Abstract: Methods and systems for mid-cycle desaturation during magnetic energy harvesting (MEH) are provided. Four different mid-cycle desaturation strategies can be employed, each of which generates multiple power transfer windows within an alternating current (AC) half-cycle. All four strategies enable much higher energy extraction compared to MEH without utilizing any of the four strategies.

Abstract: Provided herein are compositions comprising a nucleic acid encoding amyloid-beta precursor protein and/or a nucleic acid encoding presenilin-1, cells comprising the compositions, animals comprising the compositions, methods of making the cells and animals, methods of modeling Alzheimer's disease, methods of assessing a therapeutic candidate for the treatment of Alzheimer's disease or amelioration of a symptom or phenotype of Alzheimer's disease, and methods of assessing a therapeutic candidate for the prevention of Alzheimer's disease or prevention of a symptom or phenotype of Alzheimer's disease.

Abstract: A method for prognostic survival stage prediction based on machine learning includes acquiring patients' original information data within a previous preset time period and integrating the patients' original information data so as to obtain a first data set without recurrence time and a second data set with recurrence time; performing analysis based on preoperative information, postoperative information and survival status of each corresponding patient, so as to obtain a correlation degree among the preoperative information, the postoperative information and the survival status; and training in the first data set, so as to obtain a postoperative survival probability prediction model. The method includes training in the second data set, so as to obtain a survival time period prediction model if judging that a survival probability of a target patient is less than or equal to a preset value according to the postoperative survival probability prediction model.

Abstract: The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.

Abstract: A Lyophyllum decastes polysaccharide, a preparation method and an application thereof are provided in the present disclosure, relating to the technical field of biomedicine. The preparation method includes the following steps: (1) adding an aqueous solution containing EDTA-2Na into a fruiting body of Lyophyllum decastes, performing ultrasonic treatment, and then performing water extraction treatment to obtain an extractive solution; (2) concentrating the extractive solution, adding anhydrous ethanol for precipitation, followed by centrifuging to obtain precipitates, then obtaining a crude Lyophyllum decastes polysaccharide; and (3) conducting removal of proteins and dialysis of the crude Lyophyllum decastes polysaccharide to obtain the Lyophyllum decastes polysaccharide.

Abstract: A Lyophyllum decastes polysaccharide, a preparation method and an application thereof are provided in the present disclosure, relating to the technical field of biomedicine. The preparation method includes the following steps: (1) adding an aqueous solution containing EDTA-2Na into a fruiting body of Lyophyllum decastes, performing ultrasonic treatment, and then performing water extraction treatment to obtain an extractive solution; (2) concentrating the extractive solution, adding anhydrous ethanol for precipitation, followed by centrifuging to obtain precipitates, then obtaining a crude Lyophyllum decastes polysaccharide; and (3) conducting removal of proteins and dialysis of the crude Lyophyllum decastes polysaccharide to obtain the Lyophyllum decastes polysaccharide.

Abstract: The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.

Abstract: In some embodiments, a method transcodes a first location from a spatial region. The first location is associated with a first pattern defining a structure of splitting a location into smaller shapes. A bit string of bits is included for the first pattern in an encoded bitstream. The method determines the first location in the spatial region when the first pattern of the first location can be reused for a second pattern of a second location. The first location is one of a plurality of locations in the spatial region. Information for the second location is included in the encoded bitstream that indicates the first location in the spatial region without including a bit string of bits for the second pattern. The first location allows the bit string of bits for the first pattern to be retrieved for use to decode the second location from the encoded bitstream.

Abstract: A toothed power transmission belt with a smooth back side surface has a back jacket on the back side surface; wherein the back jacket comprises a closed-mesh, knit fabric tube. The fabric tube may be knitted on a circular weft knitting machine and may be heat set after knitting. The fabric tube may be treated with an epoxy, RFL or other treatment to provide for oil resistance, adhesion, frictional properties, etc.

Abstract: A method includes transcoding a first block from a spatial region. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream. The method determines a location of the first block in the spatial region when the first block tree pattern of the first block can be reused for a second block tree pattern of a second block. The spatial region includes blocks and the location is based on the first block being in the spatial region. Information for the second block is included in the encoded bitstream that indicates the location of the first block in the spatial region. The location allows the bit string for the first block tree pattern to be retrieved for use to decode the second block.

Abstract: Provided, in part, are an anti-human transferrin receptor antigen-binding proteins and fusion proteins comprising an anti-human transferrin receptor antigen-binding proteins (e.g., in scFv, Fab or antibody format) which may be fused to a payload for delivery of the payload to a targeted tissue (e.g., past the blood-brain barrier and to the brain). Payloads include, for example, alpha-glucosidase (GAA) polypeptide. Methods for treating various diseases with such molecules, e.g., glycogen storage diseases, such as Pompe Disease, with the fusions are provided.

Abstract: Nucleic acid constructs and compositions that allow insertion of a multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence into a target genomic locus such as an endogenous ALB locus and/or expression of the multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence are also provided. The nucleic acid constructs and compositions can be used in methods of integration of a multidomain therapeutic protein (e.g., GAA fusion protein) nucleic acid into a target genomic locus, methods of expression of a multidomain therapeutic protein (e.g., GAA fusion protein) in a cell, methods of reducing glycogen accumulation, methods of treating Pompe disease or GAA deficiency in a subject, and method of preventing or reducing the onset of a sign or symptom of Pompe disease in a subject, including neonatal cells and subjects.

Abstract: In some embodiments, a method performs a first calculation to select an anchor point based on a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference frame is selected as the anchor point. A third reference block in the second reference frame is selected based on the first reference frame being selected as the anchor point. The method performs a second calculation to select the anchor point based on the first reference block in the first reference frame and the third reference block in the second reference frame and determines whether to use the first reference block and the third reference block as a prediction for a current block based on the second calculation.

Abstract: A method includes transcoding a first block from a spatial region. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream. The method determines a location of the first block in the spatial region when the first block tree pattern of the first block can be reused for a second block tree pattern of a second block. The spatial region includes blocks and the location is based on the first block being in the spatial region. Information for the second block is included in the encoded bitstream that indicates the location of the first block in the spatial region. The location allows the bit string for the first block tree pattern to be retrieved for use to decode the second block.

Abstract: Technologies are disclosed for resource mapping during URL changes in multi-tenant distributed computing systems. The distributed computing system may resolve a URL by using a tenant and/or site name extracted from the URL to retrieve an entry in a site map table. The entry includes an address to a database that contains the requested content. After a tenant or site name has been changed, or if the tenant or site have been moved, the distributed computing system will resolve pre-existing URLs to the old entry, resulting in a file not found error. In some embodiments, during an operation that changes a tenant or site name, a redirect URL containing the new tenant and/or site name is added to the old entry. When a request addressed to a URL containing the old tenant and/or site names is received, the distributed system sends a redirect response that includes the redirect URL.

Abstract: A method includes transcoding a first block of a video. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream for the video. The method determines that the first block tree pattern of the first block can be reused for a second block tree pattern of a second block and includes information in the encoded bitstream that indicates that the first block tree pattern is to be used to decode the second block from the encoded bitstream.

Abstract: Textile reinforced elastomeric composites having a textile reinforcement embedded in an elastomeric matrix. The textile reinforcement includes fibers or yarns and an adhesive treatment applied to the fibers wherein the adhesive treatment comprises graphene or graphene oxide. The textile reinforcement may be a fabric or a tensile cord. The fibers may be polyester, aramid, carbon fiber, glass fiber, PBO, PEN, or polyamide. The adhesive treatment may be an epoxy treatment, an epoxy-latex treatment, an acrylic polymer treatment, a latex treatment, a polyurethane treatment, an RFL treatment, a rubber cement, or combinations thereof. The composite may be in the form of a toothed belt wherein the textile reinforcement is a tooth cover or a helically wound tensile cord embedded in the belt.

Abstract: A power transmission belt having a belt body, a tensile cord embedded in the belt body, and a jacket defining a pulley contact surface, where the jacket has been treated on at least the pulley contact surface with an aqueous fabric treatment or dip which includes an aqueous PEEK dispersion as part of the dip. The aqueous dip may further include an epoxy and a rubber latex. The aqueous dip may further include graphene or graphene oxide. The fabric may include aramid or nylon fibers. The jacket may cover the teeth of a toothed belt.

Abstract: The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.