Abstract: Oral care based imaging computer-implemented systems and methods for determining perceived attractiveness of a facial image portion of at least one person depicted in a digital image. The method has the following steps: a) obtaining a digital image comprising at least one oral feature of at least one person, wherein the digital image includes a facial image portion of the at least one person, the facial image portion having both positive and negative attributes as defined by pixel data of the digital image; b) analyzing the facial image portion; c) generating an Attractiveness Score indicative of a perceived attractiveness of the facial image portion based on the analyzed facial image portion in the obtained digital image; d) further generating an image description that identifies at least one area in said facial image portion based on the Attractiveness Score; and e) presenting the image description to a use.

Abstract: Catalyst systems that are resistant to high-temperature sintering and methods for preparing such catalyst systems that are resistant to sintering at high temperatures are provided. Methods of forming such catalyst systems include contacting a support having a surface including a catalyst particle with a solution comprising a metal salt and having an acidic pH. The metal salt is precipitated onto the surface of the support. Next, the metal salt is calcined to selectively generate a porous coating of metal oxide on the surface of the support distributed around the catalyst particle.

Abstract: Disclosed are a temporary plugging agent and a preparation method thereof, and a method for temporary plugging and fracturing of a high-temperature reservoir. The temporary plugging agent includes the following components in mass fractions: acrylamide 5%, composite crosslinking agent 1%, laponite 1%, ammonium persulfate 0.1% and water 92.9%.

Abstract: Oral care based imaging computer-implemented systems and methods for analyzing attributes of a facial image portion of at least one person depicted in a digital image. An oral care digital imaging computer-implemented method for analyzing a facial image portion of a person depicted in a digital image may include analyzing the facial image portion for positive and negative attributes as defined by pixel data of the digital image and generating a probability value based on the positive and negative attributes in the facial image portion in the digital image.

Abstract: A light emitting substrate is provided. The light emitting substrate includes a plurality of light emitting controlling units arranged in M rows and N columns, M is an integer equal to or greater than one, N is an integer equal to or greater than one, wherein a respective one of the plurality of light emitting controlling units includes a plurality of light emitting elements arranged in J rows and I columns, J being an integer equal to or greater than one, I being an integer equal to or greater than one, a i-th column of the I columns of light emitting elements includes J rows of light emitting elements, 1?i?I; (M×J) number of first voltage signal lines; and (M×J) number of groups of second voltage signal lines.

Abstract: A well cementing method is described for improving cementing quality by controlling the hydration heat of cement slurry. By controlling the degree and/or rate of hydration heat release from cement slurry, the method improves the hydration heat release during formation of cement with curing of cement slurry, improves the binding quality between the cement and the interfaces, and in turn improves the cementing quality at the open hole section and/or the overlap section. The cementing method improves cementing quality of oil and gas wells and reduces the risk of annular pressure.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and their uses.

Abstract: Disclosed are methods of treating a subject having high-risk multiple myeloma, methods of achieving negative minimal residual disease status in a subject having multiple myeloma, and methods of predicting a likelihood of, or decreasing a risk of, relapse and/or disease progression in a subject having multiple myeloma.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with bortezomib and dexamethasone.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with pomalidomide and dexamethasone.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with bortezomib, melphalan and prednisone.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with lenalidomide and dexamethasone.

Abstract: The present invention relates to methods of treating multiple myeloma using an approved drug product comprising daratumumab and hyaluronidase in combination with pomalidomide and dexamethasone. Also described are methods for improving progression-free survival in multiple myeloma patients and methods of selling or offering for sale a drug product comprising daratumumab and hyaluronidase.

Abstract: This disclosure relates to methods of treating a hematologic malignancy, comprising administering to a subject a therapeutically effective amount of an anti-CD38 antibody and a corticosteroid for a time sufficient to treat the hematologic malignancy, wherein the dosing regimen includes a reduction, elimination, or reduction followed by elimination, of corticosteroid administration to the subject. This disclosure also relates to methods of treating a hematologic malignancy, comprising administering to a subject a therapeutically effective amount of an anti-CD38 antibody and a corticosteroid dose of <0.01 mg/kg/day or equivalent for a time sufficient to treat the hematologic malignancy.

Abstract: This disclosure relates to methods of treating a hematologic malignancy, comprising administering to a subject a therapeutically effective amount of an anti-CD38 antibody and a corticosteroid for a time sufficient to treat the hematologic malignancy, wherein the dosing regimen includes a reduction, elimination, or reduction followed by elimination, of corticosteroid administration to the subject. This disclosure also relates to methods of treating a hematologic malignancy, comprising administering to a subject a therapeutically effective amount of an anti-CD38 antibody and a corticosteroid dose of < 0.01 mg/kg/day or equivalent for a time sufficient to treat the hematologic malignancy.

Abstract: Disclosed are methods of treating a subject having high-risk multiple myeloma, methods of achieving negative minimal residual disease status in a subject having multiple myeloma, and methods of predicting a likelihood of, or decreasing a risk of, relapse and/or disease progression in a subject having multiple myeloma.

Abstract: A dispenser system for dispensing a fluid product comprises: an elongated container containing the fluid product to be dispensed, a pump assembly coupled with the elongate container from the distal end, a piston which is slidably positioned in the container at the closed proximal end and contacting with the fluid product, and a standing cap. The standing cap has an opening for engaging the pump assembly, and has a supporting structure opposite to the opening, wherein the supporting structure comprises one or more supporting sections that define a supporting plane, wherein the dispenser system, when in a main standing position, stands upon the supporting structure of the standing cap, with the closed proximal end of the elongated container is on the topmost. Further the supporting structure of the standing cap has a projected area on the supporting plane which is larger than the largest cross-sectional area of the elongated container.

Abstract: Oral care based imaging computer-implemented systems and methods for determining perceived attractiveness of a facial image portion of at least one person depicted in a digital image. The method has the following steps: a) obtaining a digital image comprising at least one oral feature of at least one person, wherein the digital image includes a facial image portion of the at least one person, the facial image portion having both positive and negative attributes as defined by pixel data of the digital image; b) analyzing the facial image portion; c) generating an Attractiveness Score indicative of a perceived attractiveness of the facial image portion based on the analyzed facial image portion in the obtained digital image; d) further generating an image description that identifies at least one area in said facial image portion based on the Attractiveness Score; and e) presenting the image description to a use.

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.