Abstract: In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient.

Abstract: Deicing products designed to deter ungulates are provided, along with methods of using those products to treat iced surfaces. The deicing product comprises a mixture of a deicer along with an ungulate repellent. The repellent can repel based on conditioned avoidance, fear, chemical irritation, and/or bad taste. The deicer can be a salt or a deicer solution. The invention is useful for deterring any ungulate that might be attracted to a component of the deicing product (e.g., the salt), but it is particularly useful for deterring deer.

Abstract: A cloud manager assists in deploying and managing networks for an online service. The cloud manager system receives requests to perform operations relating to configuring, updating and performing tasks in networks that are used in providing the online service. The management of the assets may comprise deploying machines, updating machines, removing machines, performing configuration changes on servers, Virtual Machines (VMs), as well as performing other tasks relating to the management. The cloud manager is configured to receive requests through an idempotent and asynchronous application programming interface (API) that can not rely on a reliable network.

Abstract: An idempotent and asynchronous application programming interface (API) that can not rely on a reliable network is used by a cloud manager to receive and process requests. The cloud manager system is a central coordination service that receives requests using the API to perform update operations and get operations relating to the online service. For example, the API includes methods for deploying machines, updating machines, removing machines, performing configuration changes on servers, Virtual Machines (VMs), as well as performing other tasks relating to the management of the online service. Receiving and processing a same API call multiple times results in a same result.

Abstract: The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C3-8)cycloalkyl(C1-3)alkyl, each of which may be substituted by hydroxy, cyano or halogen; R2 represents 1 or 2 optional halogens; R3 is (C1-6)alkyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholester

Abstract: The present invention provides novel tetrasubstituted pyridine hedgehog pathway antagonists of the following formula I (I) or a pharmaceutically acceptable salt thereof, wherein: X is C—R1 or N; R1 is hydrogen, fluoro or cyano; R2 is formula II (II), piperidinyl, or gem di-F-substituted cyclohexyl; R3 is methyl or trifluoromethyl; R4 is pyrrolidinyl, morpholinyl or pyridyl, amino or dimethylamino; R5 is trifluoromethyl or methylsulfonyl; R6 is hydrogen or methyl; and R7, R8, R9, R10 and R11 are independently hydrogen fluoro, cyano, chloro, methyl, trifluoromethyl, trifluoromethoxy or methylsulfonyl, provided that at least two of R7, R8, R9, R10 and R11 are hydrogen useful in the treatment of cancer.

Abstract: The present disclosure provides methods, systems, and kits for detecting IgE antibodies available to bind to the Fc epsilon receptor in a biological sample from a subject receiving anti-IgE therapy. These methods, systems, and kits find use in monitoring anti-IgE therapy and determining its efficacy.

Abstract: In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient.

Abstract: The present invention provides novel tetrasubstituted pyridazine hedgehog pathway antagonists useful in the treatment of cancer.

Abstract: In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient.

Abstract: A case adapted to contain absorbent articles includes an outer surface having a bar code, a product code, and a single brand display having a trademark in logo, wherein the brand display defines a brand display area of less than 4 inches by 6 inches. A method of providing absorbent articles includes providing a case in a branded condition, wherein the case includes a brand display having a brand display area of no more than 4 inches by no more than 6 inches. The method includes converting the case, or instructing a customer to convert the case, from the branded condition to a discreet condition by covering the brand display with a discretion mask or cleanly removing the brand display.

Abstract: A method and apparatus for data multiplexing is capable of high-speed operation with acceptable timing margins and has reduced sensitivity to supply voltage, temperature, manufacturing and other variations. One implementation relates to a data multiplexer that has no significant speed limitation associated with the clock-to-data delay of data latches, flip-flops, etc. In one implementation, clock-to-data delay is compensated for by introducing a delay-compensator in the clock line that drives a selector stage of the multiplexer. In one such implementation, a timing relationship is established between clock and data waveforms by timing the data waveforms with a first in-phase clock and operating the delay-compensated selector clock line with a second clock, which is delayed with respect to the first clock. The second clock can have a quadrature-phase delay with respect to the in-phase clock.

Abstract: The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

Abstract: The present invention relates to N-benzyl,N?-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N?-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.

Abstract: A case adapted to contain absorbent articles includes an outer surface having a bar code, a product code, and a single brand display having a trademark in logo, wherein the brand display defines a brand display area of less than 4 inches by 6 inches. A method of providing absorbent articles includes providing a case in a branded condition, wherein the case includes a brand display having a brand display area of no more than 4 inches by no more than 6 inches. The method includes converting the case, or instructing a customer to convert the case, from the branded condition to a discreet condition by covering the brand display with a discretion mask or cleanly removing the brand display.

Abstract: In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient.

Abstract: The energy transducer includes an upper part and a lower part. The upper part having a housing, a helix metal spring, a first circular board, a second circular board with a short metal shaft, a ball bearing engaged to the short metal shaft, a third circular board with a groove to receive metal bearing balls, an upper metal shaft welded to the bottom of the third circular board, four arc-shaped springs welded to the bottom of the third circular board, and four sets of wheels rotatably attached to one end of the spring. The lower part includes: a housing, a lower metal shaft, a fourth circular board placed on the upper end of the lower part, bundles of electric wire, pluralities of permanent magnets, and a fifth circular board placed at the lower end of the lower part. As the helix metal spring is compressed by an external force, the bundle of electric wire turns between permanent magnets to produce electricity. Direction of the electricity alternates as the helix metal spring oscillates.

Abstract: A method is disclosed for managing access rights. The method generates a record associated with a change in a status for an individual and sends notification of the change in status to a first entity. The method also determines, by the first entity, if there is to be a change in one or more access levels associated with the individual. The method further sends notification to a second entity if the first entity determines that there is to be a change in the one or more access levels. In addition, the method changes, by the second entity, the one or more access levels.

Abstract: A method, system, and computer-readable medium is described for providing a thread messaging system for communications between users of thread client computing devices. The thread messaging system provides significant benefits over existing prior art messaging systems such as email, IM, chat and bulletin boards.

Abstract: A spring activated energy transducer is provided. The energy transducer of the current invention generates alternating current (A/C) electricity from abundant external natural forces. The energy transducer is comprised of an upper part and a lower part. The upper part is comprised of a housing, a helix metal spring, a first circular board, a second circular board, pluralities of permanent magnets embedded to the second circular board, a third circular board with pluralities of permanent magnets facing the permanent magnets embedded in the second circular board with same magnetic pole, an upper metal shaft welded to the third circular board, four arc-shaped springs welded to the third circular board, and four wheel sets rotatably attached to one end of the spring.