Abstract: It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients.

Abstract: It is described a hydrogel based transducer device for detecting an environmental state, in particular for detecting an environmental state within a biological material. The transducer device (300) comprises a base element (302), a radiation source (305), which is formed at the base element (302) and which is adapted to emit electromagnetic radiation (306), an optical element (325), which is arranged at the base element (302) and which is adapted to interact with the electromagnetic radiation (306). The transducer device (300) further comprises a radiation detector (350), which is adapted to receive the electromagnetic radiation (326) having interacted with the optical element (325), and a hydrogel material (340), which is mechanically coupled to the optical element (325) and which is adapted to change its volume when getting into contact with an environmental material of the transducer device (300) such that the spatial position of the optical element (325) is changed.

Abstract: The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion.

Abstract: An implantable drug delivery system is proposed which does not need internal electronics, but can be activated from outside the body. The system comprises a device (10) for the controlled release of a substance, the device (10) comprising at least one compartment (20) in a substrate (11), the compartment (20) being closed by a valve (30), wherein the valve is openable and comprises at least a first material (31) and a second material (32), the opening and/or closing of the valve (30) being provided upon heating and/or cooling of the first and/or second material (31, 32), the first material (31) being heated by electromagnetic induction.

Abstract: The invention relates to a device for medical treatment decision support and/or monitoring the status of a patient, the device comprising a first measuring means at the ipsilateral side and a second measuring means at the contralateral side and a comparison means in order to find the optimal and/or suboptimal time for drug treatment and/or other medical treatment steps.

Abstract: The invention relates to an osmotic pump (1) comprising at least one chargeable material (30) whereby the osmotic pressure is caused by inducing and/or de-inducing charges within the material.

Abstract: The invention relates to a micropump comprising at least one gas releasing material which drives a piston towards a second material containing a drug material which is released through a semi permeable membrane and/or flow restrictor

Abstract: The present invention relates to a pixelated electroluminescent textile, comprising a first set of spaced apart conductive lines extending in a first direction, a second set of spaced apart conductive lines extending in a second direction, the second direction being non-parallel to the first direction, the sets of conducting lines forming a matrix structure, and at least one light emitting element. The at least one light emitting element comprises two interleaving comb electrodes arranged in one plane, and light emitting means arranged in spaces between digits of the comb electrodes, wherein the light emitting element is arranged in an area formed between two adjacent conductive lines in the first set and two adjacent conductive lines in the second set, wherein each of the comb electrodes connects to at least one yarn of the first and the second set, respectively, so that when applying a driving voltage to the at least one yarn in the first and second sets, said light emitting means is excited to emit light.

Abstract: This invention provides a device for the controlled release of a substance and a method of controllably releasing a substance from a compartment.

Abstract: The invention relates to a device for drug administration and/or monitoring the status of a patient, said device comprising at least one measuring means for measuring at least one body parameter of a patient for at least ?1 measuring cycle, the measuring means being located in or in the vicinity of a bio-implantable and/or bio-implementable needle.

Abstract: The invention relates to a device comprising an ingestible capsule which measures at least one body parameter and starts a drug release program upon predefined changes in the body parameter.

Abstract: Light-emitting diode (LED) comprising a translucent substrate of ?-Al2O3 or SiC and a first layer of a light-emitting semiconductor material grown on a first side of said substrate, a first electrode and a second electrode, wherein said substrate is polycrystalline. The average grain size of the polycrystalline substrate is preferably of the same order as the wavelength of the light emitted by the semiconductor material during use of the LED.

Abstract: The present invention relates to a flexible display device (10) comprising a flexible substrate (12), and a plurality of electro-optical switching elements (14) accommodated on the substrate. The device is characterized in that the substrate has a plurality of through openings (16) being arranged in a repetitive pattern so that the electro-optical switching elements are located in areas of the substrate adjacent to the openings. The through openings allow for bending the display device in two directions simultaneously, with reduced tensile or compressive stress in the plane of the substrate.

Abstract: A method of manufacturing a component having a three-dimensional structure in a surface region, includes:—a step of forming a substantially solid layer (13) of material, which step comprises the steps of applying a substantially fluid composition over a surface, and—a step of removing an intermediate composition (12), impervious to at least a component of the substantially fluid composition and occupying at least part of the three-dimensional structure when the substantially fluid composition has at least partially set. The step of forming the substantially solid layer (13) of material is preceded by the steps of—providing a structure including recessed parts (5 to 7) on a surface of a substantially solid further layer (3), and—applying the intermediate composition (12) so as at least partially to fill at least the recessed parts (5 to 7) of the structure on the surface of the substantially solid further layer (3).

Abstract: A light-source comprising at least one lighting unit (101) being arranged on a substrate (102) and a diffusing element (103) being arranged to receive and diffuse light emitted by said at least one lighting unit (101) is provided. The diffusing element (103) comprises a layer of non-woven fabric having a lower density at a side facing the lighting unit and a higher density at a side opposite to the lighting unit to obtain good diffusing properties.

Abstract: The present invention relates to highly dense translucent and transparent aluminium oxide components for applications, e.g. in the lighting industry, where a fine crystal size has to be obtained and stabilized for use at temperatures of 800° C. or more. Disclosed are high-strength polycrystalline alumina products which include 0.001-0.5 weight-% ZrO2 stabilizing a fine crystal size <2 ?m or, preferably, <1 ?m if used at temperatures of 800° C. or more. The microstructure exhibits an extremely high relative density enabling a high real in-line transmission >30% measured over an angular aperture of at most 0.5° at a sample thickness of 0.8 mm and with a monochromatic wavelength of light ?, preferably, of 645 nm.