Patents by Inventor Mingyong Xiong
Mingyong Xiong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10907181Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.Type: GrantFiled: December 20, 2019Date of Patent: February 2, 2021Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Kechun Zhang, Mingyong Xiong
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Publication number: 20200172944Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.Type: ApplicationFiled: December 20, 2019Publication date: June 4, 2020Inventors: Kechun Zhang, Mingyong Xiong
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Patent number: 10597687Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.Type: GrantFiled: January 18, 2019Date of Patent: March 24, 2020Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Kechun Zhang, Mingyong Xiong
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Publication number: 20190153490Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.Type: ApplicationFiled: January 18, 2019Publication date: May 23, 2019Inventors: Kechun Zhang, Mingyong Xiong
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Patent number: 10202624Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.Type: GrantFiled: April 18, 2014Date of Patent: February 12, 2019Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Kechun Zhang, Mingyong Xiong
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Patent number: 10006064Abstract: This disclosure describes engineered biosynthetic pathways, recombinant cells, and methods relating to biosynthesis of esters. The recombinant cells may be modified to exhibit increased biosynthesis of an ester compared to a wild-type control. The recombinant cell may be incubated in medium that includes a carbon source under conditions effective for the recombinant cell to produce an ester. This disclosure also describes a method that generally includes introducing into a host cell a heterologous polynucleotide encoding at least one polypeptide that catalyzes a step in converting a carbon source to an ester, wherein the at least one polynucleotide is operably linked to a promoter so that the modified host cell catalyzes conversion of the carbon source to an ester.Type: GrantFiled: March 14, 2013Date of Patent: June 26, 2018Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Kechun Zhang, Mingyong Xiong, Yi-Shu Tai
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Publication number: 20180080032Abstract: This disclosure describes a recombinant microbial cells and methods of making and using such recombinant microbial cells. Generally, the recombinant cells may be modified to exhibit increased biosynthesis of a TCA derivative compared to a wild-type control. In some embodiments, the TCA derivative can include 1,4-butanediol. In various embodiments, the microbial cell is a fungal cell or a bacterial cell. In some embodiments, the increased biosynthesis of the TCA derivative can include an increase in xylose dehydrogenase activity, xylonolactonase activity, xylonate dehydratase activity, or 2-keto-3-deoxyaldonic acid dehydratase activity.Type: ApplicationFiled: December 4, 2017Publication date: March 22, 2018Inventors: Kechun ZHANG, Mingyong XIONG
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Patent number: 9909129Abstract: This disclosure describes a recombinant microbial cells and methods of making and using such recombinant microbial cells. Generally, the recombinant cells may be modified to exhibit increased biosynthesis of a TCA derivative compared to a wild-type control. In some embodiments, the TCA derivative can include 1,4-butanediol. In various embodiments, the microbial cell is a fungal cell or a bacterial cell. In some embodiments, the increased biosynthesis of the TCA derivative can include an increase in xylose dehydrogenase activity, xylonolactonase activity, xylonate dehydratase activity, or 2-keto-3-deoxyaldonic acid dehydratase activity.Type: GrantFiled: December 18, 2013Date of Patent: March 6, 2018Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Kechun Zhang, Mingyong Xiong
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Publication number: 20160068877Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.Type: ApplicationFiled: April 18, 2014Publication date: March 10, 2016Inventors: Kechun Zhang, Mingyong Xiong
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Publication number: 20150337342Abstract: This disclosure describes a recombinant microbial cells and methods of making and using such recombinant microbial cells. Generally, the recombinant cells may be modified to exhibit increased biosynthesis of a TCA derivative compared to a wild-type control. In some embodiments, the TCA derivative can include 1,4-butanediol. In various embodiments, the microbial cell is a fungal cell or a bacterial cell. In some embodiments, the increased biosynthesis of the TCA derivative can include an increase in xylose dehydrogenase activity, xylonolactonase activity, xylonate dehydratase activity, or 2-keto-3-deoxyaldonic acid dehydratase activity.Type: ApplicationFiled: December 18, 2013Publication date: November 26, 2015Inventors: Kechun ZHANG, Mingyong XIONG
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Publication number: 20150140620Abstract: This disclosure describes engineered biosynthetic pathways, recombinant cells, and methods relating to biosynthesis of esters. The recombinant cells may be modified to exhibit increased biosynthesis of an ester compared to a wild-type control. The recombinant cell may be incubated in medium that includes a carbon source under conditions effective for the recombinant cell to produce an ester. This disclosure also describes a method that generally includes introducing into a host cell a heterologous polynucleotide encoding at least one polypeptide that catalyzes a step in converting a carbon source to an ester, wherein the at least one polynucleotide is operably linked to a promoter so that the modified host cell catalyzes conversion of the carbon source to an ester.Type: ApplicationFiled: March 14, 2013Publication date: May 21, 2015Applicant: Regents of The University of MinnesotaInventors: Kechun Zhang, Mingyong Xiong, Yi-Shu Tai
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Publication number: 20140065697Abstract: Disclosed herein are cells and methods for renewably producing isobutyrate. In some cases, the cells can include a heterologous DNA that encodes at least one enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate. In other cases, the cells can include a genetically modified enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate to a degree greater than the wild-type version of the enzyme. In other cases, the cells can include one or more enzyme that catalyze the conversion of 2-ketovaline to isobutyrate. Generally, methods include growing the cells in a medium that includes a carbon source that the cells are able to convert to isobutyrate.Type: ApplicationFiled: February 10, 2012Publication date: March 6, 2014Applicant: Regents of the University of MinnesotaInventors: Kechun Zhang, Mingyong Xiong, Adam P. Woodruff