Patents by Inventor Mitchell H.

Mitchell H. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020168342
    Abstract: The present invention is directed to novel replication-deficient adenoviral vectors characterized in that they harbor at least two lethal early region gene deletions (E1 and E4) that normally transcribe adenoviral early proteins. These novel recombinant vectors find particular use in human gene therapy treatment whereby the vectors additionally carry a transgene or therapeutic gene that replaces the E1 or E4 regions. The present invention is further directed to novel packaging cell lines that are transformed at a minimum with the adenoviral E1 and E4 gene regions and function to propagate the above novel replication-deficient adenoviral vectors.
    Type: Application
    Filed: November 13, 2001
    Publication date: November 14, 2002
    Applicant: Cell Genesys, Inc.
    Inventors: Qing Wang, Mitchell H. Finer, Xiao-Chi Jia
  • Patent number: 6460549
    Abstract: Disclosed is a process of recycling and reusing an aqueous degreasing solution for further use as a component of a coolant solution which is itself recycled and reused in metal cutting machines. Also disclosed is a method of degreasing parts, and a degreasing apparatus which is controlled such that an appropriate amount of the aqueous degreasing solution is introduced into the coolant solution. Finally, disclosed herein is a method and system for preparing a coolant in which an aqueous degreasing solution is further utilized as a feeder solution for a coolant solution, with the resulting solution being able to be separated into its component parts and reused in the cutting and cleaning of metals to form metal parts.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: October 8, 2002
    Assignee: Masco Corporation of Indiana
    Inventors: Mitchell H. Berger, Dennis L. Foster, David K. Shaffer, Phillip B. Simon, John D. Wheatley
  • Patent number: 6435198
    Abstract: Disclosed is a process of recycling and reusing an aqueous degreasing solution for further use as a component of a coolant solution which is itself recycled and reused in metal cutting machines. Also disclosed is a method of degreasing parts, and a degreasing apparatus which is controlled such that an appropriate amount of the aqueous degreasing solution is introduced into the coolant solution. Finally, disclosed herein is a method and system for preparing a coolant in which an aqueous degreasing solution is further utilized as a feeder solution for a coolant solution, with the resulting solution being able to be separated into its component parts and reused in the cutting and cleaning of metals to form metal parts.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: August 20, 2002
    Assignee: Masco Corporation of Indiana
    Inventors: Mitchell H. Berger, Dennis L. Foster, David K. Shaffer, Phillip B. Simon, John D. Wheatley
  • Publication number: 20020106799
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retrovirus are produced in these transfected mammalian cells and can then transduce a mammalian target cell by cocultivation or supernatant infection. The methods of the invention include the use of the novel retroviral packaging plasmids and vectors to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation or supernatant infection at high efficiencies. The invention is useful for the rapid production of high titer viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Application
    Filed: September 4, 2001
    Publication date: August 8, 2002
    Inventors: Mitchell H. Finer, Thomas J. Dull, Krisztina M. Zsebo, Keegan Cooke, Deborah A. Farson
  • Patent number: 6413943
    Abstract: Disclosed are methods for using &Dgr;E1/&Dgr;E4 recombinant adenoviruses encoding cyclin dependent kinase inhibitors (CDKi's) as reagents for inhibiting smooth muscle cell proliferation. Also disclosed are recombinant lentiviruses encoding cyclin dependent kinase inhibitors (CDKi's).
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: July 2, 2002
    Assignees: Cell Genesys, Inc., GPC Biotech Inc.
    Inventors: James McArthur, Mitchell H. Finer, Jeno Gyuris
  • Publication number: 20020046652
    Abstract: An apparatus for efficiently removing VOC from a plurality of remotely located sources of VOC contaminated gas streams includes a plurality of liquid absorbers, each located near and communicating with a source of a VOC contaminated gas stream, the liquid absorbers associating the VOC with a scrubbing liquid. A gas conduit is associated with each liquid absorber to allow for the recycling of properly conditioned gas to the VOC source. A conduit is connected to each liquid absorber for conveying VOC laden scrubbing liquid from the liquid absorber to a separating apparatus in fluid communication with each of the conduits. A conduit recycles the scrubbing liquid from the separating apparatus to at least one of the plurality of liquid absorbers. A heat exchanger associated with the scrubbing liquid after separation transfers heat to the scrubbing liquid prior to separation, or to an HVAC system, or to the scrubbing liquid prior to the liquid absorber.
    Type: Application
    Filed: December 13, 2001
    Publication date: April 25, 2002
    Applicant: CH2M Hill, Inc.
    Inventors: Mitchell H. Lindsay, Moha Shah
  • Patent number: 6352575
    Abstract: An appartus for removing VOC from a plurality of remotely located sources of VOC contaminated gas streams includes a plurality of liquid absorbers, each located near and communicating with a source of a VOC contaminated gas stream, the liquid absorbers associating the VOC with a scrubbing liquid. A conduit is connected to each liquid absorber for conveying VOC laden scrubbing liquid from the liquid absorber to a separating apparatus in fluid communication with each of the conduits. The separating apparatus receives the VOC laden scrubbing liquid from the plurality of liquid absorbers and separates the VOC from the scrubbing liquid. A conduit recycles the scrubbing liquid from the separating apparatus to at least one of the plurality of liquid absorbers.
    Type: Grant
    Filed: June 5, 2000
    Date of Patent: March 5, 2002
    Assignee: CH2M Hill, Inc.
    Inventors: Mitchell H. Lindsay, James D. Mavis, Jr.
  • Publication number: 20020014258
    Abstract: Disclosed is a process of recycling and reusing an aqueous degreasing solution for further use as a component of a coolant solution which is itself recycled and reused in metal cutting machines. Also disclosed is a method of degreasing parts, and a degreasing apparatus which is controlled such that an appropriate amount of the aqueous degreasing solution is introduced into the coolant solution. Finally, disclosed herein is a method and system for preparing a coolant in which an aqueous degreasing solution is further utilized as a feeder solution for a coolant solution, with the resulting solution being able to be separated into its component parts and reused in the cutting and cleaning of metals to form metal parts.
    Type: Application
    Filed: October 11, 2001
    Publication date: February 7, 2002
    Inventors: Mitchell H. Berger, Dennis L. Foster, David K. Shaffer, Phillip B. Simon, John D. Wheatley
  • Patent number: 6343610
    Abstract: Disclosed is a process of recycling and reusing an aqueous degreasing solution for further use as a component of a coolant solution which is itself recycled and reused in metal cutting machines. Also disclosed is a method of degreasing parts, and a degreasing apparatus which is controlled such that an appropriate amount of the aqueous degreasing solution is introduced into the coolant solution. Finally, disclosed herein is a method and system for preparing a coolant in which an aqueous degreasing solution is further utilized as a feeder solution for a coolant solution, with the resulting solution being able to be separated into its component parts and reused in the cutting and cleaning of metals to form metal parts.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: February 5, 2002
    Assignee: Masco Corporation of Indiana
    Inventors: Mitchell H. Berger, Dennis L. Foster, David K. Shaffer, Phillip B. Simon, John D. Wheatley
  • Publication number: 20020011261
    Abstract: Disclosed is a process of recycling and reusing an aqueous degreasing solution for further use as a component of a coolant solution which is itself recycled and reused in metal cutting machines. Also disclosed is a method of degreasing parts, and a degreasing apparatus which is controlled such that an appropriate amount of the aqueous degreasing solution is introduced into the coolant solution. Finally, disclosed herein is a method and system for preparing a coolant in which an aqueous degreasing solution is further utilized as a feeder solution for a coolant solution, with the resulting solution being able to be separated into its component parts and reused in the cutting and cleaning of metals to form metal parts.
    Type: Application
    Filed: October 11, 2001
    Publication date: January 31, 2002
    Inventors: Mitchell H. Berger, Dennis L. Foster, David K. Shaffer, Phillip B. Simon, John D. Wheatley
  • Publication number: 20010046521
    Abstract: A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. Synergistically effective amounts are preferred. The first treatment procedure may be a treatment with one or more conventional cytotoxic chemical compounds. As examples, the cytotoxic chemical compound may be a nitrosourea (such as BCNU), cyclophosphamide, doxorubicin, 5-fluorouracil, paclitaxel and its derivatives, cisplatin or other platinum containing cancer treating agents. Alternatively, the first treatment may be a treatment with one or more conventional anti-hormonal agents. As examples, the anti-hormonal agents may be a LHRH (luteinizing hormone releasing hormone) agonist or an anti-androgen such as flutamide, biclutamide, nilutamide, and luprolide. These conventional cancer treatments compounds and the squalamine may be administered by any suitable route.
    Type: Application
    Filed: March 12, 2001
    Publication date: November 29, 2001
    Inventors: Michael Zasloff, Jon Williams, Mitchell H. Sokoloff
  • Patent number: 6218187
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retrovirus are produced in these transfected mammalian cells and can then transduce a mammalian target cell by cocultivation or supernatant infection. The methods of the invention include the use of the novel retroviral packaging plasmids and vectors to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation or supernatant infection at high efficiencies. The invention is useful for the rapid production of high titer viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: April 17, 2001
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Thomas J. Dull, Krisztina M. Zsebo, Keegan Cooke, Deborah A. Farson
  • Patent number: 6142255
    Abstract: A member for connecting a rail to a horizontal element of a ladder. The member comprises a first portion that connects to the horizontal member. The member also comprises a second portion which connects to the rail and extends essentially in parallel with the rail. The second portion is integrally connected to the first portion such that the first portion and the second portion are one continuous piece. The second portion is in an angular relationship of less than 90.degree. with the first portion. A member for connecting a rail having a first rail flange and a second rail flange to a horizontal element of a ladder. The member comprises a first arm which connects to the first rail flange and the horizontal member. The member is also comprised of a second arm which connects to the second rail flange and the horizontal member. Additionally, the member comprises a central body which is integrally connected to the second arm and the first arm.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: November 7, 2000
    Assignee: Werner Co.
    Inventors: David E. Plotner, Edward E. Heald, Richard P. Sulecki, Frederick J. Bartnicki, Mitchell H. Hetrich
  • Patent number: 6108743
    Abstract: The invention, in one embodiment, is a method for performing direct memory access. The method includes arbitrating between a chained, low priority, direct memory access and a high priority, direct memory access, the arbitration occurring between two links in the chained, low priority, direct memory access.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: August 22, 2000
    Assignees: Intel Corporation, Real 3D Inc.
    Inventors: Raymond E. Debs, John A. Carey, Mitchell H. Singer
  • Patent number: 6051427
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retrovirus are produced in these transfected mammalian cells and can then transduce a mammalian target cell by cocultivation or supernatant infection. The methods of the invention include the use of the novel retroviral packaging plasmids and vectors to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation or supernatant infection at high efficiencies. The invention is useful for the rapid production of high titer viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: August 21, 1995
    Date of Patent: April 18, 2000
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Margo R. Roberts, Thomas L. Dull, Krisztina M. Zsebo, Lu Qin, Deborah A. Farson
  • Patent number: 5983910
    Abstract: Disclosed is a process of recycling and reusing an aqueous degreasing solution for further use as a component of a coolant solution which is itself recycled and reused in metal cutting machines. Also disclosed is a method of degreasing parts, and a degreasing apparatus which is controlled such that an appropriate amount of the aqueous degreasing solution is introduced into the coolant solution. Finally, disclosed herein is a method and system for preparing a coolant in which an aqueous degreasing solution is further utilized as a feeder solution for a coolant solution, with the resulting solution being able to be separated into its component parts and reused in the cutting and cleaning of metals to form metal parts.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: November 16, 1999
    Assignee: Masco Corporation of Indiana
    Inventors: Mitchell H. Berger, Dennis L. Foster, David K. Shaffer, Phillip B. Simon, John D. Wheatley
  • Patent number: 5959212
    Abstract: A fluid pressure sensor (10) having a capacitive pressure transducer (12) having a thin, relatively flexible ceramic diaphragm (14) mounted in closely spaced apart relation to a rigid ceramic substrate (16) by a glass annulus (18) mounted in a housing (46) having a port (46a) for fluid whose pressure is to be sensed to be received on an outer face of the diaphragm. An electronic circuit (50) is mounted in a chamber (38) formed between a connector (36) and an outer face (12b) of the substrate. A source capacitor plate (20) and source trace (20b) are printed on the diaphragm and a detect plate (22) and detect trace (22b) are printed on a substrate with a guard plate (28, 28', 28"; 30, 30") printed on both the diaphragm and substrate completely surrounding the source and detect plates and traces.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: September 28, 1999
    Assignee: Texas Instruments Incorporated
    Inventors: Dale R. Sogge, Mitchell H. Berkson
  • Patent number: 5872005
    Abstract: The present invention is directed to novel replication-deficient adenoviral vectors characterized in that they harbor at least two lethal early region gene deletions (E1 and E4) that normally transcribe adenoviral early proteins. These novel recombinant vectors find particular use in human gene therapy treatment whereby the vectors additionally carry a transgene or therapeutic gene that replaces the E1 or E4 regions. The present invention is further directed to novel packaging cell lines that are transformed at a minimum with the adenoviral E1 and E4 gene regions and function to propagate the above novel replication-deficient adenoviral vectors.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 16, 1999
    Assignee: Cell Genesys Inc.
    Inventors: Qing Wang, Mitchell H. Finer, Xiao-Chi Jia
  • Patent number: 5858740
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging constructs and packagable vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retrovirus are produced in infected cells. The methods of the invention include the use of the novel retroviral constructs to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation at high efficiencies. The invention is useful for the rapid production of high viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: January 12, 1999
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Margo R. Roberts, Thomas J. Dull, Krisztina M. Zsebo, Lu Qin, Deborah A. Farson
  • Patent number: 5834256
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging constructs and packagable vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retrovirus are produced in infected cells. The methods of the invention include the use of the novel retroviral constructs to transduce primary human cells, including T cells and bone marrow stem cells, with foreign genes by cocultivation at high efficiencies. The invention is useful for the rapid production of high viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: November 10, 1998
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Margo R. Roberts, Thomas J. Dull, Krisztina M. Zsebo, Lu Qin, Deborah A. Farson