Abstract: The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides binding partners for the bromodomain. The present invention further provides the structural determination of the Tat-P/CAF binding complex determined by NMR spectroscopy. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.

Abstract: A fabric sleeve and hybrid yarn filament used in construction of the sleeve for protecting elongate members against at least one of EMI, RFI or ESD, and methods of construction of the sleeve and hybrid yarn filament. The sleeve includes at least one interlaced hybrid yarn filament having a non-conductive filament and at least one conductive wire filament overlying an outer surface of the non-conductive filament. The hybrid yarn filament is arranged in electrical communication with itself or other hybrid yarn filaments to provide uniform shielding against EMI, RFI, and/or ESD.

Abstract: A continuous halogen-free flame-retardant filament and method of forming thereof includes providing MC, a phosphorus compound, and PET, and then, forming a mixture of the MC, phosphorus compound, and PET. And lastly, extruding the mixture to form the halogen-free flame-retardant filament. The filament can be braided, woven or knitted into a variety of fabric constructions, such as, for example, sleeves for protecting wires.

Abstract: A halogen-free flame-retardant compound and method of forming a continuous material therefrom includes compounding poly(ethylene terephthalate) (PET) with fire-retardant ingredients melamine cyanurate (MC) and melamine polyphosphate (MPP). The compound is then formed into pellets and/or extruded as a thin film or sheet, and also as a filament or yarn, including monofilaments and multifilaments.

Abstract: A hammer 28 is provided for a material size-reducing machine of the type including a rotor on which the hammer is individually pivotally mounted. The hammer 28 includes a mounting end 36 having a throughbore for receiving a pivot pin therethrough in connection with the pivot mounting of the hammer on the rotor, an extending portion 40 with the center of mass CGM located therein. The extending portion has a non-linear body portion 44 and a linear body portion 46 with the linear body portion 46 being inclined in a direction opposite to the rotation direction at an angle between 5 to 45 degrees as measured relative to a line RFL extending through the center of the pivot pin and the center of mass CGM of the hammer.

Abstract: A fabric sleeve and hybrid yarn filament used in construction of the sleeve for protecting elongate members against at least one of EMI, RFI or ESD, and methods of construction of the sleeve and hybrid yarn filament. The sleeve includes at least one interlaced hybrid yarn filament having a non-conductive filament and at least one conductive wire filament overlying an outer surface of the non-conductive filament. The hybrid yarn filament is arranged in electrical communication with itself or other hybrid yarn filaments to provide uniform shielding against EMI, RFI, and/or ESD.

Abstract: An fire-retardant insulating material and method of construction thereof has a textile fabric fabricated of continuous basalt filaments. The continuous basalt filaments are preferably texturized or twisted. The insulating material may be arranged in any configuration, such as a sheet, panel or sleeve, and may be knit, woven or braided.

Abstract: A low profile fold protective textile sleeve for bundling elongate members has longitudinally and laterally interlaced monofilament warp and fill yarns. Flat profile monofilaments are employed in the warp direction and round monofilaments in the fill direction. The flat monofilaments are considerably wider than they are thick, and provide the sleeve with flexibility and bending out of the plane of the sleeve. The round monofilaments may be sized so that their diameter is about the same as the thickness of the flat monofilaments, and they can be bundled together so that the effective width of each bundle approximates the width of the flat monofilament yarns with which they are intertwined. The round monofilaments are heat-set along at least a portion of their length to provide biased living hinge regions of the sleeve, while also lending strength and stiffness to the sleeve along the fill direction.

Abstract: The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.

Abstract: A 360 degree swivel cushion for bathroom encompassing a rotating device having a base plate, a ball bearing plate and a rotating plate disposedly configured between a lower fixed pad and an upper rotating pad. A plurality of stainless steel ball bearings atop the ball bearing plate are used to rotate within a large circular track and a small circular track of the rotating plate. Upon a mobility handicapped person sitting atop the cushion, the body can be rotated by merely swaying the body left and right, which thereby conveniences a family member or a house keeper to assist bathing and cleaning the body of the mobility handicapped person. Waterproof antiskid pads covering the rotating pad and the fixed pad not only provide for comfortable sitting and prevent slipping; moreover, both upper and lower surfaces are available for use.

Abstract: The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.

Abstract: A 360 degree swivel cushion includes a swivel ball seat configured between a swivel plate and a base plate. The steel balls are positioned within the swivel ball seat so that the cushion can slide on circular tracks configured on a base of the swivel plate. A cover is disposed on the swivel plate, and the cushion can rotate 360 degrees on top of the base plate.

Abstract: A 360 degree swivel cushion. The cushion includes a swivel ball seat configured between a swivel plate and a base plate. The steel balls are positioned within the swivel ball seat so that the cushion can slide on circular tracks configured on a base of the swivel plate. A cover is disposed on the swivel plate, and the cushion can rotate 360 degrees on top of the base plate.

Abstract: The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides binding partners for the bromodomain. The present invention further provides the structural determination of the Tat-P/CAF binding complex determined by NMR spectroscopy. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.

Abstract: The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides binding partners for the bromodomain. The present invention further provides the structural determination of the Tat-P/CAF binding complex determined by NMR spectroscopy. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.

Abstract: The present invention relates to methods and compositions for use in the intervention of diseases associated with HIV infection. In exemplary embodiments, methods and compositions for the treatment of HIV associated nephropathy (HIVAN) are disclosed.

Abstract: The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.

Abstract: The thermal performance of the heat transfer element assemblies for rotary regenerative air preheaters is enhanced to provide a desired level of heat transfer and pressure drop with a reduced weight. The heat transfer plates in the assemblies have spaced apart dimples for maintaining plate spacing and oblique undulations with the undulations on adjacent plates preferably extending at opposite oblique angles. The dimples may be on every other plate and alternate between the two sides of the plates or they may be on every plate and all extend to the same side.