Abstract: The present invention relates to methods of improving analytical instruments and improved analytical instruments. The aforementioned method employs a calibration correction module that calibrates the machine to effect measurements with the minimum possible relative squared error. This results in a significant improvement of the analytical instrument in question that leads to more precise and accurate results.

Abstract: The disclosed embodiments provide systems and methods for managing a loan application. In one embodiment, a method is disclosed that may include identifying one or more unfulfilled conditions associated with a loan application of a customer and sending, to a customer device, a request for a loan application document based on the identified one or more unfulfilled conditions. The method may also include receiving, from the customer device, a responsive loan application document. The method may also include identifying a document type for the responsive loan application document and confirming that the responsive loan application document is a valid document. Finally, the method may also include sending loan application status information to the customer device based on the confirmation.

Abstract: The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Abstract: The disclosed embodiments provide systems and methods for managing a loan application. In one embodiment, a method is disclosed that may include identifying one or more unfulfilled conditions associated with a loan application of a customer and sending, to a customer device, a request for a loan application document based on the identified one or more unfulfilled conditions. The method may also include receiving, from the customer device, a responsive loan application document. The method may also include identifying a document type for the responsive loan application document and confirming that the responsive loan application document is a valid document. Finally, the method may also include sending loan application status information to the customer device based on the confirmation.

Abstract: A system and method for batch sizing a formula that defines one or more hair dye materials and corresponding recommended amounts for creating an individual batch sized amount of a hair dye mixture. One method includes providing a control system having at least a processor and a computer-readable memory, wherein the memory contains software configured to receive a formula defining instructions for blending a hair dye mixture using one or more colorants and/or dye blending materials and amounts recommended for the hair dye mixture. The method further includes presenting a plurality of batch sizing adjustment criteria on a display; and receiving user input, via a user input device, selecting one or more of the plurality of batch sizing adjustment criteria. The batch sizing adjustment criteria includes customer characteristics.

Abstract: A system for recalculating a formula previously used in preparing a mixture made from adding at least two components. The system includes a control system and salon management software. The control system has a processor, a computer-readable memory, and a display. The memory contains software configured to receive a formula defining instructions for blending a hair dye mixture using one or more blending materials and amounts recommended for the hair dye mixture. The salon management software is stored in the computer-readable memory and executed by the control system. The salon management software is in communication with the control system to exchange information on customers and formulas of hair dye mixtures associated with the customers.

Abstract: A method is provided for preparing a hair dye color mixture. The method includes: accessing a control system having at least a processor, a memory, and user input controls, the memory configured to store ingredients of a hair dye color mixture, receiving user input from the user input controls to change one or more ingredients of the hair dye color mixture to a new product brand; matching the color of the hair dye color mixture using one or more ingredients of the new product brand, in response to the user input; and displaying the ingredients of the hair dye color mixture in the new product brand on a display.

Abstract: The present disclosure relates to recombinant RNA molecules encoding an oncolytic virus. The present disclosure further relates to the encapsulation of the recombinant RNA molecules and the use of the recombinant RNA molecules and/or particles for the treatment and prevention of cancer.

Abstract: The present invention relates to a method of improving a mass spectrometer, a module for improving a mass spectrometer and an improved mass spectrometer. The aforementioned method employs a calibration correction module that calibrates the mass spectrometer so timely, more precise and accurate data can be obtained. In particular, real time, accurate mass determinations of low analyte quantity samples can be obtained.

Abstract: A tracking method is disclosed. The method may include displaying visual content on a screen. A base station may be stationary with respect to the screen while the visual content is being displayed. In contrast, one or more objects may move with respect to the screen while the visual content is being displayed. The one or more objects may be tracked so that the movement thereof may be used to alter the visual content. Such tracking may involve the base station and the one or more objects sending and/or receiving one or more ultrasonic pulses. The tracked object also determines information using an inertial sensor assembly that receives a synchronization signal coordinated with the one or more ultrasonic pulses.

Abstract: Systems, apparatuses, and methods for enabling indirect chaining of command buffers are disclosed. A system includes at least first and second processors and a memory. The first processor generates a plurality of command buffers and stores the plurality of command buffers in the memory. The first processor also generates and stores, in the memory, a table with entries specifying addresses of the plurality of command buffers and an order in which to process the command buffers. The first processor conveys an indirect buffer packet to the second processor, where the indirect buffer packet specifies a location and a size of the table in the memory. The second processor retrieves an initial entry from the table, processes a first command buffer at the address specified in the initial entry, and then returns to the table for the next entry upon completing processing of the first command buffer.

Abstract: A method is provided for preparing a hair dye color mixture. The method includes: accessing a control system having at least a processor, a memory, and user input controls, the memory configured to store ingredients of a hair dye color mixture, each ingredient of the hair dye color mixture being from an initial product brand; receiving user input from the user input controls to change one or more ingredients of the hair dye color mixture from the initial product brand to one or more subsequent product brands; matching the color of the hair dye color mixture made from one or more ingredients of the initial product brand using one or more ingredients of the one or more subsequent product brands, in response to the user input; and displaying the ingredients of the hair dye color mixture in the one or more subsequent product brands on a display.

Abstract: A blending system and method are described for preparing a blended mixture. The blending system includes a control system having at least a processor, and a computer-readable memory, wherein the memory contains software configured to receive a formula defining instructions for preparing a blended mixture. The blending system further includes: a plurality of receptacles to organize and store blending dye containers, the blending dye containers containing blending materials; a pumping system that pumps blending materials into a mixing bowl, wherein the pumping system is controlled by the control system; and a user input device that receives input regarding the preparation of the blended mixture. The control system monitors a weight on the scale as blending materials are added to a mixing bowl on the scale, wherein a desired batch size of the blended mixture is prepared and added to the mixing bowl on the scale.

Abstract: The present disclosure relates to polynucleotides comprising a nucleic acid sequence encoding a replication competent viral genome, wherein the polynucleotide is capable of producing a replication competent virus when introduced into a cell by a non-viral delivery vehicle. The present disclosure further relates to the encapsulation of the polynucleotides and the use of the polynucleotides and/or particles for the treatment and prevention of cancer.

Abstract: A connection arrangement for use with a wearable body harness has a first connector having a body with a first portion of a locking mechanism and a second connector having a body with a second portion of the locking mechanism. The first portion of the locking mechanism has a tab connected to the body of the first connector and a slot having a first portion extending through the body of the first connector and a second portion extending through the tab. The second portion of the locking mechanism has a tongue configured for being received through the first portion of the slot, and an intermediate connecting element having a first end connected to the body of the second connector and a second end connected to the tongue. The second end of the intermediate connecting element is offset from the body of the second connector.

Abstract: Some embodiments of the present disclosure relate to an assembly. In some embodiments the assembly comprises at least one antenna and a thermal insulation component. In some embodiments, the at least one antenna is configured to transmit a field of radiofrequency (RF) communication at an operating frequency ranging from 6 GHz to 100 GHz. In some embodiments, the thermal insulation component is disposed within the field of RF communication. In some embodiments, the thermal insulation component has a thermal conductivity ranging from 0.0025 W/m·K to 0.025 W/m·K at 25° C. and 1 atm.

Abstract: Systems, apparatuses, and methods for enabling indirect chaining of command buffers are disclosed. A system includes at least first and second processors and a memory. The first processor generates a plurality of command buffers and stores the plurality of command buffers in the memory. The first processor also generates and stores, in the memory, a table with entries specifying addresses of the plurality of command buffers and an order in which to process the command buffers. The first processor conveys an indirect buffer packet to the second processor, where the indirect buffer packet specifies a location and a size of the table in the memory. The second processor retrieves an initial entry from the table, processes a first command buffer at the address specified in the initial entry, and then returns to the table for the next entry upon completing processing of the first command buffer.

Abstract: A system for solventless calibration of volatile or semi-volatile compounds and methods thereof. The system includes a fluid path having a first end configured to be operably coupled to a fluid source and a second end configured to be operably coupled to the analytical instrument. A solid sorbent is disposed along the fluid path and is configured to absorb an analyte. The flow of fluid along the fluid path from the first end to the second end causes absorbed analyte to be desorbed from the solid sorbent at a desired concentration to the instrument.

Abstract: A blending method is described for preparing a blended mixture. The blending method for preparing a blended mixture, the method includes: providing a control system having at least a processor, a computer-readable memory, and a display, wherein the memory contains software configured to receive a recipe defining instructions for preparing a blended mixture using one or more blending materials and amounts for producing a batch size of the blended mixture on a scale; monitoring a weight on the scale as blending materials are added to a receptacle on the scale; and indicating on the display the amounts of the blending materials that have been added to the scale to prepare an amount of a custom blended mixture based upon the selected blending materials.

Abstract: Described herein are pseudotyped oncolytic viruses comprising nucleic acids encoding an engager molecule. In some embodiments, the pseudotyped oncolytic viruses comprises nucleic acids encoding an engager molecule and one or more therapeutic molecules. Pharmaceutical compositions containing the pseudotyped oncolytic virus and methods of treating cancer using the pseudotyped oncolytic viruses are further provided herein.