Abstract: A clamping device (1) for connection in which a housing (4) rotatably accommodates a worm screw (5) to mesh with an array of teeth portion (6) of a strap band (3). The strap band (3) is diametrically contracted upon operating the worm screw (5) to wind the strap band (3) around a connecting portion (2). One end portion of the strap band (3) in which the array of teeth portion (6) resides, is formed into a wavy and concavo-convex configuration in its width direction, thus increasing a meshing area of the array of teeth portion (6) against the worm screw (5). This makes it possible for the strap band (3) to cope with a situation in which the strap band (3) is required to tightly wind the connecting portion (2) with a high tightening force.

Abstract: A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.

Abstract: An object of the present invention is to provide a low molecular weight VEGF inhibitor that can be utilized to treat diseases accompanying neovascularization, such as solid tumors. It was found that a polypeptide containing immunoglobulin-like domain 1 and immunoglobulin-like domain 2 but neither immunoglobulin-like main 6 nor immunoglobulin-like domain 7 of the extracellular domain of the VEGF receptor FLT possess VEGF inhibitory activity.