Patents by Inventor Miqin Zhang

Miqin Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10814021
    Abstract: Boron-doped graphene quantum dots, methods for making the boron-doped graphene quantum dots, and methods for magnetic resonance imaging using the boron-doped graphene quantum dots.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 27, 2020
    Assignee: University of Washington
    Inventors: Miqin Zhang, Richard Revia, Hui Wang
  • Publication number: 20190184037
    Abstract: Boron-doped graphene quantum dots, methods for making the boron-doped graphene quantum dots, and methods for magnetic resonance imaging using the boron-doped graphene quantum dots.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 20, 2019
    Applicant: University of Washington
    Inventors: Miqin Zhang, Richard Revia, Hui Wang
  • Patent number: 10119958
    Abstract: Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: November 6, 2018
    Assignee: University of Washington
    Inventors: Miqin Zhang, Mandana Veiseh
  • Patent number: 9784730
    Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: October 10, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh
  • Patent number: 9687569
    Abstract: Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: June 27, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Chen Fang
  • Patent number: 9644295
    Abstract: A centrifugal electrospinning apparatus, centrifugal electrospinning method for the production of fibrous structures, and electrospun fibrous structures are provided.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: May 9, 2017
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Ashleigh Cooper, Dennis Edmondson
  • Publication number: 20160193369
    Abstract: The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (MHC) monomer. The antigenic peptide-MHC monomer may then be recognized by a T cell receptor. These nanoparticles may further comprise a signal-generating label, such as a fluorophore. Methods employing nanoparticles of the present invention may involve magnetic resonance imaging and/or fluorescence detection, such that cell imaging and localization are performed.
    Type: Application
    Filed: March 10, 2016
    Publication date: July 7, 2016
    Applicants: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Miqin Zhang, Jonathan Whitney Gunn, Cassian Yee
  • Publication number: 20160153976
    Abstract: Polyarginine-coated nanoparticle, and methods for making and using the nanoparticle. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, include one or more of an associated therapeutic agent, targeting agent, and diagnostic agent.
    Type: Application
    Filed: February 1, 2016
    Publication date: June 2, 2016
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Omid Veiseh, Chen Fang, Forrest Kievit
  • Patent number: 9345486
    Abstract: A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: May 24, 2016
    Assignee: University of Washington
    Inventors: Miqin Zhang, Narayan Bhattarai
  • Publication number: 20160054302
    Abstract: Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion.
    Type: Application
    Filed: August 25, 2015
    Publication date: February 25, 2016
    Inventors: Miqin Zhang, Mandana Veiseh
  • Publication number: 20150320890
    Abstract: Nanoparticle having a chitosan-polyethylene oxide oligomer copolymer coating, and methods for making and using the nanoparticle are provided. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, one or more of an associated targeting agent, fluorescent agent, or therapeutic agent.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Applicant: University of Washington
    Inventors: Miqin Zhang, Conroy Sun, Omid Veiseh, Narayan Bhattarai
  • Patent number: 9157908
    Abstract: Methods for culturing cancer cells in vitro using a three-dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds that include the cultured cancer cells in anticancer therapeutic drug development.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: October 13, 2015
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Forrest Kievit, Matthew Chi-hang Leung, Stephen Florczyk
  • Publication number: 20150282811
    Abstract: A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration.
    Type: Application
    Filed: June 11, 2015
    Publication date: October 8, 2015
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Miqin Zhang, Narayan Bhattarai
  • Patent number: 9146229
    Abstract: Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: September 29, 2015
    Assignee: University of Washington
    Inventors: Miqin Zhang, Mandana Veiseh
  • Publication number: 20140286872
    Abstract: Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O6-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Forrest Kievit, John R. Silber, Zachary Stephen, Omid Veiseh
  • Publication number: 20140241993
    Abstract: A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicants: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Raymond W. Sze, Omid Veiseh, James Olson, Mandana Veishe, Patrik Gabikian, S-Bahram Bahrami
  • Publication number: 20140219962
    Abstract: Porous chitosan scaffold having high mechanical strength, methods for making the porous chitosan scaffold, and method for using the porous chitosan scaffold.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 7, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Soumen Jana
  • Patent number: 8778310
    Abstract: A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: July 15, 2014
    Assignees: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Raymond W. Sze, Omid Veiseh, James M. Olson, Mandana Veiseh, Patrik Gabikian, S-Bahram Bahrami
  • Patent number: 8663686
    Abstract: The present invention provides compositions comprising an interpolymer of chitosan and polyethylene glycol, wherein the interpolymer is a liquid below 25° C. and a gel above 35° C. The present invention also provides methods for using the compositions to deliver drugs to a living body over time.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: March 4, 2014
    Assignee: University of Washington
    Inventors: Miqin Zhang, Narayan Bhattarai, Frederick A. Matsen
  • Publication number: 20140051316
    Abstract: A centrifugal electrospinning apparatus, centrifugal electrospinning method for the production of fibrous structures, and electrospun fibrous structures are provided.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 20, 2014
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Miqin Zhang, Ashleigh Cooper, Dennis Edmondson