Patents by Inventor Min Gao

Min Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11951618
    Abstract: A multi-procedure integrated automatic production line for hard alloy blades under robot control is provided. The production line includes a rail-guided robot. A cutter passivation device and a blade cleaning and drying device are arranged on one side of the rail-guided robot. A blade-coating transfer table, a blade coating device, a blade boxing transfer table, a blade-tooling dismounting device and a blade boxing device are sequentially arranged on another side of the rail-guided robot. The blade-tooling dismounting device is arranged on one side of the blade boxing transfer table. The production line further includes squirrel-cage toolings for carrying the blades. The squirrel-cage tooling that are loaded with the blades can run among the cutter passivation device, the blade cleaning and drying device, the blade-coating transfer table and the blade boxing transfer table. The blades after being treated through the blade-tooling dismounting device are sent to the blade boxing device.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: April 9, 2024
    Assignees: Qingdao University of Technology, Ningbo Sanhan Alloy Material Co., Ltd.
    Inventors: Changhe Li, Teng Gao, Liang Luo, Lizhi Tang, Yanbin Zhang, Weixi Ji, Binhui Wan, Shuo Yin, Huajun Cao, Bingheng Lu, Xin Cui, Mingzheng Liu, Jie Xu, Huiming Luo, Haizhou Xu, Min Yang, Huaping Hong, Yuying Yang, Haogang Li, Wuxing Ma, Shuai Chen
  • Patent number: 11938653
    Abstract: The present invention relates to a powder dry-pressing molding device and method.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: March 26, 2024
    Assignees: QINGDAO UNIVERSITY OF TECHNOLOGY, SHENYANG HONGYANG PRECISION CERAMICS CO., LTD.
    Inventors: Changhe Li, Mingcun Shi, Xiangyang Ma, Baoda Xing, Xiaohong Ma, Yanbin Zhang, Min Yang, Xin Cui, Teng Gao, Xiaoming Wang, Yali Hou, Han Zhai, Zhen Wang, Bingheng Lu, Huajun Cao, Naiqing Zhang, Qidong Wu
  • Patent number: 11930196
    Abstract: A method includes transcoding a first block from a spatial region. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream. The method determines a location of the first block in the spatial region when the first block tree pattern of the first block can be reused for a second block tree pattern of a second block. The spatial region includes blocks and the location is based on the first block being in the spatial region. Information for the second block is included in the encoded bitstream that indicates the location of the first block in the spatial region. The location allows the bit string for the first block tree pattern to be retrieved for use to decode the second block.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: March 12, 2024
    Assignee: HULU, LLC
    Inventors: Wenhao Zhang, Deliang Fu, Min Gao, Juncheng Ma, Chen Liu
  • Publication number: 20240052051
    Abstract: Provided, in part, are an anti-human transferrin receptor antigen-binding proteins and fusion proteins comprising an anti-human transferrin receptor antigen-binding proteins (e.g., in scFv, Fab or antibody format) which may be fused to a payload for delivery of the payload to a targeted tissue (e.g., past the blood-brain barrier and to the brain). Payloads include, for example, alpha-glucosidase (GAA) polypeptide. Methods for treating various diseases with such molecules, e.g., glycogen storage diseases, such as Pompe Disease, with the fusions are provided.
    Type: Application
    Filed: July 28, 2023
    Publication date: February 15, 2024
    Inventors: Nicole Keating, Pascaline Aimé-Wilson, John Dugan, Min Gao, Robert Babb, Maria Praggastis, Katherine Cygnar, Bojie Zhang
  • Publication number: 20230338477
    Abstract: Nucleic acid constructs and compositions that allow insertion of a multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence into a target genomic locus such as an endogenous ALB locus and/or expression of the multidomain therapeutic protein (e.g., GAA fusion protein) coding sequence are also provided. The nucleic acid constructs and compositions can be used in methods of integration of a multidomain therapeutic protein (e.g., GAA fusion protein) nucleic acid into a target genomic locus, methods of expression of a multidomain therapeutic protein (e.g., GAA fusion protein) in a cell, methods of reducing glycogen accumulation, methods of treating Pompe disease or GAA deficiency in a subject, and method of preventing or reducing the onset of a sign or symptom of Pompe disease in a subject, including neonatal cells and subjects.
    Type: Application
    Filed: February 2, 2023
    Publication date: October 26, 2023
    Inventors: Andrew Baik, Maria Praggastis, Katherine Cygnar, Leah Sabin, Poulami Samai, Evangelos Pefanis, Philip Calafati, Nicole Keating, Pascaline Aimé-Wilson, John Dugan, Min Gao, Robert Babb, Anthony Forget
  • Patent number: 11800088
    Abstract: In some embodiments, a method performs a first calculation to select an anchor point based on a first reference block in a first reference frame and a second reference block in a second reference frame. The first reference frame is selected as the anchor point. A third reference block in the second reference frame is selected based on the first reference frame being selected as the anchor point. The method performs a second calculation to select the anchor point based on the first reference block in the first reference frame and the third reference block in the second reference frame and determines whether to use the first reference block and the third reference block as a prediction for a current block based on the second calculation.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: October 24, 2023
    Assignee: HULU, LLC
    Inventors: Wenhao Zhang, Deliang Fu, Min Gao, Juncheng Ma, Chen Liu
  • Publication number: 20230179782
    Abstract: A method includes transcoding a first block from a spatial region. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream. The method determines a location of the first block in the spatial region when the first block tree pattern of the first block can be reused for a second block tree pattern of a second block. The spatial region includes blocks and the location is based on the first block being in the spatial region. Information for the second block is included in the encoded bitstream that indicates the location of the first block in the spatial region. The location allows the bit string for the first block tree pattern to be retrieved for use to decode the second block.
    Type: Application
    Filed: February 3, 2023
    Publication date: June 8, 2023
    Applicant: HULU, LLC
    Inventors: Wenhao Zhang, Deliang Fu, Min Gao, Juncheng Ma, Chen Liu
  • Patent number: 11659019
    Abstract: Technologies are disclosed for resource mapping during URL changes in multi-tenant distributed computing systems. The distributed computing system may resolve a URL by using a tenant and/or site name extracted from the URL to retrieve an entry in a site map table. The entry includes an address to a database that contains the requested content. After a tenant or site name has been changed, or if the tenant or site have been moved, the distributed computing system will resolve pre-existing URLs to the old entry, resulting in a file not found error. In some embodiments, during an operation that changes a tenant or site name, a redirect URL containing the new tenant and/or site name is added to the old entry. When a request addressed to a URL containing the old tenant and/or site names is received, the distributed system sends a redirect response that includes the redirect URL.
    Type: Grant
    Filed: December 1, 2019
    Date of Patent: May 23, 2023
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Adriana Wood, Min Gao, Yanxia Xu, Feng Zhang, Andrei-Dumitru Blotu, Hanwen Wang, Hongzhou Ma, Seshadri Mani
  • Patent number: 11601660
    Abstract: A method includes transcoding a first block of a video. The first block is associated with a first block tree pattern defining a structure of splitting a block into smaller blocks. A bit string of bits for the first block tree pattern is included in an encoded bitstream for the video. The method determines that the first block tree pattern of the first block can be reused for a second block tree pattern of a second block and includes information in the encoded bitstream that indicates that the first block tree pattern is to be used to decode the second block from the encoded bitstream.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: March 7, 2023
    Assignee: HULU, LLC
    Inventors: Wenhao Zhang, Deliang Fu, Min Gao, Juncheng Ma, Chen Liu
  • Publication number: 20230057811
    Abstract: A power transmission belt having a belt body, a tensile cord embedded in the belt body, and a jacket defining a pulley contact surface, where the jacket has been treated on at least the pulley contact surface with an aqueous fabric treatment or dip which includes an aqueous PEEK dispersion as part of the dip. The aqueous dip may further include an epoxy and a rubber latex. The aqueous dip may further include graphene or graphene oxide. The fabric may include aramid or nylon fibers. The jacket may cover the teeth of a toothed belt.
    Type: Application
    Filed: August 17, 2022
    Publication date: February 23, 2023
    Inventors: Min Gao, GuoGong Chen, Carol Weber
  • Publication number: 20230059945
    Abstract: Textile reinforced elastomeric composites having a textile reinforcement embedded in an elastomeric matrix. The textile reinforcement includes fibers or yarns and an adhesive treatment applied to the fibers wherein the adhesive treatment comprises graphene or graphene oxide. The textile reinforcement may be a fabric or a tensile cord. The fibers may be polyester, aramid, carbon fiber, glass fiber, PBO, PEN, or polyamide. The adhesive treatment may be an epoxy treatment, an epoxy-latex treatment, an acrylic polymer treatment, a latex treatment, a polyurethane treatment, an RFL treatment, a rubber cement, or combinations thereof. The composite may be in the form of a toothed belt wherein the textile reinforcement is a tooth cover or a helically wound tensile cord embedded in the belt.
    Type: Application
    Filed: August 17, 2022
    Publication date: February 23, 2023
    Inventors: Min Gao, GuoGong Chen, Kelechi C. Anyaogu, Carol Weber
  • Publication number: 20220411515
    Abstract: The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.
    Type: Application
    Filed: June 9, 2021
    Publication date: December 29, 2022
    Applicant: REGENERON PHARMACEUTICALS, INC.
    Inventors: Susan CROLL, Min GAO, Ying HU
  • Publication number: 20220361464
    Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.
    Type: Application
    Filed: June 30, 2022
    Publication date: November 17, 2022
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Alexander O. Mujica, Yajun Tang, Jeffrey D. Lee, Min Gao, Susan D. Croll, Lynn Macdonald, Ying Hu, Carmelo Romano
  • Patent number: 11458190
    Abstract: The invention relates to a mussel adhesive protein (MAP) and an application thereof in inhibiting catarrh, and specifically, to applications of a MAP or a product thereof in oral mucositis, rhinitis, otitis media, pharyngitis, laryngitis, bronchitis, esophagitis, gastritis, enteritis, cervicitis, endomyometritis, inflammation resulting from inhalation injury, and oral cavity cancer, nasopharyngeal cancer, carcinoma of middle ear, conjunctival cancer, laryngeal cancer, lung cancer, esophageal cancer, stomach cancer, bowel cancer, cervical cancer, endometrial cancer, and other cancers resulting from the inflammation. The MAP can inhibit symptoms such as flush, fever, swell, and pain owing to catarrh, facilitating healing, relieving itch and pain, and having broad applications in the fields of medicines, cosmetics, medical products, disinfection products, healthcare products, foods, and household goods.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: October 4, 2022
    Assignee: JIANGYIN BENGT I. SAMUELSSON INSTITUTE OF LIFE SCIENCE CO., LTD.
    Inventors: Min Gao, Bengt Ingemar Samuelsson
  • Publication number: 20220284075
    Abstract: The embodiments of the disclosure relate to a computing device, a computing apparatus, and a method of warp accumulation and relate to the field of computers. The computing device includes a storage unit and an accumulation computing unit coupled to the storage unit. The accumulation computing unit is configured to receive, from a vector processing unit coupled to the computing device, a first warp accumulation instruction, a plurality of first values corresponding to a warp lane number, and a first storage address; generate a current accumulation result based on the plurality of first values in response to the first warp accumulation instruction; and store the current accumulation result in the first storage address in the storage unit to be read by the vector processing unit. In this way, accumulation in a warp may be decoupled to dedicated hardware for processing, and overall accumulation performance may thus be significantly improved.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 8, 2022
    Applicant: Shanghai Biren Technology Co.,Ltd
    Inventors: YuFei ZHANG, Zhu LIANG, Min GAO
  • Patent number: 11419318
    Abstract: Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: August 23, 2022
    Assignee: Regeneran Pharmaceuticals, Inc.
    Inventors: Alexander O. Mujica, Yajun Tang, Jeffrey D. Lee, Min Gao, Susan D. Croll, Lynn Macdonald, Ying Hu, Carmelo Romano
  • Patent number: 11421561
    Abstract: A synchronous belt drive system having: a synchronous belt with a tensile cord of high-modulus fiber such as glass, carbon, PBO, or aramid; a driver sprocket and at least one driven sprocket, at least one of which is an obround sprocket; and a tensioner having: a base having a cylindrical portion extending axially with a radially outer surface and a receiving portion, an eccentric arm pivotally engaged with the radially outer surface, a torsion spring disposed within the receiving portion, the torsion spring applying a biasing force to the eccentric arm, and a pulley journalled to the eccentric arm. Preferably, no one of the eccentric arm, pulley, or torsion spring is axially displaced along an axis A-A from the others. The obround sprocket has a toothed surface and at least one linear portion disposed between two arcuate portions having a constant radius, the linear portion having a predetermined length.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: August 23, 2022
    Assignee: Gates Corporation
    Inventors: Min Gao, Cindy Decker, Carol Weber, Douglas D. Schelhaas, Kevin Ward, Leslee Brown, William Fraser Lacy, Guogong Chen, John Muri, Cindy Cookson, Jennifer E. Pease, Justin Paulsen, Patrick Joseph McNamee, Shawn Xiang Wu, Andrzej Dec
  • Patent number: 11372481
    Abstract: A dielectric actuator including an enclosure forming a cavity having a dielectric fluid therein, the enclosure having a base, a flexible membrane and a reversibly-stretchable membrane, and a pair of electrodes, one electrode of the pair of electrodes arranged at the flexible membrane, the other electrode arranged at the base, the pair of electrodes arranged to generate an electric field to an area of the cavity that is filled with the dielectric fluid, wherein when the electric field is generated between the pair of electrodes, an electrostatic pressure in the dielectric fluid causes the flexible membrane to move towards the base, reducing an initial volume of the area of the cavity, increases a pressure of the dielectric fluid inside the cavity, and causes the reversibly-stretchable membrane to bump out to an expanded state.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: June 28, 2022
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Edouard Leroy, Herbert Shea, Min Gao
  • Patent number: 11260111
    Abstract: Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: March 1, 2022
    Assignee: Jiangyin Bengt I. Samuelsson Institute of Life Science Co., Ltd.
    Inventors: Bengt Ingemar Samuelsson, Min Gao
  • Publication number: 20210316446
    Abstract: A dielectric actuator including an enclosure forming a cavity having a dielectric fluid therein, the enclosure having a base, a flexible membrane and a reversibly-stretchable membrane, and a pair of electrodes, one electrode of the pair of electrodes arranged at the flexible membrane, the other electrode arranged at the base, the pair of electrodes arranged to generate an electric field to an area of the cavity that is filled with the dielectric fluid, wherein when the electric field is generated between the pair of electrodes, an electrostatic pressure in the dielectric fluid causes the flexible membrane to move towards the base, reducing an initial volume of the area of the cavity, increases a pressure of the dielectric fluid inside the cavity, and causes the reversibly-stretchable membrane to bump out to an expanded state.
    Type: Application
    Filed: April 14, 2020
    Publication date: October 14, 2021
    Inventors: Edouard Leroy, Herbert Shea, Min Gao