Abstract: Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R5, R6, R8, R9, A, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.

Abstract: An example system and method facilitates operation of a networked software application, i.e., client application which communicates with a network resource (e.g., web service) during periods of intermittent network connectivity, by selectively intercepting and shredding and/or unshredding service response messages. In a specific embodiment, the example system includes one or more pluggable shredders and unshredders that are used to explode a complex REpresentational State Transfer (REST) payload into its constituent structured primitive objects for ease of consumption by the User Interface (UI) of the client application. The exploded, i.e., shredded response message payloads are stored in local cache, where the cached data is strategically structured as compared to the received REST payload. One or more unshredders selectively reconstruct one or more REST response message payloads if client reissues the corresponding REST request message while offline.

Abstract: A micro LED display panel defines a display area and a border area surrounding the display area. The micro LED display panel includes a TFT array substrate, a plurality of micro LEDs on the TFT array substrate, a common electrode on the TFT array substrate, the common electrode covering and electrically coupling to all of the micro LEDs; a metal layer on a side of the common electrode away from the TFT array substrate and electrically coupling to the common electrode, and a black photoresist layer on a side of the metal layer away from the TFT array substrate. The black photoresist layer defines through holes. Each through hole extends through both the black photoresist layer and the metal layer and aligns with one micro LED. The metal layer and the black photoresist layer cover the display area and the border area.

Abstract: An electric lock includes a motor, a power input port, a first control system and a second control system. The first control system includes an input unit configured to receive anput data, an internal power source, and a first processing unit configured to use electricity of the internal power source to control the motor to rotate according to the input data. The second control system includes a wireless unit configured to receive a wireless signal, and a second processing unit different from the first processing unit and configured to use electricity of an external power source to control the motor to rotate when data transmitted in the wireless signal matches predetermined data and when the power input port is electrically connected to the external power source.

Abstract: Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

Abstract: In some embodiments, a management system is configured to dynamically generate and/or adjust a step-by-step care regimen. The care regimen, or step-by-step plan, is broken down by the system into specific actions presented to a patient at specific times with tailored guidance on how to achieve the best effect of each step. The system can be configured to build tailored care plans that span contemplation phases, preparation phases, recovery phases, and long term care phases. In further embodiments, over the treatment life cycle, the system facilitates patient care compliance, planning and education, among other options. In other embodiments, the system is configured to dynamically capture and develop implicit relationship information on a patient's care journey, and augment care options for respective patients responsive to identifying implicit connections developed within the context of the patient's care journey (e.g., specified by patient provider, procedure, physician, comorbidities, etc.).

Abstract: An inner slide rail mounting structure for a two-stage server slide rail includes an outer rail, a front bracket, a rear bracket, an outer rail reinforcement bar and an inner rail. The front bracket is affixed to a front end of a front bracket supplementary rail that is slidably inserted into the outer rail reinforcement bar. The rear end of the front bracket supplementary rail is connected with a spring plate that has one end thereof connected to the outer rail reinforcement bar through a tension spring and an opposite end thereof fixedly connected with an outer rail ejection control plate that has an abutment portion abutted against the outer rail reinforcement bar and a press portion extended from the abutment portion for pressing by the user to release the abutment portion from the outer rail reinforcement bar.

Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: A class of polycyclic compounds of general formula (II), of general formula (II?), or of general formula (II?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.

Abstract: A thin film transistor array panel includes a first conductive layer (102) including a gate electrode; a channel layer (104) disposed over the gate; and a second conductive layer (105) disposed over the channel layer (104). The second conductive layer (105) includes a multi-layered portion defining a source electrode (105a) and a drain electrode (105b), which includes a first sub-layer (105-1), a second sub-layer (105-2), and a third sub-layer (105-3) sequentially disposed one over another. Both the third and the first sub-layers (105-3, 105-1) include indium and zinc oxide materials. An indium to zinc content ratio in the first sub-layer (105-1) is greater than that in the third sub-layer (105-3).

Abstract: Compounds of general formula (Ia), compounds of general formula (Ia?), compounds of general formula (Ib), compounds of general formula (Ib?), compounds of general formula (I), compounds of general formula (I?), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.

Abstract: A LCD device defining a display area includes a color filter substrate, a thin film transistor (TFT) substrate facing the color filter substrate, a backlight module on a side of the TFT substrate away from the color filter substrate, a transparent cover on a side of the color filter substrate away from the TFT substrate, and a fingerprint sensor in the display area. The fingerprint sensor defines a fingerprint sensing area in the display area. The LCD device further includes a light emitting diode on a side of the transparent cover adjacent to the color filter substrate. The light emitting diode is configured to emit light toward the fingerprint sensing area of the transparent cover.

Abstract: A LCD device defining a display area includes a color filter substrate, a thin film transistor (TFT) substrate facing the color filter substrate, a backlight module on a side of the TFT substrate away from the color filter substrate, a transparent cover on a side of the color filter substrate away from the TFT substrate, and a fingerprint sensor in the display area. The fingerprint sensor defines a fingerprint sensing area in the display area. The LCD device further includes a light emitting diode on a side of the transparent cover adjacent to the color filter substrate. The light emitting diode is configured to emit light toward the fingerprint sensing area of the transparent cover.

Abstract: A conductive layer for a thin film transistor (TFT) array panel includes a multi-layered portion defining a source electrode and a drain electrode of a TFT device, and includes a first sub-layer, a second sub-layer, a third sub-layer, and at least one additional sub-layer. The third and the first sub-layers include indium and zinc oxide materials. An indium to zinc content ratio in the first sub-layer is greater than that in the third sub-layer. An indium to zinc content ratio in the additional sub-layer is formulated between that in the first and the third sub-layers. The content ratio differentiation between the first and the third sub-layers affects a lateral etch profile associated with a gap generated in the second conductive layer between the source and the drain electrodes, where the associated gap width in the third sub-layer is wider than that in the first sub-layer.

Abstract: The embodiment of the invention provides a measurement method and a measurement device for quality of a power distribution and utilization channel. The method comprises the steps of determining priority of each branch in the power distribution and utilization channel of which the quality is to be measured; and determining quality of the power distribution and utilization channel of each branch according to the priority. The method and the device are used for improving monitoring strength on a whole optical fiber channel, and enhancing application universality.

Abstract: This patent relates to a multi-mode communication method for detecting states of power transmission line, which belongs to electric power communication technology field. In this method, there are sensing devices installed on power transmission line. These sensing devices are used to detect status signals of power transmission line. Status signals are sent to remote monitoring center through communication terminals. Both sensing devices and communication terminals are powered by battery. The main communication network between sensing devices and communication terminals is formed by ZigBee network. Meanwhile, Bluetooth network is a backup communication network between sensing devices and communication terminals. Communication terminals and remote monitoring center are linked through WinMAX.

Abstract: A semiconductor structure includes a substrate having a plurality of fin structures thereon, an isolation oxide structure in the substrate between adjacent two of the plurality of fin structures, a gate disposed on the plurality of fin structures, a gate dielectric layer disposed between the plurality of fin structures and the gate, and a source/drain doped region in each of the plurality of fin structures. The isolation oxide structure has a concave, curved top surface.

Abstract: An example method facilitates modification and generation of User Interface (UI) display screens for webpages and web applications, such as process-based software applications. The example method includes receiving a first signal to access a webpage that includes a static UI display screen for a web application; serving the webpage in response to the signal; detecting the dynamic configuration functionality associated with the webpage, wherein the configuration functionality includes code and UI metadata provided in or with a dynamic layout file, the code and UI metadata including one or more rules and specifications for configuring schema used to generate rendering instructions for the dynamic part of the webpage.