Abstract: The present disclosure provides compounds of Formulas (I?) and (I), and pharmaceutically acceptable salts thereof. The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses thereof for treating proliferative diseases.

Abstract: A current file is obtained in the data. It is determined whether a similar historical file exists based on a sampled data block from at least one predetermined location in the current file. In response to non-existence of the similar historical file, the current file and corresponding metadata are stored on a file basis. In response to existence of the similar historical file, a deduplication operation is applied on the current file on a block basis.

Abstract: The system includes a data synchronization module and a heat data module. The data synchronization module is configured to communicate with a first storage volume and a second storage volume to provide a backup for the first storage volume by synchronizing information from the first storage volume to the second storage volume. The information includes at least one of data chunks, heat map data, and first metadata relating to the first storage volume. The heat data module is coupled to the second storage volume to read the first metadata and the heat map data and adjust a location of at least one of the data chunks in the second storage volume based on the heat map data.

Abstract: Methods that copy data from mirrored storage to auxiliary storage arrays co-located with primary storage arrays are provided. One method includes requesting a subset of the data from a backup system mirroring the set of data at a remote location in response to detecting an error in a storage device of an array of primary storage devices storing a set of data. The method further includes receiving the subset of the data from the backup system and storing the subset of the data in an array of auxiliary storage devices co-located with the array of primary storage devices in which the subset of the data can correspond to data stored on the storage device. Systems and computer program products for performing the above method are also provided.

Abstract: A computer-implemented method for recovering data and concurrently rebuilding indexes for the recovered data in a database for a system configured to store fewer than all indexes in backup files may include copying data from one or more database files and storing the copied data to one or more backup files. A recovery manager executing on a processor may read the copied data from the one or more backup files and write the copied data to the one or more database files, wherein the data is recovered to the one or more database files. In response to the reading, an index manager executing on the processor may initiate a rebuilding of one or more indexes for the copied data at substantially the same time as the reading of the copied data.

Abstract: The present invention relates to an illumination device, including: a support member; and at least one first light source on the support member and at least one second light source on the support member, where the first light source has a first light distribution, the second light source has a second light distribution, and the first light distribution is different from the second light distribution.

Abstract: A computer-implemented method for recovering data and concurrently rebuilding indexes for the recovered data in a database for a system configured to store fewer than all indexes in backup files may include copying data from one or more database files and storing the copied data to one or more backup files. A recovery manager executing on a processor may read the copied data from the one or more backup files and write the copied data to the one or more database files, wherein the data is recovered to the one or more database files. In response to the reading, an index manager executing on the processor may initiate a rebuilding of one or more indexes for the copied data at substantially the same time as the reading of the copied data.

Abstract: A method for managing data storage. The method included a processor identifying a plurality of first utilization values for data within a first data storage system, wherein the data includes a plurality of extents and the plurality of first utilization values corresponds to the plurality of extents are included in the data. The method further includes a processor transferring the data from the first data storage system to a second data storage system, wherein the second data storage system includes a plurality of solid-state drives (SSDs). The method further includes a processor storing the transferred data among the plurality of SSDs based, at least in part on, the plurality of first utilization values.

Abstract: One or more processors migrate an amount of cloud data from a non-volatile memory to a volatile cache memory. One or more processors partition the amount of cloud data into a plurality of objects of a size that allow for a satisfactory read/write throughput performance. One or more processors analyze the plurality of objects for input/output performance over a time period. One or more processors migrate a first portion of the plurality of objects back to the non-volatile memory, wherein the first portion of the plurality of objects exhibit a first input/output performance lower than a first threshold value.

Abstract: A semiconductor device structure is provided. The semiconductor device structure includes a substrate having a first source region, a second source region, a first drain region, and a second drain region. The semiconductor device structure includes a first gate structure over the substrate and between the first source region and the first drain region. The semiconductor device structure includes a second gate structure over the substrate and between the second source region and the second drain region. A first thickness of the first gate structure is greater than a second thickness of the second gate structure. A first gate width of the first gate structure is less than a second gate width of the second gate structure.

Abstract: The present invention provides an LED lamp and a temperature control circuit applied to the LED lamp. The LED lamp includes at least one LED unit, a magnetic ballast, and an LED drive circuit. The magnetic ballast is coupled to a power and configured to limit and stabilize a received alternating current. The LED drive circuit includes a temperature control circuit. The temperature control circuit is coupled to the magnetic ballast and connected in parallel with the LED unit, is configured to detect an internal temperature of the LED lamp and adjust an output power of the LED unit, and includes a thermal sensitive module having a negative temperature coefficient thermistor and a phase cut circuit.

Abstract: Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1), ZA-7-CA-amide (7) and ZA-7-Nap (43) for simultaneous inhibition of influenza virus neuraminidase and suppression of proinflammatory cytokines. Synthetic methods for preparation of these enhanced anti-influenza conjugate drugs are provided. The synthetic bifunctional ZA conjugates act synergistically towards protection of mice lethally infected by H1N1 or H5N1 influenza viruses. The efficacy of ZA-7-CA, ZA-7-CA-amide and ZA-7-Nap conjugates is much greater than the combination therapy of ZA with anti-inflammatory agents.

Abstract: Methods for treating pain such as fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog may be a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the adenosine analog for use in treating pain (e.g., fibromyalgia), optionally further comprising Substance P (SP), are also provided.

Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

Abstract: The system includes a plurality of storage volumes, a data synchronization module, a space-efficient storage module, and a heat data module. A second storage volume of the plurality of storage volumes includes a backup storage location for a first storage volume. The data synchronization module, coupled to the first storage volume and the second storage volume, provides a backup by synchronizing information from the first storage volume to the second storage volume during a synchronization event. The information includes data chunks, heat map data, and first metadata. The space-efficient storage module receives the information from the data synchronization module and allocates the information to the second storage volume in accordance with a space-efficient storage model. The heat data module reads the first metadata and the heat map data and adjusts a location of the data chunks in the second storage volume based on the heat map data.

Abstract: Provided is a method of making colloidal metal nanoparticles. The method includes the steps of: mixing a metal aqueous solution and a reducing agent to form a mixture solution in a reaction tank; heating the mixture solution and undergoing a reduction reaction to produce a composition containing metal nanoparticles, residues and gas, wherein the amount of the residues is less than 20% by volume of the mixture solution, and guiding the gas out of the reaction tank; dispersing the metal nanoparticles with a medium to obtain colloidal metal nanoparticles. By separating the reduction reaction step and the dispersion step, the method of making colloidal metal nanoparticles is simple, safe, time-effective, cost-effective, and has the advantage of high yield.

Abstract: Embodiments include a load calculator, a workload analyzer, and a decision module. The load calculator generates an input/output (IO) record for an asset. The IO record includes a count of read operations and write operations corresponding to the asset from each of a plurality of sites. The workload analyzer collects the IO record and generates at least one of a write threshold and a read threshold. The decision module generates a request for at least one of a promotion and a copy of the asset in response to a determination that an operation has reached at least one of the write threshold and the read threshold for the asset.

Abstract: A semiconductor device structure is provided. The semiconductor device structure includes a substrate having a first source region, a second source region, a first drain region, and a second drain region. The semiconductor device structure includes a first gate structure over the substrate and between the first source region and the first drain region. The semiconductor device structure includes a second gate structure over the substrate and between the second source region and the second drain region. A first thickness of the first gate structure is greater than a second thickness of the second gate structure. A first gate width of the first gate structure is less than a second gate width of the second gate structure.

Abstract: A current file is obtained in the data. It is determined whether a similar historical file exists based on a sampled data block from at least one predetermined location in the current file. In response to non-existence of the similar historical file, the current file and corresponding metadata are stored on a file basis. In response to existence of the similar historical file, a deduplication operation is applied on the current file on a block basis.

Abstract: An ultrasonic gas flow meter based on FPGA and DSP consists of ultrasonic gas transducers and sensor components, transmitting/receiving signal channel switch circuits, a driving signal generation and amplification circuit, an echo signal conditioning and collection circuit, a time sequential controlling and signal processing circuit, a man-machine interface, a serial communication module and a power management module, propagation time of ultrasonic echo waves is calculated by adopting a variable ratio threshold and zero-crossing detection method of tracking maximum peak of the echo signal to obtain gas flow rates.