Patents by Inventor Mikhail Markovich Gusyatiner

Mikhail Markovich Gusyatiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing an L-amino acid using a bacterium of the family having a disrupted putrescine degradation pathway
    Patent number: 9840725
    Abstract: The present invention provides a method for producing L-amino acids such as L-amino acids belonging to the glutamate family by fermentation using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus Escherichia, which has been modified to disrupt the putrescine degradation pathway by, for example, inactivation of one gene or several genes from the puuADRCBE gene cluster.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: December 12, 2017
    Assignee: AJINOMOTO CO., INC.
    Inventors: Mikhail Markovich Gusyatiner, Yulia Georgievna Rostova, Mikhail Yurievich Kiryukhin, Anastasia Yurienva Romkina
  • Method for Producing an L-Amino Acid Using a Bacterium of the Family Enterobacteriaceae Having a Disrupted Putrescine Degradation Pathway
    Publication number: 20160237464
    Abstract: The present invention provides a method for producing L-amino acids such as L-amino acids belonging to the glutamate family by fermentation using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus Escherichia, which has been modified to disrupt the putrescine degradation pathway by, for example, inactivation of one gene or several genes from the puuADRCBE gene cluster.
    Type: Application
    Filed: April 13, 2016
    Publication date: August 18, 2016
    Applicant: AJINOMOTO CO., INC.
    Inventors: Mikhail Markovich Gusyatiner, Yulia Georgievna Rostova, Mikhail Yurievich Kiryukhin, Anastasia Yurienva Romkina
  • Method for producing an L-amino acid belonging to the glutamate family, using a coryneform bacterium
    Patent number: 9029104
    Abstract: The present invention provides a method for producing an L-amino acid belonging to the glutamate family, using a coryneform bacterium which has been modified so that expression of one or more gene(s) of the NCgl_2067-NCgl_2065 operon in said bacterium is/are attenuated.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: May 12, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Svetlana Alekseevna Samsonova, Viktor Vasilievich Samsonov, Yulia Georgievna Rostova, Mikhail Markovich Gusyatiner
  • Method for Producing L-Amino Acids Using Bacteriua of the Enterobacteriaceae Family
    Publication number: 20140287472
    Abstract: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
    Type: Application
    Filed: June 11, 2014
    Publication date: September 25, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Ekaterina Alekseevna Savrasova, Valeriy Zavenovich Akhverdian, Elena Vitalievna Klyachko, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Larisa Gotlibovna Airikh, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner, Elvira Borisovna Voroshilova, Yury Ivanovich Kozlov, Yoshihiko Hara, Takuji Ueda
  • Method for producing L-amino acids using bacteria of the enterobacteriaceae family
    Patent number: 8785161
    Abstract: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: July 22, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Ekaterina Alekseevna Savrasova, Valeriy Zavenovich Akhverdian, Elena Vitalievna Klyachko, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Larisa Gotlibovna Airikh, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner, Elvira Borisovna Voroshilova, Yury Ivanovich Kozlov, Yoshihiko Hara, Takuji Ueda
  • Method for producing L-amino acids using bacteria of the enterobacteriaceae family
    Patent number: 8728774
    Abstract: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: May 20, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Ekaterina Alekseevna Savrasova, Valeriy Zavenovich Akhverdian, Elena Vitalievna Klyachko, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Larisa Gotlibovna Airikh, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner, Elvira Borisovna Voroshilova, Yury Ivanovich Kozlov, Yoshihiko Hara, Takuji Ueda
  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase
    Patent number: 8722370
    Abstract: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: May 13, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Tatyana Viktorovna Leonova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Mika Moriya, Yuri Nagai, Keiko Noguchi
  • Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family
    Patent number: 8703446
    Abstract: The present invention provides a method for producing L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to enhance the expression of the bssR gene, which encodes a regulator of biofilm through signal secretion.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: April 22, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mikhail Yurievich Kiryukhin, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using a bacterium of the family with attenuated expression of the rcsA gene
    Patent number: 8691537
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rcsA gene.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: April 8, 2014
    Assignee: Ajinomoto Co., Ltd.
    Inventors: Dmitriy Vladimirovich Filippov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for Producing an L-Amino Acid Belonging to the Glutamate Family, Using a Coryneform Bacterium
    Publication number: 20140051132
    Abstract: The present invention provides a method for producing an L-amino acid belonging to the glutamate family, using a coryneform bacterium which has been modified so that expression of one or more gene(s) of the NCgl_2067-NCgl_2065 operon in said bacterium is/are attenuated.
    Type: Application
    Filed: October 3, 2013
    Publication date: February 20, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Svetlana Alekseevna Samsonova, Viktor Vasilievich Samsonov, Yulia Georgievna Rostova, Mikhail Markovich Gusyatiner
  • Method for producing L-arginine using a bacterium of enterobacteriaceae family, having attenuated expression of a gene encoding an L-arginine transporter
    Patent number: 8647838
    Abstract: The present invention provides a method for producing L-arginine using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or several genes encoding an L-arginine transporter.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: February 11, 2014
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mikhail Yurievich Kiryukhin, Yulia Georgievna Rostova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING AN L-CYSTEINE, L-CYSTINE, A DERIVATIVE OR PRECURSOR THEREOF OR A MIXTURE THEREOF USING A BACTERIUM OF ENTEROBACTERIACEAE FAMILY
    Publication number: 20120237986
    Abstract: The present invention provides a method for producing L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof using a bacterium of Enterobacteriaceae family which has been modified to have enhanced expression of the genes involved in the process of sulphur assimilation.
    Type: Application
    Filed: March 28, 2012
    Publication date: September 20, 2012
    Inventors: Mikhail Kharisovich Ziyatdinov, Viktor Vasilievich Samsonov, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY
    Publication number: 20120219996
    Abstract: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
    Type: Application
    Filed: May 8, 2012
    Publication date: August 30, 2012
    Inventors: Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Ekaterina Alekseevna Savrasova, Valeriy Zavenovich Akhverdian, Elena Vitalievna Klyachko, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Larisa Gotlibovna Airikh, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner, Elvira Borisovna Voroshilova, Yury Ivanovich Kozlov, Yoshihiko Hara, Takuji Ueda
  • Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA
    Patent number: 8227214
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: July 24, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, legal representative, Takuji Ueda
  • METHOD FOR PRODUCING AN L-AMINO ACID USING BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF A GENE CODING FOR SMALL RNA
    Publication number: 20120070865
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 22, 2012
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Yury Ivanovich Kozlov, Vitaly Grigorievich Paraskevov, Takuji Ueda
  • Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmACDFH-fimZ cluster or the fimZ gene
    Patent number: 8114639
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: February 14, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Dmitriy Vladimirovich Filippov, Vera Georgievna Doroshenko, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA
    Patent number: 8088606
    Abstract: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: January 3, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Konstantin Vyacheslavovich Rybak, Aleksandra Yurievna Skorokhodova, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Vitaly Grigorievich Paraskevov, Takuji Ueda
  • Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
    Patent number: 8003368
    Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: August 23, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Aleksey Nikolaevich Marchenko, Sergey Vladimirovich Benevolensky, Elena Vitalievna Klyachko, Yuri Ivanovich Kozlov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
    Patent number: 8003367
    Abstract: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino acid producing bacterium in a culture medium containing xylose, and collecting the L-amino acid from the culture medium.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: August 23, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Aleksey Nikolaevich Marchenko, Sergey Vladimirovich Benevolensky, Elena Vitalievna Klyachko, Yuri Ivanovich Kozlov, Elvira Borisovna Voroshilova, Mikhail Markovich Gusyatiner
  • METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY
    Publication number: 20110143403
    Abstract: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.
    Type: Application
    Filed: February 22, 2011
    Publication date: June 16, 2011
    Inventors: Konstantin Vyacheslavovich Rybak, Ekaterina Aleksandrovna Slivinskaya, Ekaterina Alekseevna Savrasova, Valeriy Zavenovich Akhverdian, Elena Vitalievna Klyachko, Sergei Vladimirovich Mashko, Vera Georgievna Doroshenko, Larisa Gotlibovna Airikh, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner, Elvira Borisovna Voroshilova, Yury Ivanovich Kozlov, Yoshihiko Hara, Takuji Ueda