Abstract: Systems and methods of the various embodiments may provide a battery including a rolling diaphragm configured to move to accommodate an internal volume change of one or more components of the battery. Systems and methods of the various embodiments may provide a battery housing including a rolling diaphragm seal disposed between an interior volume of the battery and an electrode assembly within the battery. Various embodiments may provide an air electrode assembly including an air electrode supported on a buoyant platform such that the air electrode is above a surface of a volume of electrolyte when the buoyant platform is floating in the electrolyte.

Abstract: Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.

Abstract: A filter is disclosed. The filter includes a sheet of filter media defining a body having an upper portion, a lower portion, a first end surface proximate the upper portion, a second end surface proximate the lower portion, and a first side surface extending between the first and second end surfaces. One or more of the upper and lower portions define a ledge, wherein the ledge defines a third end surface arranged between the first and second end surfaces, and a second side surface extending between the first and third end surfaces; and a seal disposed upon the ledge. A method for manufacturing the seal is also disclosed.

Abstract: A rotatable nacelle includes an engine inlet configured to receive air and an inlet air management system (IAMS). The IAMS includes a primary inlet configured to selectively allow air to flow into a duct associated with the engine air inlet via the primary inlet and a secondary inlet configured to selectively allow air to flow into the duct associated with the engine air inlet via the secondary inlet. The secondary inlet is configured to receive an air filter.

Abstract: A method is provided for preparing a hair dye color mixture. The method includes: accessing a control system having at least a processor, a memory, and user input controls, the memory configured to store ingredients of a hair dye color mixture, receiving user input from the user input controls to change one or more ingredients of the hair dye color mixture to a new product brand; matching the color of the hair dye color mixture using one or more ingredients of the new product brand, in response to the user input; and displaying the ingredients of the hair dye color mixture in the new product brand on a display.

Abstract: A system for recalculating a formula previously used in preparing a mixture made from adding at least two components. The system includes a control system and salon management software. The control system has a processor, a computer-readable memory, and a display. The memory contains software configured to receive a formula defining instructions for blending a hair dye mixture using one or more blending materials and amounts recommended for the hair dye mixture. The salon management software is stored in the computer-readable memory and executed by the control system. The salon management software is in communication with the control system to exchange information on customers and formulas of hair dye mixtures associated with the customers.

Abstract: Power tools described herein include a tool output, a motor driving the tool output, a battery pack interface, a power switching network coupled between the battery pack interface and the motor, and a controller coupled to the power switching network to control operation of the motor. The controller is configured to operate the motor at a no-load speed at startup and detect a load state of the power tool. The load state indicates whether the power tool is in a loaded state or an unloaded state. The controller is also configured to incrementally ramp up a speed of the motor from the no-load speed to a selected speed when the power tool is in the loaded state and incrementally ramp down the speed of the motor from the selected speed to the no-load speed when the power tool is in the unloaded state.

Abstract: The present invention relates to a method of improving a mass spectrometer, a module for improving a mass spectrometer and an improved mass spectrometer. The aforementioned method uses machine learning and can greatly reduce the number and timeframe for the elimination of false positives to a couple of hours. Such method can be integrated into a mass spectrometer by inserting a computer module programmed with such method into a mass spectrometer's computer system.

Abstract: Provided are systems and methods for configuring and implementing a loan repayment based on transactions output from a merchant POS terminal. In one example, the method may include receiving point-of-sale (POS) transactions from a merchant POS terminal, receiving, via an application programming interface (API), a request to allocate a portion of the POS transactions from the merchant POS terminal to a lender payment account, depositing the POS transactions received from the merchant POS terminal into a merchant payment account during a settlement process, and automatically triggering a payment transaction that pushes the portion of the POS transactions from the merchant payment account to the lender payment account.

Abstract: Described herein are oncolytic viruses comprising one or more nucleic acids encoding an engager molecule. In some embodiments, the oncolytic viruses comprise one or more nucleic acids encoding an engager molecule and one or more therapeutic molecules. Pharmaceutical compositions containing the oncolytic virus and methods of treating cancer using the oncolytic viruses are further provided herein.

Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: Systems and methods are provided for a fall limiting device. An embodiment includes a housing and a rotatable drum comprising an axle and two side portions, said rotatable drum comprising a single contiguous material piece. A retractable member is held, at least in part, within the housing via winding around the rotatable drum within the two side portions.

Abstract: The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R3, R4, X1, and X2 are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: Oncolytic viral vectors that incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle. Such viral vectors can be used for the treatment and prevention of cancer.

Abstract: A fall arrest system includes a line retraction device having a safety line, an energy absorber configured for connecting to a terminal end of the safety line, and a harness configured for connecting to the energy absorber such that the energy absorber is disposed between the terminal end of the safety line and the harness. The safety line is selected to have a predetermined mean breaking force with a first standard deviation, and the energy absorber is selected to have a predetermined mean deployment force with a second standard deviation. The mean breaking force of the safety line and the mean deployment force of the energy absorber overlap over an overlapping region of the first and second standard deviation. A ratio of an overlap mean force of the overlapping region to an overlap standard deviation of the overlapping region is less than or equal to 6.

Abstract: The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer. Oncolytic viral vectors incorporate one or more of the following features: viral replication restriction by insertion of tumor-suppressive microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.

Abstract: Oncolytic viral vectors that incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle. Such viral vectors can be used for the treatment and prevention of cancer.

Abstract: The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R3, and R4, are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Abstract: Time of flight between two or more ultrasonic transceivers is measured using known delays. First and second transceivers are duty cycled, each having a respective receive period that is less than a measurement period during which the transceivers are configured to receive transmissions. An ultrasonic trigger pulse is transmitted by the first transceiver. The second transceiver, upon receiving the trigger pulse, transmits an ultrasonic response pulse after a first predefined delay time that is known to the first transceiver and greater than the receive period of the second transceiver. Subsequently, the first transceiver receives the ultrasonic response pulse and determines a receive time. The first transceiver determines the distance between the first transceiver and the second transceiver from a speed of sound, an elapsed time between the time of transmission of the trigger pulse and the receive time, and the first predetermine delay time.

Abstract: Example embodiments disclose systems and methods for providing a property profile for a property. The disclosed systems and methods enable receiving, via a network at a social home buying system, identifying data from a mobile device, receiving location data, via a network at a social home buying system, from the mobile device, retrieving property data from a property information database that stores information about the property based on the at least one of the identifying data and location data, creating a property profile based on the property data, identifying data, and location data, storing the property profile in a property profile database, and providing the property profile via a network to a social networking site.