Abstract: The present disclosure relates to a pharmaceutical highly efficient anti-TFPI antibody composition including an anti-TFPI antibody for treating hemophilia, in which the content of HCP in a drug substance is less than 10.0 ng/mg, and the content of LPA in the drug substance or the drug product is less than 1.0 ng/mg. According to the present disclosure, a highly efficient anti-TFPI antibody composition having very low contents of HCP and LPA may be provided by providing a separation/purification process capable of minimizing anti-TFPI antibody polymer generation, and may be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease.

Abstract: A polarizing plate and an optical display apparatus are disclosed. A polarizing plate includes a polarizer and a protective layer on at least one surface of the polarizer, and the polarizer includes a polyvinyl alcohol film containing a dichroic substance and contains zinc cations and potassium cations, and the polarizing plate has a value of 0.1 or less, as calculated according to Equation 1.

Abstract: A Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction having neuroglobin (Ngb) activation and neuroprotective effects and, on the basis thereof, a neuroprotective composition containing, as an active ingredient, a Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction. The neuroprotective composition can be used, through the activation of neuroglobin (Ngb), as a pharmaceutical composition or a food composition for treatment, alleviation and prevention of a stroke, a cerebral infarction, thrombosis, cerebral degenerative disease, vascular dementia, memory loss, short-term memory impairment, a concentration disorder, anxiety, nervousness and the like, and for brain damage protection, brain function improvement and cranial nerve cell protection.

Abstract: Provided herein are novel compounds, e.g., those of Formula (I), as GCN2 inhibitors. Also provided are pharmaceutical compositions including one or more of the novel compounds, and pharmaceutical uses thereof. Compounds provided herein can typically inhibit an activity of a GCN2 and thus can be used for treating or preventing diseases related thereto.

Abstract: Disclosed is a substrate processing apparatus including: a support unit for supporting a substrate and rotating the substrate; a solution discharge unit for discharging a processing solution including a first material and a second material onto the substrate to remove a film on the substrate; and a controller for controlling the solution discharge unit, in which the controller sets, when the solution discharge unit discharges the processing solution to a first position and a second position on the substrate, a hydrogen ion concentration of the processing solution discharged to the first position to be different from a hydrogen ion concentration of the processing solution discharged to the second position, and the first position is a center of the substrate or is located closer to the center of the substrate than the second position.

Abstract: The present invention relates to: a substituted thiazolidinedione derivative compound having a novel structure acting as a sterol regulatory element-binding protein-1 (SREBP1) inhibitor, a hydrate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating cancer, comprising same as an active ingredient.

Abstract: An electronic device is provided that includes a first display and a second display. The electronic device also includes a processor configured to allocate a first set of resources to the first display and a second set of resources to the second display. The first set of resources is different from the second set of resources. Each of the first set of resources and the second set of resources includes one or more of at least one available hardware resource and at least one available software resource.

Abstract: The present invention relates to a composition for promoting myogenesis, containing, as an active ingredient, a processed ginseng extract in which a trace amount of a ginsenoside ingredient is increased. It has been ascertained that the processed ginseng extract promotes the differentiation of myoblasts into muscle and inhibits muscle atrophy caused by myostatin, which is a myogenesis inhibitory factor, and thus it is expected that a composition for preventing or treating muscle disorder-related diseases, having excellent effects, can be developed.

Abstract: A multilayer electronic component includes a body including a dielectric layer and internal electrodes; and an external electrode disposed on the body, wherein the dielectric layer includes dielectric grains, wherein at least one of the dielectric grains includes a twin boundary, and wherein the dielectric layer includes a region in which a sum of lengths of the twin boundaries included in a 2 ?m×2 ?m region is 1.49 ?m or more.

Abstract: A multilayer electronic component includes a body including dielectric layers and internal electrodes alternately disposed with the dielectric layers and external electrodes disposed on the body and connected to the internal electrodes. The one of the internal electrodes includes Ni, Ba, Ti, O, and Tb, and a content of Tb relative to a sum of contents of Ni, Ba, Ti, O, and Tb is 0.45 to 3.0 wt %.

Abstract: A method and apparatus for a social networking service are provided. An operating method of a server that provides a social networking service includes determining a layout of a feed page based on following information corresponding to a first user account and subscription information corresponding to the first user account, determining a type of feed content corresponding to the determined layout, based on the following information and the subscription information, and providing, to a terminal of the first user account, the feed page on which the determined feed content is arranged based on the layout.

Abstract: A muscular strength assisting apparatus includes a muscular strength assisting portion that assists a user's muscular strength and a first connecting link including one side connected to one side of the muscular strength assisting portion and an opposite side rotatable relative to a shoulder of the user about a first rotation axis. The muscular strength assisting portion includes an upper arm module that assists muscular strength of an upper arm of the user and a link assembly including one side connected to one side of the upper arm module to be rotatable about a second rotation axis non-parallel to the first rotation axis and an opposite side disposed adjacent to a portion of a body of the user to be supported on the user.

Abstract: The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmunre diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: A method of fabricating a semiconductor device includes providing a substrate, forming a target film, a first mask film, a second mask film, and an upper mask pattern on the substrate, forming a first spacer pattern that includes a first line portion and a second line portion, and a folding portion that connects the first line portion and the second line portion, forming a slit mask pattern that partially covers the first spacer pattern, forming a first mask pattern by patterning the second mask film using the slit mask pattern and the first spacer pattern as an etching mask, forming a second spacer pattern, forming a second mask pattern by patterning the first mask film using the second spacer pattern as an etching mask, and forming a plurality of target patterns by patterning the target film using the second mask pattern as an etching mask.

Abstract: In some implementations, a system may receive a user identifier associated with a user account, and may identify account identifiers associated with the user account. The system may obtain account information associated with the account identifiers, and may determine priority levels for the account identifiers based on the account information. A primary account identifier may be associated with a highest priority level. The system may transmit a first set of user interface (UI) data indicating account UI elements, corresponding to the account identifiers, and an order of the account UI elements based on the priority levels. A primary account UI element, corresponding to the primary account identifier, may be arranged first in the order. The first set of UI data may indicate a first set of the account information to be visually presented on the account UI elements and associated with the account identifiers corresponding to the account UI elements.

Abstract: The present disclosure relates to a subminiature cell assembly apparatus and an electrode stack manufacturing method using the same, and more particularly a subminiature cell assembly apparatus including a jig unit configured to allow an electrode and a separator to be stacked on an upper surface thereof, the upper surface being flat, a laser radiation unit located above the jig unit, a support unit provided with a jig groove into which the jig unit is inserted, the support unit including a vacuum suction portion located at opposite sides of the jig groove, and a display unit configured to measure and display a relative height of the jig unit or the support unit, wherein the jig unit or the support unit is movable relative to the support unit or the jig unit in a vertical direction, and an electrode stack manufacturing method using the same.

Abstract: Novel peptides and nucleotides encoding the peptides, and compositions containing the peptides and/or nucleotides are disclosed. Also disclosed are uses of the peptides, nucleotides, and compositions. N-terminus and/or a C-terminus of the peptides may be capped. The peptides, nucleotides, and compositions are suitable for treating pain or a transient receptor potential cation channel subfamily V member 1 (TRPV1)-mediated disease.

Abstract: In some implementations, a system may identify one or more account identifiers associated with a user identifier. Each account identifier may be associated with one or more categories each representing a type of interaction of one or more interactions associated with the account identifier. A respective interaction amount may be associated with each interaction. The system may determine, for each category, a total category amount that is a sum of interaction amounts for interactions in a particular category occurring within a particular time frame. The system may transmit user interface (UI) data associated with a multi-tab UI element including a plurality of tabs corresponding to the plurality of categories. Each tab may be associated with benefits information related to a category corresponding to that tab. A first tab, corresponding to a category having a highest total category amount, may be presented in a particular position in the multi-tab UI element.

Abstract: A method for an anomaly detection is provided. The method may include acquiring a score predictor trained using normal time-series data, wherein the score predictor is a deep learning model configured to output a conditional score for previous time-series data and the conditional score represents a gradient of data density, extracting data for a specific time and data segments corresponding to a period before the specific time from target time-series data, and predicting a conditional score for the data segments through the trained score predictor and conducting an anomaly determination for the data for the specific time using the predicted conditional score.