Abstract: Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.

Abstract: The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

Abstract: The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

Abstract: This invention relates to medicaments, particularly novel fused imidazolium derivatives useful for the treatment of cancers and novel synthetic intermediate compounds thereof.

Abstract: The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

Abstract: The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.

Abstract: An orally administrable uncompressed rapidly dissolving molded dosage form comprises a drug and either one or more saccharides or one saccharide and polyvinylpyrrolidone. Saccarides are chosen and used in proportion based on their solubilities. Methods for producing uncompressed rapidly dissolving solid preparations comprise mixing a drug and carriers according to the present invention and charging the mixture in a mold. Rapidly dissolving oral dosage forms facilitate administration of drugs to patients having a difficulty in swallowing such as children and the elderly.

Abstract: This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and biocompatibility, and (b) a drug. When applied directly to a joint area, this preparation can achieve a high drug concentration at the target area, can inhibit occurrence of general side effect, and can maintain drug efficacy over a long term. The preparation can therefore alleviate the burden on the patient.

Abstract: A vehicle-vehicle communication system includes an in-vehicle wire LAN established in a vehicle. The in-vehicle wire LAN includes a plurality of devices connected by optical fiber links. A terminal for radio vehicle-vehicle communication is connected to the in-vehicle wire LAN by the optical fiber link. The terminal receives an optical digital signal in a predetermined format from the in-vehicle wire LAN. The terminal includes a light controlled oscillator and applies the received optical signal to the light controlled oscillator. The light controlled oscillator outputs a transmission signal of a frequency shifted from a predetermined frequency according to the intensity of the applied optical signal. Thus the terminal generates the transmission signal using FSK-modulation technique without converting the format of the optical signal into another format. The transmission signal is transmitted to a device in another vehicle via radio waves.

Abstract: The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.

Abstract: This invention relates to a drug composition with a controlled drug release rate. The drug composition comprises: a matrix formed of the following ingredients (a) and (b): (a) a biodegradable, biocompatible high-molecular substance and/or polyvalent metal ions or polyvalent metal ion source, and (b) hyaluronic acid or a salt thereof; and a drug incorporated as an ingredient (c) in said matrix. The drug composition has biodegradability and biocompatibility, permits easy control of a release rate of the drug, and can persistently exhibit its pharmacological effect over a long time.

Abstract: A Micro-cell is formed to include a plurality of spot-cells. Communication is executed between a micro-cell base station and a mobile terminal in the micro-cell, and between a spot-cell base station and the mobile terminal in the spot cell. The micro-cell base station and spot-cell base stations are connected to an integrated base station. A signal transmitted to the micro-cell base station from the mobile terminal is transferred to the integrated base station and information transmitted to the mobile terminal is transferred to the micro-cell base station and/or spot-cell base station from the integrated base station. The respective integrated base stations are connected to a server via a dedicated backbone to enable a large-capacity transmission.

Abstract: An ECU is provided with a microcomputer for performing arithmetic operation for controlling a control target by executing a program stored in a ROM and for performing the process to transmit the control data calculated by means of the arithmetic operation to a communication target. The program comprises independent program modules, that is, a program (application unit) for performing the arithmetic operation, a program (communication conversion unit) for extracting the control data to be transmitted from among the control data calculated by the application unit and for performing the process to convert the extracted control data to the communication data string corresponding to the communication protocol of the communication target, and a program (communication driver unit) for performing the process to transmit the data string according to the communication protocol.

Abstract: A radio communication system between a mobile terminal station of a vehicle and a plurality of roadside fixed base stations is so constructed that communication areas of the base stations do not overlap with each other and satisfy the following two conditions. Condition (i): each communication area is defined so that there cannot be a plurality of terminal stations simultaneously. Condition (ii): it is needless to perform multiple access such as time division in the communication area and capable of affording the whole band and all the communication time allocated to one communication area to one terminal station and broad band communication becomes possible. Thus, each mobile terminal station can utilize all the frequency band allocated for service.

Abstract: A radio communication system performs radio communication between a terminal station installed on a vehicle and a plurality of base stations provided along a roadside. The system detects a vehicle traveling speed in each communication area formed by each base station. The vehicle traveling speed is detected by a method which uses radio communication between the terminal station and the base stations. The time of the vehicle stay in the communication area is estimated based on the detected vehicle traveling speed, and the length of a packet is determined based on the estimated time of the vehicle stay in the communication area. In this way, the present system performs data transmission using a packet of an appropriate length according to the detected vehicle traveling speed.

Abstract: This invention relates to an intra-articular preparation for the treatment of arthropathy, which comprises microcapsules of (a) a high-molecular substance, which has biodegradability and biocompatibility, and (b) a drug. When applied directly to a joint area, this preparation can achieve a high drug concentration at the target area, can inhibit occurrence of general side effect, and can maintain drug efficacy over a long term. The preparation can therefore alleviate the burden on the patient.

Abstract: A carbostyril derivative of the formula (1): ##STR1## wherein A is lower alkylene, R is H, halogen or lower alkoxy, R.sup.1 and R.sup.2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl, R.sup.3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that when R and R.sup.3 are H, R.sup.1 and R.sup.2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.

Abstract: A multi-frequency quadrature modulated signal is divided into a plurality of frequency bands. Each frequency band component is estimated as to variation in phase due to multi-path phasing, using its guard interval waveform so as to compensate the variation.

Abstract: There is disclosed a channel separating filter apparatus for separating a frequency-multiplexed signal comprised of channel signals into respective channel signals. A frequency-converting section frequency-converts the frequency-multiplexed signal into a plurality of channel signals, so that an average value of carrier wave frequencies of two channel signals which are located in the center of the frequency-multiplexed signal and are adjacent to each other becomes substantially zero, and then outputs the plurality of frequency-converted channel signals. Thereafter, a channel separating section separates the plurality of frequency-converted channel signals outputted from the frequency-converting section into respective channel signals each having only a frequency component of each channel signal, thereby separating the frequency-multiplexed signal into at least two channel signals.

Abstract: A magnetic card (10) has a base card (11), a magnetic stripe (12) formed on the base card (11), and a plurality of optical fibers (15) extended within the base card (11) substantially perpendicularly to the magnetic stripe (12). The magnetic stripe (12) consists of an arrangement of a plurality of unit magnetic segments (12a) each having a recording capacity of a predetermined number of bits, for example, eleven bits. The optical fibers (15) are assigned to the unit magnetic segments (12a), respectively. A read/write head (23) reads magnetic information from the magnetic stripe (12), an optical read device including a light-emitting device (20) and a light-receiving device (22) read optical information from the optical fibers (15), and a controller (25) examines the magnetic information with reference to the optical information to authenticate the magnetic information.