Patents by Inventor Minglin Ma

Minglin Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12097307
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: September 24, 2024
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Arturo Vegas, Joshua C. Doloff, Omid Veiseh, Minglin Ma, Robert S. Langer, Daniel G. Anderson
  • Patent number: 12041939
    Abstract: A composition for detoxifying insect pollinators from one or more organophosphate pesticides, the composition containing microparticles comprising: (i) a phosphotriesterase; (ii) nanoparticles; and (iii) a surface active agent. Also disclosed herein is an aqueous suspension comprising the above-described detoxifying microparticles in an external aqueous medium, which may also contain an insect pollinator attractant. Also described herein is a method for detoxifying insect pollinators of one or more organophosphate pesticides, the method comprising placing the detoxifying aqueous suspension in a location accessible to the insect pollinators to permit the insect pollinators to ingest the detoxifying aqueous suspension, wherein the detoxifying aqueous suspension comprises microparticles, as described above, suspended in an external aqueous medium, typically also including an insect pollinator attractant in the external aqueous medium.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: July 23, 2024
    Assignee: CORNELL UNIVERSITY
    Inventors: James Webb, Jing Chen, Minglin Ma
  • Publication number: 20240207486
    Abstract: Disclosure herein are an implantable cell containing device, its subcomponent scaffold, methods of making the same and their methods of use. The implantable cell containing device includes a scaffold and a cell-containing hydrogel encapsulating the scaffold. The scaffold has a tracheal-like internal system of continuous air-filled, hydrophobic micro-channels that traverse the scaffold's dimensions and a hydrophilic external surface. The implantable cell containing device, when implanted in a subject, can be used for delivering a therapeutic agent to a subject in need thereof for the treatment of various conditions and diseases.
    Type: Application
    Filed: April 14, 2022
    Publication date: June 27, 2024
    Inventors: Minglin MA, Longhai WANG, Alexander ERNST
  • Patent number: 11912894
    Abstract: The present application discloses a method of forming a hydrogel-coated substrate, wherein the hydrogel has antifouling and antimicrobial properties. The method comprises applying an aqueous pre-hydrogel solution to a substrate, polymerizing the aqueous pre-hydrogel solution, thereby forming a coated substrate having a conformal hydrogel coating and a non-conformal hydrogel coating, contacting the coated substrate with a swelling agent, and removing the non-conformal hydrogel coating from the coated substrate, thereby leaving the conformal hydrogel coating on the substrate to form the hydrogel-coated substrate. The aqueous pre-hydrogel solution comprises a monomer with antimicrobial activity, a monomer with antifouling activity, and either a polymer, oligomer, or macromer which, when polymerized together, form a hydrogel. Also disclosed is a coated substrate and a hydrogel coating.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: February 27, 2024
    Assignee: CORNELL UNIVERSITY
    Inventors: Minglin Ma, You Yong, Mingyu Qiao, Qingsheng Liu
  • Patent number: 11903976
    Abstract: Disclosed are an implantable therapeutic delivery system and methods of treatment utilizing the implantable therapeutic delivery system. The implantable therapeutic delivery system includes a nanofibrous core substrate including one or more internal spaces wherein one or more therapeutic agents is positioned in the one or more internal spaces; and an outer biocompatible polymeric coating surrounding said nanofibrous core substrate.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: February 20, 2024
    Assignee: CORNELL UNIVERSITY
    Inventors: Minglin Ma, James A. Flanders, Duo An
  • Publication number: 20240024089
    Abstract: The present disclosure is directed to devices and systems for oxygenating encapsulated cells. The disclosure further relates to individual components of these devices and systems and methods of using the devices and systems to deliver a therapeutic agent to a subject in need thereof.
    Type: Application
    Filed: December 9, 2021
    Publication date: January 25, 2024
    Inventors: Longhai WANG, Alexander ERNST, Minglin MA, James FLANDERS
  • Publication number: 20240018276
    Abstract: The present invention is directed to a polymer of Formula (IV): wherein A, X, Q, Y, Z, m1, m2, m3, k1, and k2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III): wherein R?, X1, Y1, Z1, m4, m5, and m6 are as described herein, and a polymeric network comprising two or more monomers of Formula (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.
    Type: Application
    Filed: March 16, 2023
    Publication date: January 18, 2024
    Inventors: Minglin MA, Qingsheng LIU
  • Publication number: 20230173141
    Abstract: The present application relates to implantable therapeutic delivery system, its method of making and use. The therapeutic delivery system includes a nanofiber core substrate having proximal and distal ends, and an interior nanofiber wall defining an internal space extending longitudinally along the core substrate, with one or more therapeutic agents positioned within the internal space. A hydrogel surrounds the nanofiber core substrate, where the hydrogel includes 0.1% to 20% of an alginate mixture. The alginate mixture includes zwitterionically modified alginate and pure alginate in a ratio of 1:1000 to 1000:1 (v/v). Also disclosed is a thermo sealing device useful for the formation of the implantable therapeutic delivery system.
    Type: Application
    Filed: April 2, 2021
    Publication date: June 8, 2023
    Inventors: Wanjun LIU, Minglin MA, James A. FLANDERS, Longhai WANG, Daniel T. BOWERS, Qingsheng LIU
  • Publication number: 20230130084
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
    Type: Application
    Filed: May 20, 2022
    Publication date: April 27, 2023
    Inventors: Arturo J. Vegas, Minglin Ma, Kaitlin M. Bratlie, Daniel G. Anderson, Robert S. Langer
  • Patent number: 11634512
    Abstract: The present invention is directed to a polymer of Formula (IV): wherein A, X, Q, Y, Z, m1; m2, m3, k1; and k2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III), wherein R?, X1, Y1, Z1, m4, m5, and m6 are as described herein, and a polymeric network comprising two or more monomers of Formula (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.
    Type: Grant
    Filed: January 27, 2018
    Date of Patent: April 25, 2023
    Assignee: CORNELL UNIVERSITY
    Inventors: Minglin Ma, Qingsheng Liu
  • Publication number: 20220380944
    Abstract: The present application relates to fibers having a diameter of 1 nm to 10,000 nm, of one or more biocompatible polymers, wherein the polymers have a backbone which includes a positively charged component from a zwitterionic moiety. Additionally, this application discloses an implantable therapeutic delivery system and its method of formation, comprising a housing defining a chamber, wherein said housing is porous and formed from the fibers. Inside of the housing includes a preparation of cells which release a therapeutic agent from the chamber. The implantable therapeutic delivery system can be used in the treatment of diabetes.
    Type: Application
    Filed: April 30, 2020
    Publication date: December 1, 2022
    Inventors: Minglin MA, Qingsheng LIU, Xi WANG, James A. FLANDERS
  • Patent number: 11446239
    Abstract: Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: September 20, 2022
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Minglin Ma, Daniel G. Anderson, Robert S. Langer, Omid Veiseh, Joshua Charles Doloff, Delai Chen, Christian J. Kastrup, Arturo Jose Vegas
  • Publication number: 20220174962
    Abstract: A composition for detoxifying insect pollinators from one or more organophosphate pesticides, the composition containing microparticles comprising: (i) a phosphotriesterase; (ii) nanoparticles; and (iii) a surface active agent. Also disclosed herein is an aqueous suspension comprising the above-described detoxifying microparticles in an external aqueous medium, which may also contain an insect pollinator attractant. Also described herein is a method for detoxifying insect pollinators of one or more organophosphate pesticides, the method comprising placing the detoxifying aqueous suspension in a location accessible to the insect pollinators to permit the insect pollinators to ingest the detoxifying aqueous suspension, wherein the detoxifying aqueous suspension comprises microparticles, as described above, suspended in an external aqueous medium, typically also including an insect pollinator attractant in the external aqueous medium.
    Type: Application
    Filed: December 7, 2021
    Publication date: June 9, 2022
    Inventors: James Webb, Jing Chen, Minglin Ma
  • Patent number: 11337930
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: May 24, 2022
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Arturo J. Vegas, Minglin Ma, Kaitlin M. Bratlie, Daniel G. Anderson, Robert S. Langer
  • Publication number: 20220118025
    Abstract: The present disclosure is directed to an implantable therapeutic delivery device. This device comprises a hydrogel core; one or more therapeutic agents suspended within the hydrogel core; and an elongated nanofibrous substrate having proximal and distal ends, said nanofiber substrate having an interior nanofiber wall defining an internal space that extends longitudinally between the proximal and distal ends of the substrate, wherein the hydrogel core comprising the one or more therapeutic agents is positioned within the internal space. The disclosure is also directed to methods of delivering a therapeutic agent to a subject in need thereof that involves implanting the device described herein.
    Type: Application
    Filed: October 15, 2021
    Publication date: April 21, 2022
    Inventors: Minglin MA, Xi WANG, James A. FLANDERS
  • Patent number: 11266606
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: March 8, 2022
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Arturo J. Vegas, Joshua C. Doloff, Omid Veiseh, Minglin Ma, Robert S. Langer, Daniel G. Anderson
  • Publication number: 20220031913
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
    Type: Application
    Filed: July 15, 2021
    Publication date: February 3, 2022
    Inventors: Arturo Vegas, Joshua C. Doloff, Omid Veiseh, Minglin Ma, Robert S. Langer, Daniel G. Anderson
  • Publication number: 20210267200
    Abstract: The present application relates to copolymers of N-halamine (HA) and dopamine (DMA) and their method of formation. The HA and DMA are present in the copolymer in a ratio of 0.4:9.6 to 9.6:0.4 (HA: DMA). The copolymers can be used in novel antimicrobial compositions that can be coated, and covalently bonded to surfaces such as metal, plastic, glass, or paint surfaces. The coating provides a rechargeable antimicrobial surface with the treatment of a halogen. The coating thickness and halogen content can be tuned by adjusting the formulation and crosslinking the coating.
    Type: Application
    Filed: June 18, 2019
    Publication date: September 2, 2021
    Inventors: Minglin MA, Randy WOROBO, Mingyu QIAO
  • Patent number: 11090413
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: August 17, 2021
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE CHILDREN'S MEDICAL CENTER CORPORATON
    Inventors: Arturo Vegas, Joshua C. Doloff, Omid Veiseh, Minglin Ma, Robert S. Langer, Daniel G. Anderson
  • Publication number: 20210186886
    Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
    Type: Application
    Filed: October 26, 2020
    Publication date: June 24, 2021
    Inventors: Arturo J. Vegas, Minglin Ma, Kaitlin M. Bratlie, Daniel G. Anderson, Robert S. Langer