Patents by Inventor Mihaly V. Toth

Mihaly V. Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6448286
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: September 10, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Amidino compounds useful as nitric oxide synthase inhibitors
    Publication number: 20020111493
    Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
    Type: Application
    Filed: March 23, 2001
    Publication date: August 15, 2002
    Inventors: Ronald Keith Webber, Alok K. Awasthi, Arija A. Bergmanis, Richard C. Durley, Kam F. Fok, Scott S. Ganser, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Brian S. Hickory, Pamela T. Manning, Michael Mao, Alan E. Moormann, Barnett S. Pitzele, Michelle A. Promo, Richard R. Schartman, Jeffrey A. Scholten, Jeffrey S. Snyder, Mihaly V. Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Siong Tjoeng
  • 2-Amino-2-alky-4 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20020103398
    Abstract: The present invention relates to 2-amino-2-alkyl-4 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: September 15, 2001
    Publication date: August 1, 2002
    Inventors: Donald W. Hansen, Mahima Trivedi, Mihaly V. Toth, Ronald Keith Webber, Barnett S. Pitzele, Alok K. Awasthi, James Sikorski
  • Imidazoles useful as nitric oxide synthase inhibitors
    Patent number: 6344473
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: February 5, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Halogenated amidino amino acid deviratives useful as nitric oxide synthase inhibitors
    Patent number: 6344483
    Abstract: The current invention discloses halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 31, 2000
    Date of Patent: February 5, 2002
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Barnett S. Pitzele, Dale P. Spangler, Mihaly V. Toth, R. Keith Webber, Arija A. Bergmanis, Timothy J. Hagen, Sofya Tsymbalov
  • Fluorescence polarization method for determining protease activity
    Publication number: 20010046668
    Abstract: A fluorescence polarization method of determining protease activity is described.
    Type: Application
    Filed: June 13, 2001
    Publication date: November 29, 2001
    Applicant: G.D. Searle & Co.
    Inventors: Leanna M. Levine, Mihaly V. Toth
  • Heterobicyclic and tricyclic nitric oxide synthase inhibitors
    Publication number: 20010044539
    Abstract: The current invention discloses useful bicyclic and tricyclic amidino derivative compounds, pharmaceutical compositions containing these novel compounds, and to their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: March 26, 2001
    Publication date: November 22, 2001
    Inventors: Donald W. Hansen, R. Keith Webber, E. Ann Hallinan, Mihaly V. Toth, Barnett S. Pitzele, Alok K. Awasthi, Alan E. Moormann, Suzanne Metz, Jeffery S. Snyder, William M. Moore, Jeffrey A. Scholten
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 6268380
    Abstract: Novel urea derivatives of the formula are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: July 31, 2001
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mihaly V. Toth
  • Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6207708
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: March 27, 2001
    Assignee: G. D. Searle & Company
    Inventors: Rolando E. Gapud, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Barnett S. Pitzele, Suzanne S. Metz, R. Keith Webber, Foe S. Tjoeng, Robert E. Manning, Mihaly V. Toth
  • L-N.sup.6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6143790
    Abstract: There is disclosed a novel amino glycol derivatives of L-N.sup.6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: November 7, 2000
    Assignee: G.D. Searle & Co.
    Inventors: E. Ann Hallinan, Foe S. Tjoeng, Kam F. Fok, Timothy J. Hagen, Mihaly V. Toth, Sofya Tsymbalov, Barnett S. Pitzele
  • Oxathiadiazole derivatives usful as iNOS inhibitors
    Patent number: 6136829
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: October 24, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Ariia A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Inhibitors of retroviral protease
    Patent number: 6121417
    Abstract: Novel inhibitors of retroviral protease, e.g., HIV protease, are provided which are peptides having from about 4 to about 8 amino acid residues and which are substrates for said protease derived from known cleavage sites and modified to contain an internal CH.sub.2 NH bond isostere.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: September 19, 2000
    Assignee: Washington University
    Inventors: Garland R. Marshall, Mihaly V. Toth
  • Imidino piperidine derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6071906
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: June 6, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Amidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6046211
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: April 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Pyrrolodino imidines useful as nitric oxide synthase inhibitors
    Patent number: 6043261
    Abstract: The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 28, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
  • Cyclic amidino agents useful as nitric oxide synthase inhibitors
    Patent number: 6011028
    Abstract: The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: January 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann. Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
  • Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5981511
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Rolando E. Gapud, Timothy J. Hagen, Ann E. Hallinan, Donald W. Hansen, Jr., Robert E. Manning, Suzanne Metz, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, R. Keith Webber
  • 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
    Patent number: 5981556
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors
    Patent number: 5958958
    Abstract: 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: September 28, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Azepine derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5883251
    Abstract: The current invention discloses azepine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: March 16, 1999
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivede, Foe S. Tjoeng, Barnett S. Pitzele