Patents by Inventor Mikhail Markovich Gusyatiner

Mikhail Markovich Gusyatiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing L-amino acid using bacteria belonging to the genus escherichia
    Publication number: 20030148473
    Abstract: A method for producing an L-amino acid, such as L-phenylalanine, L-threonine is provided using bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of protein encoded by the yedA gene.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Maria Viacheslavovna Vitushkina, Mikhail Markovich Gusyatiner, Mikhail Kharisovich Ziyatdinov, Valery Zavenovich Akhverdian, Ekaterina Alekseevna Savrasova, Vera Georgievna Doroshenko, Sergey Vladimirovich Mashko
  • Mutant N-acetylglutamate synthase and method for L-arginine production
    Publication number: 20030148475
    Abstract: L-arginine is produced using a bacterium belonging to the genus Escherichia harboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.
    Type: Application
    Filed: June 22, 2001
    Publication date: August 7, 2003
    Applicant: AJINOMOTO CO., INC.
    Inventors: Leonid Romanovich Ptitsyn, Irina Borisovna Altman, Sergey Vasil?apos;evich Smirnov, Yulia Georgievna Rostova, Tatyana Abramovna Yampolskaya, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner
  • New mutant glutamine synthetase and method for producing amino acids
    Publication number: 20030148474
    Abstract: Amino acids, such as L-glutamine, L-arginine, L-tryptophan, L-histidine and L-glutamate are produced using a bacterium belonging to the genus Escherichia harboring a mutant glutamine synthetase in which the tyrosine amino acid residue corresponding to position 397 in a wild type glutamine synthetase is replaced with any of amino acid residues, preferably with phenylalanine.
    Type: Application
    Filed: November 20, 2002
    Publication date: August 7, 2003
    Applicant: Ajinomoto Co., Inc.
    Inventors: Mikhail Markovich Gusyatiner, Lirina Valerievna Ivanovskaya, Tatyana Viktorovna Leonova, Ekaterina Igorevna Mukhanova, Yulia Georgievna Rostova, Dmitriy Vladimirovich Filippov, Daria Aleksandrovna Chudakova
  • Mutant carbamoylphosphate synthetase and method for producing compounds derived from carbamoylphosphate
    Publication number: 20030129708
    Abstract: L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5′-monophosphate (UMP), cytidine and cytidine 5′-monophosphate (CMP) are produced using a bacterium belonging to the genus Escherichia harboring a mutant carbamoylphosphate synthetase in which the amino acid sequence corresponding to positions from 947 to 951 in a wild type carbamoylphosphate synthetase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 9, and feedback inhibition by uridine 5′-monophosphate in the bacterium is desensitized.
    Type: Application
    Filed: November 12, 2002
    Publication date: July 10, 2003
    Applicant: AJINOMOTO CO., INC
    Inventors: Leonid Romanovich Ptitsyn, Sergey Vasil?apos;evich Smirnov, Irina Borisovna Altman, Anna Eugenievna Novikova, Veronika Aleksandrovna Kotliarova, Mikhail Markovich Gusyatiner, Yulia Georgievna Rostova, Tatyana Abramovna Yampolskaya
  • DNA coding for mutant isopropylmalate synthase L-leucine-producing microorganism and method for producing L-leucine
    Patent number: 6403342
    Abstract: A method for producing L-leucine, comprising the steps of: culturing a bacterium which is transformed with a DNA coding for an a-isopropylmalate synthase densensitized in feedback inhibition by L-leucine, in a culture medium to produce and accumulate L-leucine in the medium, and recovering L-leucine from the medium.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: June 11, 2002
    Assignee: Anjinomoto Co., Inc.
    Inventors: Mikhail Markovich Gusyatiner, Maria Grigorievna Lunts, Yuly Ivanovich Kozlov, Lirina Valerievna Ivanovskaya, Elvira Borisovna Voroshilova
  • Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine
    Publication number: 20020058315
    Abstract: L-Glutamic acid, L-proline or L-arginine is produced by culturing a bacterium belonging to the genus Escherichia, which is L-isoleucine auxotrophic and has ability to produce L-glutamic acid, L-proline or L-arginine, in a medium containing L-isoleucine, to produce and accumulate L-glutamic acid, L-proline or L-arginine in a culture, and collecting L-glutamic acid, L-proline or L-arginine from the culture.
    Type: Application
    Filed: September 17, 2001
    Publication date: May 16, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Maria Grigorievna Lunts, Svetlana Aleksandrovna Fomina, Tatyana Viktorovna Leonova, Mikhail Markovich Gusyatiner
  • Mutant ilvH gene and method for producing L-valine
    Publication number: 20020037562
    Abstract: A method for producing L-valine comprising the steps of cultivating the bacterium harboring a DNA coding for actohydroxy acid synthase isozime III originating from Escherichia coli which is free from a inhibition by L-valine and has an activity to catalyze two reactions to generate &agr;-acetolactate from pyruvate and &agr;-aceto-&agr;-hydroxybutyrate from &agr;-ketobutyrate and pyruvate, producing and accumulating L-valine in the culture medium, and collecting L-valine from the culture medium.
    Type: Application
    Filed: January 18, 2001
    Publication date: March 28, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Nataliya Vasilyevna Gorshkova, Alla Valentinovna Belaryeva, Lirina Valeryevna Ivanovskaya, Evgeni Moiseevich Khourges, Valery Zavenovich Akhverdian, Mikhail Markovich Gusyatiner, Yury Ivanovich Kozlov
  • L-arginine producing escherichia coli and method of producing L-arginine
    Publication number: 20020034793
    Abstract: Arginine can be efficiently produced by cultivating Escherichia coli which has an ability to produce arginine and an ability to utilize acetate in a culture medium to produce and accumulate arginine in the medium, and collecting arginine from the medium.
    Type: Application
    Filed: June 22, 2001
    Publication date: March 21, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Mikhail Markovich Gusyatiner, Tatyana Viktorovna Leonova, Leonid Romanovich Ptitsyn, Tatyana Abramovna Yampolskaya
  • Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
    Publication number: 20010049129
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Application
    Filed: July 13, 2001
    Publication date: December 6, 2001
    Applicant: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Escherichia coli strain and method for producing L-threonine
    Patent number: 6297031
    Abstract: E. coli strains derived form E. coli strain VNIIgenetika 472t23 and obtained by a process involving transduction by bacteriophage P1 which bears a transposon which inactivates threonine dehydrogenase activity and isolation of a transductant lacking threonine dehydrogenase activity are useful for producing L-threonine.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: October 2, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivancvich Kozlov, Evgeny Mciseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Christoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 6165756
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antiobiotics Research Institute under Reg. No. 1867.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: December 26, 2000
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 5976843
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: November 2, 1999
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivanovich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakovna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Olegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailovna Pozdnyakova
  • Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
    Patent number: 5705371
    Abstract: A bacterial strain of Escherichia coli BKIIM B-3996, a producer of L-threonine, containing a recombinant plasmid pVIC40 and deposited on Nov. 19, 1987 in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1867.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: January 6, 1998
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vladimir Georgievich Debabov, Jury Ivancvich Kozlov, Evgeny Moiseevich Khurges, Vitaly Arkadievich Livshits, Nelli Isaakcvna Zhdanova, Mikhail Markovich Gusyatiner, Alexandr Konstantinovich Sokolov, Tatyana Alexandrovna Bachina, Nikolai Kazimirovich Yankovsky, Jury Dmitrievich Tsygankov, Andrei Jurievich Chistoserdov, Tatyana Grigorievna Plotnikova, Irina Clegovna Shakalis, Alla Valentinovna Belareva, Raisa Alexandrovna Arsatiants, Albert Fedorovich Sholin, Tamara Mikhailcvna Pozdnyakova