Patents by Inventor Milan R. Uskokovic

Milan R. Uskokovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for chenodeoxycholic acid production
    Patent number: 4301246
    Abstract: A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.
    Type: Grant
    Filed: January 18, 1980
    Date of Patent: November 17, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Carl Despreaux, Thomas A. Narwid, Norberto J. Palleroni, Milan R. Uskokovic
  • Novel thiophene compounds
    Patent number: 4299968
    Abstract: Novel thiophene compounds having utility as biotin intermediates and blood lipid lowering agents, as well as related processes and intermediates, are disclosed.
    Type: Grant
    Filed: December 20, 1979
    Date of Patent: November 10, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale N. Confalone, Giacomo Pizzolato, Milan R. Uskokovic
  • Intermediate racemates for the preparation of biotin and a process for their preparation
    Patent number: 4284557
    Abstract: A process is disclosed for producing d-biotin from L or DL-cystine ester via novel intermediates.
    Type: Grant
    Filed: May 15, 1980
    Date of Patent: August 18, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic
  • Furo[3,2-C]isoxazol-5-ones
    Patent number: 4252964
    Abstract: A simple and economic chiral synthesis of optically active methyl L-acosaminide and methyl L-daunosaminide from propenyl acetate, said methyl L-acosaminide and methyl L-daunosaminide being coupling agents for the production of known antitumor agents.
    Type: Grant
    Filed: July 25, 1979
    Date of Patent: February 24, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Milan R. Uskokovic, Peter M. Wovkulich
  • Hexahydro thieno imadazole intermediates for the synthesis of biotin
    Patent number: 4247704
    Abstract: A process is disclosed for producing d-biotin from L or DL-cystine ester via novel intermediates.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: January 27, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic
  • Isoxazolines and isoxazolidines
    Patent number: 4245104
    Abstract: A process is disclosed for producing d-biotin from L-cystine via novel intermediates.
    Type: Grant
    Filed: December 1, 1978
    Date of Patent: January 13, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic
  • 3,4-Anhydro-2,6-dideoxy-L-ribohexose
    Patent number: 4238399
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: June 13, 1979
    Date of Patent: December 9, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • Process for chenodeoxycholic acid and intermediates therefore
    Patent number: 4230625
    Abstract: A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.
    Type: Grant
    Filed: April 12, 1979
    Date of Patent: October 28, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Carl Despreaux, Thomas A. Narwid, Norberto J. Palleroni, Milan R. Uskokovic
  • Administration of biologically active vitamin D.sub.3 and vitamin D.sub.2 materials
    Patent number: 4230701
    Abstract: A process for administering biologically active vitamin D.sub.3 and vitamin D.sub.2 materials into the blood system of a subject by providing the biologically active vitamin D.sub.3 or D.sub.2 material to the skin whereby the skin releases the biologically active vitamin D.sub.3 or D.sub.2 material into the blood system in a controlled and prolonged manner.
    Type: Grant
    Filed: March 21, 1979
    Date of Patent: October 28, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael F. Holick, Milan R. Uskokovic
  • Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribo-hexopyranoside
    Patent number: 4228080
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: June 13, 1979
    Date of Patent: October 14, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • Novel cycloheptathiophene intermediates for the synthesis of biotin
    Patent number: 4228295
    Abstract: A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: October 14, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale N. Confalone, Elizabeth D. Lollar, Giacomo Pizzolato, Milan R. Uskokovic
  • Vitamin D.sub.3 metabolite derivatives
    Patent number: 4225525
    Abstract: This disclosure relates to 3-hemisuccinate or 3-hemiglutarate derivatives of the biologically active metabolites of Vitamin D.sub.3 which possess Vitamin D activities and uses. The subject compounds also are useful as haptens which can be used to prepare immunogens which in turn elicit antibodies selective to said respective Vitamin D.sub.3 metabolites.
    Type: Grant
    Filed: February 8, 1979
    Date of Patent: September 30, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Milan R. Uskokovic
  • Preparation of biotin
    Patent number: 4189586
    Abstract: A novel procedure for the preparation of biotin employing cysteine as the starting material is disclosed. This synthesis involves the formation of the thiophane ring by a 1,3-dipolar addition. By virtue of this process pure d-biotin can be obtained, thus obviating the need for chemical resolution. Novel intermediates are also disclosed.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: February 19, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic
  • Coumarin derivatives to produce 8-methoxypsoralen
    Patent number: 4180659
    Abstract: The invention relates to synthetic processes to produce the known pharmacologically active 8-methoxypsoralen and derivatives thereof. Also disclosed are various novel intermediates utilized in these processes.
    Type: Grant
    Filed: September 29, 1978
    Date of Patent: December 25, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale N. Confalone, Elizabeth D. Lollar, Giacomo Pizzolato, Milan R. Uskokovic
  • Cycloheptathiophene derivatives
    Patent number: 4175086
    Abstract: A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.
    Type: Grant
    Filed: July 31, 1978
    Date of Patent: November 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale N. Confalone, Elizabeth D. Lollar, Giacomo Pizzolato, Milan R. Uskokovic
  • Process for the preparation of methyl 3,4-anhydro-2,6-dideoxy-L-ribo-hexopyranoside
    Patent number: 4174344
    Abstract: A process to produce methyl 3,4-anhydro-2,6-dideoxy-L-ribohexopyranoside, its enantiomer and racemate thereof.The compound is useful as an intermediate in the production of daunosamine which in turn is a prime constituent in the anti-cancer agents Daunomycin and Adriamycin. Also disclosed are novel intermediates in the process.
    Type: Grant
    Filed: November 14, 1977
    Date of Patent: November 13, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan R. Uskokovic, John Sereno
  • Asymmetric synthesis of optically active prostaglandins
    Patent number: 4140708
    Abstract: An asymmetric synthesis of optically active prostaglandin F.sub.2.alpha. from cyclopentadiene including intermediates in this synthesis.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: February 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Naresh K. Chadha, John J. Partridge, Jr., Milan R. Uskokovic
  • Asymmetric synthesis of optically active prostaglandins
    Patent number: 4137244
    Abstract: An asymmetric synthesis of optically active prostaglandin F.sub.2.alpha. from cyclopentadiene including intermediates in this synthesis.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: January 30, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Naresh K. Chadha, John J. Partridge, Jr., Milan R. Uskokovic
  • Process for producing lactones
    Patent number: 4133818
    Abstract: An asymmetric synthesis of optically active prostaglandin F.sub.2.alpha. from cyclopentadiene including intermediates in this synthesis.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: January 9, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Naresh K. Chadha, John J. Partridge, Jr., Milan R. Uskokovic
  • Biotin intermediates
    Patent number: 4130713
    Abstract: A novel procedure for the preparation of biotin employing cysteine as the starting material is disclosed. This synthesis involves the formation of the thiophane ring by a 1,3-dipolar addition. By virtue of this process pure d-biotin can be obtained, thus obviating the need for chemical resolution. Novel intermediates are also disclosed.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: December 19, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic