Abstract: Embodiments of the present disclosure provide methods and systems for processing a speech signal. The method can include: processing the speech signal to generate a plurality of speech frames; generating a first number of acoustic features based on the plurality of speech frames using a frame shift at a given frequency; and generating a second number of posteriori probability vectors based on the first number of acoustic features using an acoustic model, wherein each of the posteriori probability vectors comprises probabilities of the acoustic features corresponding to a plurality of modeling units, respectively.

Abstract: A method for heap space management includes, in response to a determination that consumption of a first heap space of an application exceeds a first threshold, determining whether a second heap space of the application after garbage collection is sufficient to accommodate data stored in the first heap space. The method further includes, in response to a determination that the second heap space after the garbage collection is sufficient to accommodate the data, performing the garbage collection on the second heap space. The method further includes storing the data into the second heap space.

Abstract: A method for heap space management includes, in response to a determination that consumption of a first heap space of an application exceeds a first threshold, determining whether a second heap space of the application after garbage collection is sufficient to accommodate data stored in the first heap space. The method further includes, in response to a determination that the second heap space after the garbage collection is sufficient to accommodate the data, performing the garbage collection on the second heap space. The method further includes storing the data into the second heap space.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22. The invention also relates to chimeric antigen receptor (CAR) specific to CD20 or CD22, vectors encoding the same, and recombinant T or natural killer (NK) cells comprising the CD20 CAR or CD22 CAR. The invention also includes methods of administering a genetically modified T cell or NK cell expressing a CAR that comprises a CD20 or CD22 binding domain.

Abstract: A method includes various operations and a computer program product may cause a processor to perform various operations. The operations include obtaining, for each of a plurality of baseboard management controllers (BMCs) that have been configured to form a baseboard management controller (BMC) group, an amount of load placed on the BMC, wherein a first BMC in the BMC group has been configured to operate as a BMC group leader for the BMC group. The operations further include, in response to a second BMC in the BMC group having less load than any other BMC in the BMC group, configuring the second BMC to operate as the BMC group leader and unconfiguring the first BMC to no longer operate as the BMC group leader. Still further, the operations include causing the second BMC to perform a BMC group operation operating as the BMC group leader.

Abstract: Disclosed are an online analysis system and method for a line loss of a transmission line. The system includes: a terminal extension and a terminal host, where time information synchronization between the terminal extension and the terminal host and between terminal extensions is performed by a clock synchronization module, and communication between the terminal extension and the terminal host and between the terminal extensions is performed by a communications module; and a line loss management platform, configured to receive measurement data of the terminal extension and the terminal host, match time information in the measurement data, and if time information in the measurement data of the terminal extension and the terminal host is matched, and time information in measurement data of the terminal extensions is matched, determine corresponding line loss information based on corresponding measurement information.

Abstract: In an embodiment, an adhesive sheet has an expandable adhesive layer 2 on one side or both sides of a base 1, wherein the expandable adhesive layer 2 contains an epoxy resin including a polyfunctional epoxy resin, a phenol resin as a curing agent, an imidazole-based compound as a curing catalyst, and a temperature-sensitive foaming agent. The adhesive sheet has properties in good balance, such as fast curability, heat resistance, and adhesiveness, and also excellent properties such as thermal conductivity attributed to a good filling property.

Abstract: The present disclosure provides antibodies and antibody fragments thereof that bind to IL-23p19. The disclosed antibodies and antibody fragments thereof can modulate a biological activity of the IL-23 receptor signaling axis and are therefore useful for the treatment of immune-mediated inflammatory disorders.

Abstract: An indication to remove one or more data in a time series database is received. A metadata index associated with the time series database is updated to indicate a soft removal of each data of the one or more data. A data hole index associated with the time series database is updated to indicate a data hole at a location of each data of the one or more data in the time series database. Responsive to an input/output rate for the time series database being below a threshold, the data hole of each data of the one or more data is optimized.

Abstract: The present disclosure provides methods and compositions for tracking nucleic acid fragment origin by target-specific barcode tagging when original nucleic acid targets break into small fragments. Nucleic acid targets are captured in vitro on a solid support with clonally localized nucleic acid barcode templates. Many nucleic acid targets can be processed simultaneously in a massively parallel fashion without partition. These nucleic acid target tracking methods can be used for a variety of applications in both whole genome sequencing and targeted sequencing in order to accurately identify genomic variants, haplotype phasing and assembly, for example.

Abstract: The present invention relates to a nanopore device with a motion control mechanism to control the speed of a polymeric molecule translocating through the nanopore for a tunneling nanogap to read out its sequences or components.

Abstract: This invention provides methods to identify or sequence a DNA or RNA molecule electronically in a single molecule level based on polymerase synthesis.

Abstract: Antibodies that specifically bind to the human tight junction molecule CLDN18.2 and have functional properties that make them suitable for use in antibody-based immunotherapies of a disease associated with aberrant expression of CLDN18.2 are disclosed.

Abstract: A connector assembly includes a connector, a circuit board having a first soldering pin and a second soldering pin electrically connected with the first soldering pin, a cable having a wire with a conductor, and an outer shield housing mounted on the circuit board and covering the connector, the cable, and the circuit board. The connector includes a shield housing, an insulation body disposed in the shield housing, and a conductive terminal held in the insulation body. The conductive terminal is soldered to the first soldering pin. The conductor is soldered to the second soldering pin.

Abstract: The present disclosure provides antibodies and antibody fragments thereof that bind to IL-23p19. The disclosed antibodies and antibody fragments thereof can modulate a biological activity of the IL-23 receptor signaling axis and are therefore useful for the treatment of immune-mediated inflammatory disorders.

Abstract: Provided is a method for determining data storage is insufficient for a program. A processor may receive a set of marked data associated with a set of source code. The processor may identify a scope of the code associated with the marked data. The processor may generate a first set of instructions for taking a first snapshot of a variable storage space associated with the marked data when entering the scope and a second snapshot of the variable storage space when exiting the scope. The processor may generate a second set of instructions for comparing the first and second snapshots to determine a usage amount of the variable storage. The processor may generate a third set of instructions for performing an action in response to the usage amount of the variable storage space exceeding a threshold. The processor may compile the code into an executable.

Abstract: The disclosure provides a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or anti-gen-binding portion thereof, wherein the subject is identified as having a high inflammatory gene signature score and a tumor that has a high tumor mutation burden (TMB) status. In some embodiments, the high inflammatory gene signature score is determined by measuring the expression of a panel of inflammatory genes in a tumor sample obtained from the subject, wherein the inflammatory gene panel comprises CD274 (PD-L1), CD8A, LAG3, and STAT1.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

Abstract: This invention provides a device for sequencing and identification of biopolymers electronically.

Abstract: Provided is a method for determining data storage is insufficient for a program. A processor may receive a set of marked data associated with a set of source code. The processor may identify a scope of the code associated with the marked data. The processor may generate a first set of instructions for taking a first snapshot of a variable storage space associated with the marked data when entering the scope and a second snapshot of the variable storage space when exiting the scope. The processor may generate a second set of instructions for comparing the first and second snapshots to determine a usage amount of the variable storage. The processor may generate a third set of instructions for performing an action in response to the usage amount of the variable storage space exceeding a threshold. The processor may compile the code into an executable.