Abstract: A wireless device determines whether a data session is performance sensitive, and in response to the data session being performance sensitive, selects a data transport node (DTN) and performs the data session using the selected DTN. Whether a data session is performance sensitive may be determined using information on a process associated with the data session, by monitoring the data session, or both. The DTN may be selected from a list of available DTNs according to which DTN will probably provide the highest performance for the data session, or according to which DTN or DTNs will probably provide adequate performance. Micro speed tests, historical performance information, or other criteria may be used to predict the performance of the available DTNs. When multiple DTNs satisfy the selection criteria, a “good neighbor” policy may be used to select the DTN.

Abstract: A computing system obtains test data for a particle source. The test data was generated by the particle source when the particle source was caused to emit particles. The test data comprises a first set of measurements of a first type and a second set of measurements of a second type. The computing system applies a data agnostic predictive model to the test data. The data agnostic predictive model is generated without a parametric analysis of variables of the first type and variables of the second type. The data agnostic predictive model outputs, based upon the test data, a value that is indicative of whether or not the test data is abnormal. Based upon the value, the computing system outputs an indication that the particle source was operating sub-optimally when emitting the particles.

Abstract: A computer-implemented method and a transport manager system operate to reduce network congestion by detecting one or more data flows in a network, determining, using a candidate flow detection threshold, whether a data flow of the one or more data flows is a candidate flow, the candidate flow detection threshold being based on one or more characteristics of the one or more data flows, and in response to determining that the data flow is the candidate flow, managing the data flow. A consumption rate, a duration, a number of bytes communicated, a throughput, or aggregated characteristics of the one or more data flows may be used to determine the candidate flow detection threshold.

Abstract: The disclosure is directed to novel predictive methods and personalized therapies for treating a patient with cancer such as breast cancer. Specifically, this disclosure relates to methods of treating a patient having cancer by selectively administering a combination of CDK 4/6 inhibitor and letrozole. Also disclosed herein are transmittable forms of information, diagnostic methods, and kits useful in predicting the likelihood that a patient having cancer, e.g., breast cancer will respond to treatment with a combination of a CDK 4/6 inhibitor, e.g., a ribociclib and an aromatase inhibitor, letrozol.

Abstract: Current antiretroviral therapy (ART) is a combination of 2-3 antiretroviral agents that has been successful in reducing HIV-1 RNA in the blood, and has improved the morbidity and mortality of HIV-1 infection and AIDS. Despite potent ART, eradication of HIV-1 infection remains elusive and there is potential for persistent virus replication in viral reservoirs that may continue to drive the pathogenic disease progression. Accordingly, there is a need for agents that assist in eradicating HIV-1 infection. The present invention relates to treating HIV-1 infection by administering N-carbamimidoyl-5-(1-methylpyrazol-4-yl)naphthalene-2-carboxamide in combination with antiretroviral agents.

Abstract: A wireless device determines whether a data session is performance sensitive, and in response to the data session being performance sensitive, selects a data transport node (DTN) and performs the data session using the selected DTN. Whether a data session is performance sensitive may be determined using information on a process associated with the data session, by monitoring the data session, or both. The DTN may be selected from a list of available DTNs according to which DTN will probably provide the highest performance for the data session, or according to which DTN or DTNs will probably provide adequate performance. Micro speed tests, historical performance information, or other criteria may be used to predict the performance of the available DTNs. When multiple DTNs satisfy the selection criteria, a “good neighbor” policy may be used to select the DTN.

Abstract: The invention relates to a computer-implemented system and method for scalable, customized general ledger processing. The method may include the step of receiving a client request for customized charts of accounts (COAs) according to a specified time frame. The customized COAs may include client-specific data and third party reference data. The method may involve automatically receiving source information, including position data and transaction data, from a number of sources. The system may include a distributed computer architecture such as Hadoop for parallel storage and processing of the source information across a plurality of nodes. The system can generate debit and credit postings from the source information, roll up the postings into the plurality of customized COAs, and deliver them to the client according to the client's preferred schedule, including in real time or near real time.

Abstract: A wireless device determines whether a data session is performance sensitive, and in response to the data session being performance sensitive, selects a data transport node (DTN) and performs the data session using the selected DTN. Whether a data session is performance sensitive may be determined using information on a process associated with the data session, by monitoring the data session, or both. The DTN may be selected from a list of available DTNs according to which DTN will probably provide the highest performance for the data session, or according to which DTN or DTNs will probably provide adequate performance. Micro speed tests, historical performance information, or other criteria may be used to predict the performance of the available DTNs. When multiple DTNs satisfy the selection criteria, a “good neighbor” policy may be used to select the DTN.

Abstract: Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.

Abstract: The invention relates to a computer-implemented system and method for scalable, customized general ledger processing. The method may include the step of receiving a client request for customized charts of accounts (COAs) according to a specified time frame. The customized COAs may include client-specific data and third party reference data. The method may involve automatically receiving source information, including position data and transaction data, from a number of sources. The system may include a distributed computer architecture such as Hadoop for parallel storage and processing of the source information across a plurality of nodes. The system can generate debit and credit postings from the source information, roll up the postings into the plurality of customized COAs, and deliver them to the client according to the client's preferred schedule, including in real time or near real time.

Abstract: A computer-implemented method and a transport manager system operate to reduce network congestion by detecting one or more data flows in a network, determining, using a candidate flow detection threshold, whether a data flow of the one or more data flows is a candidate flow, the candidate flow detection threshold being based on one or more characteristics of the one or more data flows, and in response to determining that the data flow is the candidate flow, managing the data flow. A consumption rate, a duration, a number of bytes communicated, a throughput, or aggregated characteristics of the one or more data flows may be used to determine the candidate flow detection threshold.

Abstract: A computer-implemented method and a transport manager system operate to reduce network congestion by detecting one or more data flows in a network, determining, using a candidate flow detection threshold, whether a data flow of the one or more data flows is a candidate flow, the candidate flow detection threshold being based on one or more characteristics of the one or more data flows, and in response to determining that the data flow is the candidate flow, managing the data flow. A consumption rate, a duration, a number of bytes communicated, a throughput, or aggregated characteristics of the one or more data flows may be used to determine the candidate flow detection threshold.

Abstract: A method for reserving a vehicle dwelling zone includes receiving a request from a first user via a software application, and selecting (e.g., automatically), via the software application and based on the request, an available vehicle dwelling zone. The vehicle dwelling zone can include, for example, a curb space, an alley space, a private driveway, or a parking garage. The software application reserves (e.g., automatically) at least a portion of the selected vehicle dwelling zone for occupancy of a vehicle, by causing storage, in a memory operably coupled to the software application, of a reservation record including an association between the first user and the selected vehicle dwelling zone. The at least the portion of the selected vehicle dwelling zone can be reserved for a user-configurable hold period of A second user can be alerted, via the software application, of the reservation record.

Abstract: The present invention relates to novel compositions having anti-viral activity and in particular it relates to synergistic compositions active against Hepatitis C virus (HCV). The invention also relates to methods for retarding, reducing or otherwise inhibiting HCV growth and/or functional activity.

Abstract: A wireless device determines whether a data session is performance sensitive, and in response to the data session being performance sensitive, selects a data transport node (DTN) and performs the data session using the selected DTN. Whether a data session is performance sensitive may be determined using information on a process associated with the data session, by monitoring the data session, or both. The DTN may be selected from a list of available DTNs according to which DTN will probably provide the highest performance for the data session, or according to which DTN or DTNs will probably provide adequate performance. Micro speed tests, historical performance information, or other criteria may be used to predict the performance of the available DTNs. When multiple DTNs satisfy the selection criteria, a “good neighbor” policy may be used to select the DTN.

Abstract: A computer-implemented method and a transport manager system operate to reduce network congestion by detecting one or more data flows in a network, determining, using a candidate flow detection threshold, whether a data flow of the one or more data flows is a candidate flow, the candidate flow detection threshold being based on one or more characteristics of the one or more data flows, and in response to determining that the data flow is the candidate flow, managing the data flow. A consumption rate, a duration, a number of bytes communicated, a throughput, or aggregated characteristics of the one or more data flows may be used to determine the candidate flow detection threshold.

Abstract: Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.

Abstract: The invention relates to a computer-implemented system and method for scalable, customized general ledger processing. The method may include the step of receiving a client request for customized charts of accounts (COAs) according to a specified time frame. The customized COAs may include client-specific data and third party reference data. The method may involve automatically receiving source information, including position data and transaction data, from a number of sources. The system may include a distributed computer architecture such as Hadoop for parallel storage and processing of the source information across a plurality of nodes. The system can generate debit and credit postings from the source information, roll up the postings into the plurality of customized COAs, and deliver them to the client according to the client's preferred schedule, including in real time or near real time.

Abstract: Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.

Abstract: Systems and methods for discovering content sources and/or delivering content to applications resident on mobile devices are described. In some embodiments, the systems and methods transmit information identifying one or more applications resident on a mobile device to a server, receive, from the server, information associated with content items available for retrieval from a content server and associated with the identified one or more applications, and cause the mobile device to retrieve at least one of the content items available for retrieval from the content server.