Abstract: The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the modified RNA. Aspects of the disclosure further relate to preparations and uses of formulations comprising the modified RNA in treating subjects suffering from diseases responsive to VEGF-A therapy.

Abstract: The disclosure relates to nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide. Aspects of the disclosure further relate to uses of nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide, for improving wound healing in a subject.

Abstract: This disclosure relates to mRNA therapy for (i) the promotion and/or improvement of wound healing, (ii) the prevention and/or reduction of scar formation at a wound, (iii) the reduction of the visibility of a scar, and/or (iv) the treatment of epidermolysis bullosa. mRNAs for use in the invention, when intradermally (e.g., using microneedles) or topically administered in vivo, encode a wound healing polypeptide (e.g., a growth factor, a cytokine, a chemokine, a protease inhibitor, or a collagen).

Abstract: The disclosure relates to nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide. Aspects of the disclosure further relate to uses of nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide, for improving wound healing in a subject. Some aspects of the disclosure relate to the topical administration of nanoparticles comprising a lipid component and a modified RNA.

Abstract: The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the modified RNA. Aspects of the disclosure further relate to preparations and uses of formulations comprising the modified RNA in treating subjects suffering from diseases responsive to VEGF-A therapy.

Abstract: The disclosure relates to nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide. Aspects of the disclosure further relate to uses of nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide, for improving wound healing in a subject.

Abstract: A gas generator includes at least two functional subassemblies and at least two retention parts. The functional subassemblies each have an axis defining an axial direction and at least one outer dimension in a plane normal to the axial direction. The retention parts are each radially crimped for retaining one of the at least two functional subassemblies on the gas generator. The at least two retention parts are formed on the same part of the gas generator and the at least two functional subassemblies are positioned on the gas generator with a center distance of axes less than or equal to 1.5 times this outer dimension and that each retention part is radially crimped over at least 90% of its periphery.

Abstract: A brake system and method of adjusting a brake. The method may include the steps of providing a mechanically operated brake including friction material, providing a rotor, providing an adjuster for adjusting a running clearance between the friction material and the rotor, providing a sensor system for determining a likelihood of a braking event, and upon a determination of a change in the likelihood of a braking event operating the adjuster to adjust the running clearance of the brake.

Abstract: A gas generator for an airbag includes a first gas reserve with a first orifice, a first mechanism arranged for opening the first gas reserve, and a diffusion chamber arranged for diffusing the discharge gases. The generator additionally includes a mixing chamber comprising at least one first communication surface with the diffusion chamber. The gas generator further including a second mechanism comprising a second actuator and a mobile obturator between a first obstruction position, in which it obstructs a second communication surface with a diffusion chamber and a second passage position, in which the second communication surface is free.

Abstract: A direction of a sound source located in the surrounding of a detector of a panoramic video is established. A preset view of the panoramic video is determined based on the established direction. Playback of the panoramic video is based on the determined preset view.

Abstract: A gas generator includes at least two functional subassemblies and at least two retention parts. The functional subassemblies each have an axis defining an axial direction and at least one outer dimension in a plane normal to the axial direction. The retention parts are each radially crimped for retaining one of the at least two functional subassemblies on the gas generator. The at least two retention parts are formed on the same part of the gas generator and the at least two functional subassemblies are positioned on the gas generator with a centre distance of axes less than or equal to 1.5 times this outer dimension and that each retention part is radially crimped over at least 90% of its periphery.

Abstract: A direction of a sound source located in the surrounding of a detector of a panoramic video is established. A preset view of the panoramic video is determined based on the established direction. Playback of the panoramic video is based on the determined preset view.

Abstract: A gas generator for an airbag includes a first gas reserve with a first orifice, a first mechanism arranged for opening the first gas reserve, and a diffusion chamber arranged for diffusing the discharge gases. The generator additionally includes a mixing chamber comprising at least one first communication surface with the diffusion chamber. The gas generator further including a second mechanism comprising a second actuator and a mobile obturator between a first obstruction position, in which it obstructs a second communication surface with a diffusion chamber and a second passage position, in which the second communication surface is free.

Abstract: The invention provides a method for using an ozone generating apparatus containing a power supply apparatus and ozone generating device. The apparatus can be operated by controlling the power supplied from the power supply apparatus to the ozone generating device, supplying a flow of oxygen-containing gas to the ozone generating device, and controlling the flow of the oxygen-containing gas. The power supplied to the ozone generating device and flow of oxygen to the ozone generating device can be controlled to obtain a predetermined yield of ozone and to minimize the consumption of resources of the ozone generating apparatus.

Abstract: A brake system and method of adjusting a brake. The method may include the steps of providing a mechanically operated brake including friction material, providing a rotor, providing an adjuster for adjusting a running clearance between the friction material and the rotor, providing a sensor system for determining a likelihood of a braking event, and upon a determination of a change in the likelihood of a braking event operating the adjuster to adjust the running clearance of the brake.

Abstract: A shutter arrangement for covering a camera lens includes a camera lens cover that is movable in a plane along a first direction between a first closed position and a second opened position. In the first closed position, the camera lens cover substantially covers the camera lens and in the second opened position, the camera lens is substantially uncovered. The shutter arrangement also includes a movable cover that moves between a first position and a second position which displaces the movable cover from the plane.

Abstract: The invention provides a power supply apparatus for supplying electric power to a capacitive load. The apparatus has a transformer, a positive half-period driver and a negative half-period driver supplying positive and negative half-periods of voltage to the first coil. The second coil forms an electric resonance circuit and supplies electric voltage to the load. Zero crossings of the voltage supplied to the first coil are determined from a third coil on the transformer, and alternation between positive and negative half-periods of voltage supplied to the first coil is done at the zero crossings of the voltage supplied to the first coil.

Abstract: A switch configured to contact an exposed contact on an edge of a multilayer circuit board when selectively activated. The switch is particularly useful for electronic equipment such as mobile phones, PDA's, etc. where space for key contacts on the circuit board is limited. By facilitating connection to terminals formed on edges of a circuit board and/or edges of layers of multilayer circuit boards, the switch provides additional options for button locations on the electronic device heretofore requiring routing of wiring.

Abstract: A shutter arrangement for covering a camera lens includes a camera lens cover that is movable in a plane along a first direction between a first closed position and a second opened position. In the first closed position, the camera lens cover substantially covers the camera lens and in the second opened position, the camera lens is substantially uncovered. The shutter arrangement also includes a movable cover that moves between a first position and a second position which displaces the movable cover from the plane.

Abstract: A shutter arrangement for covering a camera lens includes a camera lens cover that is movable in a plane along a first direction between a first closed position and a second opened position. In the first closed position, the camera lens cover substantially covers the camera lens and in the second opened position, the camera lens is substantially uncovered. The shutter arrangement also includes a movable cover that moves between a first position and a second position which displaces the movable cover from the plane.