Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

Abstract: This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention.

Abstract: The present invention relates to implantable medical devices, in particular stents, comprising pro-healing poly(ester-amide)s.

Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.

Abstract: The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

Abstract: The present invention provides an amorphous terpolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same

Abstract: A poly(thioester ester amide) copolymer and method of making and using the same are disclosed.

Abstract: A poly(ester amide) polymer having free carboxylic acid pendant groups and method of making and using the same are disclosed.

Abstract: A coating formed of a substituted polycaprolactone and method of making and using the same are disclosed.

Abstract: A composition including a solution suitable for introduction into a blood vessel comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid, wherein the activated diamine comprises a product of a diol and an amino acid. A method including combining a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid; and forming particles of the combination suitable for delivery through a blood vessel.

Abstract: A coating comprising a polymer that comprises units derived from an aliphatic thioester on a medical device is provided.

Abstract: A coating of fast absorption or fast dissolution on an implantable device and methods of making and using of the coating are provided.

Abstract: An implantable device including conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.

Abstract: Implantable medical devices fabricated from branched polymers are disclosed.