Abstract: The present application provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 4 (CDK4), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: The present application provides compounds of Formula (I): or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 2 and 4 (CDK2 and CDK4), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: The present application provides bicyclic amines of Formula (I): and their pharmaceutically acceptable salts thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: The present application provides heteroaryl fluoroalkene compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.

Abstract: The present application provides heteroaryl fluoroalkene compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.

Abstract: A wind power prediction method and system for optimizing a deep Transformer network by whale optimization algorithm are disclosed. The sequence data of wind power and related influence factors are taken as sample data which is divided into a training set and a test set, where the data is trained and predicted by a Transformer network model established according to values of the initialized hyper-parameters, and an average absolute error of wind power prediction is taken as a fitness value of each whale group. A local optimal position is determined according to the initial fitness value of individual whale group, and the current optimal position is updated by utilizing whale group optimization, and the best prediction effect is obtained by comparing the local optimal solution with the global optimal solution. An optimal hyper-parameter combination is obtained after multiple iterations of the whale optimization algorithm, and the wind power is predicted.

Abstract: A circuit health state prediction method and system based on an integrated deep neural network are provided and relates to a technique for predicting a power electronic circuit failure. The invention serves to identify and diagnose a health state of a simulation circuit based on historical data by using an integrated deep neural network, and the method includes: carrying out parameter aging simulation experiments for different devices; extracting a series of time domain features of output signals through a temporal transformation method, and establishing health indices of the devices based on an improved angular similarity; predicting a health state of the simulation circuit in degeneration by using CAE and LSTM-RNN; and predicting validity of the circuit health state prediction method by referring to relevant evaluation indices. The invention is capable of effectively predicting the health state of the simulation circuit and is highly accurate and easy to implement.

Abstract: The present application provides bicyclic amines of Formula (I): and their pharmaceutically acceptable salts thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: An array substrate and a manufacturing method thereof, wherein the array substrate includes a substrate; an active layer disposed on the substrate; a gate insulating layer disposed on the active layer; a gate disposed on the gate insulating layer; and a protection region dispose between the active layer and the gate, wherein the protection region is disposed on two sides of the gate and disposed on a same layer as the gate insulating layer.

Abstract: A wind power prediction method and system for optimizing a deep Transformer network by whale optimization algorithm are disclosed. The sequence data of wind power and related influence factors are taken as sample data which is divided into a training set and a test set, where the data is trained and predicted by a Transformer network model established according to values of the initialized hyper-parameters, and an average absolute error of wind power prediction is taken as a fitness value of each whale group. A local optimal position is determined according to the initial fitness value of individual whale group, and the current optimal position is updated by utilizing whale group optimization, and the best prediction effect is obtained by comparing the local optimal solution with the global optimal solution. An optimal hyper-parameter combination is obtained after multiple iterations of the whale optimization algorithm, and the wind power is predicted.

Abstract: A display unit, a display unit manufacturing method, and an organic light emitting diode display device are provided. The display unit includes: a substrate; a thin film transistor layer disposed above the substrate; an anode metal layer disposed above the thin film transistor layer; a pixel definition layer disposed above the anode metal layer; a light emitting structure disposed above the pixel definition layer. The pixel definition layer includes a first lamination layer and a second lamination layer disposed above the first lamination layer. Desiccants are distributed evenly in the second lamination layer.

Abstract: A method and a system of identifying and estimating a complex analog circuit failure, belonging to the field of power electronic circuit failure prediction. The method includes the following steps: building a degradation simulation model of an analog circuit to be diagnosed, performing a parameter aging simulation experiment on different devices; extracting a time domain feature of each of output signals by using a time-series transformation method, building a health index of each of the devices based on angle similarity; identifying whether the analog circuit to be diagnosed is degraded and a starting point of degradation by combining a time moving window and a convolutional neural network; multiplexing part of hidden layers of the convolutional neural network and a long short term memory-recurrent neural network to estimate a health state of a degraded analog circuit; and evaluating prediction accuracy.

Abstract: A circuit health state prediction method and system based on an integrated deep neural network are provided and relates to a technique for predicting a power electronic circuit failure. The invention serves to identify and diagnose a health state of a simulation circuit based on historical data by using an integrated deep neural network, and the method includes: carrying out parameter aging simulation experiments for different devices; extracting a series of time domain features of output signals through a temporal transformation method, and establishing health indices of the devices based on an improved angular similarity; predicting a health state of the simulation circuit in degeneration by using CAE and LSTM-RNN; and predicting validity of the circuit health state prediction method by referring to relevant evaluation indices. The invention is capable of effectively predicting the health state of the simulation circuit and is highly accurate and easy to implement.

Abstract: A display unit, a display unit manufacturing method, and an organic light emitting diode display device are provided. The display unit includes: a substrate; a thin film transistor layer disposed above the substrate; an anode metal layer disposed above the thin film transistor layer; a pixel definition layer disposed above the anode metal layer; a light emitting structure disposed above the pixel definition layer. The pixel definition layer includes a first lamination layer and a second lamination layer disposed above the first lamination layer. Desiccants are distributed evenly in the second lamination layer.

Abstract: The present disclosure provides a display panel, a display device, and a display method thereof. The display panel includes a display area including: a light-emitting sub-area and an external light-transmitting sub-area; the display panel further includes: an anode, a light-emitting layer, a cathode, and a cover layer. The cover layer covers at least the light-emitting sub-area, and by patterning the covering layer, the normal electrical performance of each layer is ensured, and the transparent display effect of the display panel and the display device is improved.

Abstract: A method for treatment of a liver disease, the method including administering kinsenoside to a patient in need thereof.

Abstract: A method of manufacturing a display panel, the display panel, and a display device are provided. The method includes forming a first via hole within a gate insulating layer and a dielectric layer of the display panel, forming an auxiliary electrode within the first via hole and on the dielectric layer, forming an inorganic insulating layer on the auxiliary electrode, and forming a cathode on the inorganic insulating layer. The cathode, the inorganic insulating layer, and the auxiliary electrode form a capacitance. The method maintains stability of a cathode voltage of the display panel, thereby improving uniformity of brightness of the display panel.

Abstract: A display panel and a method of fabricating the same are provided. The display panel has an active region and a non-active region. The display panel has a plurality of data lines, wherein a height difference is defined between neighboring data lines in the non-active region. The display panel can reduce an area of the non-active region by switching layers of the data lines in the non-active region.

Abstract: A method of fabricating an array substrate, an array substrate, a display panel, and a display device are provided. In an embodiment, a gate insulating layer above a channel region is doped with fluorine atoms. Since a fluorine-containing inorganic layer can absorb hydrogen atoms, it can block hydrogen atoms from diffusing downward into a metal oxide semiconductor, thereby avoiding affecting electrical properties of thin film transistors. Simultaneously, only a metal is required to use as a metal gate layer, which simplifies process and reduces production costs.

Abstract: A method of manufacturing a display panel, the display panel, and a display device are provided. The method includes forming a first via hole within a gate insulating layer and a dielectric layer of the display panel, forming an auxiliary electrode within the first via hole and on the dielectric layer, forming an inorganic insulating layer on the auxiliary electrode, and forming a cathode on the inorganic insulating layer. The cathode, the inorganic insulating layer, and the auxiliary electrode form a capacitance. The method maintains stability of a cathode voltage of the display panel, thereby improving uniformity of brightness of the display panel.