Abstract: Provided herein are conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye conjugated to a targeting molecule that binds a protein on cell, for example, an IR700-antibody conjugate. In some embodiments, the phthalocyanine-dye conjugate can be activated by irradiation with near-infrared light. Features of the conjugates, compositions and methods, including the dose of the conjugate, provide various advantages, such as lower toxicity and/or improved efficacy. In some embodiments, also provided is a dual label phthalocyanine-dye conjugate in which the targeting molecule is conjugated to an additional fluorescent dye, which can be used for photoimmunotherapy while, for example, also exhibiting improved performance for imaging or detection. Also provided are therapeutic methods using the conjugates and compositions for treatment of diseases and conditions, including tumors or cancers.

Abstract: Wind turbine comprising at least a pitch bearing comprising at least two rings, each of the at least two rings attached to a wind turbine component, being a first wind turbine component a blade and a second wind turbine component a hub, and further comprising at least one bearing reinforcement attached to at least one of the two rings. The invention also relates to the pitch bearing of the wind turbine.

Abstract: Wind turbine comprising at least a pitch bearing comprising at least two rings, each of the at least two rings attached to a wind turbine component, being a first wind turbine component a blade and a second wind turbine component a hub, and further comprising at least one bearing reinforcement attached to at least one of the two rings. The invention also relates to the pitch bearing of the wind turbine.

Abstract: The present invention provides a new animal model for mucopolysaccharidosis type lVA or Morquio A syndrome and to methods of generating the animal model and uses thereof.

Abstract: Provided herein are conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye conjugated to a targeting molecule that binds a protein on cell, for example, an IR700-antibody conjugate. In some embodiments, the phthalocyanine-dye conjugate can be activated by irradiation with near-infrared light. Features of the conjugates, compositions and methods, including the dose of the conjugate, provide various advantages, such as lower toxicity and/or improved efficacy. In some embodiments, also provided is a dual label phthalocyanine-dye conjugate in which the targeting molecule is conjugated to an additional fluorescent dye, which can be used for photoimmunotherapy while, for example, also exhibiting improved performance for imaging or detection. Also provided are therapeutic methods using the conjugates and compositions for treatment of diseases and conditions, including tumors or cancers.

Abstract: Provided are methods for manufacturing a conjugate containing a phthalocyanine dye, including methods that include one or more steps of preparing or producing the conjugate, formulating the conjugate and packaging the conjugate. In some aspects, the manufacturing methods result in the generation of a stable conjugate. Also provided are stable phthalocyanine dye conjugates, compositions and articles of manufacture containing the stable conjugates, and methods for their administration to subjects for photoimmunotherapy. In some embodiments, the phthalocyanine dye conjugates are conjugated to a targeting molecule, such as an antibody, that targets the conjugate to a cell or pathogen, such as by binding to a cell surface protein.

Abstract: A sterile body suit apparatus, system, and method is provided. In certain embodiments, the sterile body suit apparatus may comprise a helmet member, a lower extremity member, and a control interface means. The helmet member may comprise a respiratory means to provide uncontaminated, breathable air to a wearer, an ingestion means for drinking, eating, and vaping, and an audio communication means. The lower extremity may be defined by a torso, a first arm, and a second arm, and may further comprise an egestion means. Moreover, in some embodiments, the sterile body suit may further comprise a temperature control means and a tactile sensation means.

Abstract: Provided herein are conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye conjugated to a targeting molecule that binds a protein on cell, for example, an IR700-antibody conjugate. In some embodiments, the phthalocyanine-dye conjugate can be activated by irradiation with near-infrared light. Features of the conjugates, compositions and methods, including the dose of the conjugate, provide various advantages, such as lower toxicity and/or improved efficacy. In some embodiments, also provided is a dual label phthalocyanine-dye conjugate in which the targeting molecule is conjugated to an additional fluorescent dye, which can be used for photoimmunotherapy while, for example, also exhibiting improved performance for imaging or detection. Also provided are therapeutic methods using the conjugates and compositions for treatment of diseases and conditions, including tumors or cancers.

Abstract: Provided herein are conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye conjugated to a targeting molecule that binds a protein on cell, for example, an IR700-antibody conjugate. In some embodiments, the phthalocyanine-dye conjugate can be activated by irradiation with near-infrared light. Features of the conjugates, compositions and methods, including the dose of the conjugate, provide various advantages, such as lower toxicity and/or improved efficacy. In some embodiments, also provided is a dual label phthalocyanine-dye conjugate in which the targeting molecule is conjugated to an additional fluorescent dye, which can be used for photoimmunotherapy while, for example, also exhibiting improved performance for imaging or detection. Also provided are therapeutic methods using the conjugates and compositions for treatment of diseases and conditions, including tumors or cancers.

Abstract: Provided are methods for manufacturing a conjugate containing a phthalocyanine dye, including methods that include one or more steps of preparing or producing the conjugate, formulating the conjugate and packaging the conjugate. In some aspects, the manufacturing methods result in the generation of a stable conjugate. Also provided are stable phthalocyanine dye conjugates, compositions and articles of manufacture containing the stable conjugates, and methods for their administration to subjects for photoimmunotherapy. In some embodiments, the phthalocyanine dye conjugates are conjugated to a targeting molecule, such as an antibody, that targets the conjugate to a cell or pathogen, such as by binding to a cell surface protein.

Abstract: The invention relates to a method for producing particles with pore structures, by means of a hybrid process of atomization via drying-cooling, from a water-in-oil-type emulsion of a composition of a non-solubilized and in melt state matrix. The production method comprises: i) forming a water-in-oil-type emulsion consisting of a composition of a solvent that is aqueous or soluble in water (dispersed phase) and a composition of a non-solubilized and in melt state matrix (continuous phase); ii) forming discrete particles from the emulsion via atomization, using a flow of gas at high pressure and temperature; iii) immediately removing the solvent via evaporation; and iv) subsequently cooling the formed discrete particles, resulting in porous particles that are substantially free from solvents.

Abstract: Implementations include determining a set of routes for delivery of assets within a delivery network based on realized and forecasted demand for a period, during at least partial execution of the set of routes, receiving real-time data representative of delivery of assets, and updated demand forecasts, determining, by an optimization controller, a time-to-trigger, and a cut-off time, and an updated demand forecast, the time-to-trigger defining an interval, at which the set of routes for delivery of assets is to be reoptimized, in response to the time-to-trigger being achieved, re-optimizing, by a route optimization module of the continuous delivery platform, the set of routes to provide a revised set of routes, and conveying at least one route of the revised set of routes to a delivery personnel, the at least one route being different from any route in the set of routes, and being executed during the period.

Abstract: A blade for a rotor of a wind turbine having a longitudinal direction with a tip end and a root end and a transverse direction, comprising: a profiled contour that when impacted by an incident airflow, generates a lift, wherein the profiled contour is divided into: a root region having a substantially circular or elliptical profile closest to the hub, an airfoil region having a lift-generating profile furthest away from the hub, and a transition region between the root region and the airfoil region, the transition region having a profile gradually changing in the radial direction to the lift-generating profile of the airfoil region, and further comprising a shoulder, wherein the shoulder is located in the airfoil region, thus yielding a slender and relative thick blade maximizing energy output, reducing bearing loads and facilitating transportation.

Abstract: An information exchange platform referred to as a Trading Grid (TG) may perform relationship-based data processing utilizing a trading partner (TP) graph that describes relationships amongst operating units (OUs) on the TG. When the TG receives a request from an OU to exchange data with a TP, the TG accesses the TP graph and determines a relationship between the OU and their TP as reflected in the TP graph. The TP graph is maintained and controlled by the system independently of the OU and the TP. The TG may route the data based on instructions associated with the relationship that is reflected in the TP graph. The instructions associated with the relationship may specify network based services provided by the TG. An orchestration component may operate to orchestrate the performance of the network based services. The TG then communicates the processed and/or produced data to the TP.

Abstract: The invention relates to a viral expression construct and related viral vector and composition and to their use wherein the construct and vector comprise elements a) and b): a) a nucleotide sequence encoding an insulin operably linked to a first promoter, b) a nucleotide sequence encoding a glucokinase operably linked to a second promoter and the viral expression construct and related viral vector comprise at least one of elements c), d) and e): c) the first and the second promoters are positioned in reverse orientation within the expression construct, d) the first and the second promoters are positioned in reverse orientation within the expression construct and are located adjacent to each other and e) the first promoter is a CMV promoter, preferably a mini CMV promoter.

Abstract: A method for generating data indicative of a customer interaction with a product on display includes acquiring, by one or more sensors attached to a product on display in a product display area, sensor data; wirelessly transmitting the sensor data to at least one wireless receiver located in the vicinity of the product display area; and transmitting the sensor data from the at least one wireless receiver to a computer. The method further includes executing, by the computer, a machine learning algorithm in order to determine that a potential customer has interacted with the product on display and to generate insights about an interaction between the customer and the product on display.

Abstract: The present invention relates to polyurethane based solid surface materials with improved dimensional stability which can be made using conventional inorganic fillers without pre-treatment of the fillers.

Abstract: A solution to optimally manage those requirements ensuring on the one hand, that the requirements set by the grid operators are appropriately and accurately accomplished at a point of interconnection (POI) and on the other hand, preventing the wind turbines from over fulfilling the requirements, for example, by remaining connected at voltages levels higher or lower than the ones required which, although possible, may cause higher loads and currents in the wind turbines than needed to fulfill the requirements.

Abstract: The present invention relates to methods of detecting novel mutations in a PKD1 and/or PKD2 gene that have been determined to be associated with autosomal dominant polycystic kidney disease (ADPKD) in order to detect or predict the occurrence of ADPKD in an individual.

Abstract: Wind turbine foundation (1) comprising an annular base plate (2) comprising a supporting surface (3) and defining a central hollow (4) by at least an inner lateral surface (6). The central hollow (4) further comprises a lower surface (5) arranged at a level lower than a level of the supporting surface (3). In particular, the central hollow (4) has a dimension (D), defined by the distance between at least an inner upper surface (10) and the lower surface (5), established such as to allocate additional equipment between both surfaces. A method of constructing said wind turbine foundation (1) is also described.