGCCTACGGATGGGAGCGCGTGGCCCGCGACCTCCGGGCGG
GCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGGCCCTGCCCTCCTTCGG
CCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGGGACATCTCGCCCGTCC
TGAAGGACCCCGCCTCCTTCCGCGCCGCCATCGGCCTCCTGGCGCGACAC
CTGAAGGCGACCCACGGGGGCCGCATCGACTACATCGCAGGCGAGTGCCC
AGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGCGCCGAGGGCAGCAC
GTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTGGGGTGCTTCAGGGG
GCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGAAGGGTTGTGAGATT
GAGCCC
(SEQ ID NO: 123)
pARBI-904: TGCCCCGCCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCG 1806
APRT_2_ TGGCGGTCCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTC
Endogenous_2 TTCGCACGCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGA
TCCGCAGCTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACG
CACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCG
CGTGGCCCGCGACCTCCGGGGGGGGGGGGCGGGAACCCTCGTCTTTCGCC
CCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGG
GTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCG
CCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCT
TCCGCCTCTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTT
GGGGGAGGGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGC
TTGGGTCGCCCGGGAAGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGC
TGTGCAGGCGTCCTTCCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCG
TGACCGAGTTGCCGGGTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATC
CACAGGGCCCAGCTGCCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGA
GCGCCTGCCACGAGCCAGGCCTTCCCTGGTGAAGATCACGGAATGCCCAC
CCAGGGAAGGGAGGCCTGGAGGCCTCCGGGAGAGCCCAAGAGGTGGCCCA
GGGAGA
(SEQ ID NO: 124)
pARBI-905: CGTTCTGctcagtggtgcgtggaatgcgagcgcgtcttaaaatcgatggc 1806
APRT_3_ gcctaggagtccatgaaatacggTACAGGCTTCCGGCGACGGATGCCCCG
Endogenous_3 CCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCGTGGCGGT
CCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTCTTCGCAC
GCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAG
CTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACGCACAGGC
CGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCGCGTGGCC
CGCGACCTCCGGGCGGGCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGG
CCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCGC
CATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATCG
ACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCT
CTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAG
GGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTC
GCCCGGGAAGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAG
GCGTCCTTCCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGA
GTTGCCGGGTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGG
CCCAGCTGCCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTG
CCACGA
(SEQ ID NO: 125)
pARBI-906: AGTAATTTGATGGGGGCTATTATGAACTGAGAAATGAACTTTGAAAAGTA 1806
B2M_1_ TCTTGGGGCCAAATCATGTAGACTCTTGAGTGATGTGTTAAGGAATGCTA
Endogenous_4 TGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCAGAGAAAGGCT
CTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTGCTAGAAATCT
GCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTATGAGGGAAAGA
TACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTGTTGGGAAGGT
GGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAAATCGATGACC
AAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAGTTAGCCCCAA
GTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATATTCCTCAGGT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGG
AAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACA
TTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCAT
TCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACAC
TGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATG
TGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTT
TTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTT
TGATATAAAAAAGGTCTATGGCCATACTACCCTGAATGAGTCCCATCCCA
TCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAG
ATCAGA
(SEQ ID NO: 126)
pARBI-907: AAGATCTTAATCTTCTGGGTTTCCGTTTTCTCGAATGAAAAATGCAGGTC 1806
B2M_2_ CGAGCAGTTAACTGGCTGGGGCACCATTAGCAAGTCACTTAGCATCTCTG
Endogenous_5 GGGCCAGTCTGCAAAGCGAGGGGGCAGCCTTAATGTGCCTCCAGCCTGAA
GTCCTAGAATGAGCGCCCGGTGTCCCAAGCTGGGGCGCGCACCCCAGATC
GGAGGGCGCCGATGTACAGACAGCAAACTCACCCAGTCTAGTGCATGCCT
TCTTAAACATCACGAGACTCTAAGAAAAGGAAACTGAAAACGGGAAAGTC
CCTCTCTCTAACCTGGCACTGCGTCGCTGGCTTGGAGACAGGTGACGGTC
CCTGCGGGCCTTGTCCTGATTGGCTGGGCACGCGTTTAATATAAGTGGAG
GCGTCGCGCTGGCGGGCATTCCTGAAGCTGACAGCATTCGGGCCGAGATG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTCTCGCTCCGTGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTC
TGGCCTGGAGGCTATCCAGCGTGAGTCTCTCCTACCCTCCCGCTCTGGTC
CTTCCTCTCCCGCTCTGCACCCTCTGTGGCCCTCGCTGTGCTCTCTCGCT
CCGTGACTTCCCTTCTCCAAGTTCTCCTTGGTGGCCCGCCGTGGGGCTAG
TCCAGGGCTGGATCTCGGGGAAGCGGGGGGTGGCCTGGGAGTGGGGAAGG
GGGTGCGCACCCGGGACGCGCGCTACTTGCCCCTTTCGGCGGGGAGCAGG
GGAGACCTTTGGCCTACGGCGACGGGAGGGTCGGGACAAAGTTTAGGGCG
TCGATAAGCGTCAGAGCGCCGAGGTTGGGGGAGGGTTTCTCTTCCGCTCT
TTCGCGGGGCCTCTGGCTCCCCCAGCGCAGCTGGAGTGGGGGACGGGTAG
GCTCG
(SEQ ID NO: 127)
pARBI-908: AGGAATGCTATGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCA 1806
B2M_3_ GAGAAAGGCTCTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTG
Endogenous_6 CTAGAAATCTGCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTAT
GAGGGAAAGATACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTG
TTGGGAAGGTGGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAA
ATCGATGACCAAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAG
TTAGCCCCAAGTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATA
TTCCTCAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA
ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAA
AGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCT
TGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGT
GTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTC
TTACATTCTTTTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCAT
AAAGCTGCTTTGATATAAAAAAGGTCTATGGCCATACTACCCTGAATGAG
TCCCATCCCATCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAAT
GTTCTTAAAGATCAGATTAGTGGCACCTGCTGAGATACTGATGCACAGCA
TGGTTTCTGAACCAGTAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAG
CACTTG
(SEQ ID NO: 128)
pARBI-909: GATCTCACATTCTAGCGCCCAGACATGTCGGGAACGCCTTACGCCAACTT 1806
CAPNS1_1_ GGGGTCCCCACCAAGAGAACCCCCACCAGATCTGCACCCTCCCCTTCACG
Endogenous_7 CGTGCACCCAGTCCAGGCTCCCTCAAGCCCCACGGGTGCCTTTTAGACCT
GAGGAGGTTGCAAACCTGATCCCCCATACCTGCCCCACCCATCCGCGGAC
AACCCGCCCTCGCAAACTCAGACCCCCACCCGGAGGCTTCAGATTCCTCC
CAGGTCCAGCTGCCGGAAATGCGTGTTTGAAGGGAGGGTGTGGGCTCAGG
GGCGAAGCACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGC
CATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGG
GAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAGCGGGGCCGGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGG
TGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAG
TCATCAGCGCCATCAGGTAAGGCGGAGACTATCAGAGGGGGGGGCCTGGG
AATGGGAGGAGCCTCAGTGAGGCGTGGTCTGGGAGGGGCGTGGTCTAAAA
ATAGAATAGGATTAACCTGGAGGCTAACCTGGGTACATGAATTAGGCCGG
GGAGGCCTGGTTTGAGAGTTCTGCTGTAAGGGGGTGGACCCCAGTGAGGC
GGATATCAGTCATTGGGGGCGGTGCTTGATATGGGAGTAGTCTGATTGTG
TGGGACCAGGACAATGTGGTCCTGAGGGGACTGATGTGGAGTTTTGGCGG
GTGGGGCTTATGGGTCTGGGCTCAGCCTGCATTGGCTAACCTGGAGATGA
ACGTT
(SEQ ID NO: 129)
pARBI-910: CGGGCATTTAGGAAGCGGGCCATGGAGTAGGGTCTTGGGCAGATGGCACC 1806
CAPNS1_2_ TGAGGAGGATAAGGCCTTGGGAAGCTGGGGCAGAGCCTCTATGAAGTGAG
Endogenous_8 CCCTCCAAGGGGCGGGGTCTTTTGATTCTACGTGGGATTTTTTAGGTTTA
GGGTGGCCAAGATGACTGAAATCTGCCACTGGGTAGGTGTGCCTGGCAGG
AGGGGAGCCTCCCAGGGGACCGGTCTCTGGGTTTCCTCGAGGGTGGGGTT
GGCCTGAGGAAGGGAGAAGAGGGGCACGACCAGGGCAGTGTGGATTGGGA
CAGATGAGGACAAGAACAAATGAAAGGCACAGCAACCAAGTAAGGAAGAT
AACGGCTGGGGTCTGGAGCGTTGGGGCTGATGGTTCTGTAGTGCTGCCCG
TTGGAGGCCCCGCCCCTGGCACTAACCCCTCCCCCTTATCTCTTCGCAGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGGTAAGCCCCCT
CTGCAACCAGACCCCCTTCTCCTGCCAAGGCCTCTTCGAGGTCCCATCCC
TGTTCCTGTAGAGAAGCCCCACCTTCCTCCCCTTCTTGTGAAATTCCTCT
GCCAGTTCCTCCCATGCCGTGTCTGCAGCTTCGCCATGGGTCTTAGCCAT
GCCCCACATACGTGCACCCCATTCACTACCACCCCTCATTCTTTTCCTCA
TCAAGCTGCCCAGCCCACTCTGACTTCCCCACCCAGGGTACCTGGGTTTG
GGGAGCCGTCCTGGCCGGGTTCCCCTCCCCCTGCTCTGAGCTCTCCTCCC
TTTGCAGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTG
AGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGTA
AGTAAC
(SEQ ID NO: 130)
pARBI-911: GCTGATGGTTCTGTAGTGCTGCCCGTTGGAGGCCCCGCCCCTGGCACTAA 1806
CAPNS1_3_ CCCCTCCCCCTTATCTCTTCGCAGCGAGGCGGCTGCGCAGTACAACCCGG
Endogenous_9 AGCCCCCGGTAAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGC
CTCTTCGAGGTCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCC
CTTCTTGTGAAATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTT
CGCCATGGGTCTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCA
CCCCTCATTCTTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCA
CCCAGGGTACCTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCC
TGCTCTGAGCTCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACT
CTTTGCCCAGCTGGCTGGAGATGTAAGTAACCTGGGGTCCCTGGCCCCGT
CCTAACCGTTCCATCCCTTCCCTTGTGGCTGCCCTTGCACACACACCCTT
GACCATGACAATCCCAGTGTTCCCATTCTCCATGACATTCTCAGACCCCT
TTCAGTCACCCCTGACCTGCCCCTAACTTCCGCCCGCAGGACATGGAGGT
CAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACGTA
AGTGACCGGGGTTAAGGAATAGGGTAGATTCAGAGGCAGAGGGGTCAGAG
AGGATTTGACCTCTGGCCTCTGACTTTCAACCTGTTACCCACAGACCCTG
ATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCC
GTGATG
(SEQ ID NO: 131)
pARBI-912: ggagagttatagcagatggagacaaaaaagggaactgctggggatcaaac 1806
CBLB_1_ cttgtaaagtccttctaagtgatatatgaggactttgacttttattcaaa
Endogenous_10 gttagaaggctttgaacaaaagaattatttcatttgtgttttacaatggt
cacaagtgccgtagcgagaataggctgTGTAGAGAAGAGATTTTGTGGTT
TTCTTTTTTGTTCTCTGTATTCTCTTCCTGAAAAATCTGTTTTCTGCCTA
ATCATATTTCTGTAAAGAACAATAGACTTGAACGTCTGCTGTTAAGTAAC
AAAGGTTGACCTAAACCACATAAGGTCAGATTAACTTTTAAAATATCCAA
GATAATGTTAAGTGTATTAAATATGGTTCAGTATGTAATCAAAATATTTG
ATATTCTCTAGATACTAATCTCttttaatttttttattttttAGCCTTGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGCTCTATTTTGCGGAATTGGAATTTCTTAGCTGTGACACATCC
AGGTTACATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGA
AATATAGCACCAAACCCGGAAGGTAAGACTTTTTAGCAGTAATATTATGT
GATATATCCAAAGATGAAAAATTCTCCATGGTTTGTTCCTAAGTAAGTCA
GCAATACCCGCTGATGGCATGCTTGGGAGGGGGCTAGAAAAGGTAAAAGA
CCAAAATGGTGCTTCTTAACATAATGTTTTAAATTGATACATTGTGCTTA
CTCTGAAACTTGGTATTCATAAAGTGAAAGGGGATATGGTCTCCTTTCTG
TTTTCATGATATCCGTGTTTATGTGCAAAATTGAATGTATATATTTGAAT
ACTTGAATACTGTGCTAAAGAACAAATAAATAGAACAGTCTTATGTTCAT
TACTTT
(SEQ ID NO: 132)
pARBI-913: CATATTACTCATTTGTGCAATGAATAAAGGATTTCTATTATTATATGGAC 1806
CBLB_2_ CCATCATCTTATGACTGTTTTTAGAAAATGAGAATTAAATCTTGATTCAT
Endogenous_11 TATTAAATAACCTTGTATACACACATGAAGAGGTCATGACACATAAGACT
TTGACCTAATACCTTTTTTCAGATATGTTTCTATAGCTATCTTGATAGCC
TAGGACTGTTTGAGAGAAAATTAATTTAAATTTTTGTCATATTCTTAGCA
AATGCAAAATAATTGAGTTAAACAGAACCCACTACATTTGTTCTGAAATA
TGAACAATATTCTCAAATATTTGTCTGGTAGTACAAATACAATTATATTA
ATTTTATTATTGAATTTTGCTGCTTCAAAGGGAGGTATTTCTTAAATGAT
ACTTGATTCAATTATTTCCCTTTTTTTCCACCTTGCACAGAACTATCGTA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCCATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGAT
TAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTT
GCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT
CAGGTAAGTTTATACTTGCTTAGTCTATCCATTCCCTtcttctctctccc
tgtcttttctctctgtttctctctctctctgtctctctctcacacacaca
cacaTAAACAAACATATGGAAAATAGTGTCATTCCTATTAGTCTGTAATT
TTATTGGTATGTTTGGTCATTGTTAAAAGTTTAGAGTGAGCCATTTGGCT
TAAGTTTGGAGTTATCAGATGCTGTGAGCCTGGTGGCTGCTTGTTAGCTT
TGAGAGGATCCATCCAAAAGAGCTTTGTTTTAAACTCTCTACTTAGTTTC
TTACTT
(SEQ ID NO: 133)
pARBI-914: TTAAACTTTAGAGGTTCAAAATAAGGATATGATATAGAAAAGATTGAATG 1806
CBLB_3_ GTAGGAGAACAGAATAGGATTTATTTATATTATGACAAACGTGACTATCA
Endogenous_12 GTTAATAAATTGGAGATAGTAAGTTAAGATCATTATTTATATTATGGAAA
AATGAAGAAATAGGACATGGTTCTCTAACTTTTTAATTTTTCTGTGAAAT
AAAATATTATGACTTATTTTATTTTTATCTTTGTTTTTAGGTAAGACTGT
GCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGAT
ATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGA
TGACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCT
ACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGAAGGCAAGGAGAGAATGTATGAAGAACAGTCACAGGACAGGTA
AGAAGAATATTTCAGATGTTTTGGTGTAAAGGTCATTTATGTTGCTTTTT
ACTTAATAGTTAACCTAAACGTCACCATGTAATTGTTTTGGGGTAAATGT
GAGTCGCTTTGTATATagtcatgtggtacttaacgatggggatactttac
aagaaatgcatttttagacaatttcattgttgtgtggacatgatagagtg
tacttacacagagctagatggtattacctaccgcacacctaggctgtatg
atgtagcctattgctcctaggctgcaaatctatacagtatgttactgtac
tgaatactgtgggcagttgtaacacaatggtaagtatgtgtgtatctaaa
tatacctaaacatagaaaaggtatggtaaaaatactgtataaaaggccgg
gcgtgg
(SEQ ID NO: 134)
pARBI-915: AGATGAGAAAACCTATCCTTCCCAATTTTTTTGTGTGAGAATTAAAATGC 1806
CD2_1_ AGCAAGAAAACACACACTCATAAACACATCTGCTTTGGCAAAGGAGCACA
Endogenous_13_ TCAGAAGGGCTGGCTTGTGCGCGCTCTTGCTCTCTGTGTATGTGTATTAT
14_15 GTTTTATGTTACTGTAAAAGATGTAAAGAGAGGCACGTGGTTAAGCTCTC
GGGGTGTGGACTCCACCAGTCTCACTTCAGTTCCTTTTGCATGAAGAGCT
CAGAATCAAAAGAGGAAACCAACCCCTAAGATGAGCTTTCCATGTAAATT
TGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTAAGCATA
AGAGTCAAAGAAGTCCCAACCCAGCTTTCCCTGAAAGTGACTCTCAGTAA
CTCTTTTGCTTTTTATAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGAAACCTGGGGTGCCTTGGGTCAGGACATCAACTTGGACATTCC
TAGTTTTCAAATGAGTGATGATATTGACGATATAAAATGGGAAAAAACTT
CAGACAAGAAAAAGATTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAG
GAAAAAGATACATATAAGCTATTTAAAAATGGAACTCTGAAAATTAAGCA
TCTGAAGACCGATGATCAGGATATCTACAAGGTATCAATATATGATACAA
AAGGAAAAAATGTGTTGGAAAAAATATTTGATTTGAAGATTCAAGGTAAG
TGTTCATTCCCTTAATTGCTTTATTTCAGTGTGGGTGCTATTTGGCAAGT
TGGAAAATAGCATTTCTAATATTCCCCAGCGCTGACCTCTGCCTCCAGGG
GGGCTATACAGGAAACCAGATGCATGTCTCCTGCCCCAGTGGAGACTGTG
GTCCAA
(SEQ ID NO: 135)
pARBI-916: AGGATTGTTCTAGTTGATTGGTATGTGTGCACTCCTAGTTGTTAAATATT 1806
CD3E_1_ TTCACTATCACACCTGGATATACTCAACAAATATTTGTTGAGCCAAATAC
Endogenous_16 TCAACACCAGCCAAACACGTAGTATTTACTTTAGCTTAAGCGAATTATTT
AGCCCTGACAGAAGCCCTGGAATGTGGGTCTTTAAGTTCCTATTTTTGAG
ATGGGAAAGCTGAGGCTCACGGAAGGAGGTGACCAGCTCAAGTCTCCTAC
CGTCCATGCCAAATTAGAATTCCAGCCTGCCTCCTGACTTCAAGTCCAAA
GTTCTTCCCACGCACTAAAGCTAGCTCTTCAGTGTCCTTTCTTAGGAGGT
ACTTCCTCCCGCACCACTGACCGCCCCCTCTCTATTTCACCCCCAGCCCA
TCCGGAAAGGCCAGCGGGACCTGTATTCTGGCCTGAATCAGAGACGCATC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTGACCCTCTGGAGAACACTGCCTCCCGCTGGCCCAGGTCTCCTC
TCCAGTCCCCCTGCGACTCCCTGTTTCCTGGGCTAGTCTTGGACCCCACG
AGAGAGAATCGTTCCTCAGCCTCATGGTGAACTCGCGCCCTCCAGCCTGA
TCCCCCGCTCCCTCCTCCCTGCCTTCTCTGCTGGTACCCAGTCCTAAAAT
ATTGCTGCTTCCTCTTCCTTTGAAGCATCATCAGTAGTCACACCCTCACA
GCTGGCCTGCCCTCTTGCCAGGATATTTATTTGTGCTATTCACTCCCTTC
CCTTTGGATGTAACTTCTCCGTTCAGTTCCCTCCTTTTCTTGCATGTAAG
TTGTCCCCCATCCCAAAGTATTCCATCTACTTTTCTATCGCCGTCCCCTT
TTGCAGCCCTCTCTGGGGATGGACTGGGTAAATGTTGACAGAGGCCCTGC
CCCGTT
(SEQ ID NO: 136)
pARBI-917: AATAATAAAATAATAACAATACTTAACATTTATTGAGTGCTTATTAAGTC 1806
CD3E_2_ TCAAGCACTGTCTGTACCCAACACTTATCAAGGATTCTTTTTCATGTAAT
Endogenous_17_18 CCTCTCAACAACTATATGGGTTAAGTATCATTTTATTCCCATGAGTAAAG
GGATGAGGAAACAGAGGGTTTGTGAGTTGAAAACACATTTCACGCTTCTC
ACAGCTAGTGAGTAATAAAGCTGGGACTCAAACCCAGGGCTGTTTGACTC
CAGTGCCTCTACCCACGGCCACCACTCTTTGCTTGTCAATGTTGTTCTAA
ACATATTGAAGGGGGGGCTCTGACCGTGGCAAGCGTGTGAGTAGTAAGGG
GAGAATGGCCTTCATGCACTCCCTCCTCACCTCCAGCGCCTTGTGTTTTC
CTTGCTTAGTGATTTCCCCTCTCCCCACCCCACCCCCCACAGTGTGTGAG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAACTGCATGGAGATGGATGTGATGTCGGTGGCCACAATTGTCAT
AGTGGACATCTGCATCACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGA
GCAAGAATAGAAAGGCCAAGGCCAAGCCTGTGACACGAGGAGCGGGTGCT
GGCGGCAGGCAAAGGGGTAAGGCTGTGGAGTCCAGTCAGAGGAGATTCCT
GCCAAGGGGGACGACCAGCCTGGGCCAGGGTGGGTGGCAAGTCCACAGCT
AGGTCAGAACAGCTTCTCTAGAGCTTCTATGCACAGCTTCTATTACTGTG
ATGACAAGATCTCAACAGACGGTTTCAAATCTCACATCACTCCCCTCCTT
CCCATCCTAGAAAAGTGCAAAAAAGTTTATGAAAGTGATGGGCTTCCTCA
CATACCTGTCAATGCCTGCAGTCATCCGATTCCGCCCCTAAGCTGTGGGA
AGAGAG
(SEQ ID NO: 137)
pARBI-918: ACTGTGACCCATGAACCAGTAGGTATTGGCGTCACCTGGGATCCTGACGT 1806
CD3G_1_ TAGTCTCTGTCAATCCTTCTCTTTAGTTCATCTATTCTACCCAAAGTGAT
Endogenous_19_20 CTCATCATCTGGTATGCTGTTAGCAGTTTCTTACCTGTATAGTATCTTCC
AAATAACATGCCCCAAAATCCCAAAGTTTTACCCCTACTAATTACAGCAA
TGTCTCTTTTATTCTTCACCCCCTGACGCAGATATTGGCGTCACCCGAGA
GCATGTTAGTAATGCAGAATCTCCCCTCCCCAGAACTACTAAATAGCACC
TGAAATTTTAACAAGATCCCCATGTGATTCATGTGCACATCAAAGTTTGA
GAAACACTACTCTAATGATCTCCTGGTATGCAGAAGCAGGGAGAATTTCA
GAGGCAAGATCCTTAATAGAACCACGGCTTTTCTCATTTCAGGAAACCAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTGGTTAAGGTGTATGACTATCAAGAAGATGGTTCGGTACTTCT
GACTTGTGATGCAGAAGCCAAAAATATCACATGGTTTAAAGATGGGAAGA
TGATCGGCTTCCTAACTGAAGATaaaaaaaaaTGGAATCTGGGAAGTAAT
GCCAAGGACCCTCGAGGGATGTATCAGTGTAAAGGATCACAGAACAAGTC
AAAACCACTCCAAGTGTATTACAGAAGTATGTAATCCCCTTTGGTCTGTT
TGTTGTGAAATTAATCAGTATTTGCTGTTCTGGTGAGCTTTTTATCTGGG
GTGAAAGTGGAAATAGATCCTCAACAGTAATATTATCGCCTGTTCTCTTA
ATTTCAGCTTGCCTCTTTTAAAATACTGTAAGATACTTCCCTCACCCTAT
TGAAAAACTACAGCCAGTCCTGTAAAATTTTGTTTACCTTTGGGTGGGCT
CCATGG
(SEQ ID NO: 138)
pARBI-919: TTCGAGACAAGCCTGGCCAACATGATGAAACTCTGTCTCTACTAAAAATA 1806
CD3G_3_ CAAAAAAAATTAACCAGGCGTGGAGGCGCGCGCCTGTAGTCCCAGCTACT
Endogenous_21 CAGGAGGCTGAGGCAGGAGGACCACTTGAACCCAGGAGGTCGAGGTTGCA
GTGAGCTGCGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGAAAGAC
TCCGTCTCAAAAAAAAAAAAGAGAGAGAGAGAAAAAGAAAAAAGACAGAG
CCTCCATCTCCTTGTCCTCTTTCCATCCTCAGGACCATGAAGTACCCACT
CCAAATTCTCACATATAAAAAACATTCAATAAACATGCATCAAATTAATT
AATAGAGGATGGAAAAAATGACTTATGACTGTGCTGTCCTTTCCAGCCCC
TCAAGGATCGAGAAGATGACCAGTACAGCCACCTTCAAGGAAACCAGTTG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAGGAGGAATTGAACTCAGGACTCAGAGTAGGTGGGTTCTTCAAT
GCCAATTCTAATAAAGGACCCTTGCATCAACTGCCCTCGCAATTGCTTCT
AAGTCTAGCTCCCTTCCCTAAGCGGCTATAAGCATCAGACTCTGGGGATC
AGGGATTGGGACGTGGTTTGGGGTACTCTTTTCTAAAAATTCTGGGGCCA
TACTGATTGTCTTGGCCTAGGTAAATATGAATTTTATGTATCTGTAAATC
CTGTCAGAGCAGGGCCTCAAGCCATAGAGATGCTGAATATTAATCTTAAC
CTACATTTGAATTTCTCATTATCTACACTATTAACATTTTGGGCTAATTA
ATTATTTGTGATGAGGGGCTAGCCTGTGCATTGTAGGAGTTATGGAAGCA
TCCCTGGCCTCTCTCCACCAGATGCTGGTAGATTGTCCAGTGTGACAATC
AAAAAT
(SEQ ID NO: 139)
pARBI-920: GACCTCAGGTGATCTGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAG 1806
CD5_1_ GCATGAGCCACCACACCTGGCCTAAAATTAATTTTTAAAGATCTCTTAAA
Endogenous_22 AAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGACAGAATTTCCAGGA
CAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCATTTA
TCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGGTCT
AGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGTGCC
CCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGGCAG
GAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCCAGT
GGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCAGAT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCA
GCTGGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCT
GGGGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTC
TGCCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGT
CACCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCT
TCTCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTG
ACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGG
CGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAG
GCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACA
CATACC
(SEQ ID NO: 140)
pARBI-921: GGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCAT 1806
CD5_2_ TTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGG
Endogenous_23 TCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGT
GCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGG
CAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCC
AGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCA
GATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCT
GGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGG
GCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCT
TGTCACCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCT
CCTTCTCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGC
CTGACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCT
GGGCGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAG
CAGGCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAG
ACACATACCCAGGAGGGGGACTGGAAGGGGCCAGCACCCATCTGTAGGAT
GGCAATGGAGGACCTAGTTCTGCCAATCACTGACTTCATCGTCGCCTCTG
AACCTCCATTCTCCCATCTGTGAAGTGGGGTGGTACTTCCCGCCTCGCAG
GAGGCT
(SEQ ID NO: 141)
pARBI-922: tgctgggattacaggcatgagccaccacacctggcctaaaattaattttt 1806
CD5_3_ aaagaTCTCTTAAAAAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGA
Endogenous_24 CAGAATTTCCAGGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAAC
ACCTTGCCCATTTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCC
ACCCTCCTGGGTCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAA
GCCCCTGCAGTGCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGC
AGCCCACGGGGCAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAG
TGAGGGGTGCCAGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTT
TCTGACCCCCAGATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAGGGCCAGCTGGAGGTCTACCTCAAGGACGGATGGCACATGGT
TTGCAGCCAGAGCTGGGGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTC
AAGCGTCAAAAGTCTGCCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTT
GGCCCCTTCCTTGTCACCTACACACCTCAGAGCTCAATCATCTGCTACGG
ACAACTGGGCTCCTTCTCCAACTGCAGCCACAGCAGAAATGACATGTGTC
ACTCTCTGGGCCTGACCTGCTTAGGTGGGTAACTAGCCAGCCACACGGGC
ACCCTGGGCCTGGGCGCCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATC
TAGGGTCTGAGCAGGCTGGTGGAAGGGGTGGGGGGACCCCAGTTTATAAC
CACTCCCCAAGACACATACCCAGGAGGGGGACTGGAAGGGGCCAGCACCC
ATCTGT
(SEQ ID NO: 142)
pARBI-923: GGGGGCGGCCGCACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCG 1806
EDF1_1_ TGGCCCGGCCGGGGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGG
Endogenous_25 GGCGCAGCCGCCGCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCG
GGGTCCTCCCGACCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAG
GCCAGGCCCCGACGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACG
TCCCTCAGACGAGCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCG
CCCCCCGCGTGCAGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGA
GGGGACGTAGCGTCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGC
CGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAA
ATCCAAGCAGGTGCTTTGCTGACTGAGGAGCGGCCGGGCCGGGCGGGGCG
GACGCTgggccggggccacggaccgtggggcagggggctcggggaagggc
aggcggggcctgggacagggcgcaggggacggggacaaggctggGGTGCC
GGGGGCAGGACGGGGTTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGA
CCGGGCCAGGACaggggtgggaaggtggggggcggacccaggaggggatg
gacggacccaggaggcagggggCGGGCGACTGGAGGAGGAGAGGAGCAGG
GAACCGGACGGGGCAAGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGG
TGGGGCGGGGAGGGGATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGA
GGACAG
(SEQ ID NO: 143)
pARBI-924: ACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCGTGGCCCGGCCGG 1806
EDF1_2_ GGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGGGGCGCAGCCGCC
Endogenous_26 GCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCGGGGTCCTCCCGA
CCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAGGCCAGGCCCCGA
CGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACGTCCCTCAGACGA
GCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCGCCCCCCGCGTGC
AGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGAGGGGACGTAGCG
TCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGCCGGACGGACGCT
CGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGT
GCTTTGCTGACTGAGGAGCGGCCGGGCCGGGGGGGGCGGACGCTgggccg
gggccacggaccgtggggcagggggctcggggaagggcaggcggggcctg
ggacagggcgcaggggacggggacaaggctggGGTGCCGGGGGCAGGACG
GGGTTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGACCGGGCCAGGAC
aggggtgggaaggtggggggcggacccaggaggggatggacggacccagg
aggcagggggCGGGCGACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGG
GCAAGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGGTGGGGCGGGGAG
GGGATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGAGGACAGAGGCAG
GAGGTG
(SEQ ID NO: 144)
pARBI-925: CCCTGGAGTCGGTGTGAGGCAAAAGCAGAGGAGAGGATTTGGAATTAACC 1806
EDF1_3_ TGAAGAAAAACCATTTCAAAGCGGTAACCAGACCCCAGAGGCTGCCTGAA
Endogenous_27 CTCAAGGGGACATGGGAACCCAGGCTGTCCCAAGTTCACACACCTCAGGT
CGTGGACTTCCAGAGTTTTCTCTCAGTTATGAGGACAGGCAGCTGTACTC
ATGCCAACCAGAGCTGCTCTGGGAAGATGGCTGCCTCCCAGGGCTCCGGC
CAGCACCGGTGCAGGCAGGCACTCAGCTGACAACGTCCCCGGGGGCGCCG
CACACACCACACCCACCAGCACATGGACCCCACAGCACAGCCTCATGTTG
CAAGCGGAAACACAAGTACCTACATTTCTTGGAAGTCTCCACATCTTCTC
CTCGTCTCTGTGCCGCTAAGATAGCCTAGAAAATTAGAAAACATCAGTGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTTCTAAAGAGAAGATGTGCTTTATACACATCAGCTCCACTAGG
ACTGCTGCAAAACCAGGCGCGAAGCGTCGCCTGAGAACAGCAGCTTCTAG
GGCCCCTGGGGTACGCACCCACACGCAGCTGGGTTTTGTGCGAGAGGCAG
TGAGAGCCGGGCTGACCTGGCTTCCCGAGGCATTCCCTGCAGGGGAACCA
GGGGGGTGGAGCCCACCCTCCCCGTGCTATCTGAACACCGGCCATCCCCC
TCCCCAAACCCACAACCCCAGGAGTGAGAGCCCCGGCGCAGCCTCACCGT
GGCCAGGTCCTTCTGCGTAAGCCCCTTGCTCTGCCGACCTTGCTGGATCA
CCTTGCCCACCTCCAGGGTCACCCTGTCATGGTGCAGCTCCTCTGTCTCC
CGGTCCAGCTTGGCCGTGTTCTTGGTAATAGAATGTTGTTTGTTCTGGCC
AGCAGC
(SEQ ID NO: 145)
pARBI-926: CTCTTGCTTCAACAGTGTTTGGACGGAACAGATCCGGGGACTCTCTTCCA 1806
FTL_1_ GCCTCCGACCGCCCTCCGATTTCCTCTCCGCTTGCAACCTCCGGGACCAT
Endogenous_2830 CTTCTCGGCCATCTCCTGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGT
TAGCTCCTTCTTGCCAACCAACCATGAGCTCCCAGATTCGTCAGAATTAT
TCCACCGACGTGGAGGCAGCCGTCAACAGCCTGGTCAATTTGTACCTGCA
GGCCTCCTACACCTACCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCC
CTAATTTCCTCCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCT
TCTTTGTGCGGTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTC
CCGCTAACCATTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCGCGATGATGTGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGA
ATTGGCCGAGGAGAAGCGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAA
ACCAGCGTGGCGGCCGCGCTCTCTTCCAGGACATCAAGGTAACTAGTGTG
TGGGTAATGGACTACATCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGA
TTTGAGGGCGTAGGTGTCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTT
GTGAGCCCTCTTAACCGCTGGAAATAGAGGCGCACCTCGTGCAGTGCCCA
CAACACGCGGCAGTCCACACCGCTGCGTGGTCTTAGGGACGTATAGCTGT
AAGAGCTAGGACAGGGTGCGGAGAGTGATAAATACAAGCTGTCACATGTC
TTTGTGGCCTGGGCCTCTGACCCCCAACGACTCTTGGGAAATGTAGGTTT
AGTTCT
(SEQ ID NO: 146)
pARBI-927: TGGGGCGGGGGGCTGAGACTCCTATGTGCTCCGGATTGGTCAGGCACGGC 1806
FTL_2_ CTTCGGCCCCGCCTCCTGCCACCGCAGATTGGCCGCTAGCCCTCCCCGAG
Endogenous_29 CGCCCTGCCTCCGAGGGCCGGCGCACCATAAAAGAAGCCGCCCTAGCCAC
GTCCCCTCGCAGTTCGGCGGTCCCGCGGGTCTGTCTCTTGCTTCAACAGT
GTTTGGACGGAACAGATCCGGGGACTCTCTTCCAGCCTCCGACCGCCCTC
CGATTTCCTCTCCGCTTGCAACCTCCGGGACCATCTTCTCGGCCATCTCC
TGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGTTAGCTCCTTCTTGCCA
ACCAACCATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGG
CAGCCGTCAACAGCCTGGTCAATTTGTACCTGCAGGCCTCCTACACCTAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCCCTAATTTCCT
CCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCTTCTTTGTGCG
GTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTCCCGCTAACCA
TTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGACCGCGATGATG
TGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAG
CGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCG
CGCTCTCTTCCAGGACATCAAGGTAACTAGTGTGTGGGTAATGGACTACA
TCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTG
TCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACC
GCTGGA
(SEQ ID NO: 147)
pARBI-928: CTTTGCATAGTTTATCCTATTAGTAATCTATTCTGTCTTTGGAATATGTT 1806
PTEN_1_ TTGTGATGATGAAATAAATACTATAAATAGTATTATTCCTTTTGCATTGA
Endogenous_31 GAGTCCTGACGAAATGTCCATGTGACAGTTCATTTTGGGTTTAGCTCTAC
CTCTAATATGTGACCTATGCTACCAGTCCGTATAGCGTAAATTCCCAGAA
TATATCCTCCTGAATAAAATGGGGGAAAATAATACCTGGCTTCCTTAATG
ATTATATTTAAGACTTATCAAGAGACTATTTTCTATTTAACAATTAGAAA
GTTAAGCAATACATTATTTTTCTCTGGAATCCAGTGTTTCTTTTAAATAC
CTGTTAAGTTTGTATGCAACATTTCTAAAGTTACCTACTTGTTAATTAAA
AATTCAAGAGTTTTTTTTTCTTATTCTGAGGTTATCTTTTTACCACAGTT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACT
TATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACA
ATCATGTTGCAGCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTA
ATGATATGTGCATATTTATTACATCGGGGCAAATTTTTAAAGGCACAAGA
GGCCCTAGATTTCTATGGGGAAGTAAGGACCAGAGACAAAAAGGTAAGTT
ATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGATCTGAGAATTTATTGGA
AAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTTTTATTGAGGTGTAATT
GACAAGTAAAAATTATATATAAATACAATGTATAATATGATGTTTTGATG
TATGTGTATATACATTGTGAAATGATTACTACAGTCAAACTACTTAACAT
ATTCAT
(SEQ ID NO: 148)
pARBI-929: GCTACCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAA 1806
PTEN_2_ ATGGGGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTAT
Endogenous_32 CAAGAGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATT
TTTCTCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCA
ACATTTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTT
TCTTATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAA
GACCATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCT
TGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTGTA
AAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTACAT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGG
GGAAGTAAGGACCAGAGACAAAAAGGTAAGTTATTTTTTGATGTTTTTCC
TTTCCTCTTCCTGGATCTGAGAATTTATTGGAAAACAGATTTTGGGTTTC
TTTTTTTCCTTCAGTTTTATTGAGGTGTAATTGACAAGTAAAAATTATAT
ATAAATACAATGTATAATATGATGTTTTGATGTATGTGTATATACATTGT
GAAATGATTACTACAGTCAAACTACTTAACATATTCATCACCTCACATAA
TTATTATTCTCCCCCCAGGGTGAAAGCATTTAAGATCTACAAGCTACAAT
TTTCAATTATACAATGTTATTATTAACTATAGTCACTATGCTGTCCAGTA
GAGCTTCAGATCTTGTTCATCTTGTGTTCCTCCCTCCCCACCCTCAGTCC
CTGGAA
(SEQ ID NO: 149)
pARBI-930: ATAAATAGTATTATTCCTTTTGCATTGAGAGTCCTGACGAAATGTCCATG 1806
PTEN_3_ TGACAGTTCATTTTGGGTTTAGCTCTACCTCTAATATGTGACCTATGCTA
Endogenous_33 CCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAAATGG
GGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTATCAAG
AGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATTTTTC
TCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCAACAT
TTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTTTCTT
ATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAAGACC
ATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCTTGAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTG
TAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTAC
ATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAA
GTAAGGACCAGAGACAAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTC
CTCTTCCTGGATCTGAGAATTTATTGGAAAACAGATTTTGGGTTTCTTTT
TTTCCTTCAGTTTTATTGAGGTGTAATTGACAAGTAAAAATTATATATAA
ATACAATGTATAATATGATGTTTTGATGTATGTGTATATACATTGTGAAA
TGATTACTACAGTCAAACTACTTAACATATTCATCACCTCACATAATTAT
TATTCTCCCCCCAGGGTGAAAGCATTTAAGATCTACAAGCTACAATTTTC
AATTAT
(SEQ ID NO: 150)
pARBI-931: TAGTGACGGTATCAAGAGCAGCATCCCAGGTTGACTTTCTTTGGGGCAGG 1806
PTPN2_1_ ACCTTGCTTGTGTCTTAACCCTTGGTTCCTACccaagtttgtctctctag
Endogenous_34 tcctcaactctgaaagccacttgatatcttacacaattccttttttgcct
gagaaaataaaagtcagttttgatcatttacaaccaaaaatcctaactaa
cacaGACCTGTTTTTGAAATCAGGTAGATTGGAAGTCTTGGTTTACTTCT
TATAAGCCCGTCCGCTGTCTGTCTTGTAACATCCCAGGAGCAGACTTAAC
AAGGCCTTCCTGGAGCCTTGCTCTTTCTGTCTGCTTCCCTCATCTGctct
ctctcctctctctTCACAGGGTCCACTTCCTAACACATGCTGCCATTTCT
GGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatATTGTGGAGAAAGAATCGGTGAGTAATATTTAATATTTACAACT
TAGTATACTGTATGTGATCATTAGCATATAAAGATTTTCATTTTGGGGCC
AATATTCATTCCTTAGTTTTGGCCTTTAATTGCTAAAGGCTAGCGGTCAA
AGTGTTTCTGTCCGGAAAAACTCATGTATCCTTTTCCTTTCTTAAGTATT
TTTATAACAATTGCAGACCTTTCATCTCCAAGATAGAAATACAATGGAAT
AAATATGGACTAGCAGTGACATATAGATCTTTGGAATCCCTAGGAATCCT
TATTGACCTATTGTCAATAAGTCCTCTTCCAGCTTTAAGATCTTGTACTG
TTCTACTTCAGATTTCTTACTTTATTCTACATTTCATAATTGCTGGTTTT
TAATGATGATGAAAATTTCCTAATCCACTTCTAATTAGATGTGGCAATGA
CATGCC
(SEQ ID NO: 151)
pARBI-932: CAGAATTTGAATATGATGTGGCTGACCATAGATACCTCCATTGCATTAAT 1806
PTPN2_2_ TCTGCTTCATAAAGTGTTTGATGCTTGCTTGTAGGTGTTGAATAGAGCCT
Endogenous_35 AATTAGCAGTAAGTAAACAGATCTagagcacagactttggcatctgaagg
accttggttcaatgctgggactgccacttactagctatgggatctttggt
ggatttttaacctttgaaagcctttcatccctcacagatataatggggaa
gaaaatcgtttccattagtattgtgaggattaaatgattaattgatgtaa
acaatgtgctttccatagtacttggcatatcataagtgcttcatGTTATT
TTACGCTGGCTGGGAAGATAAGTTTTGCTGTGGAGAATTTAAGAGGGATA
TTAAAATATATTTTTGTTATTTTAAGGAAATTCGAAATGAGTCCCATGAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTATCCTCATAGAGTGGCCAAGTTTCCAGAAAACAGAAATCGAAA
CAGATACAGAGATGTAAGCCCATGTAAGTACTTGTGGGTTTGTGTGCATG
TGTATTTTTTGGTTTGTTTTAGGAGGCAGGATGTAGTGAAAAGGAGGGCT
TGGGGTCAGTGTTGATAAATACAGTAATTTTTTTCCTATTTACGTAAGAC
ACGTTCTTTAAGAATTTAAAGGTGTAGAATAGTGGAAGGAAAAATAATTA
CCCATAATTATTTCATCCTTCAAACATAGGCACCATTATTTTGGTGTATT
TCCCACAACCTGTTTTTCTTATGCACAGTTTTCCTTTCTTTAAAATAATT
GTAATTATAGATGTCTATATAATATCCATATGTATTTCCTTTTCATATCA
TTCCATCCCCTTTGTAAGTTTTGCTTAAAATAGTTATTGGTGTAGTTTGG
TTTTTT
(SEQ ID NO: 152)
pARBI-933: ACCAGTTATCGTTTTGTAGGTAGACCAATCAATTCTTAGGTACCAAGAAT 1806
PTPN_3_ CTGAATGATCCTTTTACTTTTAGGAAGGTAAGTACTTTATTCATTTAACT
Endogenous_36 ATGTTTACTCCTGGTCGATTTTTCAAGTCACAATGGCTAATGTGCTACAA
ACAGAAGTGCTTCCTTTCCAGCACTATAGTAATAAACAAGATTGCATTTT
ATACTCCTTACAAAAAAAGTAGAGAATAGTTTAGGATTTGTCTCAACTCT
ATTATGATGCTAATTCATTTTTCTTATTTCTTCTGTCTTTTTATAAATAC
CTAGAATATTAATATGAAGATAAAAACAGTAATTTTGAAATGACAGTTGT
GGTTTATCATTCTCTATTTTCAGATGATCACAGTCGTGTTAAACTGCAAA
ATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAAAGGAGTTACATCTTAACACAGGCAAGTAATACGATACCACG
CAAATGTCTGAAAATGATGTGTTTGTGCTTGTTCTGCTTTAAATCATAGG
TAAAAGTATATCTTGACTTCTTTTGGAAATGAAATGGTATTTCAGTTTTT
TTCTGACGATGTAATGAATTATGGACATTATAAGGTTTTGAAGCTTTGAG
TATTTAAGATAAAAGGCAAGTTATTTTTGATATTACACGTTCTGTGAAGG
AAAATTCTTAGGAAATGGCTTAGGCCAGTTCTTTGGCAGATTGTGTTCCT
TACATTATATCTGACACAGAGTGCTGCTTATGCTTCTTAGTGTCTTCTTT
TCTCTTCCCATACCCTGTGGCAAAACCAGAGGCCCTGGACAGCTCTTCTG
TAGCTCCCCCTGCCTCGCATATATCTTCAGAGAGTACACCAAGCCCTGGA
TGGTGT
(SEQ ID NO: 153)
pARBI-934: CCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTC 1806
PTPN6_1_ GCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCG
Endogenous_37 CAACCCCGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCA
CTCATTCCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGC
CCCCAACCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGT
GTGCCCCCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCC
TGCACCGACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGT
GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAG
GGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAA
GTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGAGGGCTCCGCA
CCCCCGCCATTCCCAAGCAGGGATGAGCCGGCTCCCACCCTGAACAGCCA
GGGAGGCAGGGAGACTGGCAGCCGGCGCTGCCTACCCTCCATCCCCTCCC
CTCCCTGCACCAGCTGGGGCTCTCAATGTCCCTCCTCCCTGCTGTCCTGG
GACCTGGTGTCTCAGAGCCTAACCTACCACCCTTTCCACCTAACCCCGAG
GAAGCCACAGAAAGCTGCCTCGCCCTACTCCGGGAGCCCTGGCCGCTGCA
ACCCAGGTCCCACTGGAGACAGGGAGGCCACTGCTGGTGGCCAGCATGTC
GTGCAGGCCAGCTCTGTTGTTAGAAAGCTCTTCTTCCTCTGGAATCGAGC
CTGCCT
(SEQ ID NO: 154)
pARBI-935: CTGGGTTCGAAGCCCGGTTAGAACTCTGGAGGCTAGGATGGCTTGAACCT 1806
PTPN6_2_ GGGAGGTCGAGGCTGCAGAGAGCTGTAACCGCGCCACTGCACTCCAGCCT
Endogenous_38 GGGCAACAGAGCTCTGGAAGCTTGCCCTAGAGTCAGTCAAGGGCCCTAGG
CCAGTGAGTAACAGCTCAGCGTCAGTTTCCTCATCTATAAAATGGGGGTA
ATATCATACCTAGCTCTCAGCATGTTTGTGAGAGACCTAAATGAGGTGGT
GGATTTGGAAGCATGTAGCGCAGTGCCTGGCACACAGTAGGTGCTTGATT
TCCGGCCCCTCTCTGTGAATGTCTCTGCTCAGCGCCTTCCCCTGTGGCCT
GGGTCTTACCTTCCCTGACGCTGCCTTCTCTAGGTGGTACCATGGCCACA
TGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGT
GCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCA
GGGTCACCCACATCAAGGTCATGTGCGAGGTAAGGCAGCCAGGCGGCGGG
GGAGCCTCTGCTGAGGCTCCTGTCTGTGACCACAGTGTGGGTGGCAGGGA
GGGTCTGCCTGGGCTTGAATTCAAGGCTGGGGACCCAGGGAGGGAGACTC
AAGTCCTGTGAATGGCCTAATTTGGCTCCCCCCAGGGTGGACGCTACACA
GTGGGTGGTTTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTT
CAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGC
AGGTCAGGGGTGGGCCCAGCTGCCTCCCCACTTCCCCTGAGCTGTCCCCC
AGATGT
(SEQ ID NO: 155)
pARBI-936: TGTCACATATGTGCAATGCCATGCTCCTGAGCCTTTGATTGCAGACGTGT 1806
PTPN6_3_ GGGAAGTGGGCCCCGTCCCCACCCCCAGTGCCACCCTGCTCTGCTTCTCT
Endogenous_39 TCCCTTGCTGTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGG
TCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTG
GAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGC
ACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGA
CTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCC
AGGATGGTGAGGTAAGGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGT
GCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCCTGGGCCGCCCAGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCT
CAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGA
ACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCGCAACCC
CGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCACTCATT
CCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGCCCCCAA
CCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGTGTGCCC
CCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCCTGCACC
GACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGTGACCCA
TATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAGGGGAGA
AGTTTG
(SEQ ID NO: 156)
pARBI-937: TCTTTAGCTAATGTTCTGTAGCTTGTTTTAGATCTGTGTCTACATATTAT 1806
PTPRC_1_ ATGTATCTCTGTATGCATCAATATTTGTATATATGCATGCATATATGTGT
Endogenous_40 ATGTATATTTATGAATACATATACACACCATATACATACACTTATGTATG
GTGTGTGCATATGTATGTGTAGATATATGTACATACACACTATAGTGGAC
TGGGGAGTTAGTATACTGGGAGGAGCATACATTTAGGGTATGATTCACAT
ATTTATTTTGTCCTTCTCCCATTTTCCATTAATTAACAGGATTGACTACA
GCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACAC
CACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAG
AGACCACAACTTCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGACTCTTTGGATAATGCTAGTGCTTTTAATACCACAGGTTGGCA
CACAAAAGTTGTTAACTTAAATATCAGGGAATGTCATTTAGAAAATTCTA
CAGTTATCAGTACAACTTGTCTTTAAATTATTTGCACAGTTTCTAAGTAT
GTGATTTTATTCAAGTGCAGAAATTGCAGGAAATTAGTATCTGTGAAATA
TAGATCGACTGAAGTAATTAATGCATGTTGTTAGGGAGTGGAGAGAGAAA
AGAAGGGAAGCAAGATCTCCAAGGACAATCAGGAGGGGAAATTTGTTCTA
GTATCCTCTGATCTATACACACTCGCCATGATTCTCCCGCTTGGCTTCCC
GCCACCTGGACAGATGAGAATTTCCCTAGTTCAGAGATTATCAGTTCTAC
TCTCCTTGGAAGGTGTCTTAAATGGGAGTCTTCCCATTTCTTTGTTTCAC
TCTAGA
(SEQ ID NO: 157)
pARBI-938: AGGGAATTTTTATATGTTGGTCATATTATATCCCTAGCATGTGGCATAAT 1806
PTPRC_2_ GTCTAGCACAAAATAGGTGCTCAATTAATCATCATTATCTAAATAAATAA
Endogenous_41 TGCATTTGGGAAAAAAAAGTTTCAAAAGTTTTTCAAAAGTCTTTTGCAGG
CTTGAAATTAATCCCAATAGTGATCCTTTAGTCTGTTATGTTTCTGATTT
AGCCTGGGGATTCAAAAAATAAATAACATAATTTTGATATATTTGGGCTT
TGTAAACATGGTACTAAGAGAGGAAATATAGTTTCATTAGGGTAAAAGCT
ACTGAAAATTGCCACTTGGTGAATGTTCTATCATAGACTTGAGGTACATA
TAAAAATCTAATATATGTTTACATTAATATGAATGAAATTTGAAATTTTC
TAAGAGATTTTTGTTTCTTCTTTGCAGGGCAAAGCCCAACACCTTCCCCC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACTGGTAAGAATTAATATTTATATTTTTACTAATTTTATTTTCT
TGTTGCAAAGTTTATATATTTAACTACAATTTTCTATTATTAACACTGAA
ATTATTTTTAAGGATAAATTTTATAATCATGAGTGATTCTTGACATTCAC
TTGTTCTTAAACTTTCTGCTTATACGTTATAGAGTTTAATAACTACCTAA
ACATGTTATTAAATTTGTATATATATTTTGTGTATAAATAGTAACTTTTC
CCAAACTTGACAGTAAATCACACAACAGGTTTCTACTCTCTTTTAATATT
TTAAGACTATAAAAAAATGCATTTAAATTAGATAACAAAATTTTATAGTC
TGAAAGCAGGTTAACAGCTGTCTATGTATGTTATAGATATGTAGATAACA
GATTTGCATATGTCTATATTTCTTTAAGAGTATGTTGCTTTTTTCAATGG
TATGCA
(SEQ ID NO: 158)
pARBI-939: CCTTTAGCACCATAAAGAAACTAAATTATTTAGATGTTTTTATGAGAACA 1806
PTPRC_3_ TATCAAAAAGTACTTTTCTGTCATCCAATACTTCCACAAATAAATCATTA
Endogenous_42 GTTCTTGCTAATCTTCATCTGGCATAAAAATAATGACATCAACTTTCTTC
ATGTAATTTCCCACTTAATTCCTTTACTAGGAGCAATATCAATTCCTATA
TGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAA
ACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAAGTA
AAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCC
TGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGG
GGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAATCAAGGT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTCATAGGAAAAGACATAAATGAGGAAACTCCAAACCTCCTGTTA
GCTGTTATTTCTATTTTTGTAGAAGTAGGAAGTGAAAATAGGTATACAGT
GGATTAATTAAATGCAGCGAACCAATATTTGTAGAAGGGTTATATTTTAC
TACTGTGGAAAAATATTTAAGATAGTTTTGCCAGAACAGTTTGTACAGAC
GTATGCTTATTTTAAAATTTTATCTCTTATTCAGTAAAAAACAACTTCTT
TGTAATCGTTATGTGTGTATATGTATGTGTGTATGGGTGTGTGTTTGTGT
GAGAGACAGAGAAAGAGAGAGAATTCTTTCAAGTGAATCTAAAAGCTTTT
GCTTTTCCTTTGTTTTTATGAAGAAAAAATACATTTTATATTAGAAGTGT
TAACTTAGCTTGAAGGATCTGTTTTTAAAAATCATAAACTGTGTGCAGAC
TCAATA
(SEQ ID NO: 159)
pARBI-940: aaggaaaaaggcactgagtgctggggggtgctggggtgggctgcagtgat 1806
PTPRCAP_1_ agacatcagggtagaggttaaggtcaggttcagcctcactggggtgaagt
Endogenous_43 ttgagcacggtgagcaggccatgcagcccgggggaggggaggatgggagg
aggtggagctttccgggcagagggaacagccagtgcgaaggccccaggca
ggtggcttaatgcagctgttgggggaggtgagtggtagggaggaggctgg
agggatgggggctgatctcacagggccagagcctggttgaccaaataagg
ccttggccttttctGCTTGGCTGTCCCAAGAGGATCCCAAAGAGAAAAAA
ACGAAAGTGGTCTTGGTCACCCAGCCTGCCCCACACCAGGCCCCACCCCA
GGTGCTGAGCCCTCTGAGCCCCTGCCTGTCTCCCACAGGCTCTGCCCTGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACCTTAGGGCTCGGGATGCTGCTGGCCCTGCCAGGGGCCTTGGG
CTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAGCTCTGTCACCGTTG
TCctgctgctgctgctgctcctactgctgGCCACTGGCCTAGCACTGGCC
TGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTACCACCCGGCCCGCCT
AGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTGCTCTGGGCCAGCCCCC
CAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGGGTCCACAGACAATGAC
CTTGAGCGACAGGAGGATGAGCAGGACACAGACTATGACCACGTCGCGGA
TGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAGCAGCAATGTGGAGAGG
CGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGT
GACACG
(SEQ ID NO: 160)
pARBI-941: aaggtcaggttcagcctcactggggtgaagtttgagcacggtgagcaggc 1806
PTPRCAP_2_ catgcagcccgggggaggggaggatgggaggaggtggagctttccgggca
Endogenous_44 gagggaacagccagtgcgaaggccccaggcaggtggcttaatgcagctgt
tgggggaggtgagtggtagggaggaggctggagggatgggggctgatctc
acagggccagagcctggttgaccaaataaggccttggccttttctGCTTG
GCTGTCCCAAGAGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCA
CCCAGCCTGCCCCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGC
CCCTGCCTGTCTCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGC
TGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGTGGGCTCCAGCTCTGTCACCGTTGTCctgctgctgctgctgct
cctactgctgGCCACTGGCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTG
ACTCAGGGGGCTACTACCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGC
CGCACGCGGCGCCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGC
CCGAGCTGAGCTGGGGTCCACAGACAATGACCTTGAGCGACAGGAGGATG
AGCAGGACACAGACTATGACCACGTCGCGGATGGTGGCCTGCAGGCTGAC
CCTGGGGAAGGCGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGT
CCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACGGAGGGCGACCTGG
TCCTCGGCTCCCCAGGACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTG
CTGAGT
(SEQ ID NO: 161)
pARBI-942: cagtgcgaaggccccaggcaggtggcttaatgcagctgttgggggaggtg 1806
PTPRCAP_3_ agtggtagggaggaggctggagggatgggggctgatctcacagggccaga
Endogenous 45 gcctggttgaccaaataaggccttggccttttctGCTTGGCTGTCCCAAG
AGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCACCCAGCCTGCC
CCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGCCCCTGCCTGTC
TCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGCTGCTGGCCCTG
CCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAG
CTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCACTG
GCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCG
CCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGC
TGGGGTCCACAGACAATGACCTTGAGCGACAGGAGGATGAGCAGGACACA
GACTATGACCACGTCGCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGG
CGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGG
CTGAGGAAGCCAGAGACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCC
CCAGGACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTGCTGAGTGACCT
GCACGCCTTTGCTGGCAGCGCAGCCTGGGATGACAGCGCCAGGGCAGCTG
GGGGCCAGGGCCTCCATGTCACCGCACTGTAGAGGCCGGTCTTGGTGTCC
CATCCC
(SEQ ID NO: 162)
pARBI-943: ATAGAGTAGGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGG 1806
RPS23_1_ GGAAGCGCCGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGA
Endogenous_46 GGCGTGGAGGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGC
GCTTCCTCCCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATT
CTCCGGAGCCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAG
GCCAAATGTTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCT
TAAGGGTTTATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGT
AGATGGCGTGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGT
GTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAAGTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGC
CCTAAAGGCCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGC
TGGAAAAAGTGTAAGTCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGG
AATTCGAGACATGAACTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTT
TTTGTGTAGTAGTATTCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGT
TTGTTCTATTTAAAAGTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTA
AGGTTTTAATTTAACGTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAA
TGATGAAGTAAAGGACACAAACACCTTTACTGTGGGAGTTGTTATAAGTA
AATGGCACGTGTCAGCTATTGAACTTTATCGACTTGATAAAACTAAGGTG
AAGAGA
(SEQ ID NO: 163)
pARBI-944: CAAGCGGGACTTGGGGTCTTGGGGACGGGCGGGCGGATGCGAATAGAGTA 1806
RPS23_2_ GGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGGGGAAGCGC
Endogenous_47_48 CGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGAGGCGTGGA
GGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGCGCTTCCTC
CCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATTCTCCGGAG
CCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAGGCCAAATG
TTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCTTAAGGGTT
TATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGTAGATGGCG
TGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGTGCCGCGGA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAA
GTGGCATGATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGG
CCAACCCTTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAA
GTGTAAGTCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAG
ACATGAACTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTA
GTAGTATTCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTA
TTTAAAAGTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTA
ATTTAACGTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAATGATGAAG
TAAAGGACACAAACACCTTTACTGTGGGAGTTGTTATAAGTAAATGGCAC
GTGTCA
(SEQ ID NO: 164)
pARBI-945: TTGTATATCCTTTTTAAAGTTATTCTTTTTAGTTAATTGCTCTATGTGTA
1806RTRAF_1_ TTGAGACTAGGAATCAGAAAGCTTAGATTCTAGTCCCAGGTGTAAGTTGT
Endogenous_49 GTAACCCTTGGCAAGTGTCAATCTCTAGGCCTCAGCTTTCTCATCTATAA
AATGAGGAAGTTGTCGTATTCTATTTTTTTTCTTAAGATGATACACTTAA
ATGTTCCCTTCTGTTGGGTTATATAATTGCATCAAAAGTGTAGTAATGTT
ATTAAAAAATTGTTAGAGATCCAAACTAAGGTCTCTTTCAACTCTCCCAT
TCTTTTTTCTGTGACTTTATGGTAATAATGAAACTGGTGGTTTTCTTTTC
TTCCCCCTCACAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAG
ATCGACAAGAAGCTATTGACTGGCTTCTTGGTTTAGCTGTTAGACTTGAA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTATGGAGATAATGGTACGTTTTGTGGGGAATGTGTATTTTAAAG
AGAGAGGAAAGATGGGAAAGGGAGTGTGAAAATGTAGGGAACTTTGCAGT
TTGTTTTGTCTAGTACTATTTTACCTTTGGTTTATTCTTATCACAAGTTA
AAAGCACTTTTATTGTCTTTCATTGGTGTTTATATATTTCTGTTAGAATT
TGGAAATGGTGCCCTCTGGAGAAGGCTAATTGACTGTCTTCTCACAGAGT
AACACTACTTTGATAATATGGTCTGCACCTTAGCCTTTCAAATTAAATTG
TTTTTAGTGTCCCAGAATTGATGGGACTTTGAAGTGTTGTTGCAGTAGGT
AATTTCTCAAAAGACTGAAACATGTCTAATGCCAATATACATTAATACTC
TATAGGCCAGAATATATTACTTATGTTTACTGTCTTAGCACAGATACTTC
TATGGT
(SEQ ID NO: 165)
pARBI-946: GCACCTGTTATGTAGGAGGAGTAATAAAATGAATGAATGCACTCAAAACA 1806
RTRAF_2_ CTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAAGC
Endogenous_50 CTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTGGC
TTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAAGT
TTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGGAG
CCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGATTG
GCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCTCG
CCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTCCC
GGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGACGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTG
CAAAGGTGAGGCGGCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCG
GAGGTCCCAGCCTCAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGG
CGGCCTGGTTTCCGCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCA
CGTACCTCGGCTCTTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCT
ACTCCTGTCTCGGCATGTTACTTTCTGCACTTGCTTAACTCCAAGCATCA
CGTAACTACCTTCTCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCACT
CACTATTCAACTCCATGGTTCCCTGGGTAATTAGGCGATACCTTGAGCAC
CTGCTAATTATGGGCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGT
AACTTG
(SEQ ID NO: 166)
pARBI-947: CACTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAA 1806
RTRAF_3_ GCCTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTG
Endogenous_51 GCTTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAA
GTTTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGG
AGCCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGAT
TGGCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCT
CGCCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTC
CCGGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGAC
GCAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGTGAGGCGGCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGG
CGGAGGTCCCAGCCTCAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTC
GGCGGCCTGGTTTCCGCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGC
CACGTACCTCGGCTCTTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCAC
CTACTCCTGTCTCGGCATGTTACTTTCTGCACTTGCTTAACTCCAAGCAT
CACGTAACTACCTTCTCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCA
CTCACTATTCAACTCCATGGTTCCCTGGGTAATTAGGCGATACCTTGAGC
ACCTGCTAATTATGGGCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGA
GTAACTTGAAGACTAGTTCACTGCCTGCCAGGAGCTAAAGGGACGAGGGG
TGGAAG
(SEQ ID NO: 167)
pARBI-948: CCGGGTTAGGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGC 1806
SERF2_1_ CAGCGCCCCTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATC
Endogenous_52 CCCCACGGAGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCC
CCACGCCGCCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTC
TCTAGTCCGTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTA
CCCCAAGCAGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGA
AGTGGTGTTGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGG
TGTGTGGGCAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAG
GCGGTAACCAGCGTGAGCTCGCCCGCCAGAAGAATATGAAAAAGCAGAGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGACTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGC
CGCCCGCAAGCAGAGGTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGA
GACCTGGGTTAGACCAAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGC
TTGAATGTGGACTAGTCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGT
TTTATTTCCTCCCCACCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAA
GGACGGGGGCGGGCGCCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGT
CTGACCTTAAGGGCAAGGGCAGGGAGCTTCACATTTCAAATACAGTTGTG
GTTACGGCAGCCCAGTACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCC
CTTCTCCCAACCTCCTCACTGGTGTTGCTGGGTGTGGTCCTCAATACAGA
ATAGAG
(SEQ ID NO: 168)
pARBI-949: AATCGAGCCCTTTGCCCACGGCTACTTCACGGGACCACCCTCCCGGGTTA 1806
SERF2_2_ GGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGCCAGCGCCC
Endogenous_ CTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATCCCCCACGG
53_54 AGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCCCCACGCCG
CCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTCTCTAGTCC
GTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTACCCCAAGC
AGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGAAGTGGTGT
TGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGGTGTGTGGG
CAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAGGCGGTAAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAGCGCGAGCTTGCCCGCCAGAAGAATATGAAAAAGCAGAGCGA
CTCGGTTAAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCA
AGCAGAGGTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGG
TTAGACCAAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGT
GGACTAGTCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTC
CTCCCCACCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGG
GCGGGCGCCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTT
AAGGGCAAGGGCAGGGAGCTTCACATTTCAAATACAGTTGTGGTTACGGC
AGCCCAGTACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCC
AACCTC
(SEQ ID NO: 169)
pARBI-950: TTCAAAAGGAATCTTTTTGTTTCAACTATTAGGATCTTTTTAAATCAAAT 1806
SLC38A1_1_ ATGTATTTTAATGGTGTACACCAGACCTGAAGAAAAAGATCACAGAAGGA
Endogenous_55 ATTTCCCCTTTGTAAGATAGAGGTAGTTAAAAATAAGCCTTATGACCTAA
TAGGTTAATTGTAATGCTCTGGTAGCCAACTTGAAAAAGGAGAAATGATG
GTTGCATCTCACATTTTAAAATGTTAAGAATTTGTTTTGTAATGAGGATA
CCTTAACCCCTGAAGGCCAAAATGACTATTTGTGTGAGTTTGAGAAAGGC
ACATAGTAACTTGGGGAACAGTCAATAGAATGACAAAATCTTGACTATTT
TAACTTTCTGAACCCTGTCATTTCTTGTGTTCTCAAATTTGATTTTTAAA
TAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAAGTCTTTGGCACCACA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGGAAGTTCGTAATCTTTGGAGCCACCTCTCTACAGAACACTGG
AGGTAAAAAGAACATGCTTTTCTTTACATAACTTGAAACTAATTCTGGTG
GATGAGCGGCCACATGAATTTTAACATAATTCAAGCAGTTATCATCCTCA
TTGCTAAAATGGCACAGGGAAAGTAAAGCAGAGACAGCAGTCACTTATTT
AAAGCCACAAATCCTGCTAGAGTAGCTGAAGTTGCCTTTGTGTCTTACTG
ACAGTTGGTCTAAGAACGGGCTGATAACTTTTTATGTAGCTTGCAACATA
AGCCTTCGTATCTTCTTTCTAAAAATGTTCTCATTTTCCTTCAGCAATGC
TGAGCTACCTCTTCATCGTAAAAAATGAACTACCCTCTGCCATAAAGTTT
CTAATGGGAAAGGAAGAGACATTTTCGTAAGTTATAGACCATTTTTTTAT
GATATA
(SEQ ID NO: 170)
pARBI-951: TAAAGATGTCAAGCTTCAAATCATTATCATAAGGTTAAATATATTACGCA 1806
SLC38A1_2_ TGTCTTTACAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCAC
Endogenous_56_57 AAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATGTAAGTATCATTA
TAATGAAGTATGCTTATTTTTTTAATCATATAAATTGGGACAAATCTTTT
TAATTCAAGTAGCATAGTACCAAAAGCATAACTACCTGTATTCACCAGGA
TATTCCTCATACCTTATGTATTTTCTCTTGAAATCCATTCAAGGAAATAA
CTAGATAACTAAGAATGGATTTTCTTGAATTTTACTTCCATATTGGTTCC
TGAGAGTGCATTAAAGGCTTTGGCTTGATGAACTTTCTTGGGGATTATTT
TGCTTAGTGTCAATGTTTGTTTCTTTGTTCAGATTCCAGGTACAACCTCC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTAGGCATGTCAGTTTTTAACCTAAGCAACGCCATTATGGGCAG
TGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGAATCCTACTTT
TTCTGTGAGTATTGACGTGCCGGTACTTTCCATTTTAAAACTGAACTTTT
TGTATGTTTCTGTTATTACATAGAAGAAATGTGAAATATTTATAAATAGT
TTTTTTATTAACTTGGCTAAGTTACAAGTACATACTTTGATATTTATTGC
TTGAGTGATTTTCCAAACTGTACCTAATGCTTACAACAAAGAGGAAGGAG
AAAATCTTTTTATTAATCAAAAATACTGAAATAAGCATTTGTGAAAAGGA
TTAAAACATTTGAAAATAACTTTTTTTGGTATTTTTGGAGTCTACCTGTG
ACTTTAAATCTCAGTTAAAATATTAAGAGGTGTTTAACCCCAGCCAGTCA
CCACTT
(SEQ ID NO: 171)
pARBI-952: ATCATTCTTCACACTAGTTCCTTTTCTGACTCTTCAGTCACCTCCAGAAT 1806
SMAD2_1_ TAATATCCTTAGAAGCATCTCTAAAATGAGTTTGATTTACTAAACATAGA
Endogenous_58 AGTTGACAAAGTTTTTCAAGTATAACTGCATAAACTCTCTTTTTTAAAAA
ATCAGTTTTTCCCAAGTTGTTAGCCTTTCATTGGCATTTGAGTCATTTAT
GTGACATATTTATAAGAAACATCTGCTAGTGCTGCTGCATACTTTTATCA
GATCCATTAAATAGTACATTTTTGTTCTTGATTCTCACTAAAACTAACTA
AATGGCTGTCATTCTTTTCTTTATGCTTTTATTGTACTAATTTAGCCCAT
TTGACTGCACttttttttttttttttttAAAGTTCCCTCCTTTCTTTTCC
CCTTGCTTCCCAACAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAAAGGATTGCCACATGTTATATATTGCCGATTATGGCGCTGGCC
TGATCTTCACAGTCATCATGAACTCAAGGCAATTGAAAACTGCGAATATG
CTTTTAATCTTAAAAAGGATGAAGTATGTGTAAACCCTTACCACTATCAG
AGAGTTGAGACACCAGGTAGGAATATTGCAAGTTTTTTTCTTGGTTTTGA
ATTAAATGCCTGAACTTCAGTATATTTAAGTACTCTTGTGACCCAGGAAA
ATTTTAGTGTAAATTCTAATAAATTACCTTAAATTGTGCATATTATTTGG
TGGTAATTAAAAtttttttatttttaaaaatttttAATGAGAAAACATAT
CTGTTTCTTGGAATAGCATATGATTTGGCATGAAAGTGCATATCCAGGAA
ATCCTGTAGATTGGCAGTCTGCTCAGCGCTATGCTGATGTGCTTCTACAT
GTCCCT
(SEQ ID NO: 172)
pARBI-953: TTCTATATTAAAAATCAGTTGACATCTGTTTTTAGATAATTTTTTAAAAA 1806
SMAD2_2_ ACTGGATTATAAAATGAAGCACTTAGTAAAGCTGATGGCAGAGGTTTTAG
Endogenous_59 ATCTTTTGAATACAGGAAAGTGGTAAGGGCATTATAGGTATGATTCATTG
AGCTAGAGGGCGTTGGTGTTCACATTTTAAAAACATAATCATGACTTATC
TGGAGTCACATGTTCCATTTTATTGGCTTCCTTCATATAGAAAATATAGT
AACCAGCACTACATGCCTGTGAAAAAGTGAAGCAATTGTATATTTTCTGG
GTGAAGGAAGTATTCTGTACATTCTCCATGTTTTACATCATGGTATTTTG
AATAACCATGCTTCCATGTTCACATCAATTTTTTGTTTTTCAATTTATGC
ACAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGAT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCAGTGGGATACAACAGGCCTTTACAGCTTCTCTGAACAAACCAG
GTGAATATTCTGCCCTCTGTCGAATCTTAGAGATCTTGTGGGAGGGGGGT
ATATTTTGAAAGACCTATATGGGGTTGCTTAGTATAATTTTGCCTAGGAT
GTTTCCTTAATGTAAAATAAGGCATAGCATTTAAAATATCTGCTTGCCAG
TATAAAAAATATATTAAATGTTTCAGCTGATGTTTTAATCAATGCAATTC
TAGTTTGAATCTTCTTTAAATTACTGTATCCCCTAAAGAATAATAATTTT
GATAACTATATATTTATTTTAGCTTGAGATCAGATTATAATCTGTTGTTG
GCCTAATTTTTAAGTAGATACATGATGAGTTTTGCTAAATTTCTTGTTAT
CAGAATCTCATCTTTATACTAATAAATACATACTTAATGAACCCCTTATA
TCACAA
(SEQ ID NO: 173)
pARBI-954: TCAATGTATTTTTGTATAGTCTTTTGAGATTAGAGTGAAGTTCTAAAAAG 1806
SMAD2_3_ TAAGAGAACCTTTTGTGAAAATATTTTAATTGACACTACTAAGAGTTTAA
Endogenous_60 AATAGTATTGGTGGTGAAAAATCGTTAAAAGTATCTGATTTTACTTGCAA
AATTACTGTATTTTCCCACAAGAGGAGTCCTTACAACATTCTTGTTTTTA
GAAGGGTTTGTTTCCATCATTCATTTAAATTCATAAAGATAACGTTTTCA
TGGGTGGAGAAGTCTATTGGGAAAGTCATAATTCGAATTTCTATCTTGCT
TTGCAGTTTGCTTTCTATGATAAGTTGAAATTATTACTTGATGTTCAAGG
TAGTCTCTACATCATCCTTTCAATATTTCTGCTAGGTTCGATACAAGAGG
CTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTGCCATTCACGCCGCCAGTIGTGAAGAGACTGCTGGGATGGAA
GAAGTCAGCTGGTGGGTCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGC
AGGAAGAAAAGTGGTGTGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTA
AAGAAAACAGGACGATTAGATGAGCTTGAGAAAGCCATCACCACTCAAAA
CTGTAATACTAAATGTGTTACCATACCAAGGTAAGTTTTGTTAGATCCCA
GGTTTGATCAAATTATGTCAAGGAATCTGAAGGAAAGTTACTGAATTTGT
GTTCCTTTCAAGTTGCCTGTAAAAAGTGATGATTGAAATATGACTGTTTT
TAACCTTGTATAAATTGTTTTTGCTAGCTGACTTGTTTTATAAATTATTT
TCTTGAATAGTGAGGTTTAATCAAGCTAAATAAGATACTTAGATTTATTA
TCTTCA
(SEQ ID NO: 174)
pARBI-955: GGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCGCCCAGAC 1806
SOCS1_1_ CAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGGGCGAGC
Endogenous_61 CGGGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCT
CGGTGCTGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCG
GGAAGAGCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAG
GCTGAACGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCC
GGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCT
GCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCA
CCCCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGt
ccggatccggagagggcaggggatctctccttacttgtggcgacgtggag
gagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGT
GGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCA
GCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTG
AAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGT
GACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACA
TGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAG
GAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGA
GGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCA
TCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAAC
TACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCAT
CAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAGC
TCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTG
CTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCC
CAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCG
GGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagct
tataatggttacaaataaagcaatagcatcacaaatttcacaaataaagc
atttttttcactgcattctagttgtggtttgtccaaactcatcaatgtat
cttatGTAGCACACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCA
GCAGAGCCCCGACGGCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcc
cgcggcccccgcgcgcccgcggccgtgccccgcggtcccggccccggCCC
CCGGCGACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGCGC
ATCACGCGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCC
CCTGAGCGTGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCA
CCTTCCTGGTGCGCGACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGC
GTGAAGATGGCCTCGGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGG
CCGCTTTCACCTGGATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGC
TGCTG
(SEQ ID NO: 175)
pARBI-956: GGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCGGGGC 1806
SOCS1_2_ CGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGC
Endogenous_62 TGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGA
GCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAA
CGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCC
GCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGG
CCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCG
GACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCAC
ACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCGGCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggc
ccccgcgcgcccgcggccgtgccccgcggtcccggccccggCCCCCGGCG
ACACGCACTTCCGCACATTCCGTTCGCACGCCGATTACCGGCGCATCACG
CGCGCCAGCGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAG
CGTGCACGGGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCC
TGGTGCGCGACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAG
ATGGCCTCGGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTT
TCACCTGGATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGG
AGCACTACGTGGCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAG
CGCCGC
(SEQ ID NO: 176)
pARBI-957: CGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAG 1806
SOCS1_3_ TACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGC
Endogenous_63 GGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGC
CGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGGCCCCGCAGCGC
CCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCGGACGCTATGGC
CCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACCAGGTG
GCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGA
ACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcggc
cgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCACA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAGCGC
GCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGG
CGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGAC
AGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGG
ACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATG
GCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTG
GCGGCGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCG
GCCGCTGCAGGAGCTGTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCG
AGAACCTGGCTCGCATCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGC
TCCTTC
(SEQ ID NO: 177)
pARBI-958: GGCAGACAAACAGTTAAAACAGAGGAGTGGGGTAAGTGATGACCTAACCC 1806
SRP14_1_ AGCCCCGCTGCTCTAGTTTTGTTAAACACCTCATCTGCTATCACGGTCTG
Endogenous_64 GCGAAACCCTGGAGAAACTATTATTTCCACGACGGAAACATGTAATATCG
AAGCACGTTAAATTCCACTCAAAGTGGCGGCGTCTGGGATCCCTGACAAA
GAGCCCTGGGCTGCTTGGGGCCCATTGTTACCAGAAGCAACCTAGGCGGC
TCAGTGCTGGGGACTGAGCCAGCTACAATCCCTACTATTTTCCGGGCCCG
AAGCCCCGAATGTGCTCAGTACAGGGTGGGGAAAGGTAGAGGAAGGCGGC
GGTCCGCGGCAGACAGACTCCGGTGGCTCCCAGACACCGGGAACCCAGGG
AGCATCGCCCGGCTCCCCTCCCGCTGCTTACACTTCTTCAAGGTGATATA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGACGCTGCCCGACGTCCGGCACTTCTGGAAAAGTCTGGTCAGCT
CCGTCAGGAACTGGAAAACAACAGGCCCAGCCCCGTTAGCCAGCCCCAAA
TCCTCGTCCTGCCGCGTCAAGGCCCTGGTCCTCCTGCAGGAGGCACAGGT
CTCGAGTAACGCCTGAGCCGCCCCCTTCCCTCGGCCGGCCAGGCCTAGCC
ATACCTGCTCGCTCTCCAACAACACCATCGCGGCGACGCTGGCTCGACTC
CCTCCGCTTAAGCCCCTAGCAGTGAGAGCCGGAAGTTCGGCCTAGGCTGG
GGGGACTTCCGCTACTAGACTTCCATTGTCTTCCACCAATCTCTTCTCTT
CCACCAATCCCGGCCTGCGCCCTCCCCCCTCCCCGCCCGCCTAGCGCCCG
CGCCCTGGGACGTCCGGGGGCCTGTGACCCGGAGGCGCTGGGGCTGTCCT
GGGTC
(SEQ ID NO: 178)
pARBI-959: GTCTGTCTGCCGCGGACCGCCGCCTTCCTCTACCTTTCCCCACCCTGTAC 1806
SRP14_2_ TGAGCACATTCGGGGCTTCGGGCCCGGAAAATAGTAGGGATTGTAGCTGG
Endogenous_ CTCAGTCCCCAGCACTGAGCCGCCTAGGTTGCTTCTGGTAACAATGGGCC
65_66 CCAAGCAGCCCAGGGCTCTTTGTCAGGGATCCCAGACGCCGCCACTTTGA
GTGGAATTTAACGTGCTTCGATATTACATGTTTCCGTCGTGGAAATAATA
GTTTCTCCAGGGTTTCGCCAGACCGTGATAGCAGATGAGGTGTTTAACAA
AACTAGAGCAGCGGGGCTGGGTTAGGTCATCACTTACCCCACTCCTCTGT
TTTAACTGTTTGTCTGCCGCTCAGCCACGTACGCGGCCGTGTTCACCAGG
ATGCATTTTTTCCTTCAGATGACGGTCGAACCAAACCCATTCCAAAGAAG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTT
AAGAGCTACCGATGGGAAGAAGAAGATCAGCACTGTGGTGAGCTTAATTT
CTAAGGCTGTCTTTTGAAATGTAAAGACTTGAACTTAACAGAGGATGGGG
CGTTTCTGAACCAGGCTTTTATTTGTTTTTCCCTTTTGCCCTGTGTGGCT
ATTTTTGAGACCAGGACCTTCCTATACTTTAGTAGTGGAAACCTCAAGAA
TAAAATAAGAAGGTAGAGGTCAGACAGTCGTTAGTTCTGCTAAAGCTCTT
GTGGAAATGAAAGTAGCATATTGGTCCTTATTCGTAGTACTGTAAGGAGC
AGCTGGCATAAATATTTGATTCCTTAGCCCCTTACTGTGCTGGGCCTTCA
ATAAGCAGTTTCTTGGTACCAGGTGATGCTATTATTTCCTTATCTTTGTG
GTTCAC
(SEQ ID NO: 179)
pARBI-960: CCCACGTCAGTGAGTGCTCACAAGTCTGTGAGGTAGGCGGCGCCACAGAG 1806
SRSF9_1_ AGAAACTGAGGCGCGGGAGCCCAAGCCACTTGTCCAGCGCCTCAGCCGAG
Endogenous_67 CGCGAACCGCGCTCGGGGATGGCATCCACACGGCCCGGCCCCAGGCTCTC
CCTGTCAGCGCCCGAAGGCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCG
CGCACGCGCAATGGTCGCAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGC
CTCCGCCGACCCCTTCGCTTCCGCTCCGCGTTCCCACAATGCAGTGCGGC
TGAGCGCCTCGGAGCCCGCGGGGACGCTGCGGGGGGACCCGTGCTGAggc
ggcggcggcgacgtgggctgcggcgggcccgcggcgtcgggcggtgcgga
tgtcgggctgggcggacgagcgcggcggcgAGGGCGACGGGCGCATCTAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGTGGGGAACCTTCCGACCGACGTGCGCGAGAAGGACTTGGAGGA
CCTGTTCTACAAGTACGGCCGCATCCGCGAGATCGAGCTCAAGAACCGGC
ACGGCCTCGTGCCCTTCGCCTTCGTGCGCTTCGAGGACCCCCGGTGAGGc
ccccgcgcccctgccctctcctcctcggtgcctgaggcccccgccttccc
tgctgtcccctcccccagggctcccctccccccggcctcccctccccccg
cctccgcgcagacccctcaCGGCGCCCCCTCACGGGTGGAGGATGAGGCA
GCCTCTCCTCGCAGGCCCGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTT
ATTTTTATTATTCCAATATTTTACTTAGAAACCCAAAAGCTGAGCCTTTG
GAGGGCCCAAGCCCGCCTGCACCGGCCTCGGGGGGTCCAAATGAGCCTTG
TCCGCC
(SEQ ID NO: 180)
pARBI-961: TGTGGTGTGCTTTTCGAGAAAATGCTCACGAAGATTAGAAAAACACTGAT 1806
SRSF9_2_ GGTTTATTGGCAAAATCAATAATCTGTCAGCAGTTGATTCttttttttCT
Endogenous_68 CTGAATTAGCCCTCTTATGAGTAATCTGTTTGCTCATTCATTATAATTTC
ATACCTCTAAAACTGCGTGTGACAGCTGTAAAGGTTAATTCCAGTATCAT
GAAACGTCTCCAAACCAAAGCAGAAGTGCTTCAGGATCCTGATTTGTGTG
TTTTTTTCTTCACTCTAGGTTTCCCTTTTATGCTTACTACTCATGCCCCT
CACTTGGAAAGTCACTTGGCCTCCTGAACAGCACTAACTCCAAACGtttt
ttttgttgttgttgttttttttAGAGATGCAGAGGATGCTATTTATGGAA
GAAATGGTTATGATTATGGCCAGTGTCGGCTTCGTGTGGAGTTCCCCAGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACTTATGGAGGTCGGGGTGGGTGGCCCCGTGGTGGGAGGAATGG
GCCTCCTACAAGAAGATCTGATTTCCGAGTTCTTGTTTCAGGTATGTTCC
TTTCAAACAGaatgagatgatacatgtaaaatacttaacacagagtctgt
cttccaagaaatgatagctgttattcttCAGTGCATGGGACACGGGGGCT
TTCTTTTCAATAGCCTGTGTGAAGCCTTGCCCTGGATTGCCAATGAGGAA
AGTATCCTGCAAATGAAATTGCGCTGGGAGTGCAGCCTTGGAAGAACATA
ACCATATTTCTTGTAAAGGAGTTTTCTAGTGGTGAGAAGGAAAGATGATG
GGAAAACTTGAGCTACAATTCTAAAGATGCTTCTTTTGGAATATACTTGG
CATCAGACATGGTAGAAAGGCATTCAAGGAGCCAGATTTGAACAACTTAC
CCAGCC
(SEQ ID NO: 181)
pARBI-962: GATGGCATCCACACGGCCCGGCCCCAGGCTCTCCCTGTCAGCGCCCGAAG 1806
SRSF9_3_ GCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCGCGCACGCGCAATGGTCG
Endogenous_69 CAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGCCTCCGCCGACCCCTTCG
CTTCCGCTCCGCGTTCCCACAATGCAGTGCGGCTGAGCGCCTCGGAGCCC
GCGGGGACGCTGCGGGGGGACCCGTGCTGAggcggcggcggcgacgtggg
ctgcggcgggcccgcggcgtcgggcggtgcggatgtcgggctgggcggac
gagcgcggcggcgAGGGCGACGGGCGCATCTACGTGGGGAACCTTCCGAC
CGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTACGGCCGCA
TCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGTGCGCTTCGAGGACCCCCGGTGAGGcccccgcgcccctgccct
ctcctcctcggtgcctgaggcccccgccttccctgctgtcccctccccca
gggctcccctccccccggcctcccctccccccgcctcegcgcagacccct
caCGGCGCCCCCTCACGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGCC
CGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTTATTTTTATTATTCCAAT
ATTTTACTTAGAAACCCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGCC
TGCACCGGCCTCGGGGGGTCCAAATGAGCCTTGTCCGCCTCCTGCCTGGG
GCAGCACCGTAGGGGGAAGCGGCCGCGGGGCAGCGCGGGGGTCGCCGTTC
GCCCTTCCCGCTCGCCTCTCCCCCGGCCCGTGCTCGCCGTGGCTGGAGAG
CAAGCT
(SEQ ID NO: 182)
pARBI-963: GTAACTGACTAGCCTTAGTAGACTGTGGTTTCCAGGTTTATTCAGAAGTA 1806
SUB1_1_ GCAAGATCCCTCCAtttttttttCTACCAAAGAAATCGTATGTGGGATCC
Endogenous_70 CAAACCACAAAATAACCGTTCCTGTGGTTAATACTACTATAATGCCTGAA
GTGTCTTTTGGGATCCTGAGAACAGAGTTTGAAAACATTACTAGACAGAA
GGATTGGTTAGATTCATAGTTTTGTTGTTGAGTGAAACTTGCTTATGTAT
ATATTTATGATATTTTGGATGTAGTCTTTTGATTGTTTAAATCTTAAAAA
GTAATGGGATCTTTTGACACTGGGGTATGTTTTATTTTTATGTGTGCAAA
TTTTAACCATATTCTTTTCTAGTTAAAGAGGAAAAAGCAAGTTGCTCCAG
AAAAACCTGTAAAGAAACAAAAGACAGGTGAGACTTCGAGAGCCCTGTCA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTCTTCTAAACAGAGCAGCAGCAGCAGAGATGATAACATGTTTCA
GGTAAAGTTGGCTAttttttttttttttttttttgacatggagtcatgct
ctgtcacccaggctggagtgcagtggcgccatctcggctcactgcaacct
cagcctcctgagttcaagcagttctctgcctcagcctcccgagtagctag
gattacaggcatccgccaccagacctggctaatttttgtatttttagtag
agatggggtttcaccatcttggccaggctggtcttgaactcctgaccttg
tgatccaactgcctcagcctccaaaagtgctgggtttacaggtgtgagcc
accatgccttgccAAAGTTGGCTGTTTCTTTAGATTCAGAGGAATTATTA
TCTGGCTTGATCTGAAGAATGTTAAAAGTACTATGATCTGATAATTGCCT
AATATG
(SEQ ID NO: 183)
pARBI-964: ATAAATAAACATATCCTGGAAATGGAATAAGTTGGTTATATTCTTTTTAA 1806
SUB1_2_ TTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGACTG
Endogenous_71 TGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTTCT
ACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCTGT
GGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAACAG
AGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTTGT
TGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTAGT
CTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGGGG
TATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGTTA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACA
AAAGACAGGTGAGACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCA
GCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTT
TTTTTTTTTGACATGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTG
GCGCCATCTCGGCTCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCT
CTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCATCCGCCACCAGACC
TGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCA
GGCTGGTCTTGAACTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAA
AGTGCTGGGTTTACAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGT
TTCTTT
(SEQ ID NO: 184)
pARBI-965: AATTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGAC 1806
SUB1_3_ TGTGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTT
Endogenous_72 CTACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCT
GTGGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAAC
AGAGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTT
GTTGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTA
GTCTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGG
GGTATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGT
TAAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACAGGTGAGACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAG
CAGCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTT
TTTTTTTTTTTGACATGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAG
TGGCGCCATCTCGGCTCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTT
CTCTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGCATCCGCCACCAGA
CCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGC
CAGGCTGGTCTTGAACTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCA
AAAGTGCTGGGTTTACAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCT
GTTTCTTTAGATTCAGAGGAATTATTATCTGGCTTGATCTGAAGAATGTT
AAAAGT
(SEQ ID NO: 185)
pARBI-966: CACATTTTAATTTTTGTTTCCATGCTCTTTAGAATTCAACTAGAGGGCAG 1806
TET2_1_ CCTTGTGGATGGCCCCGAAGCAAGCCTGATGGAACAGGATAGAACCAACC
Endogenous_73 ATGTTGAGGGCAACAGACTAAGTCCATTCCTGATACCATCACCTCCCATT
TGCCAGACAGAACCTCTGGCTACAAAGCTCCAGAATGGAAGCCCACTGCC
TGAGAGAGCTCATCCAGAAGTAAATGGAGACACCAAGTGGCACTCTTTCA
AAAGTTATTATGGAATACCCTGTATGAAGGGAAGCCAGAATAGTCGTGTG
AGTCCTGACTTTACACAAGAAAGTAGAGGGTATTCCAAGTGTTTGCAAAA
TGGAGGAATAAAACGCACAGTTAGTGAACCTTCTCTCTCTGGGCTCCTTC
AGATCAAGAAATTGAAACAAGACCAAAAGGCTAATGGAGAAAGACGTAAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGAAAGCAGTCAACC
AAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGAGTTCTGTAGCCC
AAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACACATAACTGCAGT
GGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCAGGAGGGGAAAAG
TGCTAATTACCATGACAAGAACATTGTATTACTTAAAAACAAGGCAGTGC
TAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTGGAACACACACAT
GGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCCAGATTGTGTTTC
CATTGCGGTGCAGAAAACCACATCTCACATAAATGCCATTAACAGTCAGG
CTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCGCATACCTCAGGG
CAGATC
(SEQ ID NO: 186)
pARBI-967: AATGGAGAAAGACGTAACTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGA 1806
TET2_2_ AAGCAGTCAACCAAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGA
Endogenous_74 GTTCTGTAGCCCAAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACA
CATAACTGCAGTGGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCA
GGAGGGGAAAAGTGCTAATTACCATGACAAGAACATTGTATTACTTAAAA
ACAAGGCAGTGCTAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTG
GAACACACACATGGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCC
AGATTGTGTTTCCATTGCGGTGCAGAAAACCACATCTCACATAAATGCCA
TTAACAGTCAGGCTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCATACCTCAGGGCAGATCAATTCCGCACAGACCTCTAACTCTGA
GCTGCCTCCAAAGCCAGCTGCAGTGGTGAGTGAGGCCTGTGATGCTGATG
ATGCTGATAATGCCAGTAAACTAGCTGCAATGCTAAATACCTGTTCCTTT
CAGAAACCAGAACAACTACAACAACAAAAATCAGTTTTTGAGATATGCCC
ATCTCCTGCAGAAAATAACATCCAGGGAACCACAAAGCTAGCGTCTGGTG
AAGAATTCTGTTCAGGTTCCAGCAGCAATTTGCAAGCTCCTGGTGGCAGC
TCTGAACGGTATTTAAAACAAAATGAAATGAATGGTGCTTACTTCAAGCA
AAGCTCAGTGTTCACTAAGGATTCCTTTTCTGCCACTACCACACCACCAC
CACCATCACAATTGCTTCTTTCTCCCCCTCCTCCTCTTCCACAGGTTCCT
CAGCTT
(SEQ ID NO: 187)
pARBI-968: GGAAAAAGCACTCTGAATGGTGGAGTTTTAGAAGAACACCACCACTACCC 1806
TET2_3_ CAACCAAAGTAACACAACACTTTTAAGGGAAGTGAAAATAGAGGGTAAAC
Endogenous_75 CTGAGGCACCACCTTCCCAGAGTCCTAATCCATCTACACATGTATGCAGC
CCTTCTCCGATGCTTTCTGAAAGGCCTCAGAATAATTGTGTGAACAGGAA
TGACATACAGACTGCAGGGACAATGACTGTTCCATTGTGTTCTGAGAAAA
CAAGACCAATGTCAGAACACCTCAAGCATAACCCACCAATTTTTGGTAGC
AGTGGAGAGCTACAGGACAACTGCCAGCAGTTGATGAGAAACAAAGAGCA
AGAGATTCTGAAGGGTCGAGACAAGGAGCAAACACGAGATCTTGTGCCCC
CAACACAGCACTATCTGAAACCAGGATGGATTGAATTGAAGGCCCCTCGT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTTCACCAAGCGGAATCCCATCTAAAACGTAATGAGGCATCACT
GCCATCAATTCTTCAGTATCAACCCAATCTCTCCAATCAAATGACCTCCA
AACAATACACTGGAAATTCCAACATGCCTGGGGGGCTCCCAAGGCAAGCT
TACACCCAGAAAACAACACAGCTGGAGCACAAGTCACAAATGTACCAAGT
TGAAATGAATCAAGGGCAGTCCCAAGGTACAGTGGACCAACATCTCCAGT
TCCAAAAACCCTCACACCAGGTGCACTTCTCCAAAACAGACCATTTACCA
AAAGCTCATGTGCAGTCACTGTGTGGCACTAGATTTCATTTTCAACAAAG
AGCAGATTCCCAAACTGAAAAACTTATGTCCCCAGTGTTGAAACAGCACT
TGAATCAACAGGCTTCAGAGACTGAGCCATTTTCAAACTCACACCTTTTG
CAACAT
(SEQ ID NO: 188)
pARBI-969: AAAGGGAGGTTGAGATGGGCTGAGGTCTTCTAGGAGGCGGGGAGGGAGTG 1806
TIGIT_1_ CAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTC
Endogenous_76 AGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGG
CTGGAGTAGAGATGTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTG
AATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTT
GAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGG
ATGGACTGGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCC
CTTAGAATTTTTCTAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCA
CATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAAACA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACGGGGAACATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACA
ATGTCACCTCTCCTCCACCACGGCACAAGTGACCCAGGTCAACTGGGAGC
AGCAGGACCAGCTTCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATC
TCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCAC
CCTCCAGTCGCTGACCGTGAACGATACAGGGGAGTACTTCTGCATCTATC
ACACCTACCCTGATGGGACGTACACTGGGAGAATCTTCCTGGAGGTCCTA
GAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCT
CTAGCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAAT
TCGGGATCACATTTGAATCACCTGAGGAGATTTTAAATCATACTGATGCC
GAGGCC
(SEQ ID NO: 189)
pARBI-970: GAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGTGGAGAAGGGTGA 1806
TIGIT_2_ GAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAG
Endogenous_77 GCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAG
CCTCTATGGAGGAGCAACAGGATGGACTGGAGAAACTATCATTCCAAAAT
CCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAGGC
CAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATG
ATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGG
CTCTATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCC
AGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTGGGGTGGCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCC
AGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACAG
GGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG
AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAG
TTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATGCAATCCTGAAACAC
TGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCTGAGGAG
ATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGA
ATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGG
TGATTCTAATGGGCAGCCAATACTGAGAACCACTGTTCTTATGTAAGAAG
CACATC
(SEQ ID NO: 190)
pARBI-971: CCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTCAGCTCTGGAAGCA 1806
TIGIT_3_ TAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGAT
Endogenous_78 GTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGG
GAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAA
CAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACTGGAGAA
ACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTC
TAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTC
CTCTTCCCTAGGAATGATGACAGGCACAATAGAAACAACGGGGAACATTT
CTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCT
TCTGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCA
AGGATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTG
ACCGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGA
TGGGACGTACACTGGGAGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTA
TTCCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTAGCATAGAAAA
TGCAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATT
TGAATCACCTGAGGAGATTTTAAATCATACTGATGCCGAGGCCTCACCCA
GACCAATTCAATCAGAATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTC
TAAAAG
(SEQ ID NO: 191)
pARBI-972: TAATGCCCAGCCTAAGTTGGGGAGACCACTCCAGATTCCAAGATGTACAG 1806
TRAC_1_ TTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCCTTTACTCTGCCAGAGTT
Endogenous_79 ATATTGCTGGGGTTTTGAAGAAGATCCTATTAAATAAAAGAATAAGCAGT
ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC
TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC
TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA
TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG
CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA
AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAA
ATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAA
ATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTG
CTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAG
CAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTC
CAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTC
GCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTG
GTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCATT
GCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAG
TCCAGA
(SEQ ID NO: 192)
pARBI-973: GATTCCAAGATGTACAGTTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCC 1806
TRAC_2_ TTTACTCTGCCAGAGTTATATTGCTGGGGTTTTGAAGAAGATCCTATTAA
Endogenous_80 ATAAAAGAATAAGCAGTATTATTAAGTAGCCCTGCATTTCAGGTTTCCTT
GAGTGGCAGGCCAGGCCTGGCCGTGAACGTTCACTGAAATCATGGCCTCT
TGGCCAAGATTGATAGCTTGTGCCTGTCCCTGAGTCCCAGTCCATCACGA
GCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGCATGAGACCGTGAC
TTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACTGGCATCTGGACTC
CAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATGTCCTAACCCTGAT
CCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTATTCACCGA
TTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGATGTGTATA
TCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAAGAGCAAC
AGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAAACGCCTT
CAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCAGGTAAGG
GCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGG
TTCTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTCCTCTGATTGGTGG
TCTCGGCCTTATCCATTGCCACCAAAACCCTCTTTTTACTAAGAAACAGT
GAGCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAAAAAAGCAGATGAA
GAGAAG
(SEQ ID NO: 193)
pARBI-974: TTCCTGTGGTAGCGGAACTCACTAAGGGGCCCATCTGGACCCGAGGTATT 1806
TRAC_3_ GTGATGATAAATTCTGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAAT
Endogenous_81 AAAATAAGAGCCAAGTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACT
GTTGGCCCTGGAAGAATGCACAGAATCTGTTTGTAAGGGGATATGCACAG
AAGCTGCAAGGGACAGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGC
CTGCTCTGCCTTGGGGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGC
CTGGGACATGCAAGCCCATAACCGCTGTGGCCTCTTGGTTTTACAGATAC
GAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCC
TGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTGAGGTGAGGGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCG
GGTCTCTGGGTGCATCCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCT
TGCTTTTAAGTCCAAAGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTG
TTACAAATTCCTCTTGTGCAATAATAATGGCCTGAAACGCTGTAAAATAT
CCTCATTTCAGCCGCCTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAA
CAGTTGTTTAGAAACGAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGG
AAGAGAGACACTTGTGTACACCACATGCCTTGTGTTGTACTTCTCTCACC
GTGTAACCTCCTCATGTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGT
AGAAAGAAGACATTACACTCATATTACACCCCAATCCTGGCTAGAGTCTC
CGCACC
(SEQ ID NO: 194)
pARBI-975: ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC 1806
TRAC_4_ TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC
Endogenous_82 TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA
TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG
CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA
AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT
ATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAG
TGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGT
CACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAG
CAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTATTC
CAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTC
GCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTG
GTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCATT
GCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAG
TCCAGAGAATGACACGGGAAAAAAGCAGATGAAGAGAAGGTGGCAGGAGA
GGGCACGTGGCCCAGCCTCAGTCTCTCCAACTGAGTTCCTGCCTGCCTGC
CTTTGCTCAGACTGTTTGCCCCTTACTGCTCTTCTAGGCCTCATTCTAAG
CCCCTT
(SEQ ID NO: 195)
pARBI-976: TTCATTTCCATTTGAGTTGTTCTTATTGAGTCATCCTTCCTGTGGTAGCG 1806
TRAC_6_ GAACTCACTAAGGGGCCCATCTGGACCCGAGGTATTGTGATGATAAATTC
Endogenous_84 TGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAATAAAATAAGAGCCAA
GTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACTGTTGGCCCTGGAAG
AATGCACAGAATCTGTTTGTAAGGGGATATGCACAGAAGCTGCAAGGGAC
AGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGCCTGCTCTGCCTTGG
GGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGCCTGGGACATGCAAG
CCCATAACCGCTGTGGCCTCTTGGTTTTACAGATACGAACCTAAACTTTC
AAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGG
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGCTGAGGTGA
GGGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCA
TCCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCA
AAGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTGTTACAAATTCCTCT
TGTGCAATAATAATGGCCTGAAACGCTGTAAAATATCCTCATTTCAGCCG
CCTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAA
CGAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGGAAGAGAGACACTTG
TGTACACCACATGCCTTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCA
TGTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATT
ACACTC
(SEQ ID NO: 196)
pARBI-977: CAGTCCATCACGAGCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGC 1806
TRAC_ ATGAGACCGTGACTTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACT
Endogenous_83 GGCATCTGGACTCCAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATG
TCCTAACCCTGATCCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGC
CGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTAT
TCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGAT
GTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAA
GAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAA
ACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCA
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTC
AGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTC
CTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTCTTTTT
ACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAA
AAAAGCAGATGAAGAGAAGGTGGCAGGAGAGGGCACGTGGCCCAGCCTCA
GTCTCTCCAACTGAGTTCCTGCCTGCCTGCCTTTGCTCAGACTGTTTGCC
CCTTACTGCTCTTCTAGGCCTCATTCTAAGCCCCTTCTCCAAGTTGCCTC
TCCTTATTTCTCCCTGTCTGCCAAAAAATCTTTCCCAGCTCACTAAGTCA
GTCTCACGCAGTCACTCATTAACCCACCAATCACTGATTGTGCCGGCACA
TGAATG
(SEQ ID NO: 197)
pARBI-978: TGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTG 1806
TRIM28_1_ GCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCG
Endogenous_85 CGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGT
TGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCC
CCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAG
CCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAG
GGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTC
GGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGG
CGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGAGAGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAG
TGCCTGCTTAGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACG
GCGGGGCGGCGGGCGACGGCACCGGTAAGTACGAAGTGATCGGTGCCACC
CCTCCCCCTACTCTCTGCCTTTGATTCCGACTGGGTGCAGAGATGAGGAT
GCCACCTGGGCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTT
CTGGGTCCTGCATACGAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACA
TCTGACTAAAGTTGGAGAAAAGAAGGCTCGGGGAGGGGAGGGGCTGGTTC
GCTGCGGGATAATGGTCGGGGGCCCACCCAGCAGGGGAATGGTGGGGGCC
ATAACCTGGGTGGGAACTTGTAACAGTCTCCCACATCCCTGCTTCTCGAA
GTGGTG
(SEQ ID NO: 198)
pARBI-979: TCGAAGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGAC 1806
TRIM28_2_ ATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGA
Endogenous_86 CGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAGCAACCACAAGGAGGT
TTCTGGGGAGGGGGCATCTGCGCAGGAGGAGCTTGGCACCAGCTCCAGGC
TGTTACTCCACTTTCCCAAGGCTCTGGGTGGGCTGCCTAGGTTGGGTCAA
GGGACCAATCTTAAATCTCCGGTTGTATTTTCTGGGATGTAAACGTGGAT
CTATCAAGTIGTCTTGCCTTCTCTGACCCTGCCTTTGTCTGGCAGTGCTG
CACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCT
CGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTAC
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatACCAAGGACCATACTGTGCGCTCTACTGGTACATGAGGCTGAGG
GGGGCTGTTGGAGTTGTTCTCCCATGTGTGCCCTCAGTTGCTTTTATGAT
GTTGGTTGCATCTGGTGGATGGGTCCTAGAGTTCTCTAGGGGGTGCCGCC
CGAAGGGCCCGAGGGCAGAACTCCAGAAGCAGAAAAACTGGGGTTGTGGT
GTGTAGTCTCTAGGGCCTAGGTGGGAGAGGGTGGGAAGGGGAAATAAGGG
AGACCTTAATGTGCTGCAGGGAGGTACAAAGGGTTTGAGAAGGCTTATCA
GGGAGTTGTCAGACCTGGTGGTGAAGGGCTCAGCATATGCAAACAGGGAA
AGGCATGGTGTGAAGGGCTTTCTGGGTTTGTGGTTCCCTGGCACACATCT
GGTATAAGATGCTGCTAGGGAAAGTAGACTGTGGGTCCATGGATTATAAG
TGATGA
(SEQ ID NO: 199)
pARBI-980: GGCGCCCAATGCGCGTGCGCGGCGGCGTCGGCGCCAGTTATTTCTGTCCC 1806
TRIM28_3_ GCCCCCCGGCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTTG
EndogenouS_87 TGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGA
AGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCG
TAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGC
GCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGA
GCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGG
CGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAG
CAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCT
tccggatccggagagggcaggggatctctccttacttgtggcgacgtgga
ggagaaccccggccccATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGG
TGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGCCACAAGTTC
AGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAAGCTGACCCT
GAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCG
TGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGC
CTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGC
TGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAG
AGGGAGCCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTT
AGGGCCCGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGG
CGGGCGACGGCACCGGTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCT
ACTCTCTGCCTTTGATTCCGACTGGGTGCAGAGATGAGGATGCCACCTGG
GCGAGAGGATGGGGGCCCGGACAGGGCACGGGAAATACTTTCTGGGTCCT
GCATACGAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACATCTGACTAA
AGTTGG
(SEQ ID NO: 200)
pARBI-596: ATCTCGGCCAATAAAGGAGAAAGGGCGCGGCCCGTACGCGCGCCAGGTGC 2541
APRT_1_ GTGGGCGAGACCAGCTCACGCCCCTCCTCCAGCCGCCAAGGCCCCGGCCC
Exogenous_1 ACAGCTGCCTGGCTGCAGTCAGAAGCGTAGCCCGAGACAAGGAAGGGCGC
CTTGACTCGCACTTTTGTCCGGTTCGAACGTTCTGctcagtggtgcgtgg
aatgcgagcgcgtcttaaaatcgatggcgcctaggagtccatgaaatacg
gTACAGGCTTCCGGCGACGGATGCCCCGCCCCTCACCCACGCTCCGCCCT
CCGGGGATGCCCCACCCCTCGTGGCGGTCCCGCCCGTCCCCGCGCAGGCG
CGCTCGGGCTGCCGCTGGCTCTTCGCACGCGGCCATGGCCGACTCCGAGC
TGCAGCTGGTTGAGCAGCGGATCCGCAGCTTCCCCGACTTCCCCACCCCA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGGCGTGGTAT
TCAGGTGCACGCACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTAC
GGATGGGAGCGCGTGGCCCGCGACCTCCGGGGGGCGGGGCGGGAACCCTC
GTCTTTCGCCCCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGC
CTGTCCTTGGGTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCC
TTCCGCGCCGCCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGG
GGGCCGCATCGACTACATCGCAGGCGAGTGCCCAGTGGCCGCATCTAGGG
CGCTTCCGCCTCTGCGCGCGCCGAGGGCAGCACGTGGGCTCTGCGCGTCT
GCTTGGGGGAGGGCCTTTGGGGTGCTTCAGGGGGCGCCGGGACGGGCGCC
GTGCTTGGGTCGCCCGGGAAGGGTTGTGAGATTGAGCCC
(SEQ ID NO: 201)
pARBI-597: TGCCCCGCCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCG 2541
APRT_2_ TGGCGGTCCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTC
Exogenous_2 TTCGCACGCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGA
TCCGCAGCTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACG
CACAGGCCGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCG
CGTGGCCCGCGACCTCCGGGGGGGGGGGGCGGGAACCCTCGTCTTTCGCC
CCCGGGGCCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGG
GTCCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCG
CCATCGGCCTCCTGGCGCGACACCTGAAGGCGACCCACGGGGGCCGCATC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGACTACATC
GCAGGCGAGTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGC
GCCGAGGGCAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTG
GGGTGCTTCAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGA
AGGGTTGTGAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAGGCGTCCTT
CCCGCAGGTTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGAGTTGCCGG
GTCAGTTGGTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGGCCCAGCTG
CCTTGCTTCTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTGCCACGAGC
CAGGCCTTCCCTGGTGAAGATCACGGAATGCCCACCCAGGGAAGGGAGGC
CTGGAGGCCTCCGGGAGAGCCCAAGAGGTGGCCCAGGGAGA
(SEQ ID NO: 202)
pARBI-598: CGTTCTGctcagtggtgcgtggaatgcgagcgcgtcttaaaatcgatggc 2541
APRT_3_ gcctaggagtccatgaaatacggTACAGGCTTCCGGCGACGGATGCCCCG
Exogenous_3 CCCCTCACCCACGCTCCGCCCTCCGGGGATGCCCCACCCCTCGTGGCGGT
CCCGCCCGTCCCCGCGCAGGCGCGCTCGGGCTGCCGCTGGCTCTTCGCAC
GCGGCCATGGCCGACTCCGAGCTGCAGCTGGTTGAGCAGCGGATCCGCAG
CTTCCCCGACTTCCCCACCCCAGGCGTGGTATTCAGGTGCACGCACAGGC
CGCCCTCGTGGCGCCCCGACCTGCGGGCCTACGGATGGGAGCGCGTGGCC
CGCGACCTCCGGGCGGGCGGGGGGGGAACCCTCGTCTTTCGCCCCCGGGG
CCCTGCCCTCCTTCGGCCCCGGCGTCACCAGGCCTGTCCTTGGGTCCAGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGACATCTCGC
CCGTCCTGAAGGACCCCGCCTCCTTCCGCGCCGCCATCGGCCTCCTGGCG
CGACACCTGAAGGCGACCCACGGGGGCCGCATCGACTACATCGCAGGCGA
GTGCCCAGTGGCCGCATCTAGGGCGCTTCCGCCTCTGCGCGCGCCGAGGG
CAGCACGTGGGCTCTGCGCGTCTGCTTGGGGGAGGGCCTTTGGGGTGCTT
CAGGGGGCGCCGGGACGGGCGCCGTGCTTGGGTCGCCCGGGAAGGGTTGT
GAGATTGAGCCCCCGAGGCCGCCGCGCTGTGCAGGCGTCCTTCCCGCAGG
TTCCGGGTCCCCAGCCCAGGACAGGCGTGACCGAGTTGCCGGGTCAGTTG
GTCTCCCTGGAGTGCCCAAGCTGAATCCACAGGGCCCAGCTGCCTTGCTT
CTTGTTCCTTCTGCGAGCTGGTATTGAGCGCCTGCCACGA
(SEQ ID NO: 203)
pARBI-599: AGTAATTTGATGGGGGCTATTATGAACTGAGAAATGAACTTTGAAAAGTA 2541
B2M_1_ TCTTGGGGCCAAATCATGTAGACTCTTGAGTGATGTGTTAAGGAATGCTA
Exogenous_4 TGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCAGAGAAAGGCT
CTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTGCTAGAAATCT
GCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTATGAGGGAAAGA
TACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTGTTGGGAAGGT
GGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAAATCGATGACC
AAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAGTTAGCCCCAA
GTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATATTCCTCAGGT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACTCCAAAG
ATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCT
GAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTAC
TGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTC
AGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCAC
TGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGC
CCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTTTTGTAAGCTGCTGAA
AGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATATAAAAAAGGT
CTATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGATATAAACAAT
CTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAGA
(SEQ ID NO: 204)
pARBI-600: AAGATCTTAATCTTCTGGGTTTCCGTTTTCTCGAATGAAAAATGCAGGTC 2541
B2M_2_ CGAGCAGTTAACTGGCTGGGGCACCATTAGCAAGTCACTTAGCATCTCTG
Exogenous_5 GGGCCAGTCTGCAAAGCGAGGGGGCAGCCTTAATGTGCCTCCAGCCTGAA
GTCCTAGAATGAGCGCCCGGTGTCCCAAGCTGGGGCGCGCACCCCAGATC
GGAGGGCGCCGATGTACAGACAGCAAACTCACCCAGTCTAGTGCATGCCT
TCTTAAACATCACGAGACTCTAAGAAAAGGAAACTGAAAACGGGAAAGTC
CCTCTCTCTAACCTGGCACTGCGTCGCTGGCTTGGAGACAGGTGACGGTC
CCTGCGGGCCTTGTCCTGATTGGCTGGGCACGCGTTTAATATAAGTGGAG
GCGTCGCGCTGGCGGGCATTCCTGAAGCTGACAGCATTCGGGCCGAGATG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTCTCGCTCCG
TGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCTATC
CAGCGTGAGTCTCTCCTACCCTCCCGCTCTGGTCCTTCCTCTCCCGCTCT
GCACCCTCTGTGGCCCTCGCTGTGCTCTCTCGCTCCGTGACTTCCCTTCT
CCAAGTTCTCCTTGGTGGCCCGCCGTGGGGCTAGTCCAGGGCTGGATCTC
GGGGAAGCGGCGGGGTGGCCTGGGAGTGGGGAAGGGGGTGCGCACCCGGG
ACGCGCGCTACTTGCCCCTTTCGGCGGGGAGCAGGGGAGACCTTTGGCCT
ACGGCGACGGGAGGGTCGGGACAAAGTTTAGGGCGTCGATAAGCGTCAGA
GCGCCGAGGTTGGGGGAGGGTTTCTCTTCCGCTCTTTCGCGGGGCCTCTG
GCTCCCCCAGCGCAGCTGGAGTGGGGGACGGGTAGGCTCG
(SEQ ID NO: 205)
pARBI-601: AGGAATGCTATGAGTGCTGAGAGGGCATCAGAAGTCCTTGAGAGCCTCCA 2541
B2M_3_ GAGAAAGGCTCTTAAAAATGCAGCGCAATCTCCAGTGACAGAAGATACTG
Exogenous_6 CTAGAAATCTGCTAGAAAAAAAACAAAAAAGGCATGTATAGAGGAATTAT
GAGGGAAAGATACCAAGTCACGGTTTATTCTTCAAAATGGAGGTGGCTTG
TTGGGAAGGTGGAAGCTCATTTGGCCAGAGTGGAAATGGAATTGGGAGAA
ATCGATGACCAAATGTAAACACTTGGTGCCTGATATAGCTTGACACCAAG
TTAGCCCCAAGTGAAATACCCTGGCAATATTAATGTGTCTTTTCCCGATA
TTCCTCAGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGA
ATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGACATTGAA
GTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGA
CTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAAT
TCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACT
TTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACATTCTTTTGTA
AGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATA
TAAAAAAGGTCTATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGA
TATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAG
ATTAGTGGCACCTGCTGAGATACTGATGCACAGCATGGTTTCTGAACCAG
TAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAGCACTTG
(SEQ ID NO: 206)
pARBI-602: GATCTCACATTCTAGCGCCCAGACATGTCGGGAACGCCTTACGCCAACTT 2541
CAPNS1_1_ GGGGTCCCCACCAAGAGAACCCCCACCAGATCTGCACCCTCCCCTTCACG
Exogenous_7 CGTGCACCCAGTCCAGGCTCCCTCAAGCCCCACGGGTGCCTTTTAGACCT
GAGGAGGTTGCAAACCTGATCCCCCATACCTGCCCCACCCATCCGCGGAC
AACCCGCCCTCGCAAACTCAGACCCCCACCCGGAGGCTTCAGATTCCTCC
CAGGTCCAGCTGCCGGAAATGCGTGTTTGAAGGGAGGGTGTGGGCTCAGG
GGCGAAGCACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGC
CATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGG
GAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAGCGGGGCC
GGGGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGG
TGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCA
GGTAAGGCGGAGACTATCAGAGGGGCGGGGCCTGGGAATGGGAGGAGCCT
CAGTGAGGCGTGGTCTGGGAGGGGCGTGGTCTAAAAATAGAATAGGATTA
ACCTGGAGGCTAACCTGGGTACATGAATTAGGCCGGGGAGGCCTGGTTTG
AGAGTTCTGCTGTAAGGGGGTGGACCCCAGTGAGGCGGATATCAGTCATT
GGGGGCGGTGCTTGATATGGGAGTAGTCTGATTGTGTGGGACCAGGACAA
TGTGGTCCTGAGGGGACTGATGTGGAGTTTTGGCGGGTGGGGCTTATGGG
TCTGGGCTCAGCCTGCATTGGCTAACCTGGAGATGAACGTT
(SEQ ID NO: 207)
pARBI-603: CGGGCATTTAGGAAGCGGGCCATGGAGTAGGGTCTTGGGCAGATGGCACC 2541
CAPNS1_2_ TGAGGAGGATAAGGCCTTGGGAAGCTGGGGCAGAGCCTCTATGAAGTGAG
Exogenous_8 CCCTCCAAGGGGCGGGGTCTTTTGATTCTACGTGGGATTTTTTAGGTTTA
GGGTGGCCAAGATGACTGAAATCTGCCACTGGGTAGGTGTGCCTGGCAGG
AGGGGAGCCTCCCAGGGGACCGGTCTCTGGGTTTCCTCGAGGGTGGGGTT
GGCCTGAGGAAGGGAGAAGAGGGGCACGACCAGGGCAGTGTGGATTGGGA
CAGATGAGGACAAGAACAAATGAAAGGCACAGCAACCAAGTAAGGAAGAT
AACGGCTGGGGTCTGGAGCGTTGGGGCTGATGGTTCTGTAGTGCTGCCCG
TTGGAGGCCCCGCCCCTGGCACTAACCCCTCCCCCTTATCTCTTCGCAGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACAT
CGCCCACAGTCCCCGAGAAGTTGGGGGGAGGGGTCGGCAATTGAACGGGT
GCCTAGAGAAGGTGGCGCGGGGTAAACTGGGAAAGTGATGTCGTGTACTG
GCTCCGCCTTTTTCCCGAGGGTGGGGGAGAACCGTATATAAGTGCAGTAG
TCGCCGTGAACGTTCTTTTTCGCAACGGGTTTGCCGCCAGAACACAGCTG
AAGCTTCGAGGGGCTCGCATCTCTCCTTCACGCGCCCGCCGCCCTACCTG
AGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCTCCCGCCTGTG
GTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAAGCTCAGGTCG
AGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTAGACTCAGCCG
GCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTACGTCTTTGTTT
CGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACCGGCGCCTACT
CTAGAGCTAGCGAATTgccgccaccATGGTGAGCAAGGGCGAGGAGCTGT
TCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGACGTAAACGGC
CACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCACCTACGGCAA
GCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCCGTGCCCTGGC
CCACCCTCGTGACCACCCTGACCTACGGCGTGCAGTGCTTCAGCCGCTAC
CCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGG
CTACGTCCAGGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGA
CCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAG
CTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCT
GGAGTACAACTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGA
AGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGC
AGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGG
CCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGA
GCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTG
ACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtt
tattgcagcttataatggttacaaataaagcaatagcatcacaaatttca
caaataaagcatttttttcactgcattctagttgtggtttgtccaaactc
atcaatgtatcttatGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGGT
AAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGCCTCTTCGAGG
TCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCCCTTCTTGTGA
AATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTTCGCCATGGGT
CTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCACCCCTCATTC
TTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCACCCAGGGTAC
CTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCCTGCTCTGAGC
TCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAACATTGAGGCCA
ACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCT
GGAGATGTAAGTAAC
(SEQ ID NO: 208)
pARBI-604: GCTGATGGTTCTGTAGTGCTGCCCGTTGGAGGCCCCGCCCCTGGCACTAA 2541
CAPNS1_3_ CCCCTCCCCCTTATCTCTTCGCAGCGAGGCGGCTGCGCAGTACAACCCGG
Exogenous_9 AGCCCCCGGTAAGCCCCCTCTGCAACCAGACCCCCTTCTCCTGCCAAGGC
CTCTTCGAGGTCCCATCCCTGTTCCTGTAGAGAAGCCCCACCTTCCTCCC
CTTCTTGTGAAATTCCTCTGCCAGTTCCTCCCATGCCGTGTCTGCAGCTT
CGCCATGGGTCTTAGCCATGCCCCACATACGTGCACCCCATTCACTACCA
CCCCTCATTCTTTTCCTCATCAAGCTGCCCAGCCCACTCTGACTTCCCCA
CCCAGGGTACCTGGGTTTGGGGAGCCGTCCTGGCCGGGTTCCCCTCCCCC
TGCTCTGAGCTCTCCTCCCTTTGCAGCCCCCACGCACACATTACTCCAAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCC
GCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCT
CCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAA
GCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTA
GACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTAC
GTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACC
GGCGCCTACTCTAGAGCTAGCGAATTgccgccaccATGGTGAGCAAGGGC
GAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGTCGAGCTGGACGGCGA
CGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGCGAGGGCGATGCCA
CCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCACCGGCAAGCTGCCC
GTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACGGCGTGCAGTGCTT
CAGCCGCTACCCCGACCACATGAAGCAGCACGACTTCTTCAAGTCCGCCA
TGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCTTCAAGGACGACGGC
AACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCGACACCCTGGTGAA
CCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGACGGCAACATCCTGG
GGCACAAGCTGGAGTACAACTACAACAGCCACAACGTCTATATCATGGCC
GACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGATCCGCCACAACAT
CGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAGCAGAACACCCCCA
TCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTACCTGAGCACCCAG
TCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGATCACATGGTCCTGCT
GGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATGGACGAGCTGTACA
Aatgattgtttattgcagcttataatggttacaaataaagcaatagcatc
acaaatttcacaaataaagcatttttttcactgcattctagttgtggttt
gtccaaactcatcaatgtatcttatATTGAGGCCAACGAGAGTGAGGAGG
TCCGGCAGTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGTAAGTAAC
CTGGGGTCCCTGGCCCCGTCCTAACCGTTCCATCCCTTCCCTTGTGGCTG
CCCTTGCACACACACCCTTGACCATGACAATCCCAGTGTTCCCATTCTCC
ATGACATTCTCAGACCCCTTTCAGTCACCCCTGACCTGCCCCTAACTTCC
GCCCGCAGGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAAT
AAGGTTGTGACACGACGTAAGTGACCGGGGTTAAGGAATAGGGTAGATTC
AGAGGCAGAGGGGTCAGAGAGGATTTGACCTCTGGCCTCTGACTTTCAAC
CTGTTACCCACAGACCCTGATCTGAAGACTGATGGTTTTGGCATTGACAC
ATGTCGCAGCATGGTGGCCGTGATG
(SEQ ID NO: 209)
pARBI-605: ggagagttatagcagatggagacaaaaaagggaactgctggggatcaaac 2541
CBLB_1_ cttgtaaagtccttctaagtgatatatgaggactttgacttttattcaaa
Exogenous_10 gttagaaggctttgaacaaaagaattatttcatttgtgttttacaatggt
cacaagtgccgtagcgagaataggctgTGTAGAGAAGAGATTTTGTGGTT
TTCTTTTTTGTTCTCTGTATTCTCTTCCTGAAAAATCTGTTTTCTGCCTA
ATCATATTTCTGTAAAGAACAATAGACTTGAACGTCTGCTGTTAAGTAAC
AAAGGTTGACCTAAACCACATAAGGTCAGATTAACTTTTAAAATATCCAA
GATAATGTTAAGTGTATTAAATATGGTTCAGTATGTAATCAAAATATTTG
ATATTCTCTAGATACTAATCTCttttaatttttttattttttAGCCTTGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGCTCTATT
TTGCGGAATTGGAATTTCTTAGCTGTGACACATCCAGGTTACATGGCATT
TCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAAC
CCGGAAGGTAAGACTTTTTAGCAGTAATATTATGTGATATATCCAAAGAT
GAAAAATTCTCCATGGTTTGTTCCTAAGTAAGTCAGCAATACCCGCTGAT
GGCATGCTTGGGAGGGGGCTAGAAAAGGTAAAAGACCAAAATGGTGCTTC
TTAACATAATGTTTTAAATTGATACATTGTGCTTACTCTGAAACTTGGTA
TTCATAAAGTGAAAGGGGATATGGTCTCCTTTCTGTTTTCATGATATCCG
TGTTTATGTGCAAAATTGAATGTATATATTTGAATACTTGAATACTGTGC
TAAAGAACAAATAAATAGAACAGTCTTATGTTCATTACTTT
(SEQ ID NO: 210)
pARBI-606: CATATTACTCATTTGTGCAATGAATAAAGGATTTCTATTATTATATGGAC 2541
CBLB_2_ CCATCATCTTATGACTGTTTTTAGAAAATGAGAATTAAATCTTGATTCAT
Exogenous_11 TATTAAATAACCTTGTATACACACATGAAGAGGTCATGACACATAAGACT
TTGACCTAATACCTTTTTTCAGATATGTTTCTATAGCTATCTTGATAGCC
TAGGACTGTTTGAGAGAAAATTAATTTAAATTTTTGTCATATTCTTAGCA
AATGCAAAATAATTGAGTTAAACAGAACCCACTACATTTGTTCTGAAATA
TGAACAATATTCTCAAATATTTGTCTGGTAGTACAAATACAATTATATTA
ATTTTATTATTGAATTTTGCTGCTTCAAAGGGAGGTATTTCTTAAATGAT
ACTTGATTCAATTATTTCCCTTTTTTTCCACCTTGCACAGAACTATCGTA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCAC
ATGAAGCAGCACGACTTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCA
GGAGCGCACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCG
AGGTGAAGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGC
ATCGACTTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAA
CTACAACAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCA
TCAAGGTGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAG
CTCGCCGACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCT
GCTGCCCGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACC
CCAACGAGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCC
GGGATCACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagc
ttataatggttacaaataaagcaatagcatcacaaatttcacaaataaag
catttttttcactgcattctagttgtggtttgtccaaactcatcaatgta
tcttatCCATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGAT
TAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAACTT
GCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTT
CAGGTAAGTTTATACTTGCTTAGTCTATCCATTCCCTtcttctctctccc
tgtcttttctctctgtttctctctctctctgtctctctctcacacacaca
cacaTAAACAAACATATGGAAAATAGTGTCATTCCTATTAGTCTGTAATT
TTATTGGTATGTTTGGTCATTGTTAAAAGTTTAGAGTGAGCCATTTGGCT
TAAGTTTGGAGTTATCAGATGCTGTGAGCCTGGTGGCTGCTTGTTAGCTT
TGAGAGGATCCATCCAAAAGAGCTTTGTTTTAAACTCTCTACTTAGTTTC
TTACTT
(SEQ ID NO: 211)
pARBI-607: TTAAACTTTAGAGGTTCAAAATAAGGATATGATATAGAAAAGATTGAATG 2541
CBLB_3_ GTAGGAGAACAGAATAGGATTTATTTATATTATGACAAACGTGACTATCA
Exogenous_12 GTTAATAAATTGGAGATAGTAAGTTAAGATCATTATTTATATTATGGAAA
AATGAAGAAATAGGACATGGTTCTCTAACTTTTTAATTTTTCTGTGAAAT
AAAATATTATGACTTATTTTATTTTTATCTTTGTTTTTAGGTAAGACTGT
GCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATATATACTTGAT
ATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGA
TGACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCT
ACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGAAGGCAAG
GAGAGAATGTATGAAGAACAGTCACAGGACAGGTAAGAAGAATATTTCAG
ATGTTTTGGTGTAAAGGTCATTTATGTTGCTTTTTACTTAATAGTTAACC
TAAACGTCACCATGTAATTGTTTTGGGGTAAATGTGAGTCGCTTTGTATA
Tagtcatgtggtacttaacgatggggatactttacaagaaatgcattttt
agacaatttcattgttgtgtggacatgatagagtgtacttacacagagct
agatggtattacctaccgcacacctaggctgtatgatgtagcctattgct
cctaggctgcaaatctatacagtatgttactgtactgaatactgtgggca
gttgtaacacaatggtaagtatgtgtgtatctaaatatacctaaacatag
aaaaggtatggtaaaaatactgtataaaaggccgggcgtgg
(SEQ ID NO: 212)
pARBI-608: AGATGAGAAAACCTATCCTTCCCAATTTTTTTGTGTGAGAATTAAAATGC 2541
CD2_1_ AGCAAGAAAACACACACTCATAAACACATCTGCTTTGGCAAAGGAGCACA
Exogenous_13_ TCAGAAGGGCTGGCTTGTGCGCGCTCTTGCTCTCTGTGTATGTGTATTAT
14_15 GTTTTATGTTACTGTAAAAGATGTAAAGAGAGGCACGTGGTTAAGCTCTC
GGGGTGTGGACTCCACCAGTCTCACTTCAGTTCCTTTTGCATGAAGAGCT
CAGAATCAAAAGAGGAAACCAACCCCTAAGATGAGCTTTCCATGTAAATT
TGTAGCCAGCTTCCTTCTGATTTTCAATGTTTCTTCCAAAGGTAAGCATA
AGAGTCAAAGAAGTCCCAACCCAGCTTTCCCTGAAAGTGACTCTCAGTAA
CTCTTTTGCTTTTTATAGGTGCAGTCTCCAAAGAGATTACGAATGCCTTG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGAAACCTGG
GGTGCCTTGGGTCAGGACATCAACTTGGACATTCCTAGTTTTCAAATGAG
TGATGATATTGACGATATAAAATGGGAAAAAACTTCAGACAAGAAAAAGA
TTGCACAATTCAGAAAAGAGAAAGAGACTTTCAAGGAAAAAGATACATAT
AAGCTATTTAAAAATGGAACTCTGAAAATTAAGCATCTGAAGACCGATGA
TCAGGATATCTACAAGGTATCAATATATGATACAAAAGGAAAAAATGTGT
TGGAAAAAATATTTGATTTGAAGATTCAAGGTAAGTGTTCATTCCCTTAA
TTGCTTTATTTCAGTGTGGGTGCTATTTGGCAAGTTGGAAAATAGCATTT
CTAATATTCCCCAGCGCTGACCTCTGCCTCCAGGGGGGCTATACAGGAAA
CCAGATGCATGTCTCCTGCCCCAGTGGAGACTGTGGTCCAA
(SEQ ID NO: 213)
pARBI-609: AGGATTGTTCTAGTTGATTGGTATGTGTGCACTCCTAGTTGTTAAATATT 2541
CD3_ TTCACTATCACACCTGGATATACTCAACAAATATTTGTTGAGCCAAATAC
E_1_ TCAACACCAGCCAAACACGTAGTATTTACTTTAGCTTAAGCGAATTATTT
Exogenous_16 AGCCCTGACAGAAGCCCTGGAATGTGGGTCTTTAAGTTCCTATTTTTGAG
ATGGGAAAGCTGAGGCTCACGGAAGGAGGTGACCAGCTCAAGTCTCCTAC
CGTCCATGCCAAATTAGAATTCCAGCCTGCCTCCTGACTTCAAGTCCAAA
GTTCTTCCCACGCACTAAAGCTAGCTCTTCAGTGTCCTTTCTTAGGAGGT
ACTTCCTCCCGCACCACTGACCGCCCCCTCTCTATTTCACCCCCAGCCCA
TCCGGAAAGGCCAGCGGGACCTGTATTCTGGCCTGAATCAGAGACGCATC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTGACCCTCTG
GAGAACACTGCCTCCCGCTGGCCCAGGTCTCCTCTCCAGTCCCCCTGCGA
CTCCCTGTTTCCTGGGCTAGTCTTGGACCCCACGAGAGAGAATCGTTCCT
CAGCCTCATGGTGAACTCGCGCCCTCCAGCCTGATCCCCCGCTCCCTCCT
CCCTGCCTTCTCTGCTGGTACCCAGTCCTAAAATATTGCTGCTTCCTCTT
CCTTTGAAGCATCATCAGTAGTCACACCCTCACAGCTGGCCTGCCCTCTT
GCCAGGATATTTATTTGTGCTATTCACTCCCTTCCCTTTGGATGTAACTT
CTCCGTTCAGTTCCCTCCTTTTCTTGCATGTAAGTIGTCCCCCATCCCAA
AGTATTCCATCTACTTTTCTATCGCCGTCCCCTTTTGCAGCCCTCTCTGG
GGATGGACTGGGTAAATGTTGACAGAGGCCCTGCCCCGTT
(SEQ ID NO: 214)
pARBI-610: AATAATAAAATAATAACAATACTTAACATTTATTGAGTGCTTATTAAGTC 2541
CD3_E_2_ TCAAGCACTGTCTGTACCCAACACTTATCAAGGATTCTTTTTCATGTAAT
Exogenous_17_18 CCTCTCAACAACTATATGGGTTAAGTATCATTTTATTCCCATGAGTAAAG
GGATGAGGAAACAGAGGGTTTGTGAGTTGAAAACACATTTCACGCTTCTC
ACAGCTAGTGAGTAATAAAGCTGGGACTCAAACCCAGGGCTGTTTGACTC
CAGTGCCTCTACCCACGGCCACCACTCTTTGCTTGTCAATGTTGTTCTAA
ACATATTGAAGGGGGGGCTCTGACCGTGGCAAGCGTGTGAGTAGTAAGGG
GAGAATGGCCTTCATGCACTCCCTCCTCACCTCCAGCGCCTTGTGTTTTC
CTTGCTTAGTGATTTCCCCTCTCCCCACCCCACCCCCCACAGTGTGTGAG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatAACTGCATGG
AGATGGATGTGATGTCGGTGGCCACAATTGTCATAGTGGACATCTGCATC
ACTGGGGGCTTGCTGCTGCTGGTTTACTACTGGAGCAAGAATAGAAAGGC
CAAGGCCAAGCCTGTGACACGAGGAGCGGGTGCTGGCGGCAGGCAAAGGG
GTAAGGCTGTGGAGTCCAGTCAGAGGAGATTCCTGCCAAGGGGGACGACC
AGCCTGGGCCAGGGTGGGTGGCAAGTCCACAGCTAGGTCAGAACAGCTTC
TCTAGAGCTTCTATGCACAGCTTCTATTACTGTGATGACAAGATCTCAAC
AGACGGTTTCAAATCTCACATCACTCCCCTCCTTCCCATCCTAGAAAAGT
GCAAAAAAGTTTATGAAAGTGATGGGCTTCCTCACATACCTGTCAATGCC
TGCAGTCATCCGATTCCGCCCCTAAGCTGTGGGAAGAGAG
(SEQ ID NO: 215)
pARBI-611: ACTGTGACCCATGAACCAGTAGGTATTGGCGTCACCTGGGATCCTGACGT 2541
CD3G_1_ TAGTCTCTGTCAATCCTTCTCTTTAGTTCATCTATTCTACCCAAAGTGAT
Exogenous_19_20 CTCATCATCTGGTATGCTGTTAGCAGTTTCTTACCTGTATAGTATCTTCC
AAATAACATGCCCCAAAATCCCAAAGTTTTACCCCTACTAATTACAGCAA
TGTCTCTTTTATTCTTCACCCCCTGACGCAGATATTGGCGTCACCCGAGA
GCATGTTAGTAATGCAGAATCTCCCCTCCCCAGAACTACTAAATAGCACC
TGAAATTTTAACAAGATCCCCATGTGATTCATGTGCACATCAAAGTTTGA
GAAACACTACTCTAATGATCTCCTGGTATGCAGAAGCAGGGAGAATTTCA
GAGGCAAGATCCTTAATAGAACCACGGCTTTTCTCATTTCAGGAAACCAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTTGGTTAAGG
TGTATGACTATCAAGAAGATGGTTCGGTACTTCTGACTTGTGATGCAGAA
GCCAAAAATATCACATGGTTTAAAGATGGGAAGATGATCGGCTTCCTAAC
TGAAGATaaaaaaaaaTGGAATCTGGGAAGTAATGCCAAGGACCCTCGAG
GGATGTATCAGTGTAAAGGATCACAGAACAAGTCAAAACCACTCCAAGTG
TATTACAGAAGTATGTAATCCCCTTTGGTCTGTTTGTTGTGAAATTAATC
AGTATTTGCTGTTCTGGTGAGCTTTTTATCTGGGGTGAAAGTGGAAATAG
ATCCTCAACAGTAATATTATCGCCTGTTCTCTTAATTTCAGCTTGCCTCT
TTTAAAATACTGTAAGATACTTCCCTCACCCTATTGAAAAACTACAGCCA
GTCCTGTAAAATTTTGTTTACCTTTGGGTGGGCTCCATGG
(SEQ ID NO: 216)
pARBI-612: TTCGAGACAAGCCTGGCCAACATGATGAAACTCTGTCTCTACTAAAAATA 2541
CD3G_3_ CAAAAAAAATTAACCAGGCGTGGAGGCGCGCGCCTGTAGTCCCAGCTACT
Exogenous_21 CAGGAGGCTGAGGCAGGAGGACCACTTGAACCCAGGAGGTCGAGGTTGCA
GTGAGCTGCGATTGTGCCACTGCACTCCAGCCTGGGCAACAGAGAAAGAC
TCCGTCTCAAAAAAAAAAAAGAGAGAGAGAGAAAAAGAAAAAAGACAGAG
CCTCCATCTCCTTGTCCTCTTTCCATCCTCAGGACCATGAAGTACCCACT
CCAAATTCTCACATATAAAAAACATTCAATAAACATGCATCAAATTAATT
AATAGAGGATGGAAAAAATGACTTATGACTGTGCTGTCCTTTCCAGCCCC
TCAAGGATCGAGAAGATGACCAGTACAGCCACCTTCAAGGAAACCAGTTG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAGGAGGAAT
TGAACTCAGGACTCAGAGTAGGTGGGTTCTTCAATGCCAATTCTAATAAA
GGACCCTTGCATCAACTGCCCTCGCAATTGCTTCTAAGTCTAGCTCCCTT
CCCTAAGCGGCTATAAGCATCAGACTCTGGGGATCAGGGATTGGGACGTG
GTTTGGGGTACTCTTTTCTAAAAATTCTGGGGCCATACTGATTGTCTTGG
CCTAGGTAAATATGAATTTTATGTATCTGTAAATCCTGTCAGAGCAGGGC
CTCAAGCCATAGAGATGCTGAATATTAATCTTAACCTACATTTGAATTTC
TCATTATCTACACTATTAACATTTTGGGCTAATTAATTATTTGTGATGAG
GGGCTAGCCTGTGCATTGTAGGAGTTATGGAAGCATCCCTGGCCTCTCTC
CACCAGATGCTGGTAGATTGTCCAGTGTGACAATCAAAAAT
(SEQ ID NO: 217)
pARBI-613: GACCTCAGGTGATCTGCCCGCCTCAGCTTCCCAAAGTGCTGGGATTACAG 2541
CD5_1_ GCATGAGCCACCACACCTGGCCTAAAATTAATTTTTAAAGATCTCTTAAA
Exogenous_22 AAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGACAGAATTTCCAGGA
CAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCATTTA
TCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGGTCT
AGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGTGCC
CCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGGCAG
GAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCCAGT
GGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCAGAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTCCAGGCA
AGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCTGGAGGTCTACCT
CAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGGGCCGGAGCTCCA
AGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGCCAGCGGCTGAAC
TGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCACCTACACACCTCA
GAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTCTCCAACTGCAGCC
ACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGACCTGCTTAGGTGGG
TAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCGCCAGCCCCGAGGA
GACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGCTGGTGGAAGGGGT
GGGGGGACCCCAGTTTATAACCACTCCCCAAGACACATACC
(SEQ ID NO: 218)
pARBI-614: GGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAACACCTTGCCCAT 2541
CD5_2_ TTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCCACCCTCCTGGG
Exogenous_23 TCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAAGCCCCTGCAGT
GCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGCAGCCCACGGGG
CAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAGTGAGGGGTGCC
AGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTTTCTGACCCCCA
GATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGCCAGGGCCAGCT
GGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGGG
GCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGCGGCTG
AACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCACCTACACACC
TCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTCTCCAACTGCA
GCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGACCTGCTTAGGT
GGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCGCCAGCCCCGA
GGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGCTGGTGGAAGG
GGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACACATACCCAGGAG
GGGGACTGGAAGGGGCCAGCACCCATCTGTAGGATGGCAATGGAGGACCT
AGTTCTGCCAATCACTGACTTCATCGTCGCCTCTGAACCTCCATTCTCCC
ATCTGTGAAGTGGGGTGGTACTTCCCGCCTCGCAGGAGGCT
(SEQ ID NO: 219)
pARBI-615: tgctgggattacaggcatgagccaccacacctggcctaaaattaattttt 2541
CD5_3_ aaagaTCTCTTAAAAAGCAGACACCAGCCCCAATCTCAGACCCCTTGAGA
Exogenous_24 CAGAATTTCCAGGACAGGGGCCATCCTGCTGGACAGTGGGTGCCGAGAAC
ACCTTGCCCATTTATCTGAGCTCCCTTCTGACTCTGAAATCTGGAGCCCC
ACCCTCCTGGGTCTAGCTTCGGGGCTGCCTGGGTCAGGGTCCTCTGGGAA
GCCCCTGCAGTGCCCCAGAAGGGACGAAGCTCACAAGGGGCAAGGCAGGC
AGCCCACGGGGCAGGAGGGAGCTCAACTGGGCGTCCTAGGGAGAGGGCAG
TGAGGGGTGCCAGTGGGGAACCCCTCCCAGCCTGACCCCCACCACACCTT
TCTGACCCCCAGATTTCCAGGCAAGGCTCACCCGTTCCAACTCGAAGTGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGCCAGC
TGGAGGTCTACCTCAAGGACGGATGGCACATGGTTTGCAGCCAGAGCTGG
GGCCGGAGCTCCAAGCAGTGGGAGGACCCCAGTCAAGCGTCAAAAGTCTG
CCAGCGGCTGAACTGTGGGGTGCCCTTAAGCCTTGGCCCCTTCCTTGTCA
CCTACACACCTCAGAGCTCAATCATCTGCTACGGACAACTGGGCTCCTTC
TCCAACTGCAGCCACAGCAGAAATGACATGTGTCACTCTCTGGGCCTGAC
CTGCTTAGGTGGGTAACTAGCCAGCCACACGGGCACCCTGGGCCTGGGCG
CCAGCCCCGAGGAGACTGCCCGAGGCCTGTGATCTAGGGTCTGAGCAGGC
TGGTGGAAGGGGTGGGGGGACCCCAGTTTATAACCACTCCCCAAGACACA
TACCCAGGAGGGGGACTGGAAGGGGCCAGCACCCATCTGT
(SEQ ID NO: 220)
pARBI-616: TGTCCAAAGTGTGTGTCACCTGCTCTGTGTTCACCCACTGGGTTCATCAG 2541
chr2_1_ AGGGGCACTTGAACAAAACAGGAATGTCACTGGAGAGGGGAACAAATGCT
Exogenous_106 GTCCCCAAGTCCTTCCCTGCCGTTTAGAGTAACGCAGCCCCTGTCCGCAC
ATCCTCACCCCCATCTGCCCTCTGCTTGCCAGAATTATCAGAATCTCTCA
ATTCTAATTTCAGCCATTCTCTGTGAAAATGAAAAGTTAGTGGCAGGCAA
TGGACACCCTATTGAAATAGAAATTGTTCTTCATATGTCAGAAAAGTCCC
AGAGTAATCTGGGAGTAATCTGAGCAAACTGATTCAAAGGATTATTACAA
TTTCTTAGTCTTCTACTGCTGCAAAAGTGGCACTCTTTGATTCTCATGTT
TGAGGTTCTAATTACTACCTCATGCAGGACTTACAAGAGATCAGCCATGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGCTTACAT
TGTGTGTAGTGAATCAATGTTATTCTGAAGGGCCTCCTGGAAGCAGTAGG
GATTGGAGAATGTATGTCTTTTAACATGATCATTCCCATCCTATGGGGGT
TGGGCACTCTTAACTCATGTTGCAGATGAGTAAACTGAGGCTTTTGAGAG
TTTGAGGGTGCACAGCTTGAGGCAGAGGTGGAATTCCCAGCTTCATCCAA
GAAATCACGAATCTCCAATGGCTTGCACACATCCAGGTTTGCTGGATCCT
ATTTGTCAAGACCACATGCAGATTAGGAGCCTTCAAACAAATTATTTCCA
AGGGAGGGCATCTTTCTCTGTAACCCCTACCCTGGCAATTCTCCATGGCC
TCAGGGAGTCCAGCCGGAAGCTCTGCAATGAGTCCTGGGGAACTCTCATC
TGGAAAAAGGCGCTCATGACAGGTGGTGCCAACCTTCCACG
(SEQ ID NO: 221)
pARBI-617: CTACAAGCATGCATCACCAGGCCTGGCTAATTTTTCTATTTTTTGTAGGG 2541
chr2_2_ ACAGGGTTTTGCTGTGTTGCCCAGGCTGGTCTCAATTTCCTGGACACAAG
Exogenous_107 CAATCTGCCTGCCTCAGCCTCATAATGTTTTTTTTTAATGTTAAACCCCT
TCTTGTGTTGAGAGGCCTGGCTTGTGTGTTTGAGCGCAGCTGCCTACCTT
TGCAGCTGTAAATGTCAGGGCTCCAGGAGGGCTGGCTGGGTCTCCCCTCC
TCCCCTGTTGGGTGGGTGGGGCCCTGAGCTTATCCAGGCATCCCTAGGTG
GATGGATGGGTGGATGGGTAGGCCCTGGCCTTCAGGGAATGCACTGTGTG
TGGTCTTCCAGCCCCAGCAAAGTCTCAGGGGGCCCGAGCGGGAAGTCGCC
ATCCTCAGGGGGTCCGAGTGGGGAGTCACCATCCTCACGGTCAGCCGTGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTTCGAATT
GAGCTCCCAGGGGCGGAGACTCCATTCCCCCGGGGAACAATCTGATAGCC
AGAAATGAGAGCAGTGAGTGACTTGGACGCTGTGTGATTCAGGAGGGTCC
CAGTCCCTCAGAGTCGCCTGGACACCAGATTGTATTTACAAAACAGATGG
ATGAGGAAATGGAGATTGGGTCTTCAAAAGAATTAACCTCAGATTTTATT
TATTTATTTTAAAAATTTTAATTTTTCCCAAGGACCCTTTCCAAGTCAAG
AATTGTTTTAAAAAGAAGCCTGGTGAAGGCAAATGCTGTCTGTGGCCGAA
GGCACCGTGAGGAGCTGAGGCTGACTTATGTTTCTCCTCTGGGCTATGTG
CGCCTCTAAGGAGTTCACACACTTTAACCCCCTTAGGAACCCTACATGAT
CATCCTCGTTTCTTAAAGAGGAAGCAGAGCCAGCAAACAAG
(SEQ ID NO: 222)
pARBI-618: TCTTGATGGATACCCATCCTTCTCTGCTGTTCTCTCTTTCCTCCATCCTC 2541
chr2_3_ AAGCACAGGGAGCTTTTGGCGAGGTTAGCTAACTTCGGGGCAGCTGTGAA
Exogenous_108 TTAGATACTGGCTGTAAGTTACCTCCAACATCCAGAGCATTTAAACGCTC
GGCTGTCAATGATTGTCATTTTCATTGTTTACATATAGTCACATCCTCAG
TTTGTGGGGTGGATGCATTTGATTCAATTCAGATATGCCTTTCAAGCTGG
CCCTGCTGAGCTGGGCCTGAAAGGCACATGGCTCATCTCATCTGCATGTG
ACAGTCTCTTTGAAGTCCCCAGAAGTGCCTGCTCAGAGTCATGCTCGGGA
GGGAAGAGGTAAGGCACAGAATGAGTACAGACTGCCACCCAGCCGCAGGA
AAGGTGACTGCACACCAGAGGTTCCTGGTAAGGAGGTGACTCACCCGCGA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCTGTCTCAC
CTGTCCAAAGTGTGTGTCACCTGCTCTGTGTTCACCCACTGGGTTCATCA
GAGGGGCACTTGAACAAAACAGGAATGTCACTGGAGAGGGGAACAAATGC
TGTCCCCAAGTCCTTCCCTGCCGTTTAGAGTAACGCAGCCCCTGTCCGCA
CATCCTCACCCCCATCTGCCCTCTGCTTGCCAGAATTATCAGAATCTCTC
AATTCTAATTTCAGCCATTCTCTGTGAAAATGAAAAGTTAGTGGCAGGCA
ATGGACACCCTATTGAAATAGAAATTGTTCTTCATATGTCAGAAAAGTCC
CAGAGTAATCTGGGAGTAATCTGAGCAAACTGATTCAAAGGATTATTACA
ATTTCTTAGTCTTCTACTGCTGCAAAAGTGGCACTCTTTGATTCTCATGT
TTGAGGTTCTAATTACTACCTCATGCAGGACTTACAAGAGA
(SEQ ID NO: 223)
pARBI-619: TGAGCAAATAGTTCTATCCTTTTTGACACATTTTCCACAGTTTGTATAAT 2541
chr3_1_ TTATTCATAGAATCCTTCTTAGACTACTAATAAATTCCTATGGGACATAG
Exogenous_112 TCCTTTTATATGCGGAGGAATCCACCACCATGAAATGTTCACAAGAAATG
ACTTTTAAAATTTTATTTGTGGCCATGCTGATTATGAATTTCTGAATTAT
GTCTGGGCTGCTCTTTTTCTCGGAATATGCAAAGTGGGATACTGGCATCT
CTGTATCTGGAGAGTTACAGCTTCTGAGTTAAAAGATGAATGGGAAGTAG
CAGGAGAGGGAGAGATCAGAAATCTCCACTCCCTGAAACACAGACACTTC
ACATACCCAGGAGGTAAATTCCTGGCATGAATTGTAACAAGTATACACAG
GCATTTGTACATTGTTTGCTTATGTGCTAGATGACATGGCAGTCTATGAA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGGCCC
CACATCTGCAGGCAGGACATTCAGCCCTGTATCTTGCCACTACCATGAAA
TCTGAGGTTCTTTCATTTTTGTTTTTCTATTCTGATGAGATTGAGGTACA
CTGACTCACTGGTAAAGAAGACAATTTATTTGTGAACTTGTAGTCACTCC
ATTTGACGGCCTCCCTCTACTCACTGAGGCACAGCACGTGTGGAACAGGA
AAAAGGCCTCTGGAGAGCTTGTGTTCCACTGGTTTCTTTGACTTTTGCCA
ACCAACTTTGCAAATGTTCTCAAAAGGCATTCATTACCTCTGCAGGTGTG
AAATAACTCTGCAGTTCAAGGGTTTGTGAAATCACGTGAAACAGCTGAAA
GCTGTTCTGGCAAAGCGACCAGAGTCAGAGTTAGCTGTCACCAAGCCACA
TCCTGGCTTAAACGATGTTATTTATATCTAACTGCACTCGA
(SEQ ID NO: 224)
pARBI-620: AGATGCCCATTGTACCACCTACCATTGCTTGACCCCCGCCCATGAGCTGT 2541
chr3_2_ TCCTTCATACTCATAACTAAAATGCCAAATGTGTGACTTGAGTAATTAAC
Exogenous_113 TAGAGACCTCCAGAAGGCTTTCCTTCTTATTCTGGGTACATTGATATTTA
CTTTAGTATTTGTTTTGCCTTTAAAGTCATGTTCCCTTTTGATTCTTTAA
TATCATATCCAAAACGAAGTCCTTTTAACCTATAACAATGCAAATCAAAA
GTGCTGTCTTTCAGCTACCTCAAGGATTTAGCAAGCGTTCCTGGAAATCT
AACCAACCTTTTAAAAAGTATTTCTATGGGAATGTATTTCTGAGCCCTAA
ATTATGGATTTTGAAACTAAAATAGAAGAATACTGTAAGTGCAAAACTTC
CAGTAGATAACAGAATTTGCAAAATCTCTAATCTCTTGTATGTGCCCCAA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGTAGTACTCT
CTATAGGCCATTGGAACAGAACATCTGGCTTAAAATAATCTCAGCACCAA
AAACGGTCTAACTATGGTCTCCACAACATAACCCGATGGTTCTCATATTT
TAGATGCTTGATGCACAAGTTGAACTGGCTAACAATTCAGACTTCAGGAC
TTGACTCCCCTGGGAATCTGCAGTTGTTTCCCTCCCCTTGAGTGAGACTG
ACTGTTGGGAGTAGAATAACCGCATGCTCTGGGTCAGAATGCCTGGCCCT
TCAGAGTAACGGCAGCCATGATCGCTGAGCTCCTACTGTGAGGCACATAC
TTCGCCACACTAACACATGGAATCCTTGCAAGCTCCTTACATAATCAGTA
TTTTATGCACTTTGCAAATGAGAATACTAAGGCTCAGAAGAGGCAAGCTC
CTCTCCCACTGTTAAACAGCTAGTGATGAACAGAGCTGGG
(SEQ ID NO: 225)
pARBI-621: ACTCCCCTGGGAATCTGCAGTTGTTTCCCTCCCCTTGAGTGAGACTGACT 2541
chr3_3_ GTTGGGAGTAGAATAACCGCATGCTCTGGGTCAGAATGCCTGGCCCTTCA
Exogenous_114 GAGTAACGGCAGCCATGATCGCTGAGCTCCTACTGTGAGGCACATACTTC
GCCACACTAACACATGGAATCCTTGCAAGCTCCTTACATAATCAGTATTT
TATGCACTTTGCAAATGAGAATACTAAGGCTCAGAAGAGGCAAGCTCCTC
TCCCACTGTTAAACAGCTAGTGATGAACAGAGCTGGGACCTAAACTTGTC
TGATTTCCCACACTGCTGCTCCATCAGATTGTTTGCCAGGTTAAGGATTC
ATGCCAGGACCTTAAATCCCTCTGAATCGACAGAGCTAACCTAAAGGGCA
CCTTGATTTCAGGTTTTGTTCCCAAACCTATGACTGTGGCCTGGCCACGT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAATGAAGAC
CCGGTTGGTTCTAGCTTCACAATGAGCTCATTGGCATTGTCCCCACAACC
ACCACCCCCTCTCCACCTCTGATCATCCACTATCATTTCTATATGGCCTT
TGCCAGGCTTGTCCTCATATCAAAGCTTCTGCCCTCTATGTTTAAATGCA
TAAGCTTGACAAATGTTTTCATTTGAGAAGGCAAGCTGCCTCCCCGTGCT
TGGTCTAATGTGAGCTTGGTAGAGTGACACTGCTGGATTCAGTTTTAGTC
ATCAACACTTCCAGCTGATGCTGATCTGAGTAATTGTCCTATTTAGACTC
TGACAGGTGAAAGTCATAGATTCAGGAAACGGAGACTCCCCTCACCCTGC
TATGAAGGGGAGTTTGAGAGGGTTGGGCAGCTCTTCCCGGCAGTGGCAGG
CAGTGTGGGGACACACGTATGGATAAATTGTTAATGCTCTT
(SEQ ID NO: 226)
pARBI-622: CTGCAGGTGGCAGACTTACTCATTCTCATGCTTCAGCTCCAGGGGTTCCC 2541
chr3: CTGTATGAGTCTTCTCTGCCCGCTCCCACACCCCAGGTAGCATTGCCCCT
1865_ GCTTGCTTTGTGCCCTCACTGTCTCCACATATATACACATCTCTTACAAT
Exogenous_109 AATATTAAATACCAGCCAACATTTATATAGTACTTCTTATGTACCAAGTA
CTGTTGTCTATCTATCTATCATCTATCTATCTATCTATGTACACACACAC
TCATATTATCTTCACAATGCTATGAAATAGGTATTATTGCTGTCCATTTT
ACAGATGGGGAAACCAATCTATAATTGGTTTAGTGAGATTTACTGAGCAT
ATCTACAGGTATTTGTCCTTGGTTATAGGAAACCAATCTGTCACTGGTTT
CCCCTTCTGTAAAATAAGTTAAATAATTTGCTTAAGCTCACTCAGATAGT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGTGTGGTTGA
GTCATAATCTGAGCTACTCTCTGGCCCAAACTGCTTATTGTAACCACCAC
ATCATATGGCCACTTCAGCACCAGTCACACCTCATTTTACTTGTTGATGT
CTCAGTTTTCCCCTCTATTCTGCGGGCTACTTGAGAAGACTTCTGTCTTC
TTCCTCTAGGTATCTCTGTGCTTGACTCAGTATCGAGACCATAGGTGTGT
GGGTGGGGTTAATCCACACTTGCTGAACACATGTGTCCGTGCCCAATGTC
CCTGTGCATAGTGGCTACTTCCCATGGTTCACACGCATCTTCATGGCTCT
TGTTTCTTCCATTCACCCATCCCATGTCCCTGGCCCTGTTCTCAGTGCTG
AGGATGGAACCTCATTGCTGCTGCTTCCAGCCCTGGCCCTGCCCCTGTTT
GGGGCTCAGTGCTTCATCCCGTGGAGCTCAAGGGGTGCTG
(SEQ ID NO: 227)
pARBI-623: CTTCTCATCCTCACACCCATTCATTTCTTAGTTTCCCATACTCTGACTTC 2541
chr3: TACTACCCCAAGTTCATAAAGACCTCATGAACACAACCTGGAGAACGCCC
1865_ TCAGCCTCATCTCACCTCCCTGCAACACATGGCTCACTTGTCTGCTTCTT
Exogenous_110 CCTTCTTAGAGTCCTCTCTCTGGTTGACCTGTCAAAGATGGGATTCTCCT
GTTAACGACCCTGACTCCTTTGTCTCCTTCTACAAAGATAATGCACTGAC
TTTCCAAATGTACTAACTAGTATGATCATCACTGTCTACTGTTGCATCGA
ACCACTACTAACCTCAATAGGGAAGGCACCAGGTTCAAGAGGCCAAAGAA
GAGACCCAGAGCCAGCAAATGAGACATGGGGTTTTATGAGGGGCTCACAT
AGAGGGGAGAGAGTCCAGTGGCAGTGGGCTGGGCAGGAGAACCACCTTAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACGTGGTCC
AGTGGTGGGAGGCTGGAAAAGAGATCTGTCTTGCCTACAGTTCAGTGGTG
GCGGGTTGGGCAGGAAAACCACAACTGCCTGCAAACATCATGCAGTTTAC
ATAACATTGTCACTTAGCAGCCTCCCCTAACGACCTCCACCTGGCAATCT
TCATTTAACCCAAAACTCAAGGCCTCAATCCCCTGTATGGACCATGTTTC
ATGGGACAGGCCAGGGGCTCAGAAGTTTATCATAGATAAGGAATGAATCT
CCGGGTTGGCCACTCCTGGATTCCCTAGCTTGGAACACACATTCAAGTGT
ATCTGCCATTCTGAGTGTATTCTTCAATTATTGCTGTCAGGTGTGTTGAC
CCTCTATCTACATAAGTATTTCTCAAACCAGGGCCCTACGATCAGCATCA
GCATCACCTGGGGTATATGTGAAAAATGCAGCTCCTGGACC
(SEQ ID NO: 228)
pARBI-624: GGGCCAAGCAAGCTCTGAGACAAGCTGTCTCACCTCCTCATCTCCTGAGC 2541
chr3: ACAACTCACCCACAGCTCTGCCCTCGCCTCCACCTACATCATGCCTTCCT
1865_ GCATGCCAACTTCCCTCTGAGGTTCCCTTCACCCACTTACAACCACAGCC
Exogenous_111 TCCTTCCGGACCTCCCCTACACGATGAACAGTCTGCCAGTTAATATACAT
CAAGCTGCCACCATGAAACAGCTCGGAAAGCCCCATTTGTTCTCAATAGC
ATTCCAGCTAGAAAGACCATCCACCACCCATGGCCACTGAAGAAGGTCCT
CCCCTGAGTGCCAGGCAGTGGGGCTCCTAACTCTGGGCCCCAATTAGCTT
AGCTTGGGGGAGCAAAGGACAGGAGCACTGTTCACCCAGTTGGACTAACA
GCTCCACACTGTGCCTAATAGGAACCTCCTTCTCACAGGTGGCACCTTTG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGAATCAGG
GTCTGTCCTGAGCCACCCTCCCTTGGAGAGATCTGAGCACTGAGAACCAC
AGAGCCTGGGACACCAGCACAGGGTTTGAAAAACTCCACTCCCAGTCAGC
TGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGT
GGATCACAAGGTCAGGAGTTCGAGACAGCTTGACCAGCATGGTAAAACCC
CATCTCTACTAAAAGTACAAAAATTAGCCAGGCATGGTGTTGGGCACCTA
TAATCCCAGCTACTCGGGAGGCTGAGGCAGGGGAATTGTTTGAACCTGGG
AGCTGGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGG
GGCTGAGCGAGATTCTGTCTCAAAAAAATGGGAAAAACATCATTCCCATG
TGTGTCCTGGTTGCTTGTCTCTTTCAAAGTACTGCATACT
(SEQ ID NO: 229)
pARBI-625: CCACATCATGGACCAGAAGCCACTTGGTCTGGTTGTGAGGATGACGGAAC 2541
chr8_1_ CTTGCCCGAGGAAATGGGCAATGAACAGGAGCCTGTTTGTTTCTCCTTCC
Exogenous_115 AGCTCCTGACCTGTCTAGCTCCTGACCCTCTCAGTGTCATTCTTGCTCAC
CCCTGGCCCTGCTCCCTGGATATGCAGACAGGATGGGCTTCTTCCCTTTA
GACCTTCACTTTGCTCTTTTGGACTCCTCTTCTGGCCTTGCCTTCCCCTG
GTGTCATCTGCTGGCTCCCTGCCTGATACTGCCACACTGGTCATGCTGGC
CTCCTGGCCTTTGGTGACACCGCATCAGCAGGCTCCTGCTTCCCTGTCAA
GGGATACAAGCCAGCACCGGTCTTTCGCCACAAGGTATGTGTGTAAAGAT
TGCTTCCTGTACTTGGTGTCCACAGGATTTTAAAGAACTCCTGGCCCACT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCGGAACTCT
ACGCTTGAAACAGAAACATCTTCTCAAAACACCTCTGGTATTGGCCCATT
TCTCTATTACTGTTTCTTGTGGTTTCATACTGAGGTTTTTGGTGCATTGC
AATTGCCCTGGAGTTTATTTTTAGTAATAAAGACAGAGTTCAATTAATGT
CAAAACATGAGGGTAATTGCAGAGGAAGGATTAGTAAGTCTAGGGGAAAA
TGTGCCCAACTTTTTTTCTTCTGATAACATCTTTCACTGATCATACACCG
TCACACCCACAGACACGGAGCTTCCTCCGTGATGTCTGCAATGCACTAGG
CCCAGTCGGGGAGCAGTGGCTGCGCCACCACCTGAAAACGAAAGCATTTC
TGAGTCTCTTTCAGTCCAGCTCATCTAGCAGCCAGCCACACAGGTGACCA
CCCACCGTAGCTGTCACTATGGGTGATGATTATCATTATGG
(SEQ ID NO: 230)
pARBI-626: AGGATCTTTCTCTCTACAGTGCCTCTTGTGGGACGGGTTCTGCTGATGGG 2541
chr8_2_ GGCTGTGTTTGGGATCTCGCCTGGAAACACGATCTCTCCAACTTTCCCTG
Exogenous_116 GGAGCAGAGCCTTGGGTCTCACTGAACCCACCTCCCCAGCACCTTGTGTG
GTGACTGGCAGGAGGTAGCCATTCCCTCCTGTCCTCTCTGCCCTTGTCCA
CTTTCCTGTTATGAGTCAGTTGCTGAGATAGGCTATGAGGAGTTAACAGA
GTGGATAAAAAAGAGCTTTGTCCTTCTTTAAAGCCTTCAAAATATACAGA
TGTATTAGTCAGGGCTTTCCAGAGAAACAGGACCAATAGAACATGAAGAT
AGATGCGTATCCATGTCTATATCAATATCTACCTTGATATTTATATCTAT
ATCTAGGAGATTTATTTATTATAAGGTATTGGCTCATGCAATTATGGACC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGAGGGGT
CCTGTGATTTGCCACCTGCAGGCTGGAGACCTAGGAAACAGCTGTCGTGT
CACAAAGGGCAGAGGGCTGGAGAACCTGTAGTGTAGATTCCAGTCCAGAT
TCGAAGGCCTGAGGACCAGGAATGCCAAGGGCAGGAGAAGATCGATGTCC
CAGAACAAGCAATCAGGCAGAGATGAAATTCAACCTTCCTGTGCCTTTCT
GTTCTATTCAGGCCTTCAGTGGGTTGAATGAGGCCCAACCCACATTGAAG
AGGACCATCTGCTTTACTCAGTCTCCTGGTTGAAGTGATAATCTCATCTG
GACATACTCAGAAATGCTGTTTAACCAGCTCTCTGGAAATCCTGTGGCCC
AGTCAAGTTGACACACAAAATTAACCATCACACTGCAGAGACACAGTCTA
TCCCAATACCTGTATTTACTGGGTAACGTGCATCTCAGCTC
(SEQ ID NO: 231)
pARBI-627: TAATAATGACTCTGCTGGTAATTTGTGTCCTTCTGCTTGGAACTGTTTCC 2541
chr8_3_ TTTTTAGTTTGGTCACCCTCCCAGAGCTGGTTTCAATGGGGGCATACCCA
Exogenous_117 TTATGGGATGCAGGGCATCCTGCATCCTGAGGAATTTTTTTTCCTCCAAA
AATGAAACCTTGAAATGAGGACATTGTCCTGTCCACGGACTGCACAACAA
CACTGAGCCTCAAGGACTCATACTGGCATTTTTCTTCTTTTGCAGAGTGT
GGGCACCCTGGCTTCAAGCTCACGAGAAACCAGGTCGGGATTTAAACAAT
GTTGGGTTAAAGCAAAGTTTCATAAAGACAGAATCAAGAAAAAAAGAAAG
AGAAACCAATCTAAGTGCCATCCTCCCTGAGTTGCATCTTACCTGAGTCT
TCAGCCGCCGCCCCCTGCTGCTGTGGGAGGAAACGGGAAAGTGACTGGCC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatATGGGGACA
GGGGTCGGGGGTGTGAGGGTTAGTGGTAGCAGGGAGGTAGCACTTCTGTG
AAGCCGGAAAGGAGACCTGAACCTGGCTCTCTGCTTTGCTGCTTGCCAGC
CCTCTGGCTGGGAAGAAGGCTCTTGGCTCTTGTGAGCCTCGGTTTCCTCT
GCAGAGTGGCCTGTTCTGAGGACAGGCTGACATTGCTGTCCATCAGTCTT
CCAGGACCCTGAGGATTTCAGCTCTACCCATGGGCACTGAACTGGAACAT
TCACTGGTCATTTGCTTTCGTTTTTTTTTTTTGTTTGTTTGTTTTTTGAT
ACAGAGTTTCACTCTTGTTGCCTAGGGTGGAGTACAATGGCGTGATCTCA
GCTCACCACAAGCTCTGCCTCCCGGGGTCAAGCGATTCTCCCCAGTAGCT
GAGATTACAGGCATGCGCCACCACGTCCGGCTAATTTTGTA
(SEQ ID NO: 232)
pARBI-628: AAGTCAACAACAGGCTCCAGAAAAAAATGGAAATATAAATGGTCCCCAAT 2541
chr9_1_ TTGGCATTTTGGAATTTGAGGCTTATATAGTATGAGCAAAATAAACTCCT
Exogenous_118 CCTGCTTCTATGAATTCTTTGCACTTTTTCTCTATAATTCCTTATCAAGC
AATGGGTTTGTCTGTTAACCAAGACTATACATAAAATGTATTCCCGTAGT
TCCTTTTATTACATTTTTTCTTTGTTGTTACTAGTGGAGAAGCTAACAAG
AGCAGAATTTCCTGCCCAACCGTAGCAAATACAGAAAATCAAAAAGAGAA
GCTTTGATACAGCCAGTGTAGATACAGCTAGGACGTCATGAATCAGAGCT
CCCACACACGATGATAATGGAAACATCTTATCCATATCTGATTTGCTCAC
ATATAGTTATTTAGACAACAAATTTTACATTCCTGGATAGGGAGCCTCCG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatATTTGATTTC
AATCTCATAGTCCAGGTAGGTGTAAAATGACTGCCAAGCCAGCAGACATA
AATCTGTATTATCTCATTTTCATCACAGTCTCTGCATTGGGAAAAAAATG
TGAGTGAAAAGACATTTTCTCCCACCTTGTTAAGTACACAATTACATAGT
TTAAAGAAGATAAGAATTTCAAATTGTTAGAATGATATCATTATTCAAAT
GATTCCCTGAGAACTTCAAGTATTCCCCTTCCCCCAAATGTAGGCAGGGC
AAAATAGAACCAGTAGGAATGAAAAATGTTAATTGTTTCAGGTTCTGTAA
TTTTGGGTTTAATGACTCAGGCTATGTGCTACTGAGTAAAATACTCATCT
GGAGAAAAAGACTGTTGCATGACATATTTCTGATTAAGGACAATTTAAAC
TAATTCTAAGAAAACTCTTACATACTGCACATGCCATAAA
(SEQ ID NO: 233)
pARBI-629: GATTAGGTCTGGAATAAGATTGCACCATGACTAAAATGACTTCTTTAGCC 2541
chr9_2_ AATGACATTCCTGAAGATTGGATCAGAGTAAAGTTAAACTAACCTACTCA
Exogenous_119 AGGAAGACTTTCCTAAATCAGCCCCTTTGCTGTATAATTTAGTATGGAGA
GCTGATTGTGGGTTTTTCTTGTTTCATTGTTTAATACATAGAGGTTTCAC
ATTTCATTTTGAAACAGAAAGAGGGACTGGAAGAGATAAGTTAGTATGAG
TGAGGAAAAGATTAGAAGGTAGAGATAGGATCGCAATGCTGTTATCACCT
TTGCTTTATTGATAATCTCAGGAAGGACTAGACTGCTAAGAAAGAGGAGC
CCAGATTGGAATAAAAGAGACGATGCCAGGATCAGCCTGTGAGAGGATGT
CTCACTTAGTACACCTCAAGGATCATGTCAGCTGAGCATCTATACCCCGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCG
AGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGGC
GAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCAC
CGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTACG
GCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTTC
TTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCTT
CAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGCG
ACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGAC
GGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACGT
CTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAGA
TCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCAG
CAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACTA
CCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGATC
ACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCATG
GACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaata
aagcaatagcatcacaaatttcacaaataaagcatttttttcactgcatt
ctagttgtggtttgtccaaactcatcaatgtatcttatGTGATGAATATT
GCATACAGACTCTGCCTTCAAGTCATCCCCCATTCGACAAGCATTTATTT
AAGGTTCTTACATTCCAGGACTTGTACTAGATGCTAGAAACAAACAGATA
AGGAAAACGTAGGAAAATGCTTCTCTCAGGAAGCAATATTGTATATGAGT
GGTGAAGAGCTTCAAATCTGGGGCCAAACTGCTGGGTTTGAAATTTGGCT
TGGCCACCTACTGGCTGTGAAATCTTGGGCAACTTTCTTAATCACTCTGT
GCCTCAGTTTCTTCATCTGTAAAATGAAATAGCCATAGTACTTATTACAA
ATAGGTAATAATTAGTGAGAATTAATTTGAGTCAATACATAAAAATGACT
CAGAATAAAAGACCAGCTAAGAATATATACACACATACTTAGCTACTTAT
AATCTAGTAGGAAAGATGGGTATGTTATCAGAGGACTT
(SEQ ID NO:
234)
pARBI-630: CAGATAAAAAAAGCTGAAGCTCAGGGATATTGTCATTTACCCATGAGCTC 2541
chr9_3_ ACAGGCAGGAAGTGGTGAAACTATCATTAAACTACGGTTGGCCTTGTTCT
Exogenous_120 TTTGTGGTTTCATTTCACTAAGCCTCTGACACCCTGACCTCAACTTCCTT
CTGTAGATATGTCACCTGGCCTCCTTCAGTCTAAGACACTACACACTGGC
CACACACTTTGTCATCCTCATAGACTGACAACCTGCTCTCACATACCCTG
CTTTCTTACTGTGTAGGCTCTCTTTTCTTGCTCAGAATGTCCTTCCCCAC
TTCTTCATGTGCCAACTCCTAGTCATCCTACAAGAACCACATTCACTTTA
AGTTTCTTTTGAAGCCTTTTCAGTGTCCCATACCCTGATCCCATTACCTC
TTCTATGTATGCAGGGCTTGCTTCATGCTTGTGTAACCCAAGGGCCCTGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatATTTGATTTA
ACACATTTTAAAATTCTTAACAATTTATGAAAAAGGAAACCCATATGTTC
ATTCTGCCCTGGACCCTGCAAATTATGCAGCCAATCCTGTGTGTGTTTTT
TCATGTTGCGTAGACTCTATTACAGTCAGTAACATATTGAGAAAGAGTGT
GTGTCTCCTCTGATAGTCTATGAGCTCCTTGAAGCAAGAGGCTTGTCTTA
GTCATTGCTGTATCCTCACACCAGACTCTACGGGATGCTCAGGATTCACC
TGTTGATCTGTGAGGAAGCCCAAGGCTCAGTTAATGCCCCCCACCCTCCT
TCCATAACAGTCTCCTGATTAGGAAACAGTGCTTGACCTCTAGACAATCT
GAGTATCCACTCCAGGAAGTGGAACATTGCCTTCCCAATGTTGAAACTGT
TAGCACTCAATCATGTTTCAGGAACATATAGAAGGTATGT
(SEQ ID NO: 235)
pARBI-631: TGGACCTTATGCAGGGTAATAAAAACCAACACGTGGGGCCTGTGCTGTAA 2541
chr10_1_ GGTGGCAGAGGGCGATGACTCACCCCACTCATGCAGGTTGAGTCATTTCA
Exogenous_90 AGGCAGAGTTGTGCCAGTTCAGTACCCAGTAATATTTTCCAGTCGACGAG
TATCAGTGAACAGGAGATAACCAGTCATTTCTAGATTCTGCTCAGAGTCC
CAGCTTAGAGGCTCCACCAGCTCAAAGAGACGGGATGGCAAAACAGCCAC
CTTAATTTCCAGATCATCTGCCAGCTCATCTGCCAGCTGACACACAGCCC
ATGGCTCCACTATTGCCAGTGCTGTAGCTGCACCAGACCAATCTGGTTCA
ACTTTTATGTAACAAAGTTGTGATTTGTTTTTCAGTTGCCCGGGACTCCC
AGGTTGAAGATCATGAGCATGCCCTGATGAGCCAAGGCATGCAACCACAG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGGAACCTA
AGTGCTTGGACTGAGGAGTGGGGACTGAAATAAGAAGCGGACACTGCAGG
GCAGGATCAGGATCCAATCAGATCGAGCCCTGGCATCACCTCATGGCAGG
ATCTAGTCAGATCGTGGCTTTTGACATCACTTCATTGTGAAATCCAATCA
GATCACACCTTATTACCCTATCCTTATAAAACCGGACCTAGCCCCCAGCT
CGAGGAGGCACTGCTTTGGGAGTTATCCCAGGTGTTCTTGTTACTAGTTG
CAAGGAATAAAATCCTCTTGCTAAATCCTCCTTGGTTGTGCAGATGTTGG
CATGGATGTGGAGAGAAGGGAACACTTACGCTTTGTTGGTGAGGATGTAA
ATTAGCTCAACTCTGTGATAAACAGTATGGAGAGTTTTCAAAGAACTAAA
AATAGAACTTCTACTCAACCCAGCAATCCTATGAGTGCATG
(SEQ ID NO: 236)
pARBI-632: ACATCTAATCCCACACCATGACTAATAAACATGGCATGCTGCAATGGGCA 2541
chr10_2_ TTAATTTATGGGTAACAGAAGCAGATCCAAGCCTTTTAGCTAATTAAATA
Exogenous_88 AAAATGCACCATACAGCAACCATCCTGCCTGCTTGGGTGTAAAATAGAGA
GGAGAAAGATGGCATGCTGGTCATTGAGAGATAATTACCTGCAATTTCAG
AGCTGGAATCTAGTGACAACATAAGAAAAATAATAACCTCTCTGGCTGTT
AGGATTCTCAGTTCTAGCTGCGAGCAAGGAGCAAAGGCACCCACAGACTT
GCCAAACCTATGTCAGGAATGACGAATAGAAGGCAGAAATCCACATCCCC
AGGTGGTAAAATTGTTATCCACCTTCGTCACCTCTTTCCTAATGGAGGAA
GTGAGGACAGGCAGCCTTGGAGTCCTACTTGAATGAGGCCTGGACCTTAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGCAGGGTAA
TAAAAACCAACACGTGGGGCCTGTGCTGTAAGGTGGCAGAGGGCGATGAC
TCACCCCACTCATGCAGGTTGAGTCATTTCAAGGCAGAGTTGTGCCAGTT
CAGTACCCAGTAATATTTTCCAGTCGACGAGTATCAGTGAACAGGAGATA
ACCAGTCATTTCTAGATTCTGCTCAGAGTCCCAGCTTAGAGGCTCCACCA
GCTCAAAGAGACGGGATGGCAAAACAGCCACCTTAATTTCCAGATCATCT
GCCAGCTCATCTGCCAGCTGACACACAGCCCATGGCTCCACTATTGCCAG
TGCTGTAGCTGCACCAGACCAATCTGGTTCAACTTTTATGTAACAAAGTT
GTGATTTGTTTTTCAGTTGCCCGGGACTCCCAGGTTGAAGATCATGAGCA
TGCCCTGATGAGCCAAGGCATGCAACCACAGGGGAACCTAA
(SEQ ID NO: 237)
pARBI-633: TGAGGTCTTGGTATGTTGCCCAGGATGGTCTCAAACTCCTGGGCTCAAGC 2541
chr10_3_ AATCCTCCTGCCTCCACCTCCCAAAGCGCTGAGATTATAGGCATGAGACA
Exogenous_89 CAGAGCCCAGCCACTGTCCGCATTTCTTTCCTGGCTTCCTTACTGGGTTC
TCTACTTTCACTCTTGCCTTCTTCCTCTCTTCCACCAGCATAAGTTTTAG
AAACTGCACTTCTGATCATGCTGCTCTGCTGCTTAAAATCCTTCATGCAG
ATCATGTAAGACCTTCCTGATCCAGTGCTGCCTTGCCCTCTAGAACCCAG
GGTGCCTTTCTCCCCTCTGCAGTTCTACTGCGCCACCTGCAGTTTCTCTC
TCCTGTGTTCATGTGTCTACTCCCTCTGAATGGTAGGCTCACACCCTCCA
CCTGGCCAACTCTTACTAAATCTTGGGCTTCAACTCAAGGATCACCTTCA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTGGTTCACTC
CACCAGGCTGGGCTGTGTGTCCTGCCCAGTTCCTATAGTGCCCTAACTCA
CTTTTTTAAAAAAATACTTTAAGTTCTGGGGTACATGTGCAGAACATGCA
GGTTTGTTACATAGGTATACACTTGCCATGGTGGTTTGCTGAAGCCATCA
ATGTCATCTACATTAGGCATTTCTCCTAATGCTGTCCCTCCCCTAGCCTC
CCACCCCCCAACAGGCCCCAGTGTGTGATGTTCCCCTTCCTGTGTCCATG
TGTTCTCGTTGTTCAGCTTCCACTTATGAGTGAGAACATGCGGTGTTTGG
TTTTCTGTTCCTGTGTTAGTTTGCTGAGAATGATGCTTTCCAGCTTCATC
CATGTCCCTGCAAAGGACATGAACTCATTCTTTTTTATGGCTGTCCATTA
TTCCATGGTGTATGTGTGCCACATTTTATTTATCCAGTCT
(SEQ ID NO: 238)
pARBI-634: CCTTCCACCCCCTTCCTTAATAGTTTTCCTCCTCCGCCTCCTGCACGGCC 2541
chr10_1_ TCCGCCTCCGCCTGACCGTCCTCGGAAACCTCCCAGCCGCAGCCCGGCCC
Exogenous_92 TCCCCAGCGGCCTGAGTGGCCTCCTCCCGCGGCGCCCCCCAGCTCCGCAC
CTCCCCAGCCCCGCCCGAGGCGCGCCCAGCGAGCGTGACCCCGACCCAGG
GCCACGGCTGCGCCCGTAGGATCGCGGGCGCGCGGGTCTCCATGAGGGAC
TGGGAGAGATGCGTCACCCGCTAATCCCTCAACTGGGTCGCACCCGGTCT
GCCTTGGTTGGTCCCTTCTGATGGCGGAGGCGGGACCTCGACTTGGTGGC
CAATGAGGAGCCTCGTGGGGGTGCTCTCGGCTGCCATGGCAACGGAGGGG
CCGCCCGCTTCCCCGCGGGGCGAGGCCGGCTCTCCCAGGACTGGCCACAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGCAGTCAC
GCGCTGTGGCCCCAGTCCTGTTAGCATGAGGTGGGGGTCAGAAGTTGAGG
AACAACTCGGACCTAAAGCCTTGACAATTGCCAACAGTGTAGACAAGTCC
CAGCATGCCCAAAATTTATAAGAGAAGGCTGCCTGGAAGAGGGACACGAT
GAGGAGGGTCTGCTGAAACGGACAAAGAAACCCAGTTCAGTGCAGTGGAG
TGGACATGGCACGGGCAGGGCACGGAGTGGGGTCGGTGCTTAGTAAGCGG
ATTAGGGTTTCCAAGCCAAGACCCACCCAGGGCAGGATGGGGAACCAAGG
TGAGCAGGTGCGCTGAATTGTGGGTCTCACACTGTCCTTCAGTGTCCCGC
AGGAAGAGAGAGCTAAGGATCACCAGGGTCATTCCCCTGCCTCAGGCAGC
CTGCACTCCACCTTAGGTACAGTCATGTCCGGTCTTCAGCA
(SEQ ID NO: 239)
pARBI-635: TGATCCTCCCACCTCAGTCTCCCAAAGAGCTGGGATTACAGGCATAAGCC 2541
chr10_2_ ACCTTGCCCCGCCAGTTTTTAGCCTGTCAGCTCTTTGAGGGACACTTGTT
Exogenous_91 ATGGTCATACCCACAGCTTTGACCCTTACCAGGTGGTCAGGTGGATGAAT
GAATGAGTAGAAAGAAGGAAGAGAAGGCAGGAGGGAGAAGAGGAAGAATG
AAGGAAGGGTTGAGTTTGTTCTGGAAGCTCCCAGCTTCCATCCGCACCAC
ACTCTCCCTCTGTCCCCAGGACACCAGGGAACTGACTCAAGGCTCTCCTC
TTACCAGGTGCTGTGTGGGGTCCAGGGAGAAGAGCCCATTTGAAATGGGG
CACTGGTCTAAACTCTGGACCTGCTGCTCACTATTGACTGAACTTAGCCA
CTTAAATATTCTCCTCTATAAAATGGGAGTGACCATAGCAACTACCTCGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGAATTGTA
GGGAGACCCAAAAAATGTATATGAATACATTTGTCAACTAAAGAGTGTTA
GGGATTATCTCAGTGGAGGGATAGGCAGTGCAGGCTCTGGAACCAGACTT
CTTGTGTTCACATCCCTGCTCCACTGCTTGGAGACCTTTGGCAAGGTCCT
TAACTCCTCTGGACCTCAGTTTTCTCATCTGTAAAACAGGGATTATACTA
GTTCCTACCTCACAGAGTTGTGAAGATTAAATGAGATAATGCATGAAAGG
CTTTTCAATAAGAGCAGGGCACACATTAGGCATGATGTCCATGATCAAGT
GCCTAATATGTGCCTGCTCTCAGGAAGGATGCTGTGAACTACTTCACACT
AAAGTGTAAATGAATGATAAGATCTACTATGCTCCACTCATGCCTGTAAT
CCTAGCACTTTGGGAGGCCGAAGCAAGTGGATCACCTGAGG
(SEQ ID NO: 240)
pARBI-636: GGTGAGGTCACCCTGGGTACCTGGAGTTACTCAGAGTGACACTAGTACAC 2541
chr10_3_ GCCTGGCAGGAGTGATGGATGAGCTAGGCTCCAGGAAAGCAGGTGGGGCT
Exogenous_93 GGAAACCACCCAAGACAAGGAAATTGTTGGGTTTGAAATTCCAGGTAAGC
AGAGTATGGCCTGAGAGCAGCGGCAGAGGCTGAAAGTGGGCTTGGTCTCG
GTATTTTTGAGGCTGAGGTAGCTCCAACTCTCTCCCTCTGAGTCAGCACC
CCACTTAAGACAGAAATACTGAGATCTGCGACCCCAGCCTCCCCCACAGC
AACTCCACAGTCCCCAAACCTTTGCTCCGCTGGGTCCTCCCAAGTATGGT
AGCTGACACAGCCCTGAGCAGCCCACTGTCCTCTGCCCTGCCAAGTCTTC
TCACTCTTGTCACTTTGTCCTACATCATTTCTTTGTCTGGCACCCCTCCT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAGAATTGGT
GCCCCAGAGGTGGGAAAAACCTACCCTGCTCACTGCTCTATCTCCTGGGC
TTAGCTCAGACTCTGGCATACGTGAGTGCTTAGTAGAAACTTGATGGGGT
ATTAAAATTGAGACCTGGGTGGGTTCTCACATTAAATTTCTAACACTCCT
TAGGTGGCTTGGGCCCACCCCTCTGAGCCCTGTTTCCACATCTGTAAAGT
AGCAAACCATCGCCATGAAGAACAGGGAAGAACCAGGTCAGCAGGCAGGG
CGGATGAAGCATCCAGCCAGTTCTAGGAAGTTTCCGATGGCTAATCCTTC
AGATGCAGCTTGTAAGCAGGTCAAATACAGAATAGGAAACTGAGGCGCAA
CGAAGTCATGCTTAGAAGTCTGTCCAGGGAGACCAGTCAAGGCCTCCCCC
ACACCCTGCAAGCCCTTCTAGGAGCTCTGGTTAAGTCACTC
(SEQ ID NO: 241)
pARBI-637: ATCTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACT 2541
chr11_1_ GTAAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAG
Exogenous_99 AATGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTTTTAAATG
AGCCAAGACTAGAGGGGAAACTATCACCTAAAATCAGTTTGGAAAACAAG
ACCTAAAAAGGGAAGGGGATGGGGATTGTGGGGAGAGAGTGGGCGAGGTG
CCTTTACTACATGTGTGATCTGAAAACCCTGCTTGGTTCTGAGCTGCGTC
TATTGAATTGGTAAAGTAATACCAATGGCTTTTTATCATTTCCTTCTTCC
CTTTAAGTTTCACTTGAAATTTTAAAAATCATGGTTATTTTTATCGTTGG
GATCTTTCTGTCTTCTGGGTTCCATTTTTTAAATGTTTAAAAATATGTTG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACATGGTAG
TTCAGTTCTTAACCAATGACTTGGGGATGATGCAAACAATTACTGTCGTT
GGGATTTAGAGTGTATTAGTCACGCATGTATGGGGAAGTAGTCTCGGGTA
TGCTGTTGTGAAATTGAAACTGTAAAAGTAGATGGTTGAAAGTACTGGTA
TGTTGCTCTGTATGGTAAGAACTAATTCTGTTACGTCATGTACATAATTA
CTAATCACTTTTCTTCCCCTTTACAGCACAAATAAAGTTTGAGTTCTAAA
CTCATTAGAATTGTTGTATTGCTATGTTACATTTCTCGACCCCTATCACA
TTGCCTTCATAACGACTTTGGATGTATCTTCATATTGTAGATTTAGGTCT
AGATTTGCTAGCTCCAAGTAATTAAGGCCATGTAGGAGAGCATGGTAACC
ACAGATAGAACTGGTATTATCCCAAGTGGTCTGCAGACTGC
(SEQ ID NO: 242)
pARBI-638: TTACAGCACAAATAAAGTTTGAGTTCTAAACTCATTAGAATTGTTGTATT 2541
chr11_2_ GCTATGTTACATTTCTCGACCCCTATCACATTGCCTTCATAACGACTTTG
Exogenous_97 GATGTATCTTCATATTGTAGATTTAGGTCTAGATTTGCTAGCTCCAAGTA
ATTAAGGCCATGTAGGAGAGCATGGTAACCACAGATAGAACTGGTATTAT
CCCAAGTGGTCTGCAGACTGCTGAGTGGGGATGGGATCTGCTCTCTGTTG
AGAGTTGGTAATCATTGGTTTGAAATGTGATGAAACCACTCAAGCCAATG
AAGGTGGGTGTGTAGGTGGGGAGTACTTTGCCATAATATTTTAAAACATT
ACCTGGTTAGAGTTCTAAGTGGTACTTATTTTTGTTTGGTTAGGGGAAAG
CCTGAATAAAAACAGAAATGGACACATAATATGCATATTCCATAGTCTTT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGGAGGCTG
GAATGTGCCTGGGATTTGGGTCTAAGTGTATGCGTAATTCTTACCTCACT
AAAGAATTTGCCTTGTTTTTTTCCTTTTGGTGAGTGACTAAAACGTCTGG
GCTTCCCTGTGTGCGTGCTACAGTAAGCAAGCAGAGGCTGTGCAAAGGTG
TGAGCAGGATCACGTGGAATCTGGAGGATACATCTTGGCTTGCAAACTGC
CTCTGTCTCCTGGGTGGGACTGTTCTGTCCTTGCACTGCTGTTCTGTGTT
ACCTCTTGGGGTGTAAGGTTTTGCTTACAGGAGACAAACTTTGGGCGTAG
AATGGAAGCCACTGCCAGCCTCTGTGCTGAGAAGGAAGGTGCTTGTTTCA
AAGGGAGCAGCAAGGGAGGCTTGTTCTACTCACCTGGGCCTGTTTGCCTG
AGAAGGGGAGATAAGGGCTGAACTGGGACTAGCCAGGGGGA
(SEQ ID NO: 243)
pARBI-639: TGGGGCTTTGGGGAATTTAGTGCGTGGGTGAGCCAAGAAAATACTAATTA 2541
chr11_3_ ATAATAGTAAGTTGTTAGTGTTGGTTAAGTTGTTGCTTGGAAGTGAGAAG
Exogenous_98 TTGCTTAGAAACTTTCCAAAGTGCTTAGAACTTTAAGTGCAAACAGACAA
ACTAACAAACAAAAATTGTTTTGCTTTGCTACAAGGTGGGGAAGACTGAA
GAAGTGTTAACTGAAAACAGGTGACACAGAGTCACCAGTTTTCCGAGAAC
CAAAGGGAGGGGTGTGTGATGCCATCTCACAGGCAGGGGAAATGTCTTTA
CCAGCTTCCTCCTGGTGGCCAAGACAGCCTGTTTCAGAGGGTTGTTTTGT
TTGGGGTGTGGGTGTTATCAAGTGAATTAGTCACTTGAAAGATGGGCGTC
AGACTTGCATACGCAGCAGATCAGCATCCTTCGCTGCCCCTTAGCAACTT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAGGTGGTTG
ATTTGAAACTGTGAAGGTGTGATTTTTTCAGGAGCTGGAAGTCTTAGAAA
AGCCTTGTAAATGCCTATATTGTGGGCTTTTAACGTATTTAAGGGACCAC
TTAAGACGAGATTAGATGGGCTCTTCTGGATTTGTTCCTCATTTGTCACA
GGTGTCTTGTGATTGAAAATCATGAGCGAAGTGAAATTGCATTGAATTTC
AAGGGAATTTAGTATGTAAATCGTGCCTTAGAAACACATCTGTTGTCTTT
TCTGTGTTTGGTCGATATTAATAATGGCAAAATTTTTGCCTATCTAGTAT
CTTCAAATTGTAGTCTTTGTAACAACCAAATAACCTTTTGTGGTCACTGT
AAAATTAATATTTGGTAGACAGAATCCATGTACCTTTGCTAAGGTTAGAA
TGAATAATTTATTGTATTTTTAATTTGAATGTTTGTGCTTT
(SEQ ID NO: 244)
pARBI-640: CGACCAACCCATCAAACTCCCCGCCCCCAGCACTTTTATTTCTCCTCTTT 2541
chr11_1_ AGGAAGTACACTTCAGTATCTTTGGCACAGTGCATGAGCACGACTAAAGT
Exogenous_94 AAAACATCGCAGAAAACATAGCTTTAGTCTACCCTTCGTGTCCTAAAAGG
AAAACCAGTAGCTTCCCAGGCCACCGGAAGGGCAACACATGTCCTCTGCA
GTTTCTGCACACGGGAAGGTAAAGACAGAGAGAGGACCTACTCCTCAACA
CAGAAACATTTCAAAATCTTTCCTCGCCTGCAACCCAAGCTGAAGTCATT
CTCCCCAGAAATAACAAAAGTTGGAAGAGAAGCCGGAGACAGGATAGGTG
CAGGAAGCCCACACTTTGAGGGCAGCACTCAGACACCCTCTCCTGTGTGC
AGGACGTGCCGAATGTTCAGGTGCAATGAGAATGAGCCATGCTTGGCTTA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCGAGGGCAA
TCTGGCCCATCAAGTGGCCTTCGCCTCTGGGAGTAACAAAAATGCACTTC
AAAATAGCTTCTGTAATCAAGCTGCATGGGTGGAGTACTCCCCAGCTGAC
TCCAGGAAGTTCTCTATCCAAAGCTATTCATTAGGCCAGAGCTGTGCAAA
TAATTAGTCACCCACTTGCTCCATAACCCTCCATGACAGCCCAGGCATTG
AGTCCAGGTGGGACCATCAAGCCATGCTCTGGTGGCTCATGCATTATCAT
AGAAATGGGAGGCTTTATTTATTTTACTAAAAAGAACAAAAACAACAGAC
TGCTGTCCTTTAGACAATAGGATCACGTCATCTGAGCCCTCTGTGCCCCA
GGTGACAAGCCCAGCCCCAAGTTCTCTTTCCTCAGCCTCCCCACACATGT
TCTGGAGGAGATGGGCCCAGCAGGCTGCTCTGAGGCCTGGC
(SEQ ID NO: 245)
pARBI-641: TCACAGAATCTTGTTTGAGCTAACAACCAGTTATTCTACCCAAAGTAAAG 2541
chr11_2_ AGTAACTTAAATTTTCCCATTGTTCTTCCAGGCTGGAAGATGTAAGAAAC
Exogenous_96 ACACACAGTATAGTGTAGGTTTCCTCCATAGTTAAGTACCCCAGAGCTAG
GCTGAAATCCAGTGTTGGATTGTTTCCAACTTATAGTAGGGAACCGCCAA
TGACATGAAAGAGCATTACCTTACCGGACTGATTCATATTCTACTTCCAG
TCATAGTACAAATGATCACATGTCCACACCCACATGTGCTCTGATAAGTA
GTCAATTGAGAGGAGTGAGTCAGGGAGCCGTAACTTTGCAGCCAACCTGC
CAAGAAGAACTGATGCTTTTAGAAATTCAGCAGCTTTCATTGGCATAGAA
GTTTCAGCCTTATAGGCCCAGGGTTTCTCTGAGGCAGAGGCAAACCCTGT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGTTATGTT
GTTATCTCAGGATTCTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTT
GCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCC
TCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACT
ACAGGCGCCCGCCACCACGCCTTTCTAAATTTTGTATTTTTAGTAGAGAC
GGGATTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGAT
CCGCCGCCCTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGC
GCCCAGCCTATCTCAGGATTCTTAATGTAAAAACAGTTCAGTATGGAAAG
CGTACTTATGACAGAGCTGTTGCAGAATGTGAAATCACCCATGTGCCTAA
GTGTCTCCCTACTACCTGGAACACTAGACCACATGCAGCAG
(SEQ ID NO: 246)
pARBI-642: CAGCCCTGAACTCAGCCTTCACGGCCCTCCCTAAACACATGGGCCAGCCA 2541
chr11_3_ CAGGGAAGAAAAAAATGCCCTGTAGCACAGGAATCTAAAACATTGCTGTT
Exogenous_95 GTTCTAGTTAATAAAAGGACTTAGAGATTGAAAAGAAGTACCATCTGTAT
GGCTGGCAACAGACAGCATGATTTTGATGACTGACTCTGGGGAGATCTGA
GAAAACAGTACATAATATGTCCTTACCTCTGCTCCATCATTCATGACCCA
AGCTCCTGCCCTGTCTTCTCAGGAAGATTCTTACAGTAACTCCAGTTTGG
AATTCCCCTTTCATATTTGAAATAACAACAGTAATAGTGACCACTAATGC
TTACCGAGTGTCCACTCTGTGCCAAGCATCGTGTTTTTATCATCTTTTTT
GTTAGGCACTGTACATGGATTAATACAATTACAACCCACCACAACCCCAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGAGATAAGT
ACTTGTACTATCCTCATTTTATGGGTGATGATACAAGAAACAGAAAGGTT
CAGCAACATGCCTAAAGCCACACAGCTACTATGAGGCAAAGTCTAGGTTT
GAACTCAGAAATTCTGACTTCAGACTCACTTATCTTATTATACTTCACTT
AGTATCTCCCATTAATTAATTCATTCATTCTTCCTTTTATTTGTTAATTC
ACCAAATATTCTGGGAAGCTACTTGTCTAGACACTGTATGAAAAATGAGA
ATGGATACAAAGCAACCTCAGACATGAACTCAAGGTCCTTACAAGCTTAA
ACGTATATGATACATTTCCAAATAGCAATACTATGAGGACAGCTGATACT
CACAACATAAGTCTTGGTGGTCACAGGAGATCTATCATAGGATTTCACGA
AGAACCTGACACTGAAAACCAGAACTTGAGGGAAATAAAAC
(SEQ ID NO: 247)
pARBI-643: GTGTCCATCCTGCATGTCTCAAGTCACAATCCTCCAGATATTCAACCAAA 2541
chr15_1_ GTGCTTGATTCTGTTGGCACAAGGACCATGAAATCTTCAGTAGCTAAGGA
Exogenous_100 GACTCTTTGACAAATAGATTTATTGCATATGATGTAAAAGGGTCTCATTC
AGAGAACTACACATTTACTACACATTTACTAGCTGTTAGATGTGAGAAAT
TGAAGCTTTGAGAATTGTCATTTTGTAAGCACGCTGTAATAATTGTGTTC
TCTACAAAAATGGAGAAATACTTAATCTTTGCAGGTTTTTATTAGCTTCG
AAAAAGGGAATACAAATATTTTGATACCTGACTTTATTTTAAAGATACTG
GCAAGCAAGGAAAGATACTCAGTTTGCTAAATTATAGCATAGATTTGAAA
GACGGAAATTTTTTTTTGTTATTTTGATTCTTTCTGATTCAGAACCTGCG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGAGTTTCC
ATTCCTGGGATAGAGAGCCCTGCCAAAGCCAACTCAGTCTCCTGTTATTG
CAGAAATTTAAAGGTTACTTGAGCTGATTGATACCAATTAAAATAAAAGC
ATCTACTGCCATTTTATTAAACGCCCTATTTAATCTCCACATCCCAAGTT
CATTCTCTCTCTCTTTTAAGGCTATACATGGGCCTCAACATTCTCTCTTC
TTCAGTATCAGCTGTCCTCATCCCTATTCAAAGTCAGAATGACTTGGAAT
CTATTCAGGGCTGCTACTTAATTGGATGAAGAAAGTACTCTGTTGCATGC
TAACCTCCCAGATTTGAATTAGAACCAAGGTCCTGAATCTACACAAGACC
TTTTTCCCTTTCCTTTCTGCATTTATTTCTTTTTTTTCTACATCTTTCTT
TTTGAATTTTTTTTTTTTTTTTTTTCTGAGATAGAGTCTTG
(SEQ ID NO: 248)
pARBI-644: ATCATCAAAATCTTCATTTATACAAATCACGGGTATTAGAAATAAAATCA 2541
chr15_2_ GGTATTGTGTACAGTCAGATCCCAGGTTTACACAAACTAGAGGTTTCAAT
Exogenous_101 TAAGTTTCCTTCATTTTATAAAACCATGACACAAGCTGTAAATAAAGGAG
CTCTGGCTTTAGGCCTTCTTCTGTTTATAGACAGTAAATTTTAATCCTCT
GTCCCTGCAGACCAACTCAAAGCAGTAACCTTGGCTACCGTTGCCGCAGA
AGAAACACACCCTGCAGATTTCCAGTTCTATATTCAGTCTTAGAAAATTG
GTCATGTTGAAAGGGAAAAAACAATTTTACTTTGCCTCAGTTATTGACAC
CAAGAAGCACTCCTCAGCCTGTTCAGAGGGGAAACAATGAGTCATTCATG
CTGTCAGCCCAGGTGGTGCATGAATTCCAGACAGAGGCCGCTGAATTAAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCCGTGGAGG
CGTCTCTCTGAGCAGAGCCCGCAATGCGCCTGCTTGGGGCTCCCTGCAGC
CTCTGGGGGAGGCAGGGCGGCCCAGAGCAGGCCTGTGCTGGAAAGGAACG
CGAAGCCCTGTAACCAAGCCTGTACCTCTGCAGTGCTAGTCCCAAGGGGC
CTCCGAGCTGTTTGTCACCATGTGATTGGCTCAGGAGAGGGGTGGAGAAA
TGAAAACACTCTGCCCAGGATATATTTAGTTGAAGTGCAGCTGGGGAAGT
GCTTAAACAAGGGAGCTTTTGTCCTTATGTTGAAGTGTTTTTCTTAACTC
CTCAAGGGTGAAAAACTTGAGCCACGTACTGATCCCATTCCCCCCCACCA
CCCCCAATATATTTTCTCTTCTTTAGGAAATGCTCTTATTCTGAAACTTT
AGAATTTTCTAGGGTTTGTTGCATAAGAGGAAACTGAATAA
(SEQ ID NO: 249)
pARBI-645: CTTTCCTTTCTGCATTTATTTCTTTTTTTTCTACATCTTTCTTTTTGAAT 2541
chr15_3_ TTTTTTTTTTTTTTTTTTCTGAGATAGAGTCTTGCTCTGTCGCCAGGCTG
Exogenous_102 GAGTGCAGTGGTGTGATCTTGGCTCACTGCAGTCTCCAACTCTGGTTCAA
GCAATTCTCCTGCCTCAGCCTCCGGGTAGCTGGGACTACAGGCATACACC
ACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCAT
AGTGGCCAGGATGGTCTCCATCTCTTGACCTCGTGACCTGACCCCCTCGG
CCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACCGCGCCCGGCCTCTT
TTTGAATTTTTTTAAAAAAACACCTAAAGTTTAGGAAAGTATAAGAGGCC
AAAGAAACAAGAGTTCAAAGAAACAAGAGTGTTATACACGCACACTTGCA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGAAAGGTAGT
AAAATATCTGTATAGTTCTGGCTGTCAAGCTTTTGGACTGAGATATGCGT
AAGCAAGGCAAAAAGATCCCATAGTCCAGGAATATCAACCAGTCCAGTTT
CCCAAGGAAACTAAAAGTAACTGAAAATGAGAAGGGTGCCATATAGGAAA
ATTGAAGGTGGGGCATAATTATTAATACACTGCTTTGGAAATGCTGGTAT
GGAAGATTCATATATGGACTTCAAAGCATACATGTCTTATACTTAGCTAT
GGGAAAATTATCATCAAAATCTTCATTTATACAAATCACGGGTATTAGAA
ATAAAATCAGGTATTGTGTACAGTCAGATCCCAGGTTTACACAAACTAGA
GGTTTCAATTAAGTTTCCTTCATTTTATAAAACCATGACACAAGCTGTAA
ATAAAGGAGCTCTGGCTTTAGGCCTTCTTCTGTTTATAGA
(SEQ ID NO: 250)
pARBI-646: TGTCTTCACGGCACGGCCCCCGCTTCACCAGCTGCACTGTTTGATGAGCT 2541
chr16_1_ TTGCAGGTCCCAGATCTTATAAGCTCATGGTGATTGATCCAAATGATGCA
Exogenous_103 GAGGTCGGCCTAAAGTTAGAAGTGGGCCCCTCTCTGCCCCAAGACAGCCC
TTCACCCCAATTCCATTCCCACAGTTTGGGCATCCACCCAGGCTGCCAAG
CCAAGCGGGGGCTGCCCGGGTTAGCAGGGACCTGGCCATGGGCCTCCTCA
GCTAGGGGCCGCCTCTCTGAGGAGTGGGTGCCCCGCCCCTCCGTGGGCCG
CCTGGTTTCTCTTATTGGCAGCGTCTGTAGTCCCCTGGCTCTGTCACCCG
CAGCTATTCTAGGCCTCTGGTTCCTTTCACTTTCTGCTCTGCGTCTTCCT
GCCTCGGTGGTTCCCCACCATCCAGCCTGAGACCTCCCCGTTGCCCGCCC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggggggcaggacagcaagggggaggattgggaagacaatagcag
gcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGTG
CCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGGG
GGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAAA
CTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGGG
GAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAAC
GGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTCC
TTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTC
GCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTC
TAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCC
TTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGC
TTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGA
TCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccaccA
TGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGTC
GAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGGG
CGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACCA
CCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTAC
GGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACTT
CTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTCT
TCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGGC
GACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGGA
CGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAACG
TCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAAG
ATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACCA
GCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCACT
ACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGAT
CACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCAT
GGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaat
aaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcat
tctagttgtggtttgtccaaactcatcaatgtatcttatTGGGTTTCTGT
CTGCTCCTCTCCGTGGTGGCCGGCCCTGGCTCTGCCCCAAAGCCATGGAG
AAGGCCAAATGCAGGCTGTAGAAAGGTCTGGGATCAGATCCCCCCATCCT
TCCATGGCCACGTGACCGGGCCCGCCTCTTCCCTCTGAGCCTCACATCCT
CATCTGAAGAGGGAATGCTGCTCATGCCCACCTTGCGGGGATGTGGGGAG
GGGGTGCTGCCAGTGGAGACTCCCAGGGGACCCTCCAGGAGTCTCATCCT
GACTCGAGACTGGGCACCTGGTGGGGGCACAGGCCCCCTCTCCCGCCATG
GGACCGCCACATCCAGGCTCTCGTGGGTTGAGATGCTGAGGAAAGGAAAG
AACAAAACCTGCTGGAGGAGCAGCGAACACGGCCCTCAGCTGGGTGACCT
TGGGCAAGTCACTTCCCCTCTCTGGGCCTCAGTTTCCAT
(SEQ ID
NO: 251)
pARBI-647: CTGAAGAGGGAATGCTGCTCATGCCCACCTTGCGGGGATGTGGGGAGGGG 2541
chr16_2_ GTGCTGCCAGTGGAGACTCCCAGGGGACCCTCCAGGAGTCTCATCCTGAC
Exogenous_104 TCGAGACTGGGCACCTGGTGGGGGCACAGGCCCCCTCTCCCGCCATGGGA
CCGCCACATCCAGGCTCTCGTGGGTTGAGATGCTGAGGAAAGGAAAGAAC
AAAACCTGCTGGAGGAGCAGCGAACACGGCCCTCAGCTGGGTGACCTTGG
GCAAGTCACTTCCCCTCTCTGGGCCTCAGTTTCCATATCTGTGAATGAGG
CAGCTGGACTGAAGAATAGAGAGTCACAAAGCAGAGTGACACAAACTGGG
CTACAGGAAACCCTGGAGGCCCTCGACCCAGGCTGGGGCCGGGGATGGTT
CTGCAAAGCCTCTTGGGAGAGGGTTGCCTGAGCTGAGTCTCCAAACAGAA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGTGGCCT
TAAGTCACGGGAGATGAGCCAGAGCAGTCCAGAGGGCACGGTCAGCACAT
GCTAAGGTCCTGGGGCACAGAGTACAGGGCTTGAGAAGGGTTCCTCTTGC
TCCATGTGACTTTCATCATCCAACAGCCTGTGGTGGCACTTGCCTGTATC
CCAGCTATCTAGGAGGCTGAGGTGGGAGGATTGCTTGAGTCTGAGAGGTC
GGGCTTGTTCTCCCGGTGTTGGCAGAGTCCAGAGGGAGCAAGTGGAAGCC
ACAGGTGTCTTGAGGCCTAGGCTGAGATCTAGCACATCACCGCGTCACTT
CATCCCTTCATTTCATCCTATTGGCCAAAGCAGCCCAATTCTAGGGATGG
GGATCTAGACTCAACTTCTTGATGGGAGAAGTAGCAAAGTCACACTGCCA
AGGGCAGGGACACAGGGAGGGATGAAGAGTTAGGAATGGTT
(SEQ ID NO: 252)
pARBI-648: AAGCCACCTCCCTGCTCTGTTGCTGGCTCTCCTTGAAGACAAGTGTTTTT 2541
chr16_3_ CAATTAACCAAAGCGGTGCATGGCAATGTGATAGGGGAATGAAACACAGC
Exogenous_105 AACAGAATCAATGCCCCACGCTGGGCAATAGCCGACTTTCTGTTCGCTCC
CATCCCTTCCTTCCCTCCCCGCCTCCTTCCCCTGCTCCTTCCATTCCACA
AACATTTATTGAGCACCCGCTGTGTGCCAGCCACTGTTCTAGGCCCTGAA
GACACAGAAGTGAACAAAAAAAAAGAGTCCCTGTGCACATCCTGGAGGGA
CTTTCCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTATACAGTGTA
TGGAGACAGTGGATAATAAAAGCTGTTTATGAGGCACTTTCTCTGAGCTG
TTCCATGTGCTTCACTTATACTCATTCAGCTAATCCTCAGGACACCCCCG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGAAGTCAG
TGATATTAGTCACAGAGGCCCAGAGAAGTGAAGTGACTTGCCCAAGGTCA
CACAGCCAGCAAGAGGCCAAGCCCGGATTGAACCCCAGCCGCCTGGCTCT
GGAGCCTGCAGCATAACCACAGCAGGGAACTGCCACCGGAGACAGACATC
GACAGCCACTAGGAGATGTTAACCAACAGGCTTGTCTTCACGGCACGGCC
CCCGCTTCACCAGCTGCACTGTTTGATGAGCTTTGCAGGTCCCAGATCTT
ATAAGCTCATGGTGATTGATCCAAATGATGCAGAGGTCGGCCTAAAGTTA
GAAGTGGGCCCCTCTCTGCCCCAAGACAGCCCTTCACCCCAATTCCATTC
CCACAGTTTGGGCATCCACCCAGGCTGCCAAGCCAAGCGGGGGCTGCCCG
GGTTAGCAGGGACCTGGCCATGGGCCTCCTCAGCTAGGGGC
(SEQ ID NO: 253)
pARBI-649: GGGGGCGGCCGCACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCG 2541
EDF1_1_ TGGCCCGGCCGGGGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGG
Exogenous_25 GGCGCAGCCGCCGCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCG
GGGTCCTCCCGACCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAG
GCCAGGCCCCGACGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACG
TCCCTCAGACGAGCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCG
CCCCCCGCGTGCAGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGA
GGGGACGTAGCGTCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGC
CGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGTGACGGTG
CTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGTGCT
TTGCTGACTGAGGAGCGGCCGGGCCGGGCGGGGCGGACGCTgggccgggg
ccacggaccgtggggcagggggctcggggaagggcaggcggggcctggga
cagggcgcaggggacggggacaaggctggGGTGCCGGGGGCAGGACGGGG
TTCGAAGGGCGGGGCGAATCGCAGGGGTAGGAGGACCGGGCCAGGACagg
ggtgggaaggtggggggcggacccaggaggggatggacggacccaggagg
cagggggCGGGCGACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGGGCA
AGGGGCAGGCGATAGGGCCGGGACCAGTGCCAGGGTGGGGGGGGGAGGGG
ATAGGGGCAGGGACTGTTGGTGGGGACAGGTGTGAGGACAG
(SEQ ID NO: 254)
pARBI-650: ACGGCTAGAGCGGAGACCCCGCGCCCCCTCCGCCCGCGTGGCCCGGCCGG 2541
EDF1_2_ GGTGCGGGGCCCGGGGAGGCACGGGGGCTGCGCGTCGGGGCGCAGCCGCC
Exogenous_26 GCCCGCGTGTGCTCGGAGGCCGCGGGGCCCGGGCTCCGGGGTCCTCCCGA
CCTGCAGCCCCAGCGGCTACCGCGCCTCGCCAGGCCAGGCCAGGCCCCGA
CGTCGCCTTCCCTACGTCGCCGGCGCCCGGCCACGACGTCCCTCAGACGA
GCCGAACGCCGAATGGCCCCGAGCACGGGAAGTGCCCGCCCCCCGCGTGC
AGCCAGCCAATGGGACGCCGAAAGCGGGGAGGTGCCGAGGGGACGTAGCG
TCGCCGCGCCAGGTCTCTAGCAGCTGCCGCTGAGCCGCCGGACGGACGCT
CGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatCGCAAGAAGG
GCCCTACGGCCGCCCAGGCCAAATCCAAGCAGGTGCTTTGCTGACTGAGG
AGCGGCCGGGCCGGGCGGGGCGGACGCTgggccggggccacggaccgtgg
ggcagggggctcggggaagggcaggcggggcctgggacagggcgcagggg
acggggacaaggctggGGTGCCGGGGGCAGGACGGGGTTCGAAGGGCGGG
GCGAATCGCAGGGGTAGGAGGACCGGGCCAGGACaggggtgggaaggtgg
ggggcggacccaggaggggatggacggacccaggaggcagggggCGGGCG
ACTGGAGGAGGAGAGGAGCAGGGAACCGGACGGGGCAAGGGGCAGGCGAT
AGGGCCGGGACCAGTGCCAGGGTGGGGCGGGGAGGGGATAGGGGCAGGGA
CTGTTGGTGGGGACAGGTGTGAGGACAGAGGCAGGAGGTG
(SEQ ID NO: 255)
pARBI-651: CCCTGGAGTCGGTGTGAGGCAAAAGCAGAGGAGAGGATTTGGAATTAACC 2541
EDF1_3_ TGAAGAAAAACCATTTCAAAGCGGTAACCAGACCCCAGAGGCTGCCTGAA
Exogenous_27 CTCAAGGGGACATGGGAACCCAGGCTGTCCCAAGTTCACACACCTCAGGT
CGTGGACTTCCAGAGTTTTCTCTCAGTTATGAGGACAGGCAGCTGTACTC
ATGCCAACCAGAGCTGCTCTGGGAAGATGGCTGCCTCCCAGGGCTCCGGC
CAGCACCGGTGCAGGCAGGCACTCAGCTGACAACGTCCCCGGGGGCGCCG
CACACACCACACCCACCAGCACATGGACCCCACAGCACAGCCTCATGTTG
CAAGCGGAAACACAAGTACCTACATTTCTTGGAAGTCTCCACATCTTCTC
CTCGTCTCTGTGCCGCTAAGATAGCCTAGAAAATTAGAAAACATCAGTGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTTCTAAAG
AGAAGATGTGCTTTATACACATCAGCTCCACTAGGACTGCTGCAAAACCA
GGCGCGAAGCGTCGCCTGAGAACAGCAGCTTCTAGGGCCCCTGGGGTACG
CACCCACACGCAGCTGGGTTTTGTGCGAGAGGCAGTGAGAGCCGGGCTGA
CCTGGCTTCCCGAGGCATTCCCTGCAGGGGAACCAGGGGGGTGGAGCCCA
CCCTCCCCGTGCTATCTGAACACCGGCCATCCCCCTCCCCAAACCCACAA
CCCCAGGAGTGAGAGCCCCGGCGCAGCCTCACCGTGGCCAGGTCCTTCTG
CGTAAGCCCCTTGCTCTGCCGACCTTGCTGGATCACCTTGCCCACCTCCA
GGGTCACCCTGTCATGGTGCAGCTCCTCTGTCTCCCGGTCCAGCTTGGCC
GTGTTCTTGGTAATAGAATGTTGTTTGTTCTGGCCAGCAGC
(SEQ ID NO: 256)
pARBI-652: CTCTTGCTTCAACAGTGTTTGGACGGAACAGATCCGGGGACTCTCTTCCA 2541
FTL_1_ GCCTCCGACCGCCCTCCGATTTCCTCTCCGCTTGCAACCTCCGGGACCAT
Exogenous_2830 CTTCTCGGCCATCTCCTGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGT
TAGCTCCTTCTTGCCAACCAACCATGAGCTCCCAGATTCGTCAGAATTAT
TCCACCGACGTGGAGGCAGCCGTCAACAGCCTGGTCAATTTGTACCTGCA
GGCCTCCTACACCTACCTCTCTCTGGTGAGTCCCCAGGACGCCCCTGGCC
CTAATTTCCTCCAGCTGCGCACCTCCGGCCCTCACTGCACGCGCCAGCCT
TCTTTGTGCGGTCGGGTAAACAGAGGGCGGAGTCCCCTTGGCCTCGCCTC
CCGCTAACCATTGTTGCCTCCATCTCTTCCCGTAGGGCTTCTATTTCGAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatCGCGATGATG
TGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAG
CGCGAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCG
CGCTCTCTTCCAGGACATCAAGGTAACTAGTGTGTGGGTAATGGACTACA
TCTCCCAGCAGGCCGTGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTG
TCGCGTGGGCTTCTGGGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACC
GCTGGAAATAGAGGCGCACCTCGTGCAGTGCCCACAACACGCGGCAGTCC
ACACCGCTGCGTGGTCTTAGGGACGTATAGCTGTAAGAGCTAGGACAGGG
TGCGGAGAGTGATAAATACAAGCTGTCACATGTCTTTGTGGCCTGGGCCT
CTGACCCCCAACGACTCTTGGGAAATGTAGGTTTAGTTCT
(SEQ ID NO: 257)
pARBI-653: TGGGGCGGGGGGCTGAGACTCCTATGTGCTCCGGATTGGTCAGGCACGGC 2541
FTL_2_ CTTCGGCCCCGCCTCCTGCCACCGCAGATTGGCCGCTAGCCCTCCCCGAG
Exogenous_29 CGCCCTGCCTCCGAGGGCCGGCGCACCATAAAAGAAGCCGCCCTAGCCAC
GTCCCCTCGCAGTTCGGCGGTCCCGCGGGTCTGTCTCTTGCTTCAACAGT
GTTTGGACGGAACAGATCCGGGGACTCTCTTCCAGCCTCCGACCGCCCTC
CGATTTCCTCTCCGCTTGCAACCTCCGGGACCATCTTCTCGGCCATCTCC
TGCTTCTGGGACCTGCCAGCACCGTTTTTGTGGTTAGCTCCTTCTTGCCA
ACCAACCATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGG
CAGCCGTCAACAGCCTGGTCAATTTGTACCTGCAGGCCTCCTACACCTAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCTCTCTCTG
GTGAGTCCCCAGGACGCCCCTGGCCCTAATTTCCTCCAGCTGCGCACCTC
CGGCCCTCACTGCACGCGCCAGCCTTCTTTGTGCGGTCGGGTAAACAGAG
GGCGGAGTCCCCTTGGCCTCGCCTCCCGCTAACCATTGTTGCCTCCATCT
CTTCCCGTAGGGCTTCTATTTCGACCGCGATGATGTGGCTCTGGAAGGCG
TGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAGCGCGAGGGCTACGAG
CGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCGCGCTCTCTTCCAGGA
CATCAAGGTAACTAGTGTGTGGGTAATGGACTACATCTCCCAGCAGGCCG
TGCGCGCGAGGAGCCTTGATTTGAGGGCGTAGGTGTCGCGTGGGCTTCTG
GGAGATTGAGTTCGGTCTTGTGAGCCCTCTTAACCGCTGGA
(SEQ ID NO: 258)
pARBI-654: CTTTGCATAGTTTATCCTATTAGTAATCTATTCTGTCTTTGGAATATGTT 2541
PTEN_1_ TTGTGATGATGAAATAAATACTATAAATAGTATTATTCCTTTTGCATTGA
Exogenous_31 GAGTCCTGACGAAATGTCCATGTGACAGTTCATTTTGGGTTTAGCTCTAC
CTCTAATATGTGACCTATGCTACCAGTCCGTATAGCGTAAATTCCCAGAA
TATATCCTCCTGAATAAAATGGGGGAAAATAATACCTGGCTTCCTTAATG
ATTATATTTAAGACTTATCAAGAGACTATTTTCTATTTAACAATTAGAAA
GTTAAGCAATACATTATTTTTCTCTGGAATCCAGTGTTTCTTTTAAATAC
CTGTTAAGTTTGTATGCAACATTTCTAAAGTTACCTACTTGTTAATTAAA
AATTCAAGAGTTTTTTTTTCTTATTCTGAGGTTATCTTTTTACCACAGTT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCG
CACCATCTTCTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGA
AGTTCGAGGGCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGAC
TTCAAGGAGGACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAA
CAGCCACAACGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGG
TGAACTTCAAGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCC
GACCACTACCAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCC
CGACAACCACTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACG
AGAAGCGCGATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATC
ACTCTCGGCATGGACGAGCTGTACAAatgattgtttattgcagcttataa
tggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttt
tttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttat
GCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTTATCAA
ACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATG
TTGCAGCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATA
TGTGCATATTTATTACATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCT
AGATTTCTATGGGGAAGTAAGGACCAGAGACAAAAAGGTAAGTTATTTTT
TGATGTTTTTCCTTTCCTCTTCCTGGATCTGAGAATTTATTGGAAAACAG
ATTTTGGGTTTCTTTTTTTCCTTCAGTTTTATTGAGGTGTAATTGACAAG
TAAAAATTATATATAAATACAATGTATAATATGATGTTTTGATGTATGTG
TATATACATTGTGAAATGATTACTACAGTCAAACTACTTAACATATTCAT
(SEQ ID NO: 259)
pARBI-655: GCTACCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAA 2541
PTEN_2_ ATGGGGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTAT
Exogenous_32 CAAGAGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATT
TTTCTCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCA
ACATTTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTT
TCTTATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAA
GACCATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCT
TGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATTCACTGTA
AAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTACAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatCGGGGCAAAT
TTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACCAGA
GACAAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGAT
CTGAGAATTTATTGGAAAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTT
TTATTGAGGTGTAATTGACAAGTAAAAATTATATATAAATACAATGTATA
ATATGATGTTTTGATGTATGTGTATATACATTGTGAAATGATTACTACAG
TCAAACTACTTAACATATTCATCACCTCACATAATTATTATTCTCCCCCC
AGGGTGAAAGCATTTAAGATCTACAAGCTACAATTTTCAATTATACAATG
TTATTATTAACTATAGTCACTATGCTGTCCAGTAGAGCTTCAGATCTTGT
TCATCTTGTGTTCCTCCCTCCCCACCCTCAGTCCCTGGAA
(SEQ ID NO: 260)
pARBI-656: ATAAATAGTATTATTCCTTTTGCATTGAGAGTCCTGACGAAATGTCCATG 2541
PTEN_3_ TGACAGTTCATTTTGGGTTTAGCTCTACCTCTAATATGTGACCTATGCTA
Exogenous_33 CCAGTCCGTATAGCGTAAATTCCCAGAATATATCCTCCTGAATAAAATGG
GGGAAAATAATACCTGGCTTCCTTAATGATTATATTTAAGACTTATCAAG
AGACTATTTTCTATTTAACAATTAGAAAGTTAAGCAATACATTATTTTTC
TCTGGAATCCAGTGTTTCTTTTAAATACCTGTTAAGTTTGTATGCAACAT
TTCTAAAGTTACCTACTTGTTAATTAAAAATTCAAGAGTTTTTTTTTCTT
ATTCTGAGGTTATCTTTTTACCACAGTTGCACAATATCCTTTTGAAGACC
ATAACCCACCACAGCTAGAACTTATCAAACCCTTTTGTGAAGATCTTGAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAATGGCTA
AGTGAAGATGACAATCATGTTGCAGCAATTCACTGTAAAGCTGGAAAGGG
ACGAACTGGTGTAATGATATGTGCATATTTATTACATCGGGGCAAATTTT
TAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACCAGAGAC
AAAAAGGTAAGTTATTTTTTGATGTTTTTCCTTTCCTCTTCCTGGATCTG
AGAATTTATTGGAAAACAGATTTTGGGTTTCTTTTTTTCCTTCAGTTTTA
TTGAGGTGTAATTGACAAGTAAAAATTATATATAAATACAATGTATAATA
TGATGTTTTGATGTATGTGTATATACATTGTGAAATGATTACTACAGTCA
AACTACTTAACATATTCATCACCTCACATAATTATTATTCTCCCCCCAGG
GTGAAAGCATTTAAGATCTACAAGCTACAATTTTCAATTAT
(SEQ ID NO: 261)
pARBI-657: TAGTGACGGTATCAAGAGCAGCATCCCAGGTTGACTTTCTTTGGGGCAGG 2541
PTPN2_1_ ACCTTGCTTGTGTCTTAACCCTTGGTTCCTACccaagtttgtctctctag
Exogenous_34 tcctcaactctgaaagccacttgatatcttacacaattccttttttgcct
gagaaaaaaaagtcagttttgatcatttacaaccaaaaatcctaactaac
acaGACCTGTTTTTGAAATCAGGTAGATTGGAAGTCTTGGTTTACTTCTT
ATAAGCCCGTCCGCTGTCTGTCTTGTAACATCCCAGGAGCAGACTTAACA
AGGCCTTCCTGGAGCCTTGCTCTTTCTGTCTGCTTCCCTCATCTGctctc
tctcctctctctTCACAGGGTCCACTTCCTAACACATGCTGCCATTTCTG
GCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCt
gacgactgtgccttctagttgccagccatctgttgtttgcccctcccccg
tgccttccttgaccctggaaggtgccactcccactgtcctttcctaataa
aatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggg
gggtggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatATTGTGGAGA
AAGAATCGGTGAGTAATATTTAATATTTACAACTTAGTATACTGTATGTG
ATCATTAGCATATAAAGATTTTCATTTTGGGGCCAATATTCATTCCTTAG
TTTTGGCCTTTAATTGCTAAAGGCTAGCGGTCAAAGTGTTTCTGTCCGGA
AAAACTCATGTATCCTTTTCCTTTCTTAAGTATTTTTATAACAATTGCAG
ACCTTTCATCTCCAAGATAGAAATACAATGGAATAAATATGGACTAGCAG
TGACATATAGATCTTTGGAATCCCTAGGAATCCTTATTGACCTATTGTCA
ATAAGTCCTCTTCCAGCTTTAAGATCTTGTACTGTTCTACTTCAGATTTC
TTACTTTATTCTACATTTCATAATTGCTGGTTTTTAATGATGATGAAAAT
TTCCTAATCCACTTCTAATTAGATGTGGCAATGACATGCC
(SEQ ID NO: 262)
pARBI-658: CAGAATTTGAATATGATGTGGCTGACCATAGATACCTCCATTGCATTAAT 2541
PTPN2_2_ TCTGCTTCATAAAGTGTTTGATGCTTGCTTGTAGGTGTTGAATAGAGCCT
Exogenous_35 AATTAGCAGTAAGTAAACAGATCTagagcacagactttggcatctgaagg
accttggttcaatgctgggactgccacttactagctatgggatctttggt
ggatttttaacctttgaaagcctttcatccctcacagatataatggggaa
gaaaatcgtttccattagtattgtgaggattaaatgattaattgatgtaa
acaatgtgctttccatagtacttggcatatcataagtgcttcatGTTATT
TTACGCTGGCTGGGAAGATAAGTTTTGCTGTGGAGAATTTAAGAGGGATA
TTAAAATATATTTTTGTTATTTTAAGGAAATTCGAAATGAGTCCCATGAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTATCCTCATA
GAGTGGCCAAGTTTCCAGAAAACAGAAATCGAAACAGATACAGAGATGTA
AGCCCATGTAAGTACTTGTGGGTTTGTGTGCATGTGTATTTTTTGGTTTG
TTTTAGGAGGCAGGATGTAGTGAAAAGGAGGGCTTGGGGTCAGTGTTGAT
AAATACAGTAATTTTTTTCCTATTTACGTAAGACACGTTCTTTAAGAATT
TAAAGGTGTAGAATAGTGGAAGGAAAAATAATTACCCATAATTATTTCAT
CCTTCAAACATAGGCACCATTATTTTGGTGTATTTCCCACAACCTGTTTT
TCTTATGCACAGTTTTCCTTTCTTTAAAATAATTGTAATTATAGATGTCT
ATATAATATCCATATGTATTTCCTTTTCATATCATTCCATCCCCTTTGTA
AGTTTTGCTTAAAATAGTTATTGGTGTAGTTTGGTTTTTT
(SEQ ID NO: 263)
pARBI-659: ACCAGTTATCGTTTTGTAGGTAGACCAATCAATTCTTAGGTACCAAGAAT 2541
PTPN2_3_ CTGAATGATCCTTTTACTTTTAGGAAGGTAAGTACTTTATTCATTTAACT
Exogenous_36 ATGTTTACTCCTGGTCGATTTTTCAAGTCACAATGGCTAATGTGCTACAA
ACAGAAGTGCTTCCTTTCCAGCACTATAGTAATAAACAAGATTGCATTTT
ATACTCCTTACAAAAAAAGTAGAGAATAGTTTAGGATTTGTCTCAACTCT
ATTATGATGCTAATTCATTTTTCTTATTTCTTCTGTCTTTTTATAAATAC
CTAGAATATTAATATGAAGATAAAAACAGTAATTTTGAAATGACAGTTGT
GGTTTATCATTCTCTATTTTCAGATGATCACAGTCGTGTTAAACTGCAAA
ATGCTGAGAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatCAAAGGAGTT
ACATCTTAACACAGGCAAGTAATACGATACCACGCAAATGTCTGAAAATG
ATGTGTTTGTGCTTGTTCTGCTTTAAATCATAGGTAAAAGTATATCTTGA
CTTCTTTTGGAAATGAAATGGTATTTCAGTTTTTTTCTGACGATGTAATG
AATTATGGACATTATAAGGTTTTGAAGCTTTGAGTATTTAAGATAAAAGG
CAAGTTATTTTTGATATTACACGTTCTGTGAAGGAAAATTCTTAGGAAAT
GGCTTAGGCCAGTTCTTTGGCAGATTGTGTTCCTTACATTATATCTGACA
CAGAGTGCTGCTTATGCTTCTTAGTGTCTTCTTTTCTCTTCCCATACCCT
GTGGCAAAACCAGAGGCCCTGGACAGCTCTTCTGTAGCTCCCCCTGCCTC
GCATATATCTTCAGAGAGTACACCAAGCCCTGGATGGTGT
(SEQ ID NO: 264)
pARBI-660: CCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTC 2541
PTPN6_1_ GCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGTAGGTGGGCCCCCCG
Exogenous_37 CAACCCCGGGCATTTTGGCCACTCTCTTGTGCCATCCAGGCCCTGAACCA
CTCATTCCTGGTTCCCCGTGGCAGTGCTGACTCCCCGTCTGTTCCCTTGC
CCCCAACCCCCACACTCCCCATCCCTGTCTGTGCCCACCCATGCCCATGT
GTGCCCCCACCCAGGACCTCAGCCGATCCCTGCCCTCCTGCCTCTACTCC
TGCACCGACTGGCCTCACCGCCTGGTGCCCTGCAGGGTGGGGGATCAGGT
GACCCATATTCGGATCCAGAACTCAGGGGATTTCTATGACCTGTATGGAG
GGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGGGTGTC
CTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGCTGAACTG
CTCCGATCCCACTAGTGAGAGGTGAGGGCTCCGCACCCCCGCCATTCCCA
AGCAGGGATGAGCCGGCTCCCACCCTGAACAGCCAGGGAGGCAGGGAGAC
TGGCAGCCGGCGCTGCCTACCCTCCATCCCCTCCCCTCCCTGCACCAGCT
GGGGCTCTCAATGTCCCTCCTCCCTGCTGTCCTGGGACCTGGTGTCTCAG
AGCCTAACCTACCACCCTTTCCACCTAACCCCGAGGAAGCCACAGAAAGC
TGCCTCGCCCTACTCCGGGAGCCCTGGCCGCTGCAACCCAGGTCCCACTG
GAGACAGGGAGGCCACTGCTGGTGGCCAGCATGTCGTGCAGGCCAGCTCT
GTTGTTAGAAAGCTCTTCTTCCTCTGGAATCGAGCCTGCCT
(SEQ ID NO: 265)
pARBI-661: CTGGGTTCGAAGCCCGGTTAGAACTCTGGAGGCTAGGATGGCTTGAACCT 2541
PTPN6_2_ GGGAGGTCGAGGCTGCAGAGAGCTGTAACCGCGCCACTGCACTCCAGCCT
Exogenous_38 GGGCAACAGAGCTCTGGAAGCTTGCCCTAGAGTCAGTCAAGGGCCCTAGG
CCAGTGAGTAACAGCTCAGCGTCAGTTTCCTCATCTATAAAATGGGGGTA
ATATCATACCTAGCTCTCAGCATGTTTGTGAGAGACCTAAATGAGGTGGT
GGATTTGGAAGCATGTAGCGCAGTGCCTGGCACACAGTAGGTGCTTGATT
TCCGGCCCCTCTCTGTGAATGTCTCTGCTCAGCGCCTTCCCCTGTGGCCT
GGGTCTTACCTTCCCTGACGCTGCCTTCTCTAGGTGGTACCATGGCCACA
TGTCTGGCGGGCAGGCAGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACGTTTCTT
GTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCTCAG
TGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCA
AGGTCATGTGCGAGGTAAGGCAGCCAGGCGGCGGGGGAGCCTCTGCTGAG
GCTCCTGTCTGTGACCACAGTGTGGGTGGCAGGGAGGGTCTGCCTGGGCT
TGAATTCAAGGCTGGGGACCCAGGGAGGGAGACTCAAGTCCTGTGAATGG
CCTAATTTGGCTCCCCCCAGGGTGGACGCTACACAGTGGGTGGTTTGGAG
ACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGAT
TGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGGTCAGGGGTGGGC
CCAGCTGCCTCCCCACTTCCCCTGAGCTGTCCCCCAGATGT
(SEQ ID NO: 266)
pARBI-662: TGTCACATATGTGCAATGCCATGCTCCTGAGCCTTTGATTGCAGACGTGT 2541
PTPN6_3_ GGGAAGTGGGCCCCGTCCCCACCCCCAGTGCCACCCTGCTCTGCTTCTCT
Exogenous_39 TCCCTTGCTGTGCTCTAAAACGAGAAGTACAAGTGAGTTCCCCCAAGGGG
TCGGCCGCGCCTCTTCCTGTCCCCGCCCTGCCGGCTGCCCCAGGCCAGTG
GAGTGGCAGCCCCAGAACTGGGACCACCGGGGGTGGTGAGGCGGCCCGGC
ACTGGGAGCTGCATCTGAGGCTTAGTCCCTGAGCTCTCTGCCTGCCCAGA
CTAGCTGCACCTCCTCATTCCCTGCGCCCCCTTCCTCTCCGGAAGCCCCC
AGGATGGTGAGGTAAGGGCCTGCCACCCACGGTAGACAGGAGGCAAGGGT
GCCTGGTGCCCACGGGACCCCTCCTCACTGCCCTGCCTGGGCCGCCCAGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGGTTTCAC
CGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGT
CCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCT
CGCTCTCCGTCAGGTAGGTGGGCCCCCCGCAACCCCGGGCATTTTGGCCA
CTCTCTTGTGCCATCCAGGCCCTGAACCACTCATTCCTGGTTCCCCGTGG
CAGTGCTGACTCCCCGTCTGTTCCCTTGCCCCCAACCCCCACACTCCCCA
TCCCTGTCTGTGCCCACCCATGCCCATGTGTGCCCCCACCCAGGACCTCA
GCCGATCCCTGCCCTCCTGCCTCTACTCCTGCACCGACTGGCCTCACCGC
CTGGTGCCCTGCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAA
CTCAGGGGATTTCTATGACCTGTATGGAGGGGAGAAGTTTG
(SEQ ID NO: 267)
pARBI-663: TCTTTAGCTAATGTTCTGTAGCTTGTTTTAGATCTGTGTCTACATATTAT 2541
PTPRC_1_ ATGTATCTCTGTATGCATCAATATTTGTATATATGCATGCATATATGTGT
Exogenous_40 ATGTATATTTATGAATACATATACACACCATATACATACACTTATGTATG
GTGTGTGCATATGTATGTGTAGATATATGTACATACACACTATAGTGGAC
TGGGGAGTTAGTATACTGGGAGGAGCATACATTTAGGGTATGATTCACAT
ATTTATTTTGTCCTTCTCCCATTTTCCATTAATTAACAGGATTGACTACA
GCAAAGATGCCCAGTGTTCCACTTTCAAGTGACCCCTTACCTACTCACAC
CACTGCATTCTCACCCGCAAGCACCTTTGAAAGAGAAAATGACTTCTCAG
AGACCACAACTTCTCTTAGTCCAGACAATACTTCCACCCAAGTATCCCCG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGACTCTTTG
GATAATGCTAGTGCTTTTAATACCACAGGTTGGCACACAAAAGTTGTTAA
CTTAAATATCAGGGAATGTCATTTAGAAAATTCTACAGTTATCAGTACAA
CTTGTCTTTAAATTATTTGCACAGTTTCTAAGTATGTGATTTTATTCAAG
TGCAGAAATTGCAGGAAATTAGTATCTGTGAAATATAGATCGACTGAAGT
AATTAATGCATGTTGTTAGGGAGTGGAGAGAGAAAAGAAGGGAAGCAAGA
TCTCCAAGGACAATCAGGAGGGGAAATTTGTTCTAGTATCCTCTGATCTA
TACACACTCGCCATGATTCTCCCGCTTGGCTTCCCGCCACCTGGACAGAT
GAGAATTTCCCTAGTTCAGAGATTATCAGTTCTACTCTCCTTGGAAGGTG
TCTTAAATGGGAGTCTTCCCATTTCTTTGTTTCACTCTAGA
(SEQ ID NO: 268)
pARBI-664: AGGGAATTTTTATATGTTGGTCATATTATATCCCTAGCATGTGGCATAAT 2541
PTPRC_2_ GTCTAGCACAAAATAGGTGCTCAATTAATCATCATTATCTAAATAAATAA
Exogenous_41 TGCATTTGGGAAAAAAAAGTTTCAAAAGTTTTTCAAAAGTCTTTTGCAGG
CTTGAAATTAATCCCAATAGTGATCCTTTAGTCTGTTATGTTTCTGATTT
AGCCTGGGGATTCAAAAAATAAATAACATAATTTTGATATATTTGGGCTT
TGTAAACATGGTACTAAGAGAGGAAATATAGTTTCATTAGGGTAAAAGCT
ACTGAAAATTGCCACTTGGTGAATGTTCTATCATAGACTTGAGGTACATA
TAAAAATCTAATATATGTTTACATTAATATGAATGAAATTTGAAATTTTC
TAAGAGATTTTTGTTTCTTCTTTGCAGGGCAAAGCCCAACACCTTCCCCC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACTGGTAAG
AATTAATATTTATATTTTTACTAATTTTATTTTCTTGTTGCAAAGTTTAT
ATATTTAACTACAATTTTCTATTATTAACACTGAAATTATTTTTAAGGAT
AAATTTTATAATCATGAGTGATTCTTGACATTCACTTGTTCTTAAACTTT
CTGCTTATACGTTATAGAGTTTAATAACTACCTAAACATGTTATTAAATT
TGTATATATATTTTGTGTATAAATAGTAACTTTTCCCAAACTTGACAGTA
AATCACACAACAGGTTTCTACTCTCTTTTAATATTTTAAGACTATAAAAA
AATGCATTTAAATTAGATAACAAAATTTTATAGTCTGAAAGCAGGTTAAC
AGCTGTCTATGTATGTTATAGATATGTAGATAACAGATTTGCATATGTCT
ATATTTCTTTAAGAGTATGTTGCTTTTTTCAATGGTATGCA
(SEQ ID NO: 269)
pARBI-665: CCTTTAGCACCATAAAGAAACTAAATTATTTAGATGTTTTTATGAGAACA 2541
PTPRC_3_ TATCAAAAAGTACTTTTCTGTCATCCAATACTTCCACAAATAAATCATTA
Exogenous_42 GTTCTTGCTAATCTTCATCTGGCATAAAAATAATGACATCAACTTTCTTC
ATGTAATTTCCCACTTAATTCCTTTACTAGGAGCAATATCAATTCCTATA
TGACGTCATTGCCAGCACCTACCCTGCTCAGAATGGACAAGTAAAGAAAA
ACAACCATCAAGAAGATAAAATTGAATTTGATAATGAAGTGGACAAAGTA
AAGCAGGATGCTAATTGTGTTAATCCACTTGGTGCCCCAGAAAAGCTCCC
TGAAGCAAAGGAACAGGCTGAAGGTTCTGAACCCACGAGTGGCACTGAGG
GGCCAGAACATTCTGTCAATGGTCCTGCAAGTCCAGCTTTAAATCAAGGT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTCATAGGAA
AAGACATAAATGAGGAAACTCCAAACCTCCTGTTAGCTGTTATTTCTATT
TTTGTAGAAGTAGGAAGTGAAAATAGGTATACAGTGGATTAATTAAATGC
AGCGAACCAATATTTGTAGAAGGGTTATATTTTACTACTGTGGAAAAATA
TTTAAGATAGTTTTGCCAGAACAGTTTGTACAGACGTATGCTTATTTTAA
AATTTTATCTCTTATTCAGTAAAAAACAACTTCTTTGTAATCGTTATGTG
TGTATATGTATGTGTGTATGGGTGTGTGTTTGTGTGAGAGACAGAGAAAG
AGAGAGAATTCTTTCAAGTGAATCTAAAAGCTTTTGCTTTTCCTTTGTTT
TTATGAAGAAAAAATACATTTTATATTAGAAGTGTTAACTTAGCTTGAAG
GATCTGTTTTTAAAAATCATAAACTGTGTGCAGACTCAATA
(SEQ ID NO: 270)
pARBI-666: aaggaaaaaggcactgagtgctggggggtgctggggtgggctgcagtgat
PTPRCAP_1_ agacatcagggtagaggttaaggtcaggttcagcctcactggggtgaagt
Exogenous_43 ttgagcacggtgagcaggccatgcagcccgggggaggggaggatgggagg
aggtggagctttccgggcagagggaacagccagtgcgaaggccccaggca
ggtggcttaatgcagctgttgggggaggtgagtggtagggaggaggctgg
agggatgggggctgatctcacagggccagagcctggttgaccaaataagg
ccttggccttttctGCTTGGCTGTCCCAAGAGGATCCCAAAGAGAAAAAA
ACGAAAGTGGTCTTGGTCACCCAGCCTGCCCCACACCAGGCCCCACCCCA
GGTGCTGAGCCCTCTGAGCCCCTGCCTGTCTCCCACAGGCTCTGCCCTGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatACCTTAGGGC
TCGGGATGCTGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCG
GAGGACAGCGTGGGCTCCAGCTCTGTCACCGTTGTCctgctgctgctgct
gctcctactgctgGCCACTGGCCTAGCACTGGCCTGGCGCCGCCTCAGCC
GTGACTCAGGGGGCTACTACCACCCGGCCCGCCTAGGTGCCGCGCTGTGG
GGCCGCACGCGGCGCCTGCTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCA
GGCCCGAGCTGAGCTGGGGTCCACAGACAATGACCTTGAGCGACAGGAGG
ATGAGCAGGACACAGACTATGACCACGTCGCGGATGGTGGCCTGCAGGCT
GACCCTGGGGAAGGCGAGCAGCAATGTGGAGAGGCGTCCAGCCCAGAGCA
GGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACG 2541
(SEQ ID NO: 271)
pARBI-667: aaggtcaggttcagcctcactggggtgaagtttgagcacggtgagcaggc 2541
PTPRCAP_2_ catgcagcccgggggaggggaggatgggaggaggtggagctttccgggca
Exogenous_44 gagggaacagccagtgcgaaggccccaggcaggtggcttaatgcagctgt
tgggggaggtgagtggtagggaggaggctggagggatgggggctgatctc
acagggccagagcctggttgaccaaataaggccttggccttttctGCTTG
GCTGTCCCAAGAGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCA
CCCAGCCTGCCCCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGC
CCCTGCCTGTCTCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGC
TGCTGGCCCTGCCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGTGGGCTCC
AGCTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCAC
TGGCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACT
ACCACCCGGCCCGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTG
CTCTGGGCCAGCCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGG
GTCCACAGACAATGACCTTGAGCGACAGGAGGATGAGCAGGACACAGACT
ATGACCACGTCGCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAG
CAGCAATGTGGAGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGA
GGAAGCCAGAGACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCCCCAG
GACCAGCGAGCGCAGGGGGCAGTGCTGAGGCCCTGCTGAGT
(SEQ ID NO: 272)
pARBI-668: cagtgcgaaggccccaggcaggtggcttaatgcagctgttgggggaggtg 2541
PTPRCAP_3_ agtggtagggaggaggctggagggatgggggctgatctcacagggccaga
Exogenous_45 gcctggttgaccaaataaggccttggccttttctGCTTGGCTGTCCCAAG
AGGATCCCAAAGAGAAAAAAACGAAAGTGGTCTTGGTCACCCAGCCTGCC
CCACACCAGGCCCCACCCCAGGTGCTGAGCCCTCTGAGCCCCTGCCTGTC
TCCCACAGGCTCTGCCCTGCACCTTAGGGCTCGGGATGCTGCTGGCCCTG
CCAGGGGCCTTGGGCTCGGGTGGCAGCGCGGAGGACAGCGTGGGCTCCAG
CTCTGTCACCGTTGTCctgctgctgctgctgctcctactgctgGCCACTG
GCCTAGCACTGGCCTGGCGCCGCCTCAGCCGTGACTCAGGGGGCTACTAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCACCCGGCC
CGCCTAGGTGCCGCGCTGTGGGGCCGCACGCGGCGCCTGCTCTGGGCCAG
CCCCCCAGGTCGCTGGCTGCAGGCCCGAGCTGAGCTGGGGTCCACAGACA
ATGACCTTGAGCGACAGGAGGATGAGCAGGACACAGACTATGACCACGTC
GCGGATGGTGGCCTGCAGGCTGACCCTGGGGAAGGCGAGCAGCAATGTGG
AGAGGCGTCCAGCCCAGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAG
ACAGTGACACGGAGGGCGACCTGGTCCTCGGCTCCCCAGGACCAGCGAGC
GCAGGGGGCAGTGCTGAGGCCCTGCTGAGTGACCTGCACGCCTTTGCTGG
CAGCGCAGCCTGGGATGACAGCGCCAGGGCAGCTGGGGGCCAGGGCCTCC
ATGTCACCGCACTGTAGAGGCCGGTCTTGGTGTCCCATCCC
(SEQ ID NO: 273)
pARBI-669: ATAGAGTAGGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGG 2541
RPS23_1_ GGAAGCGCCGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGA
Exogenous_46 GGCGTGGAGGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGC
GCTTCCTCCCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATT
CTCCGGAGCCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAG
GCCAAATGTTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCT
TAAGGGTTTATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGT
AGATGGCGTGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGT
GTCGTGGACTTCGTACTGCTAGGAAGCTCCGTAGTCACCGACGAGACCAG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAAGTGGCAT
GATAAACAGTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCC
TTTTGGAGGTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTGTAAG
TCCATTGCTCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAGACATGAA
CTTACGAATTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTAGTAGTAT
TCATTTGGGCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTATTTAAAA
GTTGGTAAAATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTAATTTAAC
GTTGGCCTGGAAGGAATTGGAGAAGATACTAGCAATGATGAAGTAAAGGA
CACAAACACCTTTACTGTGGGAGTTGTTATAAGTAAATGGCACGTGTCAG
CTATTGAACTTTATCGACTTGATAAAACTAAGGTGAAGAGA
(SEQ ID NO: 274)
pARBI-670: CAAGCGGGACTTGGGGTCTTGGGGACGGGCGGGCGGATGCGAATAGAGTA 2541
RPS23_2_ GGGCGGGGGATGCCATGGAGAGGCTCCATGGGGGAGGGCCGGGGAAGCGC
Exogenous_ CGCTCCAGGAGGCACGTGGTCCGGCGCGGAAGGGGCCCATGAGGCGTGGA
47_48 GGCCGCCGAGGTCGGGGTACCGAGGGACGCAGGGAGGCCAGCGCTTCCTC
CCGGGCATTCGAGCGGGGCCTCGTCCTTCGGGAGAACACATTCTCCGGAG
CCCTCTTCGAACGTTTATTAGTCGGTTCAGGGCAACTTGAAGGCCAAATG
TTTGGCCCACAGGCCAATAAATAGTACGAGAGCCAATCGGCTTAAGGGTT
TATTCCAGGTGAGGCGAGTGTCTTAGAAGATGGGAAACACGTAGATGGCG
TGTTTTTACGGAAGAACTAAAATATTTAATTTTTAGGCAAGTGCCGCGGA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCTTCGTACT
GCTAGGAAGCTCCGTAGTCACCGACGAGACCAGAAGTGGCATGATAAACA
GTATAAGAAAGCTCATTTGGGCACAGCCCTAAAGGCCAACCCTTTTGGAG
GTGCTTCTCATGCAAAAGGAATCGTGCTGGAAAAAGTGTAAGTCCATTGC
TCCCGTCAAGTTTTAGTTTATTATAGGAATTCGAGACATGAACTTACGAA
TTCTTGTTTTGAAAGTAATTGCAGGTTTTTGTGTAGTAGTATTCATTTGG
GCATTGTGGGGTAAAATTGCAAAGCGTTTGTTCTATTTAAAAGTTGGTAA
AATTAGTTTTTGGGAATTAGGTAGTTAAGGTTTTAATTTAACGTTGGCCT
GGAAGGAATTGGAGAAGATACTAGCAATGATGAAGTAAAGGACACAAACA
CCTTTACTGTGGGAGTTGTTATAAGTAAATGGCACGTGTCA
(SEQ ID NO: 275)
pARBI-671: TTGTATATCCTTTTTAAAGTTATTCTTTTTAGTTAATTGCTCTATGTGTA 2541
RTRAF_1_ TTGAGACTAGGAATCAGAAAGCTTAGATTCTAGTCCCAGGTGTAAGTTGT
Exogenous_49 GTAACCCTTGGCAAGTGTCAATCTCTAGGCCTCAGCTTTCTCATCTATAA
AATGAGGAAGTTGTCGTATTCTATTTTTTTTCTTAAGATGATACACTTAA
ATGTTCCCTTCTGTTGGGTTATATAATTGCATCAAAAGTGTAGTAATGTT
ATTAAAAAATTGTTAGAGATCCAAACTAAGGTCTCTTTCAACTCTCCCAT
TCTTTTTTCTGTGACTTTATGGTAATAATGAAACTGGTGGTTTTCTTTTC
TTCCCCCTCACAGTATCTCAGAGATGTTAACTGTCCTTTCAAGATTCAAG
ATCGACAAGAAGCTATTGACTGGCTTCTTGGTTTAGCTGTTAGACTTGAA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTATGGAGATA
ATGGTACGTTTTGTGGGGAATGTGTATTTTAAAGAGAGAGGAAAGATGGG
AAAGGGAGTGTGAAAATGTAGGGAACTTTGCAGTTTGTTTTGTCTAGTAC
TATTTTACCTTTGGTTTATTCTTATCACAAGTTAAAAGCACTTTTATTGT
CTTTCATTGGTGTTTATATATTTCTGTTAGAATTTGGAAATGGTGCCCTC
TGGAGAAGGCTAATTGACTGTCTTCTCACAGAGTAACACTACTTTGATAA
TATGGTCTGCACCTTAGCCTTTCAAATTAAATTGTTTTTAGTGTCCCAGA
ATTGATGGGACTTTGAAGTGTTGTTGCAGTAGGTAATTTCTCAAAAGACT
GAAACATGTCTAATGCCAATATACATTAATACTCTATAGGCCAGAATATA
TTACTTATGTTTACTGTCTTAGCACAGATACTTCTATGGT
(SEQ ID NO: 276)
pARBI-672: GCACCTGTTATGTAGGAGGAGTAATAAAATGAATGAATGCACTCAAAACA 2541
RTRAF_2_ CTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAAGC
Exogenous_50 CTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTGGC
TTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAAGT
TTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGGAG
CCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGATTG
GCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCTCG
CCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTCCC
GGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGACGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAAGTTGACG
GCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAAGGTGAGGCGGC
GGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCGGAGGTCCCAGCCTCA
GTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGGCGGCCTGGTTTCCGC
CGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCACGTACCTCGGCTCTT
CGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCTACTCCTGTCTCGGCA
TGTTACTTTCTGCACTTGCTTAACTCCAAGCATCACGTAACTACCTTCTC
TGTACATAAAAGGGAGAGCATTCGTCTTTCTCACTCACTATTCAACTCCA
TGGTTCCCTGGGTAATTAGGCGATACCTTGAGCACCTGCTAATTATGGGC
CAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGTAACTTG
(SEQ ID NO: 277)
pARBI-673: CACTAAACAGTAATTCTGTAATCCAACGGGAGGTACAGCGAATACCAAAA 2541
RTRAF_3_ GCCTACATATACTATTCTCTGCATGCTATAGCAAGAAAGAAAGGAAAGTG
Exogenous_51 GCTTCCCGGTGGTTTTCTGCCTATTGTACAACCAGGAAGCTGACAATAAA
GTTTATTTGAGCGTCGACGTGCGCCGACGTGGCCCCGCCTCCCCAGCCGG
AGCCGCGATTGGTGGGCATTTGCCGGCGGCCACCGCTTTTAAGCCACGAT
TGGCGAAGGCCGCCGTCATTTCGGAGCGACTCAGCGCCTGCCCGCCCTCT
CGCCGCGTCGCCGGTGCCTGCGCCTCCCGCTCCACCTCGCTTCTTCTCTC
CCGGCCGAGGCCCGGGGGACCAGAGCGAGAAGCGGGGACCATGTTCCGAC
GCAAGTTGACGGCTCTCGACTACCACAACCCCGCCGGCTTCAACTGCAAA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGTGAGGCG
GCGGCCTCAGCCCGGCCGCGTGTCCCTGACCTGGGCGGAGGTCCCAGCCT
CAGTGCCCGCACCCCACCTCCCCGTCGGGACCCTCGGCGGCCTGGTTTCC
GCCGGCAGCCTCCGGGCCCCTCTCCTCTGGGTCGCCACGTACCTCGGCTC
TTCGCCGCCCCTTCCCGCCTTTAAAGCCCTCTCACCTACTCCTGTCTCGG
CATGTTACTTTCTGCACTTGCTTAACTCCAAGCATCACGTAACTACCTTC
TCTGTACATAAAAGGGAGAGCATTCGTCTTTCTCACTCACTATTCAACTC
CATGGTTCCCTGGGTAATTAGGCGATACCTTGAGCACCTGCTAATTATGG
GCCAGCGCGGTGCTGGATTCTGAGGAAGGTGCTGAGTAACTTGAAGACTA
GTTCACTGCCTGCCAGGAGCTAAAGGGACGAGGGGTGGAAG
(SEQ ID NO: 278)
pARBI-674: CCGGGTTAGGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGC 2541
SERF2_1_ CAGCGCCCCTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATC
Exogenous_52 CCCCACGGAGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCC
CCACGCCGCCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTC
TCTAGTCCGTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTA
CCCCAAGCAGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGA
AGTGGTGTTGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGG
TGTGTGGGCAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAG
GCGGTAACCAGCGTGAGCTCGCCCGCCAGAAGAATATGAAAAAGCAGAGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGACTCGGTT
AAGGGAAAGCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCAAGCAGAG
GTAGCCCCAGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGGTTAGACC
AAGGGTTATAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGTGGACTAG
TCGTGAGGAGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTCCTCCCCA
CCCTCCAAATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGGGCGGGCG
CCTGCCCTCAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTTAAGGGCA
AGGGCAGGGAGCTTCACATTTCAAATACAGTTGTGGTTACGGCAGCCCAG
TACTTTTGGCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCCAACCTCC
TCACTGGTGTTGCTGGGTGTGGTCCTCAATACAGAATAGAG
(SEQ ID NO: 279)
DARBI-675: AATCGAGCCCTTTGCCCACGGCTACTTCACGGGACCACCCTCCCGGGTTA 2541
SERF2_2_ GGCATAGGCCCTCCCGGATCTTCCGCGGTGTAAGGAGAAGGCCAGCGCCC
Exogenous_ CTGTGATAGGCCCAGAGCCCCCACTCCACAAGCCAGCCCATCCCCCACGG
53_54 AGACCCAAACCGTCCACACACACCTTGCCAGCTGTTTGGGCCCCACGCCG
CCCCAAAACACGCCTCCAGCTGGCCCCTTGGGACCTCCCTTCTCTAGTCC
GTATTTTGACCTGGCCCGTGGCAGATTCGCCACTCCCCCCTACCCCAAGC
AGCCTGGGCCTCGATGGGCCGTTGTCGGGGCCCGGAGATTGAAGTGGTGT
TGGATCCTGCTGCTGGCCGCGCTGGGGTAGAAGGGTCGCCGGTGTGTGGG
CAGAGCGGCCCCCGCGTCTCACCTTTAATTTTCTTTCCTTAGGCGGTAAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGCGCGAG
CTTGCCCGCCAGAAGAATATGAAAAAGCAGAGCGACTCGGTTAAGGGAAA
GCGCCGAGATGACGGGCTTTCTGCTGCCGCCCGCAAGCAGAGGTAGCCCC
AGGGAGGGGAGGGAAAGGGACGGTGGAGACCTGGGTTAGACCAAGGGTTA
TAGAAGGAAAGAGAGCTACCTCAGGGCTTGAATGTGGACTAGTCGTGAGG
AGCAGAGTGCATTGCTTCCTCTAGGGTTTTATTTCCTCCCCACCCTCCAA
ATTGTTAGCTCACAGCCTTACAGGAAAGGACGGGGGCGGGCGCCTGCCCT
CAGTCTGATTTCTGAGCGTCCCTGGGTCTGACCTTAAGGGCAAGGGCAGG
GAGCTTCACATTTCAAATACAGTTGTGGTTACGGCAGCCCAGTACTTTTG
GCCCTCCTTGCTGTTCGGTTCTCCTCCCTTCTCCCAACCTC
(SEQ ID NO: 280)
pARBI-676: TTCAAAAGGAATCTTTTTGTTTCAACTATTAGGATCTTTTTAAATCAAAT 2541
SLC38A1_1_ ATGTATTTTAATGGTGTACACCAGACCTGAAGAAAAAGATCACAGAAGGA
Exogenous_55 ATTTCCCCTTTGTAAGATAGAGGTAGTTAAAAATAAGCCTTATGACCTAA
TAGGTTAATTGTAATGCTCTGGTAGCCAACTTGAAAAAGGAGAAATGATG
GTTGCATCTCACATTTTAAAATGTTAAGAATTTGTTTTGTAATGAGGATA
CCTTAACCCCTGAAGGCCAAAATGACTATTTGTGTGAGTTTGAGAAAGGC
ACATAGTAACTTGGGGAACAGTCAATAGAATGACAAAATCTTGACTATTT
TAACTTTCTGAACCCTGTCATTTCTTGTGTTCTCAAATTTGATTTTTAAA
TAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAAGTCTTTGGCACCACA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGGGAAGTTCG
TAATCTTTGGAGCCACCTCTCTACAGAACACTGGAGGTAAAAAGAACATG
CTTTTCTTTACATAACTTGAAACTAATTCTGGTGGATGAGCGGCCACATG
AATTTTAACATAATTCAAGCAGTTATCATCCTCATTGCTAAAATGGCACA
GGGAAAGTAAAGCAGAGACAGCAGTCACTTATTTAAAGCCACAAATCCTG
CTAGAGTAGCTGAAGTTGCCTTTGTGTCTTACTGACAGTTGGTCTAAGAA
CGGGCTGATAACTTTTTATGTAGCTTGCAACATAAGCCTTCGTATCTTCT
TTCTAAAAATGTTCTCATTTTCCTTCAGCAATGCTGAGCTACCTCTTCAT
CGTAAAAAATGAACTACCCTCTGCCATAAAGTTTCTAATGGGAAAGGAAG
AGACATTTTCGTAAGTTATAGACCATTITTTTATGATATA
(SEQ ID NO: 281)
pARBI-677: TAAAGATGTCAAGCTTCAAATCATTATCATAAGGTTAAATATATTACGCA 2541
SLC38A1_2_ TGTCTTTACAGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCAC
Exogenous_ AAACAGCCATTTGGAAAAAAAGAAGTGTGATGAGTATGTAAGTATCATTA
56_57 TAATGAAGTATGCTTATTTTTTTAATCATATAAATTGGGACAAATCTTTT
TAATTCAAGTAGCATAGTACCAAAAGCATAACTACCTGTATTCACCAGGA
TATTCCTCATACCTTATGTATTTTCTCTTGAAATCCATTCAAGGAAATAA
CTAGATAACTAAGAATGGATTTTCTTGAATTTTACTTCCATATTGGTTCC
TGAGAGTGCATTAAAGGCTTTGGCTTGATGAACTTTCTTGGGGATTATTT
TGCTTAGTGTCAATGTTTGTTTCTTTGTTCAGATTCCAGGTACAACCTCC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTAGGCATG
TCAGTTTTTAACCTAAGCAACGCCATTATGGGCAGTGGGATTTTGGGACT
CGCCTTTGCCCTGGCAAACACTGGAATCCTACTTTTTCTGTGAGTATTGA
CGTGCCGGTACTTTCCATTTTAAAACTGAACTTTTTGTATGTTTCTGTTA
TTACATAGAAGAAATGTGAAATATTTATAAATAGTTTTTTTATTAACTTG
GCTAAGTTACAAGTACATACTTTGATATTTATTGCTTGAGTGATTTTCCA
AACTGTACCTAATGCTTACAACAAAGAGGAAGGAGAAAATCTTTTTATTA
ATCAAAAATACTGAAATAAGCATTTGTGAAAAGGATTAAAACATTTGAAA
ATAACTTTTTTTGGTATTTTTGGAGTCTACCTGTGACTTTAAATCTCAGT
TAAAATATTAAGAGGTGTTTAACCCCAGCCAGTCACCACTT
(SEQ ID NO: 282)
pARBI-678: ATCATTCTTCACACTAGTTCCTTTTCTGACTCTTCAGTCACCTCCAGAAT 2541
SMAD2_1_ TAATATCCTTAGAAGCATCTCTAAAATGAGTTTGATTTACTAAACATAGA
Exogenous_58 AGTTGACAAAGTTTTTCAAGTATAACTGCATAAACTCTCTTTTTTAAAAA
ATCAGTTTTTCCCAAGTTGTTAGCCTTTCATTGGCATTTGAGTCATTTAT
GTGACATATTTATAAGAAACATCTGCTAGTGCTGCTGCATACTTTTATCA
GATCCATTAAATAGTACATTTTTGTTCTTGATTCTCACTAAAACTAACTA
AATGGCTGTCATTCTTTTCTTTATGCTTTTATTGTACTAATTTAGCCCAT
TTGACTGCACttttttttttttttttttAAAGTTCCCTCCTTTCTTTTCC
CCTTGCTTCCCAACAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatAAAGGATTGC
CACATGTTATATATTGCCGATTATGGCGCTGGCCTGATCTTCACAGTCAT
CATGAACTCAAGGCAATTGAAAACTGCGAATATGCTTTTAATCTTAAAAA
GGATGAAGTATGTGTAAACCCTTACCACTATCAGAGAGTTGAGACACCAG
GTAGGAATATTGCAAGTTTTTTTCTTGGTTTTGAATTAAATGCCTGAACT
TCAGTATATTTAAGTACTCTTGTGACCCAGGAAAATTTTAGTGTAAATTC
TAATAAATTACCTTAAATTGTGCATATTATTTGGTGGTAATTAAAAtttt
tttatttttaaaaatttttAATGAGAAAACATATCTGTTTCTTGGAATAG
CATATGATTTGGCATGAAAGTGCATATCCAGGAAATCCTGTAGATTGGCA
GTCTGCTCAGCGCTATGCTGATGTGCTTCTACATGTCCCT
(SEQ ID NO: 283)
pARBI-679: TTCTATATTAAAAATCAGTTGACATCTGTTTTTAGATAATTTTTTAAAAA 2541
SMAD2_2_ ACTGGATTATAAAATGAAGCACTTAGTAAAGCTGATGGCAGAGGTTTTAG
Exogenous_59 ATCTTTTGAATACAGGAAAGTGGTAAGGGCATTATAGGTATGATTCATTG
AGCTAGAGGGCGTTGGTGTTCACATTTTAAAAACATAATCATGACTTATC
TGGAGTCACATGTTCCATTTTATTGGCTTCCTTCATATAGAAAATATAGT
AACCAGCACTACATGCCTGTGAAAAAGTGAAGCAATTGTATATTTTCTGG
GTGAAGGAAGTATTCTGTACATTCTCCATGTTTTACATCATGGTATTTTG
AATAACCATGCTTCCATGTTCACATCAATTTTTTGTTTTTCAATTTATGC
ACAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCAGTGGGAT
ACAACAGGCCTTTACAGCTTCTCTGAACAAACCAGGTGAATATTCTGCCC
TCTGTCGAATCTTAGAGATCTTGTGGGAGGGGGGTATATTTTGAAAGACC
TATATGGGGTTGCTTAGTATAATTTTGCCTAGGATGTTTCCTTAATGTAA
AATAAGGCATAGCATTTAAAATATCTGCTTGCCAGTATAAAAAATATATT
AAATGTTTCAGCTGATGTTTTAATCAATGCAATTCTAGTTTGAATCTTCT
TTAAATTACTGTATCCCCTAAAGAATAATAATTTTGATAACTATATATTT
ATTTTAGCTTGAGATCAGATTATAATCTGTTGTTGGCCTAATTTTTAAGT
AGATACATGATGAGTTTTGCTAAATTTCTTGTTATCAGAATCTCATCTTT
ATACTAATAAATACATACTTAATGAACCCCTTATATCACAA
(SEQ ID NO: 284)
pARBI-680: TCAATGTATTTTTGTATAGTCTTTTGAGATTAGAGTGAAGTTCTAAAAAG 2541
SMAD2_3_ TAAGAGAACCTTTTGTGAAAATATTTTAATTGACACTACTAAGAGTTTAA
Exogenous_60 AATAGTATTGGTGGTGAAAAATCGTTAAAAGTATCTGATTTTACTTGCAA
AATTACTGTATTTTCCCACAAGAGGAGTCCTTACAACATTCTTGTTTTTA
GAAGGGTTTGTTTCCATCATTCATTTAAATTCATAAAGATAACGTTTTCA
TGGGTGGAGAAGTCTATTGGGAAAGTCATAATTCGAATTTCTATCTTGCT
TTGCAGTTTGCTTTCTATGATAAGTTGAAATTATTACTTGATGTTCAAGG
TAGTCTCTACATCATCCTTTCAATATTTCTGCTAGGTTCGATACAAGAGG
CTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTTGCCATTCA
CGCCGCCAGTIGTGAAGAGACTGCTGGGATGGAAGAAGTCAGCTGGTGGG
TCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGCAGGAAGAAAAGTGGTG
TGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTAAAGAAAACAGGACGAT
TAGATGAGCTTGAGAAAGCCATCACCACTCAAAACTGTAATACTAAATGT
GTTACCATACCAAGGTAAGTTTTGTTAGATCCCAGGTTTGATCAAATTAT
GTCAAGGAATCTGAAGGAAAGTTACTGAATTTGTGTTCCTTTCAAGTTGC
CTGTAAAAAGTGATGATTGAAATATGACTGTTTTTAACCTTGTATAAATT
GTTTTTGCTAGCTGACTTGTTTTATAAATTATTTTCTTGAATAGTGAGGT
TTAATCAAGCTAAATAAGATACTTAGATTTATTATCTTCA
(SEQ ID NO: 285)
pARBI-681: GGGCTCCCGCAGCACAGCCTTTCTCCGGCCCTAGCCCAAATCGCCCAGAC 2541
SOCS1_1_ CAGGCGCGGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAG
Exogenous_61 CCGGGGCCGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTC
TCGGTGCTGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCC
GGGAAGAGCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGA
GGCTGAACGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGC
CGGGTCCGCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACC
TGCCCGGCCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGC
ACCCCCGGACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGTAGCACAC
AACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACG
GCGGCCAGAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgc
gcccgcggccgtgccccgcggtcccggccccggCCCCCGGCGACACGCAC
TTCCGCACATTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAG
CGCGCTCCTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACG
GGGCGCACGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGC
GACAGCCGCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTC
GGGACCCACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGG
ATGGCAGCCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTG
(SEQ ID NO: 286)
pARBI-682: GGATCCCAGCCTGGCCAGCAGGCGGCGGGCGCGGGGCGGCGAGCCGGGGC 2541
SOCS1_2_ CGGACGGCTGGAGCCAGAACCGGCTGCTCTCCACGCCCCCCTCTCGGTGC
Exogenous_62 TGCCCGGAGGCCGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGA
GCTCCGCGGAGTACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAA
CGGATCCGCGCGGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCC
GCCGGGAGCGCCGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGG
CCCCGCAGCGCCCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCG
GACGCTATGGCCCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCAC
ACAACCAGGTGGCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCGGCGGCCA
GAACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcg
gccgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCA
CATTCCGTTCGCACGCCGATTACCGGCGCATCACGCGCGCCAGCGCGCTC
CTGGACGCCTGCGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGGCGCA
CGAGCGGCTGCGCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACAGCC
GCCAGCGGAACTGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCC
ACGAGCATCCGCGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAG
CCGCGAGAGCTTCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTGGCGG
CGCCGCGCCGCATGCTGGGGGCCCCGCTGCGCCAGCGCCGC
(SEQ ID NO: 287)
pARBI-683: CGGACTCCGCCTCCACCGAGCCCCCACCCGCCGGGAAGAGCTCCGCGGAG 2541
SOCS1_3_ TACAGAGCCCATTTTCTAGCTGTGTCCACTGAGGCTGAACGGATCCGCGC
Exogenous_63 GGACTTGGTGCTCCGTGCTCGCCCCCTAGGGCCGGGTCCGCCGGGAGCGC
CGCCCTCCGGAGTTGTCCGGCCGGCGCACACCTGCCCGGCCCCGCAGCGC
CCCAGCTCACCTCTTTGTCTCTCCCGCAGCGCACCCCCGGACGCTATGGC
CCACCCCTCCGGCTGGCCCCTTCTGTAGGATGGTAGCACACAACCAGGTG
GCAGCCGACAATGCAGTCTCCACAGCAGCAGAGCCCCGACGGCGGCCAGA
ACCTTCCTCCTCTTCCTCCTCCTcgcccgcggcccccgcgcgcccgcggc
cgtgccccgcggtcccggccccggCCCCCGGCGACACGCACTTCCGCACA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTCCGTTCG
CACGCCGATTACCGGCGCATCACGCGCGCCAGCGCGCTCCTGGACGCCTG
CGGATTCTACTGGGGGCCCCTGAGCGTGCACGGGGCGCACGAGCGGCTGC
GCGCCGAGCCCGTGGGCACCTTCCTGGTGCGCGACAGCCGCCAGCGGAAC
TGCTTTTTCGCCCTTAGCGTGAAGATGGCCTCGGGACCCACGAGCATCCG
CGTGCACTTTCAGGCCGGCCGCTTTCACCTGGATGGCAGCCGCGAGAGCT
TCGACTGCCTCTTCGAGCTGCTGGAGCACTACGTGGCGGCGCCGCGCCGC
ATGCTGGGGGCCCCGCTGCGCCAGCGCCGCGTGCGGCCGCTGCAGGAGCT
GTGCCGCCAGCGCATCGTGGCCACCGTGGGCCGCGAGAACCTGGCTCGCA
TCCCCCTCAACCCCGTCCTCCGCGACTACCTGAGCTCCTTC
(SEQ ID NO: 288)
pARBI-684: GGCAGACAAACAGTTAAAACAGAGGAGTGGGGTAAGTGATGACCTAACCC 2541
SRP14_1_ AGCCCCGCTGCTCTAGTTTTGTTAAACACCTCATCTGCTATCACGGTCTG
Exogenous_64 GCGAAACCCTGGAGAAACTATTATTTCCACGACGGAAACATGTAATATCG
AAGCACGTTAAATTCCACTCAAAGTGGCGGCGTCTGGGATCCCTGACAAA
GAGCCCTGGGCTGCTTGGGGCCCATTGTTACCAGAAGCAACCTAGGCGGC
TCAGTGCTGGGGACTGAGCCAGCTACAATCCCTACTATTTTCCGGGCCCG
AAGCCCCGAATGTGCTCAGTACAGGGTGGGGAAAGGTAGAGGAAGGCGGC
GGTCCGCGGCAGACAGACTCCGGTGGCTCCCAGACACCGGGAACCCAGGG
AGCATCGCCCGGCTCCCCTCCCGCTGCTTACACTTCTTCAAGGTGATATA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGACGCTGCC
CGACGTCCGGCACTTCTGGAAAAGTCTGGTCAGCTCCGTCAGGAACTGGA
AAACAACAGGCCCAGCCCCGTTAGCCAGCCCCAAATCCTCGTCCTGCCGC
GTCAAGGCCCTGGTCCTCCTGCAGGAGGCACAGGTCTCGAGTAACGCCTG
AGCCGCCCCCTTCCCTCGGCCGGCCAGGCCTAGCCATACCTGCTCGCTCT
CCAACAACACCATCGCGGCGACGCTGGCTCGACTCCCTCCGCTTAAGCCC
CTAGCAGTGAGAGCCGGAAGTTCGGCCTAGGCTGGGCGGGACTTCCGCTA
CTAGACTTCCATTGTCTTCCACCAATCTCTTCTCTTCCACCAATCCCGGC
CTGCGCCCTCCCCCCTCCCCGCCCGCCTAGCGCCCGCGCCCTGGGACGTC
CGGGGGCCTGTGACCCGGAGGCGCTGGGGCTGTCCTGGGTC
(SEQ ID NO: 289)
pARBI-685: GTCTGTCTGCCGCGGACCGCCGCCTTCCTCTACCTTTCCCCACCCTGTAC 2541
SRP14_2_ TGAGCACATTCGGGGCTTCGGGCCCGGAAAATAGTAGGGATTGTAGCTGG
Exogenous_ CTCAGTCCCCAGCACTGAGCCGCCTAGGTTGCTTCTGGTAACAATGGGCC
65_66 CCAAGCAGCCCAGGGCTCTTTGTCAGGGATCCCAGACGCCGCCACTTTGA
GTGGAATTTAACGTGCTTCGATATTACATGTTTCCGTCGTGGAAATAATA
GTTTCTCCAGGGTTTCGCCAGACCGTGATAGCAGATGAGGTGTTTAACAA
AACTAGAGCAGCGGGGCTGGGTTAGGTCATCACTTACCCCACTCCTCTGT
TTTAACTGTTTGTCTGCCGCTCAGCCACGTACGCGGCCGTGTTCACCAGG
ATGCATTTTTTCCTTCAGATGACGGTCGAACCAAACCCATTCCAAAGAAG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGTACTGTG
GAGGGCTTTGAGCCCGCAGACAACAAGTGTCTGTTAAGAGCTACCGATGG
GAAGAAGAAGATCAGCACTGTGGTGAGCTTAATTTCTAAGGCTGTCTTTT
GAAATGTAAAGACTTGAACTTAACAGAGGATGGGGCGTTTCTGAACCAGG
CTTTTATTTGTTTTTCCCTTTTGCCCTGTGTGGCTATTTTTGAGACCAGG
ACCTTCCTATACTTTAGTAGTGGAAACCTCAAGAATAAAATAAGAAGGTA
GAGGTCAGACAGTCGTTAGTTCTGCTAAAGCTCTTGTGGAAATGAAAGTA
GCATATTGGTCCTTATTCGTAGTACTGTAAGGAGCAGCTGGCATAAATAT
TTGATTCCTTAGCCCCTTACTGTGCTGGGCCTTCAATAAGCAGTTTCTTG
GTACCAGGTGATGCTATTATTTCCTTATCTTTGTGGTTCAC
(SEQ ID NO: 290)
pARBI-686: CCCACGTCAGTGAGTGCTCACAAGTCTGTGAGGTAGGCGGCGCCACAGAG 2541
SRSF9_1_ AGAAACTGAGGCGCGGGAGCCCAAGCCACTTGTCCAGCGCCTCAGCCGAG
Exogenous_67 CGCGAACCGCGCTCGGGGATGGCATCCACACGGCCCGGCCCCAGGCTCTC
CCTGTCAGCGCCCGAAGGCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCG
CGCACGCGCAATGGTCGCAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGC
CTCCGCCGACCCCTTCGCTTCCGCTCCGCGTTCCCACAATGCAGTGCGGC
TGAGCGCCTCGGAGCCCGCGGGGACGCTGCGGGGGGACCCGTGCTGAggc
ggcggcggcgacgtgggctgcggcgggcccgcggcgtcgggcggtgcgga
tgtcgggctgggcggacgagcgcggcggcgAGGGCGACGGGCGCATCTAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatGTGGGGAACC
TTCCGACCGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTAC
GGCCGCATCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTT
CGCCTTCGTGCGCTTCGAGGACCCCCGGTGAGGcccccgcgcccctgccc
tctcctcctcggtgcctgaggcccccgccttccctgctgtcccctccccc
agggctcccctccccccggcctcccctccccccgcctccgcgcagacccc
tcaCGGCGCCCCCTCACGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGC
CCGGGCCGTCCTTCGCGCCGTCGTCACTTCCTTTATTTTTATTATTCCAA
TATTTTACTTAGAAACCCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGC
CTGCACCGGCCTCGGGGGGTCCAAATGAGCCTTGTCCGCC
(SEQ ID NO: 291)
pARBI-687: TGTGGTGTGCTTTTCGAGAAAATGCTCACGAAGATTAGAAAAACACTGAT 2541
SRSF9_2_ GGTTTATTGGCAAAATCAATAATCTGTCAGCAGTTGATTCttttttttCT
Exogenous_68 CTGAATTAGCCCTCTTATGAGTAATCTGTTTGCTCATTCATTATAATTTC
ATACCTCTAAAACTGCGTGTGACAGCTGTAAAGGTTAATTCCAGTATCAT
GAAACGTCTCCAAACCAAAGCAGAAGTGCTTCAGGATCCTGATTTGTGTG
TTTTTTTCTTCACTCTAGGTTTCCCTTTTATGCTTACTACTCATGCCCCT
CACTTGGAAAGTCACTTGGCCTCCTGAACAGCACTAACTCCAAACGtttt
ttttgttgttgttgttttttttAGAGATGCAGAGGATGCTATTTATGGAA
GAAATGGTTATGATTATGGCCAGTGTCGGCTTCGTGTGGAGTTCCCCAGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggggggtggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatACTTATGGAG
GTCGGGGTGGGTGGCCCCGTGGTGGGAGGAATGGGCCTCCTACAAGAAGA
TCTGATTTCCGAGTTCTTGTTTCAGGTATGTTCCTTTCAAACAGaatgag
atgatacatgtaaaatacttaacacagagtctgtcttccaagaaatgata
gctgttattcttCAGTGCATGGGACACGGGGGCTTTCTTTTCAATAGCCT
GTGTGAAGCCTTGCCCTGGATTGCCAATGAGGAAAGTATCCTGCAAATGA
AATTGCGCTGGGAGTGCAGCCTTGGAAGAACATAACCATATTTCTTGTAA
AGGAGTTTTCTAGTGGTGAGAAGGAAAGATGATGGGAAAACTTGAGCTAC
AATTCTAAAGATGCTTCTTTTGGAATATACTTGGCATCAGACATGGTAGA
AAGGCATTCAAGGAGCCAGATTTGAACAACTTACCCAGCC
(SEQ ID NO: 292)
pARBI-688: GATGGCATCCACACGGCCCGGCCCCAGGCTCTCCCTGTCAGCGCCCGAAG 2541
SRSF9_3_ GCCCTTCGCACCTCCAGGGGGCGCCGGCCTGCGCGCACGCGCAATGGTCG
Exogenous_69 CAGCCGCGTTCTCTTTAAGAGGACTCCTTTTGCCTCCGCCGACCCCTTCG
CTTCCGCTCCGCGTTCCCACAATGCAGTGCGGCTGAGCGCCTCGGAGCCC
GCGGGGACGCTGCGGGGGGACCCGTGCTGAggcggcggcggcgacgtggg
ctgcggcgggcccgcggcgtcgggcggtgcggatgtcgggctgggcggac
gagcgcggcggcgAGGGCGACGGGCGCATCTACGTGGGGAACCTTCCGAC
CGACGTGCGCGAGAAGGACTTGGAGGACCTGTTCTACAAGTACGGCCGCA
TCCGCGAGATCGAGCTCAAGAACCGGCACGGCCTCGTGCCCTTCGCCTTC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGTGCGCTTC
GAGGACCCCCGGTGAGGcccccgcgcccctgccctctcctcctcggtgcc
tgaggcccccgccttccctgctgtcccctcccccagggctcccctccccc
cggcctcccctccccccgcctccgcgcagacccctcaCGGCGCCCCCTCA
CGGGTGGAGGATGAGGCAGCCTCTCCTCGCAGGCCCGGGCCGTCCTTCGC
GCCGTCGTCACTTCCTTTATTTTTATTATTCCAATATTTTACTTAGAAAC
CCAAAAGCTGAGCCTTTGGAGGGCCCAAGCCCGCCTGCACCGGCCTCGGG
GGGTCCAAATGAGCCTTGTCCGCCTCCTGCCTGGGGCAGCACCGTAGGGG
GAAGCGGCCGCGGGGCAGCGCGGGGGTCGCCGTTCGCCCTTCCCGCTCGC
CTCTCCCCCGGCCCGTGCTCGCCGTGGCTGGAGAGCAAGCT
(SEQ ID NO: 293)
pARBI-689: GTAACTGACTAGCCTTAGTAGACTGTGGTTTCCAGGTTTATTCAGAAGTA 2541
SUB1_1_ GCAAGATCCCTCCAtttttttttCTACCAAAGAAATCGTATGTGGGATCC
Exogenous_70 CAAACCACAAAATAACCGTTCCTGTGGTTAATACTACTATAATGCCTGAA
GTGTCTTTTGGGATCCTGAGAACAGAGTTTGAAAACATTACTAGACAGAA
GGATTGGTTAGATTCATAGTTTTGTTGTTGAGTGAAACTTGCTTATGTAT
ATATTTATGATATTTTGGATGTAGTCTTTTGATTGTTTAAATCTTAAAAA
GTAATGGGATCTTTTGACACTGGGGTATGTTTTATTTTTATGTGTGCAAA
TTTTAACCATATTCTTTTCTAGTTAAAGAGGAAAAAGCAAGTTGCTCCAG
AAAAACCTGTAAAGAAACAAAAGACAGGTGAGACTTCGAGAGCCCTGTCA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTCTTCTAAAC
AGAGCAGCAGCAGCAGAGATGATAACATGTTTCAGGTAAAGTTGGCTAtt
ttttttttttttttttttgacatggagtcatgctctgtcacccaggctgg
agtgcagtggcgccatctcggctcactgcaacctcagcctcctgagttca
agcagttctctgcctcagcctcccgagtagctaggattacaggcatccgc
caccagacctggctaatttttgtatttttagtagagatggggtttcacca
tcttggccaggctggtcttgaactcctgaccttgtgatccaactgcctca
gcctccaaaagtgctgggtttacaggtgtgagccaccatgccttgccAAA
GTTGGCTGTTTCTTTAGATTCAGAGGAATTATTATCTGGCTTGATCTGAA
GAATGTTAAAAGTACTATGATCTGATAATTGCCTAATATG
(SEQ ID NO: 294)
pARBI-690: ATAAATAAACATATCCTGGAAATGGAATAAGTTGGTTATATTCTTTTTAA 2541
SUB1_2_ TTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGACTG
Exogenous_71 TGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTTCT
ACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCTGT
GGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAACAG
AGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTTGT
TGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTAGT
CTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGGGG
TATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGTTA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAAGAGGAAA
AAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAGACAGGTGAGAC
TTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCAGCAGCAGAGATGATA
ACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTTTTTTTTTTTGACATG
GAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTC
ACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCTCTGCCTCAGCCTCCC
GAGTAGCTAGGATTACAGGCATCCGCCACCAGACCTGGCTAATTTTTGTA
TTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACT
CCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAAAGTGCTGGGTTTACA
GGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGTTTCTTT
(SEQ ID NO: 295)
pARBI-691: AATTAGTATATCTGCTTCGTAAAATAAGTAACTGACTAGCCTTAGTAGAC 2541
SUB1_3_ TGTGGTTTCCAGGTTTATTCAGAAGTAGCAAGATCCCTCCATTTTTTTTT
Exogenous_72 CTACCAAAGAAATCGTATGTGGGATCCCAAACCACAAAATAACCGTTCCT
GTGGTTAATACTACTATAATGCCTGAAGTGTCTTTTGGGATCCTGAGAAC
AGAGTTTGAAAACATTACTAGACAGAAGGATTGGTTAGATTCATAGTTTT
GTTGTTGAGTGAAACTTGCTTATGTATATATTTATGATATTTTGGATGTA
GTCTTTTGATTGTTTAAATCTTAAAAAGTAATGGGATCTTTTGACACTGG
GGTATGTTTTATTTTTATGTGTGCAAATTTTAACCATATTCTTTTCTAGT
TAAAGAGGAAAAAGCAAGTTGCTCCAGAAAAACCTGTAAAGAAACAAAAG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACAGGTGAG
ACTTCGAGAGCCCTGTCATCTTCTAAACAGAGCAGCAGCAGCAGAGATGA
TAACATGTTTCAGGTAAAGTTGGCTATTTTTTTTTTTTTTTTTTTTGACA
TGGAGTCATGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGC
TCACTGCAACCTCAGCCTCCTGAGTTCAAGCAGTTCTCTGCCTCAGCCTC
CCGAGTAGCTAGGATTACAGGCATCCGCCACCAGACCTGGCTAATTTTTG
TATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAA
CTCCTGACCTTGTGATCCAACTGCCTCAGCCTCCAAAAGTGCTGGGTTTA
CAGGTGTGAGCCACCATGCCTTGCCAAAGTTGGCTGTTTCTTTAGATTCA
GAGGAATTATTATCTGGCTTGATCTGAAGAATGTTAAAAGT
(SEQ ID NO: 296)
pARBI-692: CACATTTTAATTTTTGTTTCCATGCTCTTTAGAATTCAACTAGAGGGCAG 2541
TET2_1_ CCTTGTGGATGGCCCCGAAGCAAGCCTGATGGAACAGGATAGAACCAACC
Exogenous_73 ATGTTGAGGGCAACAGACTAAGTCCATTCCTGATACCATCACCTCCCATT
TGCCAGACAGAACCTCTGGCTACAAAGCTCCAGAATGGAAGCCCACTGCC
TGAGAGAGCTCATCCAGAAGTAAATGGAGACACCAAGTGGCACTCTTTCA
AAAGTTATTATGGAATACCCTGTATGAAGGGAAGCCAGAATAGTCGTGTG
AGTCCTGACTTTACACAAGAAAGTAGAGGGTATTCCAAGTGTTTGCAAAA
TGGAGGAATAAAACGCACAGTTAGTGAACCTTCTCTCTCTGGGCTCCTTC
AGATCAAGAAATTGAAACAAGACCAAAAGGCTAATGGAGAAAGACGTAAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTCGGGGTA
AGCCAAGAAAGAAATCCAGGTGAAAGCAGTCAACCAAATGTCTCCGATTT
GAGTGATAAGAAAGAATCTGTGAGTTCTGTAGCCCAAGAAAATGCAGTTA
AAGATTTCACCAGTTTTTCAACACATAACTGCAGTGGGCCTGAAAATCCA
GAGCTTCAGATTCTGAATGAGCAGGAGGGGAAAAGTGCTAATTACCATGA
CAAGAACATTGTATTACTTAAAAACAAGGCAGTGCTAATGCCTAATGGTG
CTACAGTTTCTGCCTCTTCCGTGGAACACACACATGGTGAACTCCTGGAA
AAAACACTGTCTCAATATTATCCAGATTGTGTTTCCATTGCGGTGCAGAA
AACCACATCTCACATAAATGCCATTAACAGTCAGGCTACTAATGAGTTGT
CCTGTGAGATCACTCACCCATCGCATACCTCAGGGCAGATC
(SEQ ID NO: 297)
pARBI-693: AATGGAGAAAGACGTAACTTCGGGGTAAGCCAAGAAAGAAATCCAGGTGA 2541
TET2_2_ AAGCAGTCAACCAAATGTCTCCGATTTGAGTGATAAGAAAGAATCTGTGA
Exogenous_74 GTTCTGTAGCCCAAGAAAATGCAGTTAAAGATTTCACCAGTTTTTCAACA
CATAACTGCAGTGGGCCTGAAAATCCAGAGCTTCAGATTCTGAATGAGCA
GGAGGGGAAAAGTGCTAATTACCATGACAAGAACATTGTATTACTTAAAA
ACAAGGCAGTGCTAATGCCTAATGGTGCTACAGTTTCTGCCTCTTCCGTG
GAACACACACATGGTGAACTCCTGGAAAAAACACTGTCTCAATATTATCC
AGATTGTGTTTCCATTGCGGTGCAGAAAACCACATCTCACATAAATGCCA
TTAACAGTCAGGCTACTAATGAGTTGTCCTGTGAGATCACTCACCCATCG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatCATACCTCA
GGGCAGATCAATTCCGCACAGACCTCTAACTCTGAGCTGCCTCCAAAGCC
AGCTGCAGTGGTGAGTGAGGCCTGTGATGCTGATGATGCTGATAATGCCA
GTAAACTAGCTGCAATGCTAAATACCTGTTCCTTTCAGAAACCAGAACAA
CTACAACAACAAAAATCAGTTTTTGAGATATGCCCATCTCCTGCAGAAAA
TAACATCCAGGGAACCACAAAGCTAGCGTCTGGTGAAGAATTCTGTTCAG
GTTCCAGCAGCAATTTGCAAGCTCCTGGTGGCAGCTCTGAACGGTATTTA
AAACAAAATGAAATGAATGGTGCTTACTTCAAGCAAAGCTCAGTGTTCAC
TAAGGATTCCTTTTCTGCCACTACCACACCACCACCACCATCACAATTGC
TTCTTTCTCCCCCTCCTCCTCTTCCACAGGTTCCTCAGCTT
(SEQ ID NO: 298)
pARBI-694: GGAAAAAGCACTCTGAATGGTGGAGTTTTAGAAGAACACCACCACTACCC 2541
TET2_3_ CAACCAAAGTAACACAACACTTTTAAGGGAAGTGAAAATAGAGGGTAAAC
Exogenous_75 CTGAGGCACCACCTTCCCAGAGTCCTAATCCATCTACACATGTATGCAGC
CCTTCTCCGATGCTTTCTGAAAGGCCTCAGAATAATTGTGTGAACAGGAA
TGACATACAGACTGCAGGGACAATGACTGTTCCATTGTGTTCTGAGAAAA
CAAGACCAATGTCAGAACACCTCAAGCATAACCCACCAATTTTTGGTAGC
AGTGGAGAGCTACAGGACAACTGCCAGCAGTTGATGAGAAACAAAGAGCA
AGAGATTCTGAAGGGTCGAGACAAGGAGCAAACACGAGATCTTGTGCCCC
CAACACAGCACTATCTGAAACCAGGATGGATTGAATTGAAGGCCCCTCGT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatTTTCACCAAG
CGGAATCCCATCTAAAACGTAATGAGGCATCACTGCCATCAATTCTTCAG
TATCAACCCAATCTCTCCAATCAAATGACCTCCAAACAATACACTGGAAA
TTCCAACATGCCTGGGGGGCTCCCAAGGCAAGCTTACACCCAGAAAACAA
CACAGCTGGAGCACAAGTCACAAATGTACCAAGTTGAAATGAATCAAGGG
CAGTCCCAAGGTACAGTGGACCAACATCTCCAGTTCCAAAAACCCTCACA
CCAGGTGCACTTCTCCAAAACAGACCATTTACCAAAAGCTCATGTGCAGT
CACTGTGTGGCACTAGATTTCATTTTCAACAAAGAGCAGATTCCCAAACT
GAAAAACTTATGTCCCCAGTGTTGAAACAGCACTTGAATCAACAGGCTTC
AGAGACTGAGCCATTTTCAAACTCACACCTTTTGCAACAT
(SEQ ID NO: 299)
pARBI-695: AAAGGGAGGTTGAGATGGGCTGAGGTCTTCTAGGAGGCGGGGAGGGAGTG 2541
TIGIT_1_ CAGCCTTGACAAGCCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTC
Exogenous_76 AGCTCTGGAAGCATAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGG
CTGGAGTAGAGATGTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTG
AATGGGGGACTGGGAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTT
GAAATGGAAGAAACAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGG
ATGGACTGGAGAAACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCC
CTTAGAATTTTTCTAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCA
CATGTGCTTCGTCCTCTTCCCTAGGAATGATGACAGGCACAATAGAAACA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACGGGGAAC
ATTTCTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTC
CACCACGGCACAAGTGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTC
TGGCCATTTGTAATGCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAG
GATCGAGTGGCCCCAGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGAC
CGTGAACGATACAGGGGAGTACTTCTGCATCTATCACACCTACCCTGATG
GGACGTACACTGGGAGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATT
CCTGCTGGAGCAAGTTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATG
CAATCCTGAAACACTGCACAGCAGGGCTTCTCAATTCGGGATCACATTTG
AATCACCTGAGGAGATTTTAAATCATACTGATGCCGAGGCC
(SEQ ID NO: 300)
pARBI-696: GAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGATGTGTGGAGAAGGGTGA 2541
TIGIT_2_ GAAGACTGGAAAGACAACCTGAATGGGGGACTGGGAGCCTTGAATAACAG
Exogenous_77 GCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAACAGGAAATAATTACAG
CCTCTATGGAGGAGCAACAGGATGGACTGGAGAAACTATCATTCCAAAAT
CCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTCTAGGAAGGTTGAAGGC
CAGCTGCTGACCCAGGACTCACATGTGCTTCGTCCTCTTCCCTAGGAATG
ATGACAGGCACAATAGAAACAACGGGGAACATTTCTGCAGAGAAAGGTGG
CTCTATCATCTTACAATGTCACCTCTCCTCCACCACGGCACAAGTGACCC
AGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAATGCTGAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTGGGGTGG
CACATCTCCCCATCCTTCAAGGATCGAGTGGCCCCAGGTCCCGGCCTGGG
CCTCACCCTCCAGTCGCTGACCGTGAACGATACAGGGGAGTACTTCTGCA
TCTATCACACCTACCCTGATGGGACGTACACTGGGAGAATCTTCCTGGAG
GTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAGTTGGTGGATAAACCT
CTCCCTCTAGCATAGAAAATGCAATCCTGAAACACTGCACAGCAGGGCTT
CTCAATTCGGGATCACATTTGAATCACCTGAGGAGATTTTAAATCATACT
GATGCCGAGGCCTCACCCAGACCAATTCAATCAGAATCCCTAATAGCAGA
GCTAAACAAGGGTAAGGTCTAAAAGCATTTCCAGGTGATTCTAATGGGCA
GCCAATACTGAGAACCACTGTTCTTATGTAAGAAGCACATC
(SEQ ID NO: 301)
pARBI-697: CCTCCCTGTGGGCGAGGTGTAAAGAGGGGCAGAAGTCAGCTCTGGAAGCA 2541
TIGIT_3_ TAGGGCAGTGGGTGGGGAGGAGATGGGCTGGGCTGGGCTGGAGTAGAGAT
Exogenous_78 GTGTGGAGAAGGGTGAGAAGACTGGAAAGACAACCTGAATGGGGGACTGG
GAGCCTTGAATAACAGGCATGGAGAGGAGCGTCTCTTGAAATGGAAGAAA
CAGGAAATAATTACAGCCTCTATGGAGGAGCAACAGGATGGACTGGAGAA
ACTATCATTCCAAAATCCAGTTGGGGCCTCAAAGGCCCTTAGAATTTTTC
TAGGAAGGTTGAAGGCCAGCTGCTGACCCAGGACTCACATGTGCTTCGTC
CTCTTCCCTAGGAATGATGACAGGCACAATAGAAACAACGGGGAACATTT
CTGCAGAGAAAGGTGGCTCTATCATCTTACAATGTCACCTCTCCTCCACC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggggggcaggacagcaagggggaggattgggaagacaatagca
ggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGGT
GCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGG
GGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAA
ACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG
GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAA
CGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTC
CTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGT
CGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGT
CTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCC
CTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTG
CTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAG
ATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccacc
ATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGGT
CGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAGG
GCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCACC
ACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCTA
CGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGACT
TCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTTC
TTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGGG
CGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAGG
ACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAAC
GTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCAA
GATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTACC
AGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCAC
TACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCGA
TCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGCA
TGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaaa
taaagcaatagcatcacaaatttcacaaataaagcatttttttcactgca
ttctagttgtggtttgtccaaactcatcaatgtatcttatACGGCACAAG
TGACCCAGGTCAACTGGGAGCAGCAGGACCAGCTTCTGGCCATTTGTAAT
GCTGACTTGGGGTGGCACATCTCCCCATCCTTCAAGGATCGAGTGGCCCC
AGGTCCCGGCCTGGGCCTCACCCTCCAGTCGCTGACCGTGAACGATACAG
GGGAGTACTTCTGCATCTATCACACCTACCCTGATGGGACGTACACTGGG
AGAATCTTCCTGGAGGTCCTAGAAAGCTCAGGTATTCCTGCTGGAGCAAG
TTGGTGGATAAACCTCTCCCTCTAGCATAGAAAATGCAATCCTGAAACAC
TGCACAGCAGGGCTTCTCAATTCGGGATCACATTTGAATCACCTGAGGAG
ATTTTAAATCATACTGATGCCGAGGCCTCACCCAGACCAATTCAATCAGA
ATCCCTAATAGCAGAGCTAAACAAGGGTAAGGTCTAAAAG
(SEQ ID NO: 302)
pARBI-698: TAATGCCCAGCCTAAGTTGGGGAGACCACTCCAGATTCCAAGATGTACAG 2541
TRAC_1_ TTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCCTTTACTCTGCCAGAGTT
Exogenous_79 ATATTGCTGGGGTTTTGAAGAAGATCCTATTAAATAAAAGAATAAGCAGT
ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC
TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC
TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA
TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG
CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA
AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatATCCAGAAC
CCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTC
TGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTA
AGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCT
ATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTT
TGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCT
TCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTT
GCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAA
AACTCCTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTC
TTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGA
(SEQ ID NO: 303)
pARBI-699: GATTCCAAGATGTACAGTTTGCTTTGCTGGGCCTTTTTCCCATGCCTGCC 2541
TRAC_2_ TTTACTCTGCCAGAGTTATATTGCTGGGGTTTTGAAGAAGATCCTATTAA
Exogenous_80 ATAAAAGAATAAGCAGTATTATTAAGTAGCCCTGCATTTCAGGTTTCCTT
GAGTGGCAGGCCAGGCCTGGCCGTGAACGTTCACTGAAATCATGGCCTCT
TGGCCAAGATTGATAGCTTGTGCCTGTCCCTGAGTCCCAGTCCATCACGA
GCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGCATGAGACCGTGAC
TTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACTGGCATCTGGACTC
CAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATGTCCTAACCCTGAT
CCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGCCGTGTACCAGCTG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatAGAGACTCT
AAATCCAGTGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAAC
AAATGTGTCACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTG
TGCTAGACATGAGGTCTATGGACTTCAAGAGCAACAGTGCTGTGGCCTGG
AGCAACAAATCTGACTTTGCATGTGCAAACGCCTTCAACAACAGCATTAT
TCCAGAAGACACCTTCTTCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCT
TCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTC
TGGTCAATGATGTCTAAAACTCCTCTGATTGGTGGTCTCGGCCTTATCCA
TTGCCACCAAAACCCTCTTTTTACTAAGAAACAGTGAGCCTTGTTCTGGC
AGTCCAGAGAATGACACGGGAAAAAAGCAGATGAAGAGAAG
(SEQ ID NO: 304)
pARBI-700: TTCCTGTGGTAGCGGAACTCACTAAGGGGCCCATCTGGACCCGAGGTATT 2541
TRAC_3_ GTGATGATAAATTCTGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAAT
Exogenous_81 AAAATAAGAGCCAAGTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACT
GTTGGCCCTGGAAGAATGCACAGAATCTGTTTGTAAGGGGATATGCACAG
AAGCTGCAAGGGACAGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGC
CTGCTCTGCCTTGGGGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGC
CTGGGACATGCAAGCCCATAACCGCTGTGGCCTCTTGGTTTTACAGATAC
GAACCTAAACTTTCAAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCC
TGAAAGTGGCCGGGTTTAATCTGCTCATGACGCTGCGGCTGTGGTCCAGC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTGAGGTGAG
GGGCCTTGAAGCTGGGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCAT
CCTAAGCTCTGAGAGCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCAA
AGCCTGAGCCCACCAAACTCTCCTACTTCTTCCTGTTACAAATTCCTCTT
GTGCAATAATAATGGCCTGAAACGCTGTAAAATATCCTCATTTCAGCCGC
CTCAGTTGCACTTCTCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAAC
GAAGAAACTGAGGCCCCACAGCTAATGAGTGGAGGAAGAGAGACACTTGT
GTACACCACATGCCTTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCAT
GTCCTCTCTCCCCAGTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATTA
CACTCATATTACACCCCAATCCTGGCTAGAGTCTCCGCACC
(SEQ ID NO: 305)
pARBI-701: ATTATTAAGTAGCCCTGCATTTCAGGTTTCCTTGAGTGGCAGGCCAGGCC 2541
TRAC_4_ TGGCCGTGAACGTTCACTGAAATCATGGCCTCTTGGCCAAGATTGATAGC
Exogenous_82 TTGTGCCTGTCCCTGAGTCCCAGTCCATCACGAGCAGCTGGTTTCTAAGA
TGCTATTTCCCGTATAAAGCATGAGACCGTGACTTGCCAGCCCCACAGAG
CCCCGCCCTTGTCCATCACTGGCATCTGGACTCCAGCCTGGGTTGGGGCA
AAGAGGGAAATGAGATCATGTCCTAACCCTGATCCTCTTGTCCCACAGAT
ATCCAGAACCCTGACCCTGCCGTGTACCAGCTGAGAGACTCTAAATCCAG
TGACAAGTCTGTCTGCCTATTCACCGATTTTGATTCTCAAACAAATGTGT
CACAAAGTAAGGATTCTGATGTGTATATCACAGACAAAACTGTGCTAGAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatATGAGGTCT
ATGGACTTCAAGAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTT
TGCATGTGCAAACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCT
TCCCCAGCCCAGGTAAGGGCAGCTTTGGTGCCTTCGCAGGCTGTTTCCTT
GCTTCAGGAATGGCCAGGTTCTGCCCAGAGCTCTGGTCAATGATGTCTAA
AACTCCTCTGATTGGTGGTCTCGGCCTTATCCATTGCCACCAAAACCCTC
TTTTTACTAAGAAACAGTGAGCCTTGTTCTGGCAGTCCAGAGAATGACAC
GGGAAAAAAGCAGATGAAGAGAAGGTGGCAGGAGAGGGCACGTGGCCCAG
CCTCAGTCTCTCCAACTGAGTTCCTGCCTGCCTGCCTTTGCTCAGACTGT
TTGCCCCTTACTGCTCTTCTAGGCCTCATTCTAAGCCCCTT
(SEQ ID NO: 306)
pARBI-702: TTCATTTCCATTTGAGTTGTTCTTATTGAGTCATCCTTCCTGTGGTAGCG 2541
TRAC_6_ GAACTCACTAAGGGGCCCATCTGGACCCGAGGTATTGTGATGATAAATTC
Exogenous_84 TGAGCACCTACCCCATCCCCAGAAGGGCTCAGAAATAAAATAAGAGCCAA
GTCTAGTCGGTGTTTCCTGTCTTGAAACACAATACTGTTGGCCCTGGAAG
AATGCACAGAATCTGTTTGTAAGGGGATATGCACAGAAGCTGCAAGGGAC
AGGAGGTGCAGGAGCTGCAGGCCTCCCCCACCCAGCCTGCTCTGCCTTGG
GGAAAACCGTGGGTGTGTCCTGCAGGCCATGCAGGCCTGGGACATGCAAG
CCCATAACCGCTGTGGCCTCTTGGTTTTACAGATACGAACCTAAACTTTC
AAAACCTGTCAGTGATTGGGTTCCGAATCCTCCTCCTGAAAGTGGCCGGG
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatTTTAATCTG
CTCATGACGCTGCGGCTGTGGTCCAGCTGAGGTGAGGGGCCTTGAAGCTG
GGAGTGGGGTTTAGGGACGCGGGTCTCTGGGTGCATCCTAAGCTCTGAGA
GCAAACCTCCCTGCAGGGTCTTGCTTTTAAGTCCAAAGCCTGAGCCCACC
AAACTCTCCTACTTCTTCCTGTTACAAATTCCTCTTGTGCAATAATAATG
GCCTGAAACGCTGTAAAATATCCTCATTTCAGCCGCCTCAGTTGCACTTC
TCCCCTATGAGGTAGGAAGAACAGTTGTTTAGAAACGAAGAAACTGAGGC
CCCACAGCTAATGAGTGGAGGAAGAGAGACACTTGTGTACACCACATGCC
TTGTGTTGTACTTCTCTCACCGTGTAACCTCCTCATGTCCTCTCTCCCCA
GTACGGCTCTCTTAGCTCAGTAGAAAGAAGACATTACACTC
(SEQ ID NO: 307)
pARBI-703: CAGTCCATCACGAGCAGCTGGTTTCTAAGATGCTATTTCCCGTATAAAGC 2541
TRAC_ ATGAGACCGTGACTTGCCAGCCCCACAGAGCCCCGCCCTTGTCCATCACT
Exogenous_83 GGCATCTGGACTCCAGCCTGGGTTGGGGCAAAGAGGGAAATGAGATCATG
TCCTAACCCTGATCCTCTTGTCCCACAGATATCCAGAACCCTGACCCTGC
CGTGTACCAGCTGAGAGACTCTAAATCCAGTGACAAGTCTGTCTGCCTAT
TCACCGATTTTGATTCTCAAACAAATGTGTCACAAAGTAAGGATTCTGAT
GTGTATATCACAGACAAAACTGTGCTAGACATGAGGTCTATGGACTTCAA
GAGCAACAGTGCTGTGGCCTGGAGCAACAAATCTGACTTTGCATGTGCAA
ACGCCTTCAACAACAGCATTATTCCAGAAGACACCTTCTTCCCCAGCCCA
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGTAAGGGC
AGCTTTGGTGCCTTCGCAGGCTGTTTCCTTGCTTCAGGAATGGCCAGGTT
CTGCCCAGAGCTCTGGTCAATGATGTCTAAAACTCCTCTGATTGGTGGTC
TCGGCCTTATCCATTGCCACCAAAACCCTCTTTTTACTAAGAAACAGTGA
GCCTTGTTCTGGCAGTCCAGAGAATGACACGGGAAAAAAGCAGATGAAGA
GAAGGTGGCAGGAGAGGGCACGTGGCCCAGCCTCAGTCTCTCCAACTGAG
TTCCTGCCTGCCTGCCTTTGCTCAGACTGTTTGCCCCTTACTGCTCTTCT
AGGCCTCATTCTAAGCCCCTTCTCCAAGTTGCCTCTCCTTATTTCTCCCT
GTCTGCCAAAAAATCTTTCCCAGCTCACTAAGTCAGTCTCACGCAGTCAC
TCATTAACCCACCAATCACTGATTGTGCCGGCACATGAATG
(SEQ ID NO: 308)
pARBI-704: TGAGGAAGAAGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTG 2541
TRIM28_1_ GCCGTGCCGTAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCG
Exogenous_85 CGTGGCGGCGCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGT
TGGCGGCGAGCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCC
CCCCCTGGGCGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAG
CCTCGGCAGCAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAG
GGCTCCGCTGGCGGCGAAAAGCGCTCCACCGCCCCTTCGGCCGCAGCCTC
GGCCTCTGCCTCAGCCGCGGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGG
CGCTGGAGCTGCTGGAGCACTGCGGCGTGTGCAGAGAGCGCCTGCGACCC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGAGAGGGAG
CCCCGCCTGCTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCC
CGCGGCCCCCGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCG
ACGGCACCGGTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCTACTCTC
TGCCTTTGATTCCGACTGGGTGCAGAGATGAGGATGCCACCTGGGCGAGA
GGATGGGGGCCCGGACAGGGCACGGGAAATACTTTCTGGGTCCTGCATAC
GAACGTGGGTTTGTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGG
AGAAAAGAAGGCTCGGGGAGGGGAGGGGCTGGTTCGCTGCGGGATAATGG
TCGGGGGCCCACCCAGCAGGGGAATGGTGGGGGCCATAACCTGGGTGGGA
ACTTGTAACAGTCTCCCACATCCCTGCTTCTCGAAGTGGTG
(SEQ ID NO: 309)
pARBI-705: TCGAAGTGGTGGACTGTCCCGTGTGCAAGCAACAGTGCTTCTCCAAAGAC 2541
TRIM28_2_ ATCGTGGAGAATTATTTCATGCGTGATAGTGGCAGCAAGGCTGCCACCGA
Exogenous_86 CGCCCAGGATGCGAACCAGGTGCGTCCTATCTCAGCAACCACAAGGAGGT
TTCTGGGGAGGGGGCATCTGCGCAGGAGGAGCTTGGCACCAGCTCCAGGC
TGTTACTCCACTTTCCCAAGGCTCTGGGTGGGCTGCCTAGGTTGGGTCAA
GGGACCAATCTTAAATCTCCGGTTGTATTTTCTGGGATGTAAACGTGGAT
CTATCAAGTIGTCTTGCCTTCTCTGACCCTGCCTTTGTCTGGCAGTGCTG
CACTAGCTGTGAGGATAATGCCCCAGCCACCAGCTACTGTGTGGAGTGCT
CGGAGCCTCTGTGTGAGACCTGTGTAGAGGCGCACCAGCGGGTGAAGTAC
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatACCAAGGAC
CATACTGTGCGCTCTACTGGTACATGAGGCTGAGGGGGGCTGTTGGAGTT
GTTCTCCCATGTGTGCCCTCAGTTGCTTTTATGATGTTGGTTGCATCTGG
TGGATGGGTCCTAGAGTTCTCTAGGGGGTGCCGCCCGAAGGGCCCGAGGG
CAGAACTCCAGAAGCAGAAAAACTGGGGTTGTGGTGTGTAGTCTCTAGGG
CCTAGGTGGGAGAGGGTGGGAAGGGGAAATAAGGGAGACCTTAATGTGCT
GCAGGGAGGTACAAAGGGTTTGAGAAGGCTTATCAGGGAGTTGTCAGACC
TGGTGGTGAAGGGCTCAGCATATGCAAACAGGGAAAGGCATGGTGTGAAG
GGCTTTCTGGGTTTGTGGTTCCCTGGCACACATCTGGTATAAGATGCTGC
TAGGGAAAGTAGACTGTGGGTCCATGGATTATAAGTGATGA
(SEQ ID NO: 310)
pARBI-706: GGCGCCCAATGCGCGTGCGCGGCGGCGTCGGCGCCAGTTATTTCTGTCCC 2541
TRIM28_3_ GCCCCCCGGCCTCGGCTCTTTCTGCGAGCGGGCGCGCGGGCGAGCGGTTG
Exogenous_87 TGCTTGTGCTTGTGGCGCGTGGTGCGGGTTTCGGCGGCGGCTGAGGAAGA
AGCGCGGGCGGCGCCTTCGGGAGGCGAGCAGGCAGCAGTTGGCCGTGCCG
TAGCAGCGTCCCGCGCGCGGCGGGCAGCGGCCCAGGAGGCGCGTGGCGGC
GCTCGGCCTCGCGGCGGCGGCGGCGGCAGCGGCCCAGCAGTTGGCGGCGA
GCGCGTCTGCGCCTGCGCGGCGGGCCCCGCGCCCCTCCTCCCCCCCTGGG
CGCCCCCGGCGGCGTGTGAATGGCGGCCTCCGCGGCGGCAGCCTCGGCAG
CAGCGGCCTCGGCCGCCTCTGGCAGCCCGGGCCCGGGCGAGGGCTCCGCT
tgacgactgtgccttctagttgccagccatctgttgtttgcccctccccc
gtgccttccttgaccctggaaggtgccactcccactgtcctttcctaata
aaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctgg
ggggtggggtggggcaggacagcaagggggaggattgggaagacaatagc
aggcatgctggggatgcggtgggctctatggGGATCTGCGATCGCTCCGG
TGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGG
GGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTA
AACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGG
GGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCA
ACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCT
CCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAG
TCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCG
TCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTC
CCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCT
GCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACA
GATCCAAGCTGTGACCGGCGCCTACTCTAGAGCTAGCGAATTgccgccac
cATGGTGAGCAAGGGCGAGGAGCTGTTCACCGGGGTGGTGCCCATCCTGG
TCGAGCTGGACGGCGACGTAAACGGCCACAAGTTCAGCGTGTCCGGCGAG
GGCGAGGGCGATGCCACCTACGGCAAGCTGACCCTGAAGTTCATCTGCAC
CACCGGCAAGCTGCCCGTGCCCTGGCCCACCCTCGTGACCACCCTGACCT
ACGGCGTGCAGTGCTTCAGCCGCTACCCCGACCACATGAAGCAGCACGAC
TTCTTCAAGTCCGCCATGCCCGAAGGCTACGTCCAGGAGCGCACCATCTT
CTTCAAGGACGACGGCAACTACAAGACCCGCGCCGAGGTGAAGTTCGAGG
GCGACACCCTGGTGAACCGCATCGAGCTGAAGGGCATCGACTTCAAGGAG
GACGGCAACATCCTGGGGCACAAGCTGGAGTACAACTACAACAGCCACAA
CGTCTATATCATGGCCGACAAGCAGAAGAACGGCATCAAGGTGAACTTCA
AGATCCGCCACAACATCGAGGACGGCAGCGTGCAGCTCGCCGACCACTAC
CAGCAGAACACCCCCATCGGCGACGGCCCCGTGCTGCTGCCCGACAACCA
CTACCTGAGCACCCAGTCCAAGCTGAGCAAAGACCCCAACGAGAAGCGCG
ATCACATGGTCCTGCTGGAGTTCGTGACCGCCGCCGGGATCACTCTCGGC
ATGGACGAGCTGTACAAatgattgtttattgcagcttataatggttacaa
ataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgc
attctagttgtggtttgtccaaactcatcaatgtatcttatGGCGGCGAA
AAGCGCTCCACCGCCCCTTCGGCCGCAGCCTCGGCCTCTGCCTCAGCCGC
GGCGTCGTCGCCCGCGGGGGGCGGCGCCGAGGCGCTGGAGCTGCTGGAGC
ACTGCGGCGTGTGCAGAGAGCGCCTGCGACCCGAGAGGGAGCCCCGCCTG
CTGCCCTGTTTGCACTCGGCCTGTAGTGCCTGCTTAGGGCCCGCGGCCCC
CGCCGCCGCCAACAGCTCGGGGGACGGCGGGGCGGCGGGCGACGGCACCG
GTAAGTACGAAGTGATCGGTGCCACCCCTCCCCCTACTCTCTGCCTTTGA
TTCCGACTGGGTGCAGAGATGAGGATGCCACCTGGGCGAGAGGATGGGGG
CCCGGACAGGGCACGGGAAATACTTTCTGGGTCCTGCATACGAACGTGGG
TTTGTGCTGGCCGCTGAGATGGGACATCTGACTAAAGTTGG
(SEQ ID NO: 311)
