Abstract: An intelligent obstacle detection system for an unmanned mine vehicle is provided to solve the problem of existing intelligent obstacle detection systems for unmanned mine vehicles cannot compare and analyze the actual driving data with the preset data and includes an intelligent detection platform, a route planning device, an obstacle detection device, a planning management device, an operation monitoring device, and a storage device. The route planning device is configured to perform route planning analysis for the unmanned mine vehicle to obtain a planned route of the unmanned mine vehicle. The planned route is sent to the obstacle detection device. The intelligent obstacle detection system can plan and analyze the travel route. By locking onto starting and target positions of the unmanned mine vehicles, and then obtaining point cloud data through the detection terminals and calculating with algorithms, the optimal planned route can be determined.

Abstract: Improving power amplifier efficiency and linearity in a wireless transmission circuit is disclosed. Like conventional Doherty power amplifiers, a power amplifier circuit disclosed herein amplifies a signal using a carrier path and a peaking path. Contrary to activating the peaking path based on a conventional feedback-based activation scheme, the power amplifier circuit is configured to activate the peaking path based on a feedforward activation scheme. Specifically, the power amplifier circuit is configured to receive an envelope signal that is time-aligned with a time-variant power envelope of the signal to be amplified therein. Herein, the power amplifier circuit is configured to process the envelope signal to ensure that activation of the peaking path tracks compression of the carrier path under various local environmental conditions.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: Disclosed is an amplifier having a carrier amplifier configured as a common-emitter carrier power stage and a peaking amplifier configured as a common-emitter peaking power stage. Further included is power adaptive biasing circuitry coupled between the carrier amplifier and the peaking amplifier, wherein the power adaptive biasing circuitry is configured to sense direct current base voltages of the common-emitter carrier power stage and to generate control currents that debias the common-emitter carrier power stage in response to the current base voltages of the common-emitter carrier power stage.

Abstract: A large ship safety supervision system, configured to realize shipmen monitoring and ship safety supervision, wherein shipmen monitoring comprising monitoring of real time positions of shipmen in cabins and shipmen health data, and ship safety supervision comprises oceanic condition warning, on board devices running condition monitoring, ship navigation/construction monitoring and ship remote guidance. Data transmission in between ships and shores is realized by the hybrid self-adaptive compression technology based on model classification and the data transmission link intelligent selection technology based on fuzzy neural network creatively, in the meanwhile, real time safety management and supervision and ship remote work analysis and guidance can be realized.

Abstract: Disclosed is an amplifier having a carrier amplifier configured as a common-emitter carrier power stage and a peaking amplifier configured as a common-emitter peaking power stage. Further included is power adaptive biasing circuitry coupled between the carrier amplifier and the peaking amplifier, wherein the power adaptive biasing circuitry is configured to sense direct current base voltages of the common-emitter carrier power stage and to generate control currents that debias the common-emitter carrier power stage in response to the current base voltages of the common-emitter carrier power stage.

Abstract: The present invention relates to the technical field of medicine, and disclosed a maleate of a nicotinyl alcohol ether derivative, a crystal form thereof, and an application thereof, i.e., (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate and a stereoisomer and a crystal form thereof, a preparation method therefor, a pharmaceutical composition, and a use thereof. Specifically, the present invention relates to the (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate represented by formula I, and a crystal form thereof, a stereoisomer thereof, a preparation method therefor, a composition containing said compound or the crystal form thereof, and a use of said compound or the crystal form thereof in the preparation of a medicine for treating diseases related to a PD-1/PD-L1 signaling pathway, such as cancer, infectious diseases and autoimmune diseases.

Abstract: The present invention relates to the technical field of medicine, and disclosed a maleate of a nicotinyl alcohol ether derivative, a crystal form thereof, and an application thereof, i.e., (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate and a stereoisomer and a crystal form thereof, a preparation method therefor, a pharmaceutical composition, and a use thereof. Specifically, the present invention relates to the (S)-N-(2-(pyridin-3-yl-methoxy)-4-(2-bromo-3-phenylbenzyloxy)-5-chlorobenzyl) serine isopropyl ester maleate represented by formula I, and a crystal form thereof, a stereoisomer thereof, a preparation method therefor, a composition containing said compound or the crystal form thereof, and a use of said compound or the crystal form thereof in the preparation of a medicine for treating diseases related to a PD-1/PD-L1 signaling pathway, such as cancer, infectious diseases and autoimmune diseases.

Abstract: The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.

Abstract: An amplifier is disclosed having a carrier amplifier and a peaking amplifier coupled in parallel with the carrier amplifier, wherein the peaking amplifier has peaking output transistors. A peaking power supply adaptive bias generator is coupled to bias control terminals of the peaking output transistors. The peaking power supply adaptive bias generator is configured to sense supply voltage to the peaking amplifier and increase bias currents to the peaking output transistors as the supply voltage decreases.

Abstract: A large ship safety supervision system, configured to realize shipmen monitoring and ship safety supervision, wherein shipmen monitoring comprising monitoring of real time positions of shipmen in cabins and shipmen health data, and ship safety supervision comprises oceanic condition warning, on board devices running condition monitoring, ship navigation/construction monitoring and ship remote guidance. Data transmission in between ships and shores is realized by the hybrid self-adaptive compression technology based on model classification and the data transmission link intelligent selection technology based on fuzzy neural network creatively, in the meanwhile, real time safety management and supervision and ship remote work analysis and guidance can be realized.

Abstract: An intelligent obstacle detection system for an unmanned mine vehicle is provided to solve the problem of existing intelligent obstacle detection systems for unmanned mine vehicles cannot compare and analyze the actual driving data with the preset data and includes an intelligent detection platform, a route planning device, an obstacle detection device, a planning management device, an operation monitoring device, and a storage device. The route planning device is configured to perform route planning analysis for the unmanned mine vehicle to obtain a planned route of the unmanned mine vehicle. The planned route is sent to the obstacle detection device. The intelligent obstacle detection system can plan and analyze the travel route. By locking onto starting and target positions of the unmanned mine vehicles, and then obtaining point cloud data through the detection terminals and calculating with algorithms, the optimal planned route can be determined.

Abstract: A traction apparatus, comprising a clip portion (2) and a traction portion (1), the traction portion containing a closed traction structure (11); the closed traction structure being made from an elastic material; the clip portion comprising a main clip body (23, 25) and a clip arm (24, 26); the main clip body being capable of passing through a biopsy channel (4) of an endoscope (3), the clip arm being capable of clip the closed traction structure. Also disclosed is a traction ring used for the traction apparatus, the traction ring being a single closed traction structure or being formed by connecting several closed traction structures, the traction ring being made from an elastic material.

Abstract: An endoscope end cap, including a sleeve member, protrusion elements, and a movable sleeve. The sleeve member is connected to the front end of an endoscope, the sleeve member, the protrusion elements, and the movable sleeve are connected in sequence, and the movable sleeve can move freely on the outer surface of the endoscope. When the endoscope is inserted for examination, the end cap is easy to enter and does not scratch the digestive tract since the end cap has a cylinder-like structure which is smooth and has no angularity; when the endoscope is being withdrawn, the movable sleeve moves distally and abuts against the sleeve member, so as to support the protrusion elements to enable the protrusion elements to dilate the inner wall of the intestine, improving the quality of single endoscope examination, and reducing discomfort of a patient, operation risk, and operation time.

Abstract: Aspects of the disclosure relate to validating map data using challenge questions. For instance, an attributes to be validated may be identified from the map data. At least one challenge question may be selected from a plurality of predetermined challenge questions based on the attribute. An image may be retrieved based on image information associated with the at least one challenge question. The image and the at least one challenge question may be provided for display. In response to the providing, operator input identifying an answer to the at least one challenge question may be received. This answer may be then used to validate the attribute.

Abstract: Disclosed is an amplifier having a carrier amplifier configured as a common-emitter carrier power stage and a peaking amplifier configured as a common-emitter peaking power stage. Further included is power adaptive biasing circuitry coupled between the carrier amplifier and the peaking amplifier, wherein the power adaptive biasing circuitry is configured to sense direct current base voltages of the common-emitter carrier power stage and to generate control currents that debias the common-emitter carrier power stage in response to the current base voltages of the common-emitter carrier power stage.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.