Abstract: The disclosed embodiments provide systems and methods for managing a loan application. In one embodiment, a method is disclosed that may include identifying one or more unfulfilled conditions associated with a loan application of a customer and sending, to a customer device, a request for a loan application document based on the identified one or more unfulfilled conditions. The method may also include receiving, from the customer device, a responsive loan application document. The method may also include identifying a document type for the responsive loan application document and confirming that the responsive loan application document is a valid document, Finally, the method may also include sending loan application status information to the customer device based on the confirmation.

Abstract: The disclosed embodiments provide systems and methods for managing a loan application. In one embodiment, a method is disclosed that may include identifying one or more unfulfilled conditions associated with a loan application of a customer and sending, to a customer device, a request for a loan application document based on the identified one or more unfulfilled conditions. The method may also include receiving, from the customer device, a responsive loan application document. The method may also include identifying a document type for the responsive loan application document and confirming that the responsive loan application document is a valid document, Finally, the method may also include sending loan application status information to the customer device based on the confirmation.

Abstract: A method is provided for preparing a hair dye color mixture. The method includes: accessing a control system having at least a processor, a memory, and user input controls, the memory configured to store ingredients of a hair dye color mixture, each ingredient of the hair dye color mixture being from an initial product brand; receiving user input from the user input controls to change one or more ingredients of the hair dye color mixture from the initial product brand to one or more subsequent product brands; matching the color of the hair dye color mixture made from one or more ingredients of the initial product brand using one or more ingredients of the one or more subsequent product brands, in response to the user input; and displaying the ingredients of the hair dye color mixture in the one or more subsequent product brands on a display.

Abstract: The disclosed embodiments provide systems and methods for managing a loan application. In one embodiment, a method is disclosed that may include identifying one or more unfulfilled conditions associated with a loan application of a customer and sending, to a customer device, a request for a loan application document based on the identified one or more unfulfilled conditions. The method may also include receiving, from the customer device, a responsive loan application document. The method may also include identifying a document type for the responsive loan application document and confirming that the responsive loan application document is a valid document. Finally, the method may also include sending loan application status information to the customer device based on the confirmation.

Abstract: The disclosed embodiments provide systems and methods for managing a loan application. In one embodiment, a method is disclosed that may include identifying one or more unfulfilled conditions associated with a loan application of a customer and sending, to a customer device, a request for a loan application document based on the identified one or more unfulfilled conditions. The method may also include receiving, from the customer device, a responsive loan application document. The method may also include identifying a document type for the responsive loan application document and confirming that the responsive loan application document is a valid document. Finally, the method may also include sending loan application status information to the customer device based on the confirmation.

Abstract: A connector includes a frame having a first end, a second end, and a pass-through opening extending between the first end and the second end along a longitudinal axis of the frame. The connector further has a gate positioned between the first end and the second end of the frame and movable between a closed position to close the pass-through opening and an open position to open the pass-through opening. A locking mechanism selectively locks the gate in the closed position. The locking mechanism has a rotatable knob connected to at least one of the first end and the second end of the frame and rotatable in a direction about the longitudinal axis, and a locking indent on the gate configured for receiving at least a portion of the rotatable knob when the gate is in the closed position. The rotatable knob is rotationally biased by a biasing mechanism.

Abstract: A connector includes a frame having a first end, a second end, and a pass-through opening extending between the first end and the second end along a longitudinal axis of the frame. The connector further has a gate positioned between the first end and the second end of the frame and movable between a closed position to close the pass-through opening and an open position to open the pass-through opening. A locking mechanism selectively locks the gate in the closed position. The locking mechanism has a rotatable knob connected to at least one of the first end and the second end of the frame and rotatable in a direction about the longitudinal axis, and a locking indent on the gate configured for receiving at least a portion of the rotatable knob when the gate is in the closed position. The rotatable knob is rotationally biased by a biasing mechanism.

Abstract: A fall protection device, including: a housing; a hub rotatable with respect to the housing; a line wrapped around the hub and configured to pay out from and retract into the housing, an engagement mechanism configured to prevent rotation of the hub and further payout of the line; and an adjustment mechanism configured to adjust a length of the line paid out from the housing, the adjustment mechanism comprising: (i) at least one gear attached to the housing; (ii) a pivot having a track configured to interact with the at least one gear and pivot as the at least one gear rotates; and (iii) an arm configured to urge at least a portion of the engagement mechanism causing it to move into an engagement position, to thereby prevent further rotation of the hub and payout of the line from the fall protection device.

Abstract: A method is provided for preparing a hair dye color mixture. The method includes: providing a control system having at least a memory, input controls, and a display; storing in the memory at least one formula, the formula including one or more colorants and/or dye blending materials, and wherein each colorant and/or blending material is separately assigned to an initial product brand; receiving input from the input controls to change a colorant and/or blending material from the initial product brand to one or more subsequent product brands, and wherein the control system recalculates components of the formula using the one or more subsequent product brands in response to receiving input from the input controls; and matching the color of the hair dye color mixture made from colorants and/or dye blending materials of the initial product brand using colorants and/or dye blending materials of the one or more subsequent product brands, in response to the input.

Abstract: An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.

Abstract: The present disclosure relates to recombinant viral vectors for the treatment and prevention of cancer. Oncolytic viral vectors incorporate one or more of the following features: viral replication restriction by insertion of tumor-suppressive microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle.

Abstract: The present invention generally provides vectors, compositions, and methods of using the same for gene therapy.

Abstract: A blending method is described for preparing a blended mixture.

Abstract: An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.

Abstract: A system and method for batch sizing a formula that defining one or more hair dye materials and corresponding recommended amounts for creating an individual batch sized amount of a hair dye mixture. One method includes providing a control system having at least a processor and a computer-readable memory, wherein the memory contains software configured to receive a formula defining instructions for blending a hair dye mixture using one or more colorants and/or dye blending materials and amounts recommended for the hair dye mixture. The method further includes presenting a plurality of batch sizing adjustment criteria on a display; and receiving user input, via a user input device, selecting one or more of the plurality of batch sizing adjustment criteria. The batch sizing adjustment criteria includes service characteristics.

Abstract: The present invention generally provides vectors, compositions, and methods of using the same for treating neurological disorders, including managing pain. The compositions and methods include the use of G protein-coupled receptors and ligand-gated ion channels to treat neurological indications including pain, epilepsy and satiety disorders. The compositions and methods further include the use of synthetic ligands to activate the G protein-coupled receptors and ligand-gated ion channels in the treatment of neurological disease.

Abstract: A fall protection device, including: a housing; a hub rotatable with respect to the housing; a line wrapped around the hub and configured to pay out from and retract into the housing, an engagement mechanism configured to prevent rotation of the hub and further payout of the line; and an adjustment mechanism configured to adjust a length of the line paid out from the housing, the adjustment mechanism comprising: (i) at least one gear attached to the housing; (ii) a pivot having a track configured to interact with the at least one gear and pivot as the at least one gear rotates; and (iii) an arm configured to urge at least a portion of the engagement mechanism causing it to move into an engagement position, to thereby prevent further rotation of the hub and payout of the line from the fall protection device.

Abstract: A method is provided for preparing a hair dye color mixture. The method includes: providing a control system having at least a memory, input controls, and a display; storing in the memory at least one formula, the formula including one or more colorants and/or dye blending materials, and wherein each colorant and/or blending material is separately assigned to an initial product brand; receiving input from the input controls to change a colorant and/or blending material from the initial product brand to one or more subsequent product brands, and wherein the control system recalculates components of the formula using the one or more subsequent product brands in response to receiving input from the input controls; and matching the color of the hair dye color mixture made from colorants and/or dye blending materials of the initial product brand using colorants and/or dye blending materials of the one or more subsequent product brands, in response to the input.

Abstract: The present invention generally provides HSV-based genome editing vectors, cell-based compositions, and methods of using the same.

Abstract: A tracking method is disclosed. The method may include displaying visual content on a screen. A base station may be stationary with respect to the screen while the visual content is being displayed. In contrast, one or more objects may move with respect to the screen while the visual content is being displayed. The one or more objects may be tracked so that the movement thereof may be used to alter the visual content. Such tracking may involve the base station and the one or more objects sending and/or receiving one or more ultrasonic pulses. Time-difference-of-arrival and/or time-of-flight of the one or more ultrasonic pulses may then be used to estimate a relative location and/or a relative orientation of the one or more objects with respect to the base station in three dimensional space.