Abstract: An agent capable of binding to CLEVER-1 in an individual can be used in activating macrophages to switch their phenotype from M2 macrophages into M1 macrophages. The invention relates to methods for utilizing the macrophages ability to switch their phenotype. In one aspect, the invention relates to a method for estimating of the efficacy of anti-CLEVER-1 therapy by monitoring a modulation of M2 macrophages into M1 macrophages, when an agent capable of binding to CLEVER-1 is administered in a patient, wherein an increased TNF-alpha secretion or HLA-DR expression is indicative of modulation of M2 macrophages into M1 macrophages.

Abstract: An orthopedic system configured for pre-operative, intra-operative and post-operative assessment of a musculoskeletal system. The orthopedic system comprises a first screw, a second screw, a first device, a second device, and a computer. The first screw and the second screw are respectively coupled in a first bone and a second bone of a musculoskeletal system. The first and second screws each include electronic circuitry, one or more sensors, and an IMU. In one embodiment, a first device and a second device can be respectively located in proximity to the first and second screws. The first and second devices respectively transmit a radio frequency signal to the first and second screws. The first and second screws harvest a predetermined amount of energy and then are enabled to perform at least one task and an orderly shutdown. The computer receives measurement data from the first and second screws.

Abstract: An orthopedic system configured for use in a pre-operative, intra-operative, and post-operative assessment. The orthopedic system comprises a first screw, a second screw, a first device, a second device, and a computer. The first device and the second device are respectively coupled to a first bone and a second bone of a musculoskeletal system. The first and second devices each include electronic circuitry, one or more sensors, and an IMU. A bracket, wrap, or sleeve can be used to hold the first and second devices to the musculoskeletal system. The first and second devices are configured to send measurement data to a computer. The first and second devices each have an antenna system. Electronic circuitry in the first or second devices are configured to harvest energy from a received radio frequency signal to recharge a battery to maintain operation.

Abstract: A medical system comprising a patch device and a computer. The patch device is in communication with the computer. The patch device is configured for generating measurement data or providing a therapy. The patch device comprises electronic circuitry, a battery, an antenna system, one or more sensors, an IMU (inertial measurement unit), and a flexible enclosure. The antenna system can comprise a dual antenna formed on a dielectric substrate with a first antenna on a first side of the dielectric substrate and a second antenna on a second side of the dielectric substrate. The one or more sensors can comprise devices configured to provide measurement data or a therapy. The IMU is configured to measure position, movement, and trajectory of the patch device. The electronic circuitry is configured to harvest energy from one or more radio frequency signals received by the antenna system to recharge the battery.

Abstract: A wireless system comprising a first wireless device and a second wireless device. The first wireless device is configured to operate with less than 15 milliamperes of current. The second wireless device has an internal power source and is configured to transmit one or more radio frequency signals to the first wireless device. The first wireless device is configured to receive the one or more radio frequency signals from the second wireless device. The first wireless device is configured to harvest energy from the one or more radio frequency signals. The first wireless device is enabled for operation after a predetermined amount of energy is harvested from the one or more radio frequency signals. A communication handshake occurs between the first and second wireless devices to indicate that the first wireless device is in communication with the second wireless device. The first wireless device is configured to perform at least one task from harvested energy.

Abstract: A medical system comprising a first medical device, a second medical device, and a computer. The first medical device is configured to be placed beneath the dermis. The first medical device comprises an enclosure comprising non-electrically conductive material. A cap couples to the enclosure and is configured to seal the enclosure. The enclosure houses electronic circuitry configured to measure one or more parameter or provide a therapy. The cap couples to the ground of the electronic circuitry. The first medical device includes a dual band antenna. A first antenna is configured to operate within a first frequency band below 1 gigahertz. The second antenna is configured to operate at a frequency above 1 gigahertz. The second medical device is configured to transmit a radio frequency signal to the first medical device. The first medical device is configured to harvest the energy received from the radio frequency signal to enable the electronic circuitry and perform at least one task.

Abstract: A roofing, cladding, or siding apparatus comprises a roofing, cladding, or siding module and at least one clip. The module comprises an underlapping region and an exposed region. The underlapping region is adapted to be substantially covered by the exposed region of an adjacent overlapping module when installed on a building surface. A projection extends from the exposed region to provide a bearing surface facing the under surface of the exposed region. The clip or clips is attachable to the underlapping region to provide a tongue adapted to be received between the bearing surface and the under surface of the exposed region of an adjacent overlapping module when installed on a building surface.

Abstract: A roofing, cladding or siding product which is light weight, easy to install, durable, and resistant to environmental wear includes a module that can be used to form a weatherproof covering over top of a building surface. The module can also form a weatherproof covering, and be used as part of a thermal energy recovery or removal system. The module can also form part of a thermal energy recovery system that includes an array of solar cells to generate electrical energy.

Abstract: Devices, systems, and methods herein relate to cooling a head of a patient. These systems and methods may comprise a cooling cap assembly comprising a heat exchanger configured to be wrapped around a head of a patient and a compression assembly releasably coupled to the heat exchanger. The compression assembly may comprise an enclosure and an inflatable member coupled to an internal surface of the enclosure. When coupled, the inflatable member may be positioned between the enclosure and the heat exchanger. The heat exchanger may be separate from and moveable relative to the inflatable member.

Abstract: The invention relates to an electric switch defining a front surface and including at least two rocker keys, which rock about a corresponding rocker axis, and at least one base provided with at least two operating points for electrical connection and disconnection located at a point corresponding to the center of the corresponding key, where the rocking of the keys presses on the corresponding at least one operating point and causes the electrical connection or disconnection, wherein the key has two sections separated by the rocker axis, a first transmission section of the operating force and a second section that does not transmit the operating force to the operating point, and in that the rocker axes of the at least two keys are parallel to each other.

Abstract: A frame is provided with at least two holes (12, 15) to fasten electrical and/or electronic devices. The frame includes a single body having fastening means to be fastened on at least one flush-mounted box (21), and that includes a first part incorporating a hole (12) intended to be fastened on a flush-mounted box (21) by fastening means adapted to fasten the frame (1) on the flush-mounted box (21) and a second part incorporating a hole (15) that is not associated to a flush-mounted box (21). The frame (1), at least on the part incorporating the hole (15) that is not associated to a box (21) shows at least a separator element (16) supporting the frame (1) on the wall on which it is to be installed. The separator element (16) is constituted by the frame (1) itself folded creating a flap or rim, the separator element (16) spanning on the whole or part of the perimeter of the frame (1).

Abstract: A colposcope includes an inserter including an elongated body defining an interior space and an image capture device configured to be selectively and slidably positioned within the interior space of the elongated body. The elongated body has a distal end portion and a proximal end portion. The distal end portion is substantially funnel shaped and has a distal end that includes first and second portions. The first portion includes a base at a first edge of the distal end, and the second portion includes a lip at a second edge of the distal end that is diametrically opposed from the first edge. The lip is positioned further from the proximal end portion than the base.

Abstract: Cover and frame assembly for a housing, the cover and the frame being hinged by a hinge, the hinge being composed of a protrusion and a cavity with an envelope complementary to the protrusion, the protrusion being arranged in the cover and the cavity in the frame, or rather the cavity being arranged in the cover and the protrusion in the frame, the axis of the protrusion or of the cavity being perpendicular to the cover such that the protrusion can rotate with respect to the cavity in a direction that is perpendicular to the cover, wherein either the protrusion or part of the envelope of the cavity is made of a magnetic material, the other being made of a magnetic or ferromagnetic material such that the hinge is disassembled when pulling the cover in the direction perpendicular to the surface of the cover.

Abstract: A method may include polymerizing ethylene in a tubular reactor, where the polymerization is substantially free of a chain transfer agent. A method may include polymerizing ethylene in a tubular reactor, the ethylene having a specific delivery pressure and the polymerization having one or more specific peak temperatures. The molecular weight of the resulting polyethylene may be controlled by the selection of the delivery pressure and the one or more peak temperatures.

Abstract: A technologically improved system and corresponding method of operation tracks and manages activities and tasks occurring at an activity venue. In particular, the system operates to track locations and pace of play or participation of the patrons at the activity venue and through various improved technological processes and interactions enabled by the unique hardware of the system, provide the patrons with feedback to manage their locations for an improved participation experience. Furthermore, the system leverages collected information and data to enable live traffic control of the patrons, provide predictive analytics related to gameplay and flow of traffic, and provide operators and patrons with information necessary to maximize a pace of place while optimally maintaining the venue around the patrons without interruption to the patrons and thereby improve the experience of the patrons at the activity venue.

Abstract: A technologically improved system and corresponding method of operation tracks and manages activities occurring at an activity venue. The system operates to track locations and pace of play or participation of the patrons at the activity venue and through various improved technological processes and interactions enabled by the unique hardware of the system, to provide the patrons with feedback to manage their locations for an improved participation experience. The system leverages collected information and data to enable live traffic control of the patrons, provide predictive analytics related to gameplay and flow of traffic, and provide operators and patrons with information necessary to maximize a pace of play while optimally maintaining the venue around the patrons without interruption to the patrons and thereby improve the experience of the patrons at the activity venue.

Abstract: A receiving circuit of a communications link comprises: a first data buffer configured to input, under control of a first clock signal, data of a first data stream transmitted by a transmitting circuit, and to generate a credit trigger signal indicating when a data value is read from the first data buffer, wherein data is read from the first data buffer, or from a further data buffer coupled to the output of the first data buffer, under control of a second clock signal; and a credit generation circuit configured to generate, based on the credit trigger signal, a credit signal for transmission to the transmitting circuit under control of the first clock signal, the credit signal indicating that one or more further data values of the first data stream can be transmitted by the transmitting circuit.

Abstract: A system for moving electrically powered apparatuses is described, comprising at least one fixed supporting track along which the apparatuses are moved. The track is made by a tubular section bar having an opening extending for its whole length and at least one carriage is movably housed inside the track. The system further comprises at least one motor for moving the carriage in the track.

Abstract: A method for managing the charge state of a battery includes activating a float-charge phase of the battery, in which the battery is intermittently charged with a view to maintaining the charge state thereof above a predetermined target charge-state value. The method also includes detecting critical conditions of use of the battery likely to prevent the battery charge state from being maintained above the predetermined target charge-state value and increasing the predetermined target charge-state value when the critical conditions of use of the battery are detected, such as to anticipate activating the battery float-charge phase.