Abstract: An aptamer for specifically detecting patulin and a method for detecting patulin using the same. The aptamer for specifically detecting patulin is a single-stranded DNA aptamer serving as a bioreceptor capable of effectively detecting patulin. Since such an aptamer for specifically detecting patulin is capable of specifically binding to patulin which is a mycotoxin having a simple chemical structure and a low molecular weight, it can be effectively employed as a bioreceptor in various bioassays for specifically detecting patulin. The aptamer for specifically detecting patulin can achieve more effective detection of patulin in apples or apple juice.

Abstract: Provided are a titanium dioxide-coated upconverting nanoparticle (UCNP) and a photocatalyst complex containing a gold nanorod (GNR) combined with the titanium dioxide-coated UCNP.

Abstract: The present invention relates to a membrane sensor having a multi-hole film attached thereto and a method for measuring immunological reactions or enzymatic reactions using the same. More specifically, the present invention relates to a membrane sensor in which a multi-hole film is joined to the top of a membrane on which receptors are immobilized, and a method for measuring immunological reactions or enzymatic reactions using the same. The present invention makes it possible to adjust the sensitivity of membrane biosensors by adjusting the hole size in the multi-hole film and so makes it possible to measure analytes with a high degree of sensitivity using just a small amount of sample, and makes it possible to simultaneously measure diverse types of analyte by attaching various types of receptor on the membrane sensor.

Abstract: The present disclosure relates to a complex for detecting a target material comprising upconverting nanoparticles; and at least one target material specific aptamer-quencher, connected through a linker with the upconverting nanoparticles, a method of preparing the same, a kit for detecting a target material comprising the same, and a method of detecting a target material using the same. According to the present disclosure, different target materials in samples can be quantified or detected accurately based on luminescence resonance energy transfer (LRET) of the upconverting nanoparticles (UCNPs) excited by a near infrared (NIR) light source.

Abstract: The present invention relates to a method for detecting cadmium capable of easily, rapidly, and simply detecting cadmium quantitatively and qualitatively by sequentially adding albumin and a reducing agent to a sample, the albumin and the reducing agent inducing synthesis of a cadmium nanocluster capable of measuring a change in fluorescence intensity. In addition, the albumin and the reducing agent used for the method for detecting cadmium have excellent sensitivity even though they are low-cost, such that concentration of the cadmium present in the sample is capable of being directly measured.

Abstract: A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.

Abstract: Provided are a titanium dioxide-coated upconverting nanoparticle (UCNP) and a photocatalyst complex containing a gold nanorod (GNR) combined with the titanium dioxide-coated UCNP.

Abstract: A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.

Abstract: The present invention relates to an immunochromatography strip sensor capable of measuring a biomaterial concentration over a broad concentration range, and a method for measuring a biomaterial concentration over a broad concentration range using the sensor. A detection method using the sensor according to the present invention can accurately measure an antigen concentration over a broad concentration range, and achieve a low cost, rapidity and convenience, and thus the method is suitable for a point of care test (POCT) requiring rapidity and high sensitivity.

Abstract: Disclosed is a platform detecting glycated hemoglobin as an indicator for diabetes in the blood based on upconverting nanoparticles excited by near-infrared light and luminescence resonance energy transfer.

Abstract: The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of the optical waveguide and the colored conjugate in the band formed on the membrane, resulting in the absorbance signal from the colored conjugate being greatly amplified to improve the sample detection sensitivity, and to a detection method using the same.

Abstract: Disclosed is a method for activating a catalyst using the photothermal effects of photothermal nanomaterials, and more particularly to a method of activating a catalyst at a temperature, at which the catalyst has low or no activity, by irradiating a catalyst-photothermal nanomaterial composite with light. The method can activate the catalyst by increasing only the temperature around the nanomaterials without substantially changing the temperature of the reaction medium. A catalyst that generally has high activity at room temperature can be activated even at low temperature. Catalysts having high activity only under mild conditions are immobilized on photothermal nanomaterials so that they have activity even under low temperature and extreme conditions. The invention is useful when a catalyst substrate unstable at room temperature is used or a catalytic product unstable at room temperature is produced.

Abstract: Provided are a method of analyzing a target substance to be measured, the method including: dividing a surface of a measuring unit of a CMOS image sensor into a plurality of pixels, directly fixing a bioreceptor onto the surface of the measuring unit of the CMOS image sensor, and measuring chemiluminescent signals depending on concentrations of the target substance to be measured, and a CMOS image sensor applied to the same.

Abstract: The present disclosure provides an optical biosensor including a complex including a porous support and an enzyme supported inside the pores of the porous support and a method for preparing the same. Since a dye does not flow but is concentrated in one place, the optical biosensor of the present disclosure has remarkably improved sensitivity. In addition, it is possible to carry out quantitative determination and qualitative analysis since color intensity increases with time.

Abstract: Provided is a method for manufacturing a multiple-diagnosis membrane sensor provided with multiple channels by using screen printing, and more specifically, to a method for manufacturing a membrane sensor capable of performing multiple-diagnosis by screen-printing hydrophobic ink on a membrane to form multiple channels. The membrane sensor according to the present invention may enable mass-production of sensors and secure reliability of detection by forming the plurality of channels on the membrane by a simple method.

Abstract: Disclosed herein are a method for manufacturing a multi-functional bio-material conjugate used as a biosensor for detecting microorganisms, and the like, and a multi-functional bio-material conjugate manufactured by means of the same. The method for manufacturing a multi-functional bio-material conjugate includes: (a) coating a first nanoparticle having magnetic or fluorescent characteristics with protein; (b) manufacturing a conjugate by adsorbing a second nanoparticle having metallic characteristics onto the first nanoparticle coated with protein; and (c) manufacturing the multi-functional bio-material conjugate by adsorbing a bio-material onto the conjugate. The method for manufacturing a multi-functional bio-material conjugate according to the present invention may prevent precipitation of the nanoparticles, easily immobilize the bio-material, and manufacture a bio-material conjugate having multiple functions, by using two kinds of the particles.

Abstract: Disclosed herein are a membrane sensor capable of changing a reaction condition by a single sample injection and a method for measuring a reaction using the same, and more specifically, a membrane sensor designed so that a bio reaction having two or more reaction conditions is sequentially generated by a single sample injection, by forming an asymmetric membrane between a reactant storing part and a reaction membrane.

Abstract: The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of the optical waveguide and the colored conjugate in the band formed on the membrane, resulting in the absorbance signal from the colored conjugate being greatly amplified to improve the sample detection sensitivity, and to a detection method using the same.

Abstract: Disclosed herein is a method for detecting an antigen. The method includes: reacting an antigen as an analyte having an absorption wavelength at 300 nm to 400 nm with an antibody to form an antigen-antibody conjugate; irradiating light to the antigen-antibody conjugate to induce fluorescence resonance energy transfer, thereby obtaining a fluorescence spectrum; and determining the presence of the antigen as the analyte by analyzing the fluorescence spectrum, and then measuring the concentration of the antigen. The method is capable of directly detecting various antigens in a homogeneous liquid state, which induces no competitive reaction, with high sensitivity and high selectivity through fluorescent resonance energy transfer, without any modification.

Abstract: The present invention relates to a method of rapidly detecting microorganisms using nanoparticles, and more particularly to a method and device of rapidly detecting microorganisms by adding, to the microorganisms to be detected, nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, subjecting the mixture to an immune reaction to form a reaction solution, passing the reaction solution through a microorganism-concentrating film to concentrate the microorganisms, capturing microorganisms, which was immune-reacted with the antibody-immobilized nanoparticles, by a microorganism-capturing filtration membrane, and determining the presence and concentration of the microorganisms.