Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: A spectral imaging device (1312) for capturing one or more, two-dimensional, spectral images (1313A) of a sample (1310) including (i) an image sensor (1328), (ii) an illumination source (1314), (iii) a beam path adjuster (1362), and (iv) a control system (1330). The illumination source (1314) that generates an illumination beam (1316) that is directed along an incident sample beam path (1360) at the sample (1310). The beam path adjuster (1362) selectively adjusts the incident sample beam path (1360).

Abstract: A flow cell assembly (16) for a fluid analyzer (14) that analyzes a sample (12) includes (i) a base (350) that includes a base window (350B); (ii) a cap (352) having a cap window (352B) that is spaced apart from the base window (350B); and (iii) a gasket (360) that is secured to and positioned between the base (350) and the cap (352), the gasket (360) having a gasket body (360A) that includes a gasket opening (360B). The gasket body (360A), the base (350) and the cap (352) cooperate to define a flow cell chamber (362). Moreover, an inlet passageway (366) extends into the flow cell chamber (362) to direct the sample (12) into the flow cell chamber (362); and an outlet passageway (368) extends into the flow cell chamber (362) to allow the sample (12) to exit the flow cell chamber (362).

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: A spectral imaging device (1312) for capturing one or more, two-dimensional, spectral images (1313A) of a sample (1310) including (i) an image sensor (1328), (ii) an illumination source (1314), (iii) a beam path adjuster (1362), and (iv) a control system (1330). The illumination source (1314) that generates an illumination beam (1316) that is directed along an incident sample beam path (1360) at the sample (1310). The beam path adjuster (1362) selectively adjusts the incident sample beam path (1360).

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: An analyzer system (10) for analyzing a sample (12) includes a MIR analyzer (34) for spectrally analyzing the sample (12) while the sample (12) is flowing in the MIR analyzer (34). The MIR analyzer (34) includes (i) a MIR flow cell (35C) that receives the flowing sample (12), (ii) a MIR laser source (35A) that directs a MIR beam (35B) in a MIR wavelength range at the sample (12) in the MIR flow cell (35C), and (iii) a MIR detector (35D) that receives light from the sample (12) in the MIR flow cell (35C) and generates MIR data of the sample (12) for a portion of the MIR wavelength range.

Abstract: A spectral imaging device (12) includes an image sensor (28), a tunable light source (14), an optical assembly (17), and a control system (30). The optical assembly (17) includes a first refractive element (24A) and a second refractive element (24B) that are spaced apart from one another by a first separation distance. The refractive elements (24A) (24B) have an element optical thickness and a Fourier space component of the optical frequency dependent transmittance function. Further, the element optical thickness of each refractive element (24A) (24B) and the first separation distance are set such that the Fourier space components of the optical frequency dependent transmittance function of each refractive element (24A) (24B) fall outside a Fourier space measurement passband.

Abstract: A laser assembly (10) for generating a pulsed output beam (16) includes a quantum cascade device (12); and a laser driver (14A) that controls the voltage to the quantum cascade device (12) in a pulsed drive profile (950) to generate the pulsed output beam (16). The pulsed drive profile (950) includes a plurality of spaced on-time segments (952) in which the laser driver (14A) directs voltage to the quantum cascade device (12), and at least one off-time segment (954) in which the laser driver (14A) pulls down the voltage from the quantum cascade device (12). The off-time segment (954) occurs between two on-time segments (952).

Abstract: A method for identifying one or more analytes (12A)(12B)(12C) includes (i) directing a solvent (18) into a test cell (22); (ii) directing a first laser probe beam (26) at the solvent (18) in the test cell (22); (iii) acquiring a solvent intensity spectrum of the solvent (18); (iv) directing a sample (12) that includes one or more analytes (12A)(12B)(12C) and the solvent (18) into the flow cell (22); (v) directing a second laser probe beam (26) at the sample (12) in the test cell (22); (vi) acquiring a sample intensity spectrum of the sample (12); (vii) calculating a solvent referenced transmittance spectrum that details a solvent reference transmittance as a function of wavelength using the solvent intensity spectrum and the sample intensity spectrum; and (viii) identifying one or more analytes (12A)(12B)(12C) in the sample (12) using the solvent referenced transmittance spectrum.

Abstract: A chromatography analyzer system (10) for analyzing a sample (12) includes a MIR analyzer (34) for spectrally analyzing a sample fraction (12A) while the sample fraction (12A) is flowing in the MIR analyzer (34). The MIR analyzer (34) includes (i) a MIR flow cell (35C) that receives the flowing sample fraction (12A), (ii) a MIR laser source (35A) that directs a MIR beam (35B) in a MIR wavelength range at the sample fraction (12A) in the MIR flow cell (35C), and (iii) a MIR detector (35D) that receives light from the sample fraction (12A) in the MIR flow cell (35C) and generates MIR data of the sample fraction (12A) for a portion of the MIR wavelength range.

Abstract: A flow cell assembly (16) for a fluid analyzer (14) that analyzes a sample (12) includes (i) a base (350) that includes a base window (350B); (ii) a cap (352) having a cap window (352B) that is spaced apart from the base window (350B); and (iii) a gasket (360) that is secured to and positioned between the base (350) and the cap (352), the gasket (360) having a gasket body (360A) that includes a gasket opening (360B). The gasket body (360A), the base (350) and the cap (352) cooperate to define a flow cell chamber (362). Moreover, an inlet passageway (366) extends into the flow cell chamber (362) to direct the sample (12) into the flow cell chamber (362); and an outlet passageway (368) extends into the flow cell chamber (362) to allow the sample (12) to exit the flow cell chamber (362).

Abstract: A spectral imaging device (12) includes an image sensor (28), a tunable light source (14), an optical assembly (17), and a control system (30). The optical assembly (17) includes a first refractive element (24A) and a second refractive element (24B) that are spaced apart from one another by a first separation distance. The refractive elements (24A) (24B) have an element optical thickness and a Fourier space component of the optical frequency dependent transmittance function. Further, the element optical thickness of each refractive element (24A) (24B) and the first separation distance are set such that the Fourier space components of the optical frequency dependent transmittance function of each refractive element (24A) (24B) fall outside a Fourier space measurement passband.

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: A spectral imaging device (12) includes an image sensor (28), a tunable light source (14), an optical assembly (17), and a control system (30). The optical assembly (17) includes a first refractive element (24A) and a second refractive element (24B) that are spaced apart from one another by a first separation distance. The refractive elements (24A) (24B) have an element optical thickness and a Fourier space component of the optical frequency dependent transmittance function. Further, the element optical thickness of each refractive element (24A) (24B) and the first separation distance are set such that the Fourier space components of the optical frequency dependent transmittance function of each refractive element (24A) (24B) fall outside a Fourier space measurement passband.

Abstract: A flow cell assembly (16) for a fluid analyzer (14) that analyzes a sample (12) includes (i) a base (350) that includes a base window (350B); (ii) a cap (352) having a cap window (352B) that is spaced apart from the base window (350B); and (iii) a gasket (360) that is secured to and positioned between the base (350) and the cap (352), the gasket (360) having a gasket body (360A) that includes a gasket opening (360B). The gasket body (360A), the base (350) and the cap (352) cooperate to define a flow cell chamber (362). Moreover, an inlet passageway (366) extends into the flow cell chamber (362) to direct the sample (12) into the flow cell chamber (362); and an outlet passageway (368) extends into the flow cell chamber (362) to allow the sample (12) to exit the flow cell chamber (362).

Abstract: A laser assembly (10) for generating a pulsed output beam (16) includes a quantum cascade device (12); and a laser driver (14A) that controls the voltage to the quantum cascade device (12) in a pulsed drive profile (950) to generate the pulsed output beam (16). The pulsed drive profile (950) includes a plurality of spaced on-time segments (952) in which the laser driver (14A) directs voltage to the quantum cascade device (12), and at least one off-time segment (954) in which the laser driver (14A) pulls down the voltage from the quantum cascade device (12). The off-time segment (954) occurs between two on-time segments (952).

Abstract: A method for identifying one or more analytes (12A)(12B)(12C) includes (i) directing a solvent (18) into a test cell (22); (ii) directing a first laser probe beam (26) at the solvent (18) in the test cell (22); (iii) acquiring a solvent intensity spectrum of the solvent (18); (iv) directing a sample (12) that includes one or more analytes (12A)(12B)(12C) and the solvent (18) into the flow cell (22); (v) directing a second laser probe beam (26) at the sample (12) in the test cell (22); (vi) acquiring a sample intensity spectrum of the sample (12); (vii) calculating a solvent referenced transmittance spectrum that details a solvent reference transmittance as a function of wavelength using the solvent intensity spectrum and the sample intensity spectrum; and (viii) identifying one or more analytes (12A)(12B)(12C) in the sample (12) using the solvent referenced transmittance spectrum.

Abstract: An imaging microscope (12) for generating an image of a sample (10) comprises a beam source (14) that emits a temporally coherent illumination beam (20), the illumination beam (20) including a plurality of rays that are directed at the sample (10); an image sensor (18) that converts an optical image into an array of electronic signals; and an imaging lens assembly (16) that receives rays from the beam source (14) that are transmitted through the sample (10) and forms an image on the image sensor (18). The imaging lens assembly (16) can further receive rays from the beam source (14) that are reflected off of the sample (10) and form a second image on the image sensor (18). The imaging lens assembly (16) receives the rays from the sample (10) and forms the image on the image sensor (18) without splitting and recombining the rays.

Abstract: A spectral imaging device (12) includes an image sensor (28), a tunable light source (14), an optical assembly (17), and a control system (30). The optical assembly (17) includes a first refractive element (24A) and a second refractive element (24B) that are spaced apart from one another by a first separation distance. The refractive elements (24A) (24B) have an element optical thickness and a Fourier space component of the optical frequency dependent transmittance function. Further, the element optical thickness of each refractive element (24A) (24B) and the first separation distance are set such that the Fourier space components of the optical frequency dependent transmittance function of each refractive element (24A) (24B) fall outside a Fourier space measurement passband.