Abstract: Provided are compositions, combinations, and methods and uses for treating a subject having a tumor, lesion or cancer. In some aspects, the methods and uses include administering a targeting molecule that binds PD-L1, conjugated with phthalocyanine dye, such as IR700. In some aspects, after administration of the conjugate, a target area is illuminated with a wavelength of light suitable for the activation of the conjugate. In some aspects, the illumination leads to the killing of PD-L1-expressing cells. The provided embodiments result in growth inhibition, volume reduction, and elimination of tumors, lesions or cancers, including metastatic tumor cells, invasive tumor cells, heterogeneous tumors and/or tumors that are not responsive to and/or resistant to other therapies.

Abstract: Embodiments of the invention relate to a clinical instrument analyzer system for the automatic analysis of patient samples. In one embodiment, the analyzer may be used to analyze bodily fluid samples, such as blood, plasma, serum, urine or cerebrospinal fluid, for example. Embodiments of the invention relate to an apparatus and method, for example, an immunoassay method, for separating out target molecules in a magnetic field and then analyzing those target molecules with a luminometer.

Abstract: Examples methods, apparatus/systems and articles of manufacture for auditing point-of-sale images are disclosed herein. Example methods disclosed herein include comparing a region of interest of an image displayed via a user interface with a plurality of reference product images stored in a database to identify a plurality of candidate product images from the plurality of reference product images as potential matches to a first product depicted in the image. For example, the candidate product images are associated with respective confidence levels indicating respective likelihoods of matching the first product. Disclosed example methods also include displaying, via the user interface, the candidate product images simultaneously with the image in a manner based on the respective confidence levels, and automatically selecting a first one of the candidate product images as matching the first product based on the respective confidence levels.

Abstract: Wind turbine comprising at least a pitch bearing comprising at least two rings, each of the at least two rings attached to a wind turbine component, being a first wind turbine component a blade and a second wind turbine component a hub, and further comprising at least one bearing reinforcement attached to at least one of the two rings. The invention also relates to the pitch bearing of the wind turbine.

Abstract: The present invention describes a wind turbine comprising a hub, at least one blade and at least one pitch bearing to connect the at least one blade to the hub, the at least one pitch bearing comprising at least an inner ring and an outer ring, and at least a rolling race, wherein the wind turbine further comprises at least a tensioning system configured to exert a radial compression force to at least a part of the outer ring of the at least one pitch bearing, thus increasing the resultant stiffness of the at least one pitch bearing.

Abstract: The present invention relates to an enhanced catalytic nickel oxide sheet having an organic part which includes non-stoichiometric nickel oxides dispersed in an organic matrix, wherein the catalytic sheet is supported on a substrate. The invention also relates to a method for obtaining the catalytic film and to its uses as an electrode in electrocatalysis of water or in photocatalysis.

Abstract: The present disclosure relates to near-infrared (NIR) photoimmunotherapy (PIT) for treating a subject having a cancer, such as a cancer comprising a first tumor or a primary tumor, metastatic tumor cells and/or invasive tumor cells. The method includes administering to the subject a targeting molecule that binds CD25 conjugated with phthalocyanine dye, such as IR700, and administering an immune checkpoint inhibitor such as an anti PD-1 antibody, followed by illuminating the first tumor or primary tumor with a wavelength of light suitable for the activation of the phthalocyanine dye.

Abstract: Provided are compositions, combinations, and methods and uses for treating a subject having a tumor or lesion, including those not responsive or resistant to prior therapeutic treatments, such as prior immune checkpoint inhibitor treatments. In some aspects, the methods include administering to the subject a targeting molecule that binds CTLA-4 conjugated with phthalocyanine dye, such as IR700. In some cases, the methods include administering an immune modulatory agent. The tumor or lesion, in some cases, a first tumor, is illuminated with a wavelength of light suitable for the activation of the phthalocyanine dye of the conjugate. The provided methods and uses provide for growth inhibition, volume reduction, and elimination of tumors and tumor cells including primary tumors, metastatic tumor cells, and/or invasive tumor cells. Also provided are compositions, combinations, methods and uses for provoking or enhancing systemic and local immune responses and for synergistic responses against tumor growth.

Abstract: This disclosure provides an efficient, hands-free system and method for capturing and recording patient treatment and physiological data in critical care environments. The systems and methods described herein enables clinicians to record and transcribe patient information and physiological data onto an individual disposable medical record tag, which accompanies the patientthroughout initial stabilization and presentation to a treatment center. The data tag digitally stores a patient's health status, and displays a specific color based on a patient's degree of injury or if treatment is required. The data tag forms the center of a patient centric network PCN of connectedhealth devices. An artificial intelligence machine learning model is used in combination with predictive analytics to assess a patient's condition and provide clinical decision support for clinicians based on predictive analytical models.

Abstract: This document describes a computer-implemented method that includes storing information in a standardized format about an organization's susceptibility to social engineering in a plurality of network-based, non-transitory storage devices having a collection of social engineering risk indicators stored thereon; importing, using an integration layer, non-standardized updated information about the organization from one or more data sources; converting, using a first analytics engine, the non-standardized updated information into the standardized format; and transmitting, via the integration layer, the standardized updated information for one or more organizations to a second analytics engine configured to determine a transaction risk indicator for a transaction.

Abstract: A control system and control method of a wind farm which allows taking into account dynamic variations in the possibilities of reactive power generation of each wind turbine with respect to maximum reactive power generation capacities. The system calculates an initial torque and a maximum reactive power limit such that it is not necessary to apply limitations to the initial torque.

Abstract: A solution to optimally manage those requirements ensuring on the one hand, that the requirements set by the grid operators are appropriately and accurately accomplished at a point of interconnection (POI) and on the other hand, preventing the wind turbines from over fulfilling the requirements, for example, by remaining connected at voltages levels higher or lower than the ones required which, although possible, may cause higher loads and currents in the wind turbines than needed to fulfill the requirements.

Abstract: Examples methods, apparatus/systems and articles of manufacture for auditing point-of-sale images are disclosed herein. Example methods disclosed herein include comparing a region of interest of an image displayed via a user interface with a plurality of reference product images stored in a database to identify a plurality of candidate product images from the plurality of reference product images as potential matches to a first product depicted in the image. For example, the candidate product images are associated with respective confidence levels indicating respective likelihoods of matching the first product. Disclosed example methods also include displaying, via the user interface, the candidate product images simultaneously with the image in a manner based on the respective confidence levels, and automatically selecting a first one of the candidate product images as matching the first product based on the respective confidence levels.

Abstract: The present invention relates to a method for controlling power ramps with prediction in intermittent power generation plants, such as, for example, a photovoltaic solar plant, which minimizes the storage capacity required for compliance with the maximum ramp requirements for power fluctuation as well as the cycling of said storage systems, thus extending its lifespan and also reducing associated energy losses, thus reducing investment costs in the plant, such that, in order to achieve the same maximum fluctuation ramp, a minor use is made of the energy storage system.

Abstract: Disclosed is a method of determining a characteristic of interest, in particular focus, relating to a structure on a substrate formed by a lithographic process, and an associated patterning device and lithographic system. The method comprises forming a modified substrate feature on the substrate using a corresponding modified reticle feature on a patterning device, the modified substrate feature being formed for a primary function other than metrology, more specifically for providing a support for a vertically integrated structure. The modified reticle feature is such that said modified substrate feature is formed with a geometry dependent on the characteristic of interest during formation. The modified substrate feature can be measured to determine said characteristic of interest.

Abstract: The present invention relates to methods for the production of high titer recombinant viral vectors, more particularly recombinant AAV vectors, so that the methods can be effectively employed on a scale that is suitable for the practical application of gene therapy techniques.

Abstract: Anchor cage for a foundation of a wind turbine. The anchor cage comprises at least an upper load distribution plate (1), at least a lower load distribution plate (2), and a plurality of first reinforcement elements (3) extending between said plates (1, 2). It further comprises at least one intermediate load distribution plate (4) placed between the upper load distribution plate (1) and the lower load distribution plate (2), and a plurality of second reinforcement elements (5) extending between the upper load distribution plate (1) and the intermediate load distribution plate (4), and being shorter than the first reinforcement elements (3). An assembly method for the anchor cage is also described. A foundation is also provided in which the total post-tensioning value provided in the upper part of the foundation (6) is different from the total post-tensioning value provided in the lower part of the foundation (7).

Abstract: The invention relates to an internal combustion engine that comprises a first Brayton cycle comprising a mixed ionic-electronic conducting (MIEC) membrane that separates the O2 from the air such that the suctioned air current is free from N2; a second Brayton cycle combined in a binary manner with the first Brayton cycle and nested with a cycle selected from an Otto cycle and a diesel cycle performed by means of oxy-combustion. The second Brayton cycle transmits mechanical energy and thermal energy from exhaust gases to the first Brayton cycle. The first Brayton cycle provides to the second Brayton cycle compressed O2 from the MIEC membrane. By means of the present engine, the NOx emission into the atmosphere is prevented by the separation of N2 in the MIEC membrane.

Abstract: Provided are methods involving the use of biomarkers, in relation to photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye conjugated to a targeting molecule that binds a protein on tumor cell, for example, an IR700-antibody conjugate, and combination therapies, for example, that include photoimmunotherapy and an additional therapeutic agent, such as an immune modulating agent. In some aspects, the provided embodiments can be used to identify or select subjects for photoimmunotherapy and/or the combination therapy, or to assess the likelihood of response to photoimmunotherapy and/or to the additional therapeutic agents. Features of the methods and uses provide various advantages, such as improved efficacy. In some aspects, the provided embodiments can be used to provide personalized medicine and tailored therapy regimens for subjects.

Abstract: A control system and control method of a wind farm allows taking into account dynamic variations in the possibilities of reactive power generation of each wind turbine with respect to maximum reactive power generation capacities. The system is configured to receive from at least one first wind turbine of the wind turbines of the wind farm a maximum reactive power limit desired lower than a minimum reactive power capacity required. The system is configured to calculate the individual reactive power setpoints for each of the at least two wind turbines of the wind farm such that the individual reactive power setpoint for the at least one first wind turbine of the wind farm does not exceed the maximum reactive power limit desired.