Abstract: In general, a temperature control device for use in laser assemblies and optical subassemblies is disclosed that includes at least two electrically conductive terminals to enable flexible electrical coupling to associated components, e.g., monitor photodiodes and laser diodes, and accommodate a range of laser assembly configurations without the necessity of supplying a negative voltage rail. In more detail, a temperature control device consistent with the present disclosure includes a bottom plate, a top plate, and a plurality of semiconductor elements disposed therebetween. The top plate includes a component mounting surface that provides at least a first and second electrically conductive terminal/pad. The first and second electrically conductive terminals/pads can be electrically isolated, e.g., via a gap, and configured to provide first and second voltage potentials respectively.

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and their uses.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for rule generation and interaction. A rules engine is provided that does not require manual effort to generate or maintain high-quality rules over time for detecting malicious accounts or events. Rules no longer need to be manually added, tuned, or removed from the system. The system is able to determine the health of each rule and automatically add, tune, and remove rules to maintain a consistent, effective rule set.

Abstract: The present invention relates to methods of treating multiple myeloma using an approved drug product comprising daratumumab and hyaluronidase. Also described are drug products containing daratumumab and hyaluronidase, and methods of selling or offering for sale a drug product comprising daratumumab and hyaluronidase.

Abstract: A formulation of androgen receptor inhibitor HC-1119 is prepared from the following ingredients by weight ratio: 1 to 100 parts of the androgen receptor inhibitor HC-1119, 100 to 1000 parts of a solvent, and 0.11 to 11 parts of an antioxidant. The HC-1119 is dissolved in Labrasol so as to significantly improve the solubility of HC-1119, and thus greatly improve the bioavailability, reduce the difference in blood drug concentration and exposure among individuals, and increase the safety of medication. And the HC-1119 soft capsule has good stability.

Abstract: An electrochemical cell includes an air electrode in flow communication with a storage tank containing an aqueous solution of hydrogen peroxide, a lithium electrode, a catalyst layer in contact with the air electrode or a gas diffusion layer associated with the air electrode, and a separator layer in contact with the lithium electrode and catalyst layer. The catalyst layer includes a catalyst for two electron reversible oxygen reduction. The catalyst comprises gold, and a cobalt coordination complex or polymer thereof. The cobalt coordination complex comprises a cobalt ion chelated by a tetradentate organic chelating ligand.

Abstract: In general, a temperature control device for use in laser assemblies and optical subassemblies is disclosed that includes at least two electrically conductive terminals to enable flexible electrical coupling to associated components, e.g., monitor photodiodes and laser diodes, and accommodate a range of laser assembly configurations without the necessity of supplying a negative voltage rail. In more detail, a temperature control device consistent with the present disclosure includes a bottom plate, a top plate, and a plurality of semiconductor elements disposed therebetween. The top plate includes a component mounting surface that provides at least a first and second electrically conductive terminal/pad. The first and second electrically conductive terminals/pads can be electrically isolated, e.g., via a gap, and configured to provide first and second voltage potentials respectively.

Abstract: A dispenser having a nozzle, wherein the distal opening is larger than the proximate opening, has an improved user experience in dosing oral care compositions (such as toothpaste on a toothbrush).

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with bortezomib, melphalan and prednisone.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with bortezomib and dexamethasone.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and their uses.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with lenalidomide and dexamethasone.

Abstract: The present invention relates to clinically proven subcutaneous pharmaceutical compositions comprising anti-CD38 antibodies and methods of their uses in combination with pomalidomide and dexamethasone.

Abstract: Disclosed herein are methods of treating multiple myeloma using an antibody that specifically binds CD38 in combination with lenalidomide and dexamethasone.

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract: An electrochemical cell includes an air electrode in flow communication with a storage tank containing an aqueous solution of hydrogen peroxide, a lithium electrode, a catalyst layer in contact with the air electrode or a gas diffusion layer associated with the air electrode, and a separator layer in contact with the lithium electrode and catalyst layer. The catalyst layer includes a catalyst for two electron reversible oxygen reduction. The catalyst comprises gold, and a cobalt coordination complex or polymer thereof. The cobalt coordination complex comprises a cobalt ion chelated by a tetradentate organic chelating ligand.

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.