Abstract: This application relates to, in part, modified botulinum Neurotoxins (BoNTs) comprising modified BoNT/A2 receptor binding domains with increased receptor binding activity, and methods of treatment using the modified BoNT.

Abstract: Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify the binding of the BoNT to the receptor. Specific mutations and combinations of mutations are also disclosed. Isolated modified HC, polypeptides comprising the modified HC, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed.

Abstract: A method, system and apparatus are disclosed. According to one or more Examples, an infrastructure network node (16) for providing a virtual multiple-input multiple-output. MIMO, cellular network supporting a plurality of network nodes (16) associated with a plurality of service providers. SPs is provided. The infrastructure network node (16) is configured to determine a downlink coordinated precoder for online multi-cell MIMO wireless network virtualization. WNV, where the downlink coordinated precoder is based at least on imperfect channel state information. CSI, and to optionally indicate the downlink coordinated precoder.

Abstract: The present disclosure pertains to the technical field of pharmaceutics, and relates to a 3,4-alkoxy substituted phenethyl lactam compound as an enzyme inhibitor of phosphodiesterases, a preparation method therefor, and pharmaceutical use thereof. Specifically, the present disclosure relates to a compound represented by general formula (I), a preparation method therefor, and use thereof in a medicament for preventing and/or treating a phosphodiesterase-associated disease.

Abstract: Described herein are Bacillus cells comprising a nucleotide sequence encoding a Botulinum neurotoxin (BoNT) and methods of producing the BoNT.

Abstract: A method and network node for distributed coordinated downlink precoding for multi-cell multiple input multiple output (MIMO) wireless network virtualization are disclosed. According to one aspect, a network node is configured to, in each of a plurality of successive transmission time periods: transmit to each of a plurality of SPs a corresponding set of channel information; receive from each of the plurality of SPs a service demand and a normalized precoding matrix, the normalized precoding matrix being determined by the corresponding SP based on the corresponding set of channel information; allocate a virtual transmit power to each of the plurality of SPs based at least in part on the received service demands and normalized precoding matrices; and determine a downlink precoding matrix to transmit messages to WDs, the downlink precoder matrix being based at least in part on the received service demands and normalized precoding matrices.

Abstract: A method and network node configured to perform wireless network virtualization to allocate resources of an infrastructure provider (InP) among a plurality of service providers (SPs) are provided. According to one aspect, a method in a network node includes, in each of a plurality of successive time slots in a time interval, T: receiving precoding feedback information from each SP, allocating a virtual transmit power to each cell served by an SP based at least in part on the received precoding feedback information and determining a precoding matrix for each SP. The method also includes minimizing a loss function based at least in part on the received precoding feedback information received in multiple previous time slots.

Abstract: A stator lamination includes a middle part, an annular yoke, and a plurality of stator teeth. The middle part includes a central hole. The plurality of stator teeth extend from the inner side of the annular yoke and are evenly distributed. A wire slot is formed between every two adjacent stator teeth, whereby the annular yoke includes a plurality of wire slots. Each of the plurality of stator teeth includes a tooth root and a pole shoe disposed at one end of the tooth root. The stator lamination has an outer diameter ranging from 61.75 mm to 68.25 mm, and the central hole has a diameter ranging from 31.6 mm to 35 mm. The plurality of wire slots are evenly distributed around an edge of a circle, and the bottom part of each wire slot is tangent to the circle.

Abstract: The present application describes in part isolated and modified Enterococci toxin (Epx) polypeptides, immunogenic compositions comprising Exp polypeptides, nanopores formed by Epx polypeptides, apparatus comprising Epx nanopores, and methods of use thereof.

Abstract: Aspects of the disclosure relate to Botulinum toxin X (BoNT X) protein variants. The variants provided herein have been evolved to cleave GTP cyclohydrolase 1 (GCH1). Some of the variants provided herein were evolved from a procaspase-1 cleaving polypeptide. Further aspects of the disclosure relate to nucleic acids encoding the GCH1 cleaving polypeptides described herein and expression vectors comprising the nucleic acids, as well as host cells and fusion proteins comprising the GCH1 cleaving polypeptides described herein, and kits comprising the GCH1 polypeptides, fusion proteins, nucleic acids, expression vectors, or host cells described herein. Further aspects of the disclosure relate to methods of producing BoNT X variants and methods of using the BoNT X protein variants, for example, to reduce pain.

Abstract: Embodiments of a method and network node for managing wireless devices (WDs) in a network are disclosed. In some embodiments, the method comprises grouping the plurality of WDs into clusters based at least in part on correlations between channels of the WDs. The method also includes determining beam forming weights for each cluster, the grouping into clusters and the determining of beam forming weights being performed to minimize a total transmit power to the plurality of WDs.

Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.

Abstract: Provided herein are methods of treating a Clostridioides difficile (C. difficile) infection in a subject. In some embodiments, a method of treating a C. difficile infection comprises administering an antagonist of neurogenic inflammation to a subject.

Abstract: A method, system and apparatus are disclosed. An edge node configured to communicate with a plurality of wireless devices (WDs) is described. The edge node includes a communication interface configured to receive a plurality of signal vectors from the plurality of WDs, where the plurality of signal vectors is based on a plurality of updated local models associated with the plurality of WDs. The edge node also includes processing circuitry in communication with the communication interface, where the processing circuitry is configured to update a global model based at least on the plurality of signal vectors; and cause at least one transmission of the updated global model to the plurality of WDs.

Abstract: Provided herein is a novel homolog of Clostridial botulinum neurotoxin (BoNT) identified in the bacterial species Enterococcus faecium (BoNT/EN). BoNT/EN variants and chimeric toxins comprising domains from BoNT/EN and other BoNTs are also provided. Further provided herein are methods of producing BoNT/EN and its use, e.g., in therapeutic applications.

Abstract: A method, system and apparatus are disclosed. According to one or more Examples, an infrastructure network node (16) for providing a virtual multiple-input multiple-output. MIMO, cellular network supporting a plurality of network nodes (16) associated with a plurality of service providers. SPs is provided. The infrastructure network node (16) is configured to determine a downlink coordinated precoder for online multi-cell MIMO wireless network virtualization. WNV, where the downlink coordinated precoder is based at least on imperfect channel state information. CSI, and to optionally indicate the downlink coordinated precoder.

Abstract: A method, system and apparatus are disclosed. According to one aspect, a network node configured to communicate with a wireless device (WD), includes processing circuitry configured to perform downlink wireless network virtualization by minimizing an expected deviation of received signals at WDs subject to network node power constraints.

Abstract: A method, network node and processor for processing uplink signals transmitted from a wireless device (WD) to provide a combination of quantize-forwarding and decode-forwarding relayed signals in massive multiple input multiple output (MIMO) heterogeneous networks (HetNets). According to one aspect, whether quantize-forwarding or decode-forwarding is used depends on a ratio of a quality of a WD signal received at a Small Cell Base Station (SCBS) to a quality of the WD signal received at a Macro Cell Base Station (MCBS). When the ratio is less than a first threshold, signals received at the SCBS may be quantize-forwarded to the MCBS and when the ratio exceeds a second threshold larger than the first threshold, signals received at the SCBS may be decode-forwarded to the MCBS. When the ratio lies between the first and second threshold, signals received at the SCBS may be quantize-forwarded to the MCB.

Abstract: Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified protease domains of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations, isolated modified protease domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed.

Abstract: A method and network node for online coordinated multi-cell precoding are provided. According to one aspect, a method includes receiving from each of the plurality of service providers a virtual precoder matrix determined by the corresponding service provider. The method also includes determining a precoder matrix by minimizing a precoding deviation from a virtualization demand of the network subject to at least one power constraint, the virtualization demand being based at least in part on a product of a channel state matrix and a virtual precoder matrix. The method further includes applying the determined precoder matrix to signals applied to a plurality of antennas to achieve a sum of throughputs for the plurality of service providers that is greater than a sum of throughputs for the plurality of service providers achievable when the virtual precoder matrices are applied to the signals.