Abstract: Described herein are cell lines for recombinant adeno-associated virus (AAV) production, cell lines for AAV-implemented protein production, and cell lines for use in titering AAV; methods of making each of those cell lines; and methods of using each of those cell lines. In some aspects, the cell lines disclosed herein may be used in a manufacturing process that is seed virus-free, helper virus-free, and transfection-free that uses synthetic elements to control viral genes in a stable cell line.

Abstract: The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.

Abstract: Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R5, R6, R8, R9, A, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

Abstract: The present invention provides implementation and communication methods, an apparatus and a system of a virtual subscriber identity module. The implementation method includes: receiving a VSIM application request sent by a terminal, where the VSIM application request carries an identifier of a VSIM desired by the terminal; obtaining corresponding VSIM installation information according to the identifier of the desired VSIM; and sending the VSIM installation information to the terminal, so that the terminal installs the VSIM according to the VSIM installation information. The embodiments of the present invention effectively solve a problem where an existing mobile operator network does not support the VSIM, and provide an effective and convenient operation scheme for an existing domestic or international roaming service.

Abstract: A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: A display panel has a plurality of pixel areas and a peripheral area surrounding the pixel areas, and includes a substrate, at least two planarization layers, a plurality of pads, a first dummy pattern, and a plurality of light-emitting devices. The substrate has a first substrate edge extending in a first direction. The at least two planarization layers are disposed on the substrate. The pads are disposed on the at least two planarization layers, and are located in the pixel areas. The pads include at least one first edge pad closest to the first substrate edge. The first dummy pattern is disposed on the at least two planarization layers, and extends in the peripheral area between the at least one first edge pad and the first substrate edge. The light-emitting devices are electrically connected to the pads.

Abstract: A sensor using ultrasound to detect presence and nature of analyte includes an ultrasonic element and a receptor thereon. The ultrasonic element includes a first electrode, a second electrode facing and spaced apart from the first electrode, an insulating layer between the first electrode and the second electrode, and a vibrating film between the insulating layer and the first electrode. The vibrating film carries the first electrode. A cavity is formed between the vibrating film and the insulating layer. The receptor is on a side of the first electrode away from the second electrode. The receptor can combine with a target substance in a test analyte. When the first electrode and the second electrode are applied with different voltages, certain ultrasound frequencies are generated as the vibrating film vibrates, and the presence and weight of different target substances are indicated by the changes in resonance.

Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.

Abstract: A method for bundling network functions as a single microservice in a cloud environment. A service deployment manager may acquire subscriber location information associated with a subscriber or a subscriber profile associated with the subscriber. Moreover, the service deployment manager may utilize the subscriber location information or the subscriber profile to select a cloud location. For example, the cloud location may be based on load, geographical proximity, service profile, etc.

Abstract: An electronic lock includes a latch mechanism and a rotation assembly. The rotation assembly includes a rotator, a single sensor and a processor, the rotator can be rotated toward a first direction or a second direction to drive a latch of the latch mechanism to be extended or retracted. The sensor is provided to sense a protrusion, an auxiliary protrusion, a recess and an auxiliary recess of the rotator to output a sensing signal. The processor is electrically connected to the sensor to receive the sensing signal and is provided to distinguish whether an actuation of extension or retraction of the latch is complete according to a potential variation of the sensing signal.

Abstract: An intelligent power distribution device is provided, which includes a power distribution diagnosis module and a power distribution monitoring module. The power distribution monitoring module includes a power measuring and controlling instrument. The power measuring and controlling instrument is configured to connect to a power supply line to be protected, and measure power data of the power supply line. The power distribution diagnosis module is connected to the power measuring and controlling instrument, and is configured to analyze the power data uploaded by the power measuring and controlling instrument, and protect the power supply line when it is determined based on an analysis result that the power supply line requires protection. Based on the analysis result of the power data of the power supply line, the intelligent power distribution device can protect the power supply line precisely and accurately, thereby improving protection effect of the power supply line.

Abstract: A method for periodically activating a battery unit applied to an electronic device equipped with the battery unit includes steps as follows. A plurality of intervals are defined, wherein each of the intervals has an initial voltage value and a target voltage value, and the initial voltage value is greater than the target voltage value. An activation strategy for each of the intervals is defined. A voltage value of the battery unit is detected. One of the intervals is selected as a selected interval according to the voltage value of the battery unit, wherein the voltage value of the battery unit is less than or equal to the initial voltage value of the selected interval, and the voltage value of the battery unit is greater than the target voltage value of the selected interval. The battery unit is activated according to the activation strategy of the selected interval.

Abstract: The present invention provides implementation and communication methods, an apparatus and a system of a virtual subscriber identity module. The implementation method includes: receiving a VSIM application request sent by a terminal, where the VSIM application request carries an identifier of a VSIM desired by the terminal; obtaining corresponding VSIM installation information according to the identifier of the desired VSIM; and sending the VSIM installation information to the terminal, so that the terminal installs the VSIM according to the VSIM installation information. The embodiments of the present invention effectively solve a problem where an existing mobile operator network does not support the VSIM, and provide an effective and convenient operation scheme for an existing domestic or international roaming service.

Abstract: An example method facilitates modification and generation of User Interface (UI) display screens for webpages and web applications, such as process-based software applications. The example method includes receiving a first signal to access a webpage that includes a static UI display screen for a web application; serving the webpage in response to the signal; detecting the dynamic configuration functionality associated with the webpage, wherein the configuration functionality includes code and UI metadata provided in or with a dynamic layout file, the code and UI metadata including one or more rules and specifications for configuring schema used to generate rendering instructions for the dynamic part of the webpage.

Abstract: An example method facilitates modification and generation of User Interface (UI) display screens for webpages and web applications, such as process-based software applications. The example method includes receiving a first signal to access a webpage that includes a static UI display screen for a web application; serving the webpage in response to the signal; detecting the dynamic configuration functionality associated with the webpage, wherein the configuration functionality includes code and UI metadata provided in or with a dynamic layout file, the code and UI metadata including one or more rules and specifications for configuring schema used to generate rendering instructions for the dynamic part of the webpage.

Abstract: A lock device includes a shell, a bolt mechanism, a magnetic member, and a magnetic sensing module. The magnetic member is movable with the bolt mechanism. When the bolt mechanism is moved between a locking position and an unlocking position, the magnetic sensing module senses a magnetic force variation of the magnetic member. The lock device further includes a magnetic force generation member disposed on a wall. When a door located at a door-closed position with the bolt mechanism being moved to the locking position is shaken relative to the wall, the magnetic sensing module senses a magnetic force variation of the magnetic force generation member.

Abstract: A method for bundling network functions as a single microservice in a cloud environment. A service deployment manager may acquire subscriber location information associated with a subscriber or a subscriber profile associated with the subscriber. Moreover, the service deployment manager may utilize the subscriber location information or the subscriber profile to select a cloud location. For example, the cloud location may be based on load, geographical proximity, service profile, etc.

Abstract: An example system and method facilitates operation of a networked software application that communicates with a network resource during periods of intermittent network connectivity and includes determining when a networked software application is offline and when it is online; selectively intercepting one or more request messages from the networked software application addressed to a network resource when the software application is offline, resulting in a store of intercepted request messages; detecting when the networked software application transitions from being offline to being online; and selectively issuing the one or more request messages to the network resource in a sequence in which the one or more request messages were stored in the store of intercepted request messages.

Abstract: An example system and method facilitates operation of a networked software application during periods of intermittent network connectivity, by selectively intercepting and shredding and/or unshredding service response messages. In a specific embodiment, the example system includes one or more pluggable shredders and unshredders to explode a payload into its constituent structured primitive objects for ease of consumption by the User Interface (UI) of the client application. The exploded payloads are stored in local cache, where the cached data is structured as compared to the received payload. One or more unshredders selectively reconstruct one or more response message payloads if client reissues the corresponding request message while offline. The client may operate as if it is online, and the system will provide one or more mock responses containing the last known data set for the scenario wherein the server cannot be reached.

Abstract: A method for bundling network functions as a single microservice in a cloud environment. A service deployment manager may acquire subscriber location information associated with a subscriber or a subscriber profile associated with the subscriber. Moreover, the service deployment manager may utilize the subscriber location information or the subscriber profile to select a cloud location. For example, the cloud location may be based on load, geographical proximity, service profile, etc.