Abstract: The present invention provides a sludge scraping apparatus which includes a piston attached to a traction core member, a body formed of a driving cylinder provided with front and rear sealing connection parts, a sludge scraper attached to the body, position switching means that switches the sludge scraper to a scraping position at advancement of the body and switches the sludge scraper to a non-scraping position at retreat of the body, and a treatment part attached in front of the driving cylinder and has a treatment chamber therein, the extending part of the traction core member passing through the treatment chamber, and the body can be moved along the traction core member in an advancing and retreating direction by injection/discharge of water into/from the driving cylinder by fluid control means, and at movement of the body, injection/discharge of water into/from the treatment chamber is performed.

Abstract: The present invention provides a therapeutic agent for dementia comprising a pharmaceutically active substance derived from Hericium ramosum.

Abstract: The present invention provides a therapeutic agent for dementia comprising a pharmaceutically active substance derived from Hericium ramosum.

Abstract: The present invention provides a sludge scraping apparatus which includes a piston attached to a traction core member, a body formed of a driving cylinder provided with front and rear sealing connection parts, a sludge scraper attached to the body, position switching means that switches the sludge scraper to a scraping position at advancement of the body and switches the sludge scraper to a non-scraping position at retreat of the body, and a treatment part attached in front of the driving cylinder and has a treatment chamber therein, the extending part of the traction core member passing through the treatment chamber, and the body can be moved along the traction core member in an advancing and retreating direction by injection/discharge of water into/from the driving cylinder by fluid control means, and at movement of the body, injection/discharge of water into/from the treatment chamber is performed.

Abstract: It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.

Abstract: It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.

Abstract: The objects of the present invention is to provide a preventive method for the progress of neuropsychiatric disorders, a therapeutic agent for neuropsychiatric disorders, a screening method thereof, and a therapeutic method through the analysis of the mechanisms leading to neuropsychiatric disorders such as Nasu-Hakola diseases and the like. The non-human animal model of oligodendrocytes developmental disorders was generated by making the DAP12 gene function deficient on its chromosome. The DAP12 knockout mouse develops myelination disorders including hypomyelinosis in the brain, particularly in the frontal head and the thalamus, further leading to neuropsychiatric disorders such as Nasu-Hakola disease and the like with aging. The screening method for a therapeutic agent, the diagnostic method, and the therapeutic method, wherein the DAP12 knockout mouse developing these disorders are used, have been developed.

Abstract: The present invention provides a sludge or the like scraping and collecting apparatus. This apparatus has a whole structure more simplified and can realize a cost-down. Further, it is advantageously installed. The scraping and collecting apparatus comprises a carriage having a main body formed from a single long member constant in section in a front and rear direction. The carrier main body has a front end and a rear end provided with sludge scrapers. These front and rear sludge scrapers are adapted to be able to simultaneously and interlockingly move by a pulling and conveying means through a longitudinally and interlockingly moving member which advances and retreats in parallel with the carriage main body.

Abstract: The present invention provides a sludge or the like scraping and collecting apparatus. This apparatus has a whole structure more simplified and can realize a cost-down. Further, it is advantageously installed. The scraping and collecting apparatus comprises a carriage having a main body formed from a single long member constant in section in a front and rear direction. The carrier main body has a front end and a rear end provided with sludge scrapers. These front and rear sludge scrapers are adapted to be able to simultaneously and interlockingly move by a pulling and conveying means through a longitudinally and interlockingly moving member which advances and retreats in parallel with the carriage main body.

Abstract: The objects of the present invention is to provide a preventive method for the progress of neuropsychiatric disorders, a therapeutic agent for neuropsychiatric disorders, a screening method thereof, and a therapeutic method through the analysis of the mechanisms leading to neuropsychiatric disorders such as Nasu-Hakola diseases and the like. The non-human animal model of oligodendrocytes developmental disorders was generated by making the DAP12 gene function deficient on its chromosome. The DAP12 knockout mouse develops myelination disorders including hypomyelinosis in the brain, particularly in the frontal head and the thalamus, further leading to neuropsychiatric disorders such as Nasu-Hakola disease and the like with aging.

Abstract: The object of the present invention is to provide a tocotrienol derivative which is highly water-soluble and shows high bioavailability in the living body and &ggr;-CEHC delivering agent. (A tocotrienolcarboxylic acid ester derivative represented by the general formula (I). (wherein R2 means a carboxylic acid residue having a nitrogen substituent, and R1 and R3 mean a hydrogen atom or a methyl group.

Abstract: The object of the present invention is to provide a tocotrienol derivative which is highly water-soluble and shows high bioavailability in the living body and &ggr;-CEHC delivering agent.

Abstract: A sludge collecting apparatus comprising: a vehicle body which is long in advance/retreat directions and has driving means; and a plurality of scrapers which are disposed at intervals in the advance/retreat directions including a sludge scraper which is most advanced to the sludge collecting pit side and performs a collecting operation to collect and drop sludge into the sludge collecting pit and following sludge scrapers which perform a collecting operation, the front and rear sludge scrapers have the relation such that the collecting state and the noncollecting state are interlockingly switched, the interval between the neighboring front and rear sludge scrapers is shorter than the advance/retreat stroke of the vehicle body, the following sludge scraper in the collecting motion pushes the sludge toward the sludge collecting pit further than the return position of the advanced sludge scraper in the collecting motion, and the most advanced sludge scraper sequentially collects and drops the sludge collected by

Abstract: A work member comprising a sludge scraping member is guided by a monorail guide so that the guide and work member can be constructed in the most simplified form, and the working performance can be made excellent at the same time. By simplification of the construction, the installation work can be made easily, and the running and maintenance costs become low.

Abstract: A scum removal apparatus operable in association with a movable member operating within a sewage treatment pool is provided with a trough, a weir member and a transmission mechanism. The trough is fixed in position, and the transmission mechanism transmits a force from the movable member to the weir member to cause the latter to move up and down with respect to a fluid surface level. When the weir member is sunken, the scum is drawn into the trough, while when the weir member floats above the fluid surface level, the drawing of the scum into the trough is interrupted.Support of the weir member is carried out through a rotary shaft and the weir member is employed in the form of an elongated member having an elliptical cross-section so that the drawing of the scum can be carried out smoothly and stably with the transmission mechanism simplified in structure.

Abstract: A scum removal apparatus of a trough type including a weir movable in response to a movable element moving within a treatment pool. This apparatus includes an actuating mechanism operable in response to the movable element moving within the treatment pool and a transmission means for driving the weir, in which the transmission means includes a hydraulic pump and a control valve such that, while the actuating mechanism drives the pump, a hydraulic drive machine is driven selectively in one of two directions opposite to each other with the control valve being switched, thereby to selectively float and sink the weir above and below a water surface.In a different mode of carrying out the invention, the actuating mechanism includes a plurality of cam means each having a series of projections and recesses alternating with each other, said cam means being rotatable about a rotary shaft, and the transmission means is in the form of a mechanical transmission mechanism including the rotary shaft.

Abstract: The invention relates to a method of treating dementia, such as cerebro-vascular dementia, for example, multiple infarct dementia and amyloid angiopathic dementia, cerebro-parenchymatous dementia, such as Alzheimer's dementia and Pick's disease, and dementia caused by brain tumor, hydrocephalus, hepatic meningitis, cerebral trauma, or cerebral function disorders, comprising administering rolipram.

Abstract: The present invention is a scum-treating apparatus installed in the disposal pond for removing the scum floating on the surface of the water with the movement of the flights in the disposal pond as the motive power to purify the water. The trough is fixed and the damming-up device is provided in front of the trough to move up and down the damming-up device by being interlocked with the flights. In particular, the interlocking is provided by a plurality of projecting portions and dented portions between the projecting portions at a pointed end thereof, so that the large scum are flowed into the trough when the flights correspond to the respective projecting portions while the float is slightly risen up under the surface of the water when the flights correspond to the dented portions to collect the far scum toward the trough. Thus, both the large scums and the small scums can be effectively introduced into the trough.