Abstract: The present invention provides a process of producing a trifluoromcthoxylated aryl or trifluoromothoxylated heteroaryl having the structure: wherein A is an aryl or heteroaryl, each with or without substitution; and R1 is —H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), -(alkylaryl), -(alkylheteroaryl), —NH-(alkyl), —N(alkyl)2, —NH-(alkenyl), —NH-(alkynyl) —NH-(aryl), —NH-(heteroaryl), —O-(alkyl), —O-(alkenyl), —O-(alkynyl), —O-(aryl), —O-(heteroaryl), —S-(alkyl), —S-(alkenyl), —S-(alkynyl), —S-(aryl), or —S-(heteroaryl), comprising: (a) reacting a compound having the structure: with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure:

Abstract: A semiconductor structure includes an isolation feature formed in the semiconductor substrate and a first fin-type active region. The first fin-type active region extends in a first direction. A dummy gate stack is disposed on an end region of the first fin-type active region. The dummy gate stack may overlie an isolation structure. In an embodiment, any recess such as formed for a source/drain region in the first fin-type active region will be displaced from the isolation region by the distance the dummy gate stack overlaps the first fin-type active region.

Abstract: The present disclosure provides compounds of Formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. where R1, alk, R2, Z1, Z2, X, R3, R4, B, a, and b are as described herein.

Abstract: An oral rehabilitation device for rehabilitating the oral cavity of a user includes a device body, a first activating member, an upper-jaw member, a lower-jaw member, and a processing unit. The first activating member is disposed on an end of the device body. The upper-jaw member and the lower-jaw member are connected to the same end of the device body and are for contacting an upper jaw and lower jaw of the user, respectively. The processing unit is coupled to the first activating member and is used to control the first activating member to drive one of the upper-jaw member and the lower jaw member to open or close relative to the other of the upper-jaw member and the lower-jaw member, such that the upper jaw and the lower jaw can be rehabilitated. The present invention further discloses a medical treatment system to which the oral rehabilitation device is linked.

Abstract: This invention provides an adjustable oral interface for adapting a user's oral anatomy to deliver a negative pressure generated by an oral negative-pressure therapy system. The adjustable oral interface comprises a shield adapted for being situated between a user's lips and front teeth, a negative pressure deliverable part coupled with the shield, and a tube fluidly communicated between the negative pressure deliverable part and a negative pressure generation source. The negative pressure deliverable part is adapted for being adjustably situated at a space between the user's tongue and upper palate so as to be conformable to the contour of the upper palate, whereby the adjustable oral interface delivers negative pressure via the negative pressure deliverable part to the front and back of the user's oral cavity to eliminate air space between the tongue and the upper palate.

Abstract: A method for obtaining a handwriting trajectory is provided. The method includes the following steps: capturing images of handwriting that is written with a writing brush on a piece of paper on a writing platform; obtaining positions where pixels in each of the images are lower than a threshold according to the threshold; and outputting handwriting images according to the positions.

Abstract: A device includes a plurality of semiconductor fins extending from a substrate. A plurality of first source/drain regions are epitaxially grown from first regions of the semiconductor fins. Adjacent two of the plurality of first source/drain regions grown from adjacent two of the plurality of semiconductor fins are spaced apart by an isolation dielectric. A gate structure laterally surrounds second regions of the plurality of semiconductor fins above the first regions of the plurality of semiconductor fins. A plurality of second source/drain regions are over third regions of the plurality of semiconductor fins above the second regions of the plurality of semiconductor fins.

Abstract: In various examples, a generative model is used to synthesize datasets for use in training a downstream machine learning model to perform an associated task. The synthesized datasets may be generated by sampling a scene graph from a scene grammar—such as a probabilistic grammar— and applying the scene graph to the generative model to compute updated scene graphs more representative of object attribute distributions of real-world datasets. The downstream machine learning model may be validated against a real-world validation dataset, and the performance of the model on the real-world validation dataset may be used as an additional factor in further training or fine-tuning the generative model for generating the synthesized datasets specific to the task of the downstream machine learning model.

Abstract: Provided in an embodiment of the present disclosure is a method for acquiring data of a data source associated with a production line, including: acquiring a semantic model, the semantic model including semantic relationships between respective semantic units and data source identifiers corresponding to one or more production lines; receiving production line identifiers and acquiring one or more semantic units; converting, based upon the semantic model, the one or more semantic units to data source identifiers corresponding to production lines indicated by the production line identifiers; and acquiring data of data sources indicated by the data source identifiers. Implementing the embodiments disclosed in the present disclosure simplifies a configuration file required for a virtual model of a production line, thereby greatly reducing configuration workload, and enhancing convenience of acquiring data of a data source.

Abstract: Provided are an image sensor and a manufacturing method thereof. In the image sensor, an insulating layer and a first silicon layer are sequentially on a silicon base. A first isolation structure is in the first silicon layer to define an active area (AA). A doped region is in a part of the first silicon layer in the AA and in a part of the silicon base thereunder. A second silicon layer is in a part of the first silicon layer in the AA and extends into the silicon base. An interconnection structure is on the first silicon layer and electrically connected with a transistor. A second isolation structure is in the silicon base under the first isolation structure and connected to the insulating layer. A passivation layer surrounds the silicon base and is connected to the doped region. A microlens is on the silicon base.

Abstract: Disclosed herein are methods for selecting an antibody fragment specific to an influenza virus. According to certain embodiments of the present disclosure, the influenza virus may be influenza virus type A (IAV) or influenza virus type B (IBV). Also disclosed herein are the selected antibodies, recombinant antibody produced from the selected antibodies, and the uses thereof in the diagnosis of influenza virus infection.

Abstract: A backlight module includes a light guide plate, a light source, an optical film, and a prism sheet. The optical film includes a first substrate having opposite first and second surfaces and multiple optical microstructures disposed on the second surface and each having a first light receiving surface away from a light incident surface. The prism sheet is located on a side of the second surface of the first substrate. The prism sheet includes a second substrate having opposite third and fourth surfaces and multiple prism structures disposed on the fourth surface and each having a second light receiving surface away from the light incident surface. A first angle between the first light receiving surface and the second surface is different from a second angle between the second light receiving surface and the fourth surface. A display apparatus includes the backlight module and a display panel.

Abstract: The disclosure relates to methods for treating a subject suffering from a burn injury or associated complications by administering to the subject an effective amount of an aromatic-cationic peptide. For example, a burn injury may be associated with distant pathophysiological effects, such as hypermetabolism, skeletal muscle dysfunction, and organ damage. The disclosure also relates to methods for protecting a subject from a burn injury by administering an effective amount of an aromatic-cationic peptide to a subject at risk of a burn injury.

Abstract: A device for generating alternating electric field of low frequency, a system for generating alternating electric field of low frequency, and a signal regulating method are provided. According to implementations herein, a device for generating alternating electric field of low frequency may comprise an input control module, a transformer, an output control module, and an electric discharge module. In one aspect, an input end of the input control module is configured to be coupled with an external AC power supply, the input control module is coupled with a primary side winding of the transformer, one end of a secondary side winding of the transformer is coupled with the output control module, the output control module is coupled with the electric discharge module, and the other end of the secondary side winding of the transformer is coupled with ground potential.

Abstract: A semantics-based Internet of Things (IOT) device data processing-related application installation method and apparatus are disclosed. In an embodiment, the method includes receiving a data processing demand from a client, retrieving, from an industrial cloud, at least one application which needs to be installed for fulfilment of the data processing demand, and analyzing required source data and an installation demand of the application; analyzing at least one device end capable of providing the source program in the IOT to determine whether the device meets the installation demand of the application and provides the required source data; and installing the application in a gateway corresponding to the device end, upon the device end being determined to be able to meet the installation demand of the application.

Abstract: Input devices can employ ultrasonic touch sensing capabilities that allow user inputs to be detected through conductive materials, such as metal enclosures. The ultrasonic touch sensing can include generation of ultrasound signals with a piezoelectric layer. The ultrasound signals can be reflected when a user or other object is in contact with a housing, and the reflected signal can be detected by the same piezoelectric layer that produced the ultrasound signal. Such a piezoelectric layer can include a piezoelectric polymer, such as polyvinylidene fluoride (PVDF). An array of electrodes distributed on opposing sides of the use of electric layer can be operated to generate ultrasound signals and detect reflected signals. Such an input device can be operated in conjunction with a conductive (e.g.

Abstract: Disclosed herein are recombinant antibodies or the fragment thereof for detecting severe acute respiratory syndrome coronavirus (SARS-CoV). According to some embodiments, the SARS-CoV is SARS-CoV-1. According to some alternative embodiments, the SARS-CoV is SARS-CoV-2. Also disclosed herein are a kit comprising the recombinant antibodies, and a method for diagnosing the infection of SARS-CoV by using the recombinant antibody or the kit.

Abstract: The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract: The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Abstract: A method for allocating wireless resources based on sensitivity to interference provides a base station controller which, within an area of overlap of adjacent wireless cells, determines a set of neighboring cell pairs from a plurality of cells. The base station controller sorts the set of neighboring cell pairs according to the number of inner-pair interfered user equipment devices of each neighboring cell pair where inner-pair interfered user equipment devices are user equipment devices located in coverage areas of the neighboring cell pair and allocates resource blocks for each neighboring cell pair sequentially based on the sorted set. An apparatus employing the method is also disclosed.