Abstract: A method and network node configured to perform wireless network virtualization to allocate resources of an infrastructure provider (InP) among a plurality of service providers (SPs) are provided. According to one aspect, a method in a network node includes, in each of a plurality of successive time slots in a time interval, T: receiving precoding feedback information from each SP, allocating a virtual transmit power to each cell served by an SP based at least in part on the received precoding feedback information and determining a precoding matrix for each SP. The method also includes minimizing a loss function based at least in part on the received precoding feedback information received in multiple previous time slots.

Abstract: The present disclosure relates to a passive fiber optic cabinet and a system for detecting a state of a door of a passive fiber optic cabinet. A passive fiber optic cabinet is provided, comprising: a housing; a door coupled to the housing and configured to be switchable between an open state and a closed state; a switch sensor module including a detection fiber Bragg grating (FBG) sensor and a stress applying mechanism corresponding to the detection FBG sensor, the stress applying mechanism configured to apply a stress o the detection FBG sensor, one of the detection FBG sensor and the stress applying mechanism being positioned at the door, and the other of the detection FBG sensor and the stress applying mechanism being positioned at the housing.

Abstract: A method and network node for distributed coordinated downlink precoding for multi-cell multiple input multiple output (MIMO) wireless network virtualization are disclosed. According to one aspect, a network node is configured to, in each of a plurality of successive transmission time periods: transmit to each of a plurality of SPs a corresponding set of channel information; receive from each of the plurality of SPs a service demand and a normalized precoding matrix, the normalized precoding matrix being determined by the corresponding SP based on the corresponding set of channel information; allocate a virtual transmit power to each of the plurality of SPs based at least in part on the received service demands and normalized precoding matrices; and determine a downlink precoding matrix to transmit messages to WDs, the downlink precoder matrix being based at least in part on the received service demands and normalized precoding matrices.

Abstract: Deimmunized botulinum toxin light chain (e.g., botulinum toxin serotype A light chains (BoNT/A-LC)) or fragments thereof are provided. Methods for treating or preventing diseases or disorders comprising administering to a subject a deimmunized botulinum toxin light chain (e.g., BoNT/A-LC) are provided.

Abstract: A method and network node for online coordinated multi-cell precoding are provided. According to one aspect, a method includes receiving from each of the plurality of service providers a virtual precoder matrix determined by the corresponding service provider. The method also includes determining a precoder matrix by minimizing a precoding deviation from a virtualization demand of the network subject to at least one power constraint, the virtualization demand being based at least in part on a product of a channel state matrix and a virtual precoder matrix. The method further includes applying the determined precoder matrix to signals applied to a plurality of antennas to achieve a sum of throughputs for the plurality of service providers that is greater than a sum of throughputs for the plurality of service providers achievable when the virtual precoder matrices are applied to the signals.

Abstract: Disclosed herein are means for the detection and characterization of neurotoxins such as botulinum neurotoxin (BoNT) or tetanus neurotoxin. The present disclosure provides methods for determining potency and activity of neurotoxins in vitro and in vivo. Also disclosed are polypeptides comprising N- and C-terminal fragments of a reporter protein that are split by a linker comprising a neurotoxin cleavage site. Cleavage of the linker by a neurotoxin decreases reporter protein activity, thereby indicating activity of the neurotoxin. Compositions and kits comprising the disclosed polypeptides, nucleic acids comprising nucleotide sequences encoding such polypeptides, and cells expressing such polypeptides are also disclosed.

Abstract: In accordance with some aspects of the disclosure, a modular telecommunications patch panel system is shown and described. The panel can include a mounting frame extending between a first end and a second end, the mounting frame defining a plurality of apertures for receiving telecommunications components, a first mounting ear forming a snap-fit connection with the mounting frame first end, in a first orientation, and a second mounting ear, identical to the first mounting ear, forming a snap-fit connection with the mounting frame second end, in a second orientation.

Abstract: A splice cassette (100) includes a housing (114) which defines a first and a second interiors (132,134) facing in opposite directions. A first splice region (150) is disposed in the first interior (132) and a second splice region (152) is disposed in the second interior (134). A splice holder (180,185) can be mounted removably at one or more of the splice regions (150,152).

Abstract: A method, network node and processor for processing uplink signals transmitted from a wireless device (WD) to provide a combination of quantize-forwarding and decode-forwarding relayed signals in massive multiple input multiple output (MIMO) heterogeneous networks (HetNets). According to one aspect, whether quantize-forwarding or decode-forwarding is used depends on a ratio of a quality of a WD signal received at a Small Cell Base Station (SCBS) to a quality of the WD signal received at a Macro Cell Base Station (MCBS). When the ratio is less than a first threshold, signals received at the SCBS may be quantize-forwarded to the MCBS and when the ratio exceeds a second threshold larger than the first threshold, signals received at the SCBS may be decode-forwarded to the MCBS. When the ratio lies between the first and second threshold, signals received at the SCBS may be quantize-forwarded to the MCB.

Abstract: Provided herein, in aspects, are catalytically inactive BoNT-like toxins from Clostridium botulinum, serotype X (BoNT/NX) from Enterococcus faecium (BoNT/En) or from Paraclostridium bifermentans (BoNT/PMP1) and their use as delivery vehicles to deliver an agent (e.g., a therapeutic agent or a diagnostic agent) to a cell. Methods of treating a disease (e.g., botulism) are also provided.

Abstract: Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides, e.g., in therapeutic applications.

Abstract: Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify the binding of the BoNT to the receptor. Specific mutations and combinations of mutations are also disclosed. Isolated modified HC, polypeptides comprising the modified HC, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed.

Abstract: Disclosed herein are means for the detection and characterization of neurotoxins such as botulinum neurotoxin (BoNT) or tetanus neurotoxin. The present disclosure provides methods for determining potency and activity of neurotoxins in vitro and in vivo. Also disclosed are polypeptides comprising N- and C-terminal fragments of a reporter protein that are split by a linker comprising a neurotoxin cleavage site. Cleavage of the linker by a neurotoxin decreases reporter protein activity, thereby indicating activity of the neurotoxin. Compositions and kits comprising the disclosed polypeptides, nucleic acids comprising nucleotide sequences encoding such polypeptides, and cells expressing such polypeptides are also disclosed.

Abstract: A method, system and apparatus are disclosed. According to one aspect, a network node configured to communicate with a wireless device (WD), includes processing circuitry configured to perform downlink wireless network virtualization by minimizing an expected deviation of received signals at WDs subject to network node power constraints.

Abstract: Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides, e.g., in therapeutic applications.

Abstract: The present disclosure relates to a fiber optic closure which comprises a tray, a fiber optic adapter arranged on the tray, an output fiber optic connector and an input fiber optic connector inserted into both sides of the fiber optic adapter, and a fiber optic management device configured to accommodate an overlength portion of an output fiber optic connected to the output fiber optic connector. The fiber optic management device comprises a closure fixing part and a fiber optic storage which are mutually connected, the closure fixing part being provided for fixing the fiber optic storage into the fiber optic closure and the fiber optic storage being provided for accommodating the overlength portion of the output fiber optic. The present fiber optic management device can individually store the overlength portion of each of the internal optical fibers, thereby preventing the problem of stacking and entanglement of a plurality of internal optical fibers.

Abstract: Disclosed herein is a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify the binding of the BoNT to the receptor. Specific mutations and combinations of mutations are also disclosed. Isolated modified HC, polypeptides comprising the modified HC, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed.

Abstract: Provided herein are Clostridial Botulinum neurotoxin (BoNT) polypeptides of a novel serotype (BoNT/X) and methods of making and using the BoNT polypeptides, e.g., in therapeutic applications.

Abstract: Disclosed herein are methods for the isolation and purification of a botulinum neurotoxin (BoNT) protein, or a polypeptide comprising a receptor binding domain of BoNT, from a solution. The method comprises contacting the solution containing the protein or polypeptide to a matrix which has attached thereto a non-toxic non-hemagglutinin (NTNHA) under conditions appropriate for binding, washing the matrix to thereby remove unbound materials, and eluting the protein or polypeptide with a solution that dissociates the bound protein from the NTNHA. Conditions appropriate for binding are a pH of less than 7.5 (e.g, 6). Conditions appropriate for dissociation are a pH greater than or equal to 7.5 (e.g., 8). Compositions specific to the methods are also disclosed.

Abstract: Disclosed herein are botulinum neurotoxin (BoNT) polypeptides with a modified BoNT/B4 receptor binding domain (B4-HC) having amino acid mutations that modify the binding of the BoNT to the human SytII receptor. Specific mutations and combinations of mutations are disclosed. Isolated modified HCs, polypeptides comprising such modified HCs, chimeric molecules, pharmaceutical compositions, and methods of making and using the same are also disclosed. Methods of identifying additional such modified receptor binding domains, are further disclosed.