Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device can be a wearable automatic injector configured to be worn on the patient's skin. The delivery device of the present disclosure may allow a user or the patient to view a status of a container. For example, the delivery device of the present disclosure may provide a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: A delivery device for delivering a medical fluid to a patient has a housing configured for receiving a container at least partially filled with the medical fluid. The delivery device further has a drive mechanism associated with the housing configured for delivering the medical fluid from the container to the patient in a dosing procedure. The delivery device further has a module configured for detecting at least one of a property of the dosing procedure and a property of the medical fluid. The module has at least one dose detection sensor configured for detecting an initiation, progression, and completion of the dosing procedure based on a position of a stopper within the container. The module further has at least one temperature sensor configured for measuring a temperature of the medical fluid within the container based on a temperature of the container.

Abstract: A controlled delivery syringe device includes a syringe barrel having a proximal end and distal end which defines a chamber for containing an injectable material. A plunger rod is associated with the syringe barrel and a plunger is secured thereto which is axially movable within the syringe barrel. A plurality of equally and sequentially spaced periodic features are associated with the plunger rod and a counter member is engageable with the periodic features. Application of a distally directed force to the plunger rod results in disengagement and reengagement of the counter member with the sequentially spaced periodic features on the plunger rod, enabling advancement of the plunger rod and plunger in the syringe barrel while providing tactile feedback of dose progression of the injectable material. A method of retrofitting a syringe with a device for injecting a metered dose of injectable material is also provided.

Abstract: A delivery device for delivering a medical fluid to a patient has a housing configured for receiving a container at least partially filled with the medical fluid. The delivery device further has a drive mechanism associated with the housing configured for delivering the medical fluid from the container to the patient in a dosing procedure. The delivery device further has a module configured for detecting at least one of a property of the dosing procedure and a property of the medical fluid. The module has at least one dose detection sensor configured for detecting an initiation, progression, and completion of the dosing procedure based on a position of a stopper within the container. The module further has at least one temperature sensor configured for measuring a temperature of the medical fluid within the container based on a temperature of the container.

Abstract: A delivery assembly includes a console including a vial containment region and a vial engagement mechanism extending from the console within the vial containment region. The engagement mechanism is configured to engage a vial assembly. The delivery assembly further includes a sled assembly removably coupled to the console at the vial containment region and a safety shield removably coupled to the console over the vial containment region such that the vial engagement mechanism and the sled assembly are encapsulated within the safety shield when the safety shield is coupled thereto. The sled assembly, the vial assembly, and the safety shield are configured to inhibit radioactive emissions from within the vial containment region.

Abstract: Methods and systems for determination of flow parameters of administered fluid from a radioembolization delivery device may include translationally moving a device delivery arm of the radioembolization delivery device in a translational direction, wherein the device delivery arm is coupled to a syringe holder such that move in the translational direction one of proximally or distally advances the syringe holder; sensing, via one or more pattern sensors, a corresponding movement of a pattern associated with the translational device delivery arm movement as a sensed pattern movement; generating, via the one or more pattern sensors, one or more output signals based on the sensed pattern movement; and generating, via a processor, a flow rate of the administered fluid, a flow amount of the administered fluid, and/or the translational direction of movement of the device delivery arm with respect to the syringe holder based on the one or more

Abstract: A controlled delivery syringe device includes a syringe barrel having a proximal end and distal end which defines a chamber for containing an injectable material. A plunger rod is associated with the syringe barrel and a plunger is secured thereto which is axially movable within the syringe barrel. A plurality of equally and sequentially spaced periodic features are associated with the plunger rod and a counter member is engageable with the periodic features. Application of a distally directed force to the plunger rod results in disengagement and reengagement of the counter member with the sequentially spaced periodic features on the plunger rod, enabling advancement of the plunger rod and plunger in the syringe barrel while providing tactile feedback of dose progression of the injectable material. A method of retrofitting a syringe with a device for injecting a metered dose of injectable material is also provided.

Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device is a wearable automatic injector configured to be worn on the patient's skin. A delivery device of the present disclosure allows a user or patient to view the status of a container. For example, a delivery device of the present disclosure provides a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: A delivery device for delivering a medical fluid to a patient has a housing configured for receiving a container at least partially filled with the medical fluid. The delivery device further has a drive mechanism associated with the housing configured for delivering the medical fluid from the container to the patient in a dosing procedure. The delivery device further has a module configured for detecting at least one of a property of the dosing procedure and a property of the medical fluid. The module has at least one dose detection sensor configured for detecting an initiation, progression, and completion of the dosing procedure based on a position of a stopper within the container. The module further has at least one temperature sensor configured for measuring a temperature of the medical fluid within the container based on a temperature of the container.

Abstract: A medication filling and management system comprises a medication storage device for assisting patients in filling and managing medication supplies. The medication storage device includes a number of electronically monitored storage compartments and a communication system to identify a medication to be provided from an adjacent medication commercial package, automatically identify to a user which compartments of the storage device are to be filled with the identified medication from the commercial package, and detect and communicate the filling and dispensing of the medication from the storage device.

Abstract: Disclosed are systems and methods of detecting an impulse of energy given off by an injection device and determining a dosage of medicine based on the impulse. In one example, a module detects the vibrations given off by dialing a click-wheel on an autoinjector and determining the selected dosage of medicine based on the dialed dosage.

Abstract: A medication filling and management system comprises a medication storage device for assisting patients in filling and managing medication supplies. The medication storage device includes a number of electronically monitored storage compartments and a communication system to identify a medication to be provided from an adjacent medication commercial package, automatically identify to a user which compartments of the storage device are to be filled with the identified medication from the commercial package, and detect and communicate the filling and dispensing of the medication from the storage device.

Abstract: A die for forming an extrusion includes a die body, a body feed section and an extrusion forming section. The die body may include an inlet and an outlet defining an extrudate flow path through the die body. The body feed section may be positioned between the inlet and outlet and includes an arrangement of body feed channels. The extrusion forming section may be positioned between the body feed section and the outlet and includes a thin-wall forming portion fluidly coupled to at least one thick-wall forming portion. The thin-wall forming portion may include an array of pins extending from the body feed section towards the outlet and the thick-wall forming portion may include at least one baffle section positioned in the extrudate flow path through the thick-wall forming portion. The area of the thick-wall forming portion may be greater than an interstitial area between the pins.

Abstract: Surfaces of thermoplastic articles are rendered microporous by contacting the surface with a composition that includes a solvent. The article has a birefringence of 0.0001 or greater and the composition has a solvent strength configured to swell but not dissolve the polymer.

Abstract: Methods for making extrusion dies using a LIGA process, a German acronym for lithography (Lithographie), electroplating (Galvanoformung), and molding (Abformung), are described. The resulting extrusion dies can be used, for example, for extrusion of cellular ceramic substrates, precision extrusion of optical fiber or optical fiber precursors, or other applications where profile extrusion requires high dimensional precision and/or has otherwise intricate patterns.

Abstract: A lamination or replication method for making an article having a structured solid layer, including: dispensing a curable liquid onto a first member; contacting the curable liquid on the first member with a complimentary second member having a curvature aspect, to form an assembly having the curable liquid disposed between the first and second members; and curing the curable liquid to form the article, the structure being imparted by at least one of the first and second members. A display system that incorporates the article, as defined herein, is also disclosed.

Abstract: A die for forming an extrusion includes a die body, a body feed section and an extrusion forming section. The die body may include an inlet and an outlet defining an extrudate flow path through the die body. The body feed section may be positioned between the inlet and outlet and includes an arrangement of body feed channels. The extrusion forming section may be positioned between the body feed section and the outlet and includes a thin-wall forming portion fluidly coupled to at least one thick-wall forming portion. The thin-wall forming portion may include an array of pins extending from the body feed section towards the outlet and the thick-wall forming portion may include at least one baffle section positioned in the extrudate flow path through the thick-wall forming portion. The area of the thick-wall forming portion may be greater than an interstitial area between the pins.

Abstract: Methods for making extrusion dies using a LIGA process, a German acronym for lithography (Lithographie), electroplating (Galvanoformung), and molding (Abformung), are described. The resulting extrusion dies can be used, for example, for extrusion of cellular ceramic substrates, precision extrusion of optical fiber or optical fiber precursors, or other applications where profile extrusion requires high dimensional precision and/or has otherwise intricate patterns.

Abstract: A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.