Patents by Inventor Mihaly V. Toth

Mihaly V. Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amidino dervatives useful as nitric oxide synthase inhibitors
    Patent number: 5854234
    Abstract: The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 29, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors
    Patent number: 5710166
    Abstract: Novel N-Acyl Beta Amino Acid derivatives of the formula ##STR1## are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: January 20, 1998
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth
  • Reagent and method for determining activity of herpes protease
    Patent number: 5708137
    Abstract: A class of compounds is described for use as fluorogenic substrates for herpesvirus proteases and for use in an assay to identify inhibitors of herpesvirus proteases. ##STR1## wherein W is selected from glycine, 4-aminobutyric acid, 5-aminopentanoic acid, 6-aminocaproic acid and 7-aminoheptanoic acid; wherein Y is selected from EDANS, Abz, DANSYL, nicotinic acid, 4-guanidino-benzoic acid, N-methyl-Abz, 4-chloro-Abz, 5-chloro-Abz, 6-chloro-Abz, 3,5-dibromo-Abz, 6-amino-nicotinic acid, 2-amino-nicotinic acid, 2-chloronicotinic acid, niflumic acid and fluorogenic derivatives thereof; and wherein Z is selected from tryptophan, tyrosine, phenylalanine, p-nitrophenylalanine, m-nitrophenylalanine, DABSYL, DABCYL and halogenated derivatives thereof.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: January 13, 1998
    Assignee: G.D. Searle & Co.
    Inventors: Mihaly V. Toth, Arthur J. Wittwer, Barry C. Holwerda
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5624956
    Abstract: Novel urea derivatives and pharmaceutical compositions thereof are provided which inhibit platelet aggregation.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 29, 1997
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Reagent and method for determining activity of herpes protease
    Patent number: 5506115
    Abstract: A class of compounds is described for use as fluorogenic substrates for herpesvirus proteases and for use in an assay to identify inhibitors of herpesvirus proteases. Compounds of particular interest are defined by Formula II ##STR1## wherein W is selected from glycine, 4-aminobutyric acid, 5-aminopentanoic acid, 6-aminocaproic acid and 7-aminoheptanoic acid; wherein Y is selected from EDANS, Abz, DANSYL, nicotinic acid, 4-guanidino-benzoic acid, N-methyl-Abz, 4-chloro-Abz, 5-chloro-Abz, 6-chloro-Abz, 3,5-dibromo-Abz, 6-amino-nicotinic acid, 2-aminonicotinic acid, 2-chloronicotinic acid, niflumic acid and fluorogenic derivatives thereof; and wherein Z is selected from tryptophan, tyrosine, phenylalanine, p-nitrophenylalanine, m-nitrophenylalanine, DABSYL, DABCYL and halogenated derivatives thereof.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: April 9, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Mihaly V. Toth, Arthur J. Wittwer, Barry C. Holwerda
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5475025
    Abstract: Novel urea compounds are provided which inhibit platelet aggregation as well as pharmaceutical compositions and methods of using said compounds.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: December 12, 1995
    Assignee: The Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Inhibitors of retroviral protease
    Patent number: 5342922
    Abstract: Novel inhibitors of retroviral protease, e.g., HIV protease, are provided which are peptides having from about 4 to about 8 amino acid residues and which are substrates for said protease derived from known cleavage sites and modified to contain an internal CH.sub.2 NH bond isostere.
    Type: Grant
    Filed: March 8, 1989
    Date of Patent: August 30, 1994
    Assignee: Washington University
    Inventors: Garland R. Marshall, Mihaly V. Toth
  • Urea derivatives useful as platelet aggregation inhibitors
    Patent number: 5314902
    Abstract: Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: May 24, 1994
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Mihaly V. Toth, Dudley E. McMackins, Steven P. Adams
  • Peptide mimetic compounds useful as platelet aggregation inhibitors
    Patent number: 5220050
    Abstract: This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: June 15, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Philippe R. Bovy, Dudley E. McMackins, Joseph G. Rico, Foe S. Tjoeng, Mihaly V. Toth, Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki
  • Method for determining activity of retroviral protease
    Patent number: 5164300
    Abstract: Novel fluorogenic substrates for retroviral protease, e.g. HIV protease, having the chemical structure X-Thr-Ile-Nle-Phe(Y)-Gln-Arg-NH.sub.2 wherein X is a fluorogenic group and Y is an acceptor for the fluorogenic group, and their use in a fluorometric method for the determination of retroviral protease is disclosed.
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: November 17, 1992
    Assignee: Washington University
    Inventors: Garland R. Marshall, Mihaly V. Toth
  • Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond
    Patent number: 5086165
    Abstract: Disclosed herein are compounds of the class of peptides having from about 4 to about 8 amino acid residues that are substrates for retroviral protease, e.g., HIV protease, derived from known cleavage sites and that are modified to contain an internal COCH.sub.2 bond isostere, useful as inhibitors of said retroviral protease, e.g., HIV protease, and exemplified by the modified peptide, Abz-Thr-Ile-Nle.PSI.(K)Nle-Gln-Arg-NH.sub.2, wherein K is COCH.sub.2.
    Type: Grant
    Filed: February 7, 1991
    Date of Patent: February 4, 1992
    Assignee: Washington University
    Inventors: Garland R. Marshall, Mihaly V. Toth
  • Reagent and method for determining activity of retroviral protease
    Patent number: 5011910
    Abstract: Novel fluorogenic substrates for retroviral protease, e.g. HIV protease, having the chemical structure X--Thr--Ile--Nle--Phe(Y)--Gln--Arg--NH.sub.2 wherein X is a fluorogenic group and Y is an acceptor for the fluorogenic group, and their use in a fluorometric method for the determination of retroviral protease is disclosed.
    Type: Grant
    Filed: December 28, 1989
    Date of Patent: April 30, 1991
    Assignee: Washington University
    Inventors: Garland R. Marshall, Mihaly V. Toth