Patents by Inventor Mitsuo Numata
Mitsuo Numata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5120841Abstract: A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C.sub.3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.Type: GrantFiled: March 18, 1987Date of Patent: June 9, 1992Assignee: Takeda Chemical Industries, Ltd.Inventors: Tatsuo Nishimura, Yoshinobu Yoshimura, Mitsuo Numata
-
Patent number: 4963542Abstract: Disclosed 2-(syn)-hydroxyimino-acetamide derivatives of the formula: ##STR1## wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.Type: GrantFiled: May 17, 1989Date of Patent: October 16, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Minamida, Susumu Tsushima
-
Patent number: 4797395Abstract: A compound of the formula ##STR1## wherein (1) R.sub.1 is a lower alkyl group of 2 to 6 carbon atoms or a cycloalkyl group of 5 to 7 carbon atoms and R.sub.2 is a cycloalkyl group of 5 to 7 carbon atoms or a lower alkyl group of 1 to 3 carbon atoms which is substituted by a cycloalkyl group of 5 to 7 carbon atoms or by a phenyl group, or (2) R.sub.1 is a cycloalkyl group of 5 to 7 carbon atoms and R.sub.2 is a lower alkyl group of 1 to 5 carbon atoms, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a pharmaceutical composition thereof are provided. The compound can orally be applied as antibiotics having improved bioavailability.Type: GrantFiled: July 18, 1986Date of Patent: January 10, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Akio Miyake, Yoshinobu Yoshimura, Mitsuo Numata
-
Patent number: 4755598Abstract: A compound of the formula: ##STR1## wherein R is 2-methylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, n-pentyl, an alkyl group of 6 or 7 carbon atoms, or an alkenyl group of 2 to 7 carbon atoms, or a pharmaceutically acceptable salt thereof and processes for preparing the same are provided. The compound can orally be applied as antibiotics having improved absorbability.Type: GrantFiled: June 1, 1984Date of Patent: July 5, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Kunio Takanohashi, Tomoyuki Fujii, Mitsuo Numata
-
Patent number: 4729992Abstract: A compound of the formula: ##STR1## or a pharmaceutical acceptable salt thereof, processes for preparing the same and a pharmaceutical composition containing the compound or the salt thereof mentioned above are provided. The compound has antibiotic activity and has improved absorbability.Type: GrantFiled: April 19, 1985Date of Patent: March 8, 1988Assignee: Tatsuo Chemical Ind., Ltd.Inventors: Tatsuo Nishimura, Yoshinobu Yoshimura, Mitsuo Numata
-
Patent number: 4725592Abstract: A compound of the formula: ##STR1## wherein R.sub.1 stands for n-propyl or isopropyl; and R.sub.2 stands for n-butyl, isobutyl, n-pentyl, n-hexyl or 2-ethylbutyl, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a pharmaceutical composition thereof are provided. The compound can orally be applied as antibiotics having improved bioavailability.Type: GrantFiled: August 3, 1984Date of Patent: February 16, 1988Assignee: Takeda Chemical Industries, Ltd.Inventors: Akio Miyake, Masayoshi Yamaoka, Mitsuo Numata
-
Patent number: 4517361Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula -SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: March 31, 1983Date of Patent: May 14, 1985Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Minamida, Masayoshi Yamaoka, Mitsuru Shiraishi, Toshio Miyawaki
-
Patent number: 4427586Abstract: 2-Oxoazetidine derivatives represented by the formula; ##STR1## wherein R.sup.1 stands for phthalimido group, benzyloxycarbonylamino group, a halogen on an alkyl group which may have hydroxyl group, R.sup.2 stands for hydrogen, an alkyl group, an alkylthio group or an arylthio group, and R.sup.3 and R.sup.4 independently stand for an acyl group or cyano group, and a method of preparing them, which is shown by the following reaction scheme; ##STR2## wherein R.sup.5 stands for a carboxyl-protective group, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are of the same meanings as defined above.This compound (I) can be utilized as intermediates for carba-2-penem compounds having excellent anti-bacterial activity and .beta.-lactamase inhibitory activity.Type: GrantFiled: November 13, 1981Date of Patent: January 24, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Masayoshi Yamaoka, Tatsuo Nishimura, Norichika Matsumoto
-
Patent number: 4421912Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: February 18, 1981Date of Patent: December 20, 1983Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Mimamida, Masayoshi Yamaoka, Mitsuru Shiraishi, Toshio Miyawaki
-
Patent number: 4379924Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: December 23, 1977Date of Patent: April 12, 1983Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Mimamida, Masayoshi Yamaoka, Mitsura Shiraishi, Toshio Miyawaki
-
Patent number: 4264595Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: ##STR1## wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.Type: GrantFiled: June 17, 1977Date of Patent: April 28, 1981Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Minamida, Susumu Tsushima
-
Patent number: 4239758Abstract: A novel cephalosporin derivative of the formula: ##STR1## [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula --SR.sup.1 (where R.sup.1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, particularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.Type: GrantFiled: May 31, 1979Date of Patent: December 16, 1980Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Masayoshi Yamaoka, Isao Minamida, Mitsuru Shiraishi, Tatsuo Nishimura
-
Patent number: 4238608Abstract: A novel compound of the formula: ##STR1## wherein R is lower alkyl or a group of the formula ##STR2## where R.sup.1 and R.sup.2 are the same or different and each is hydrogen, carboxyl or halogen; Y is acyloxy or a group of the formula --S--Het where Het is a nitrogen-containing heterocyclic group which may optionally be substituted, or a pharmaceutically acceptable salt thereof is found to be effective for treatment of diseases in animals including domestic fowls and human beings, particularly the infectious diseases caused by gram-positive and gram-negative bacteria.Type: GrantFiled: May 29, 1979Date of Patent: December 9, 1980Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Masayoshi Yamaoka
-
Patent number: 4200575Abstract: Novel [2-(syn)-carbamoyloximinoacetamido]cephalosporins of the formula: ##STR1## [wherein, Y.sup.1 is hydrogen, hydroxyl, carbamoyloxy, acyloxy, quaternary ammonium or nitrogen-containing heterocyclic thio; R.sup.1 is alkyl, aralkyl or aryl; R.sup.2 is hydrogen or an ester residue; k is 0 or 1] and a salt thereof show strong antibacterial activities particularly against Gram-negative bacteria and they are useful as antibacterial agents.Type: GrantFiled: August 1, 1978Date of Patent: April 29, 1980Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Tatsuo Nishimura
-
Patent number: 4179502Abstract: 2-Hydroxyiminoacetamide compounds of the following formula and salts thereof: ##STR1## [wherein X is S, O or an imino group which may optionally be substituted; B is a hydrogen atom or a hydroxyl, amino, mercapto or hydrocarbon residue group which may optionally be substituted; and COOR is a carboxyl group which may optionally be esterified] and pharmaceutically acceptable salts thereof are novel and useful as antibacterial agents.Type: GrantFiled: February 14, 1978Date of Patent: December 18, 1979Inventors: Mitsuo Numata, Isao Minamida, Susumu Tsushima
-
Patent number: 4172891Abstract: A novel cephalosporin derivative of the formula: ##STR1## [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula --SR.sup.1 (where R.sup.1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, particularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.Type: GrantFiled: March 31, 1977Date of Patent: October 30, 1979Assignee: Takeda Chemical Industries, Inc.Inventors: Mitsuo Numata, Masayoshi Yamaoka, Isao Minamida, Mitsuru Shiraishi, Tatsuo Nishimura
-
Patent number: 4080498Abstract: A compound of the formula: ##STR1## wherein R.sup.1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula --NR.sup.2 (where R.sup.2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R.sup.1), and Y represents acetoxy group or a group of formula --SR.sup.3 (where R.sup.3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.Type: GrantFiled: December 20, 1974Date of Patent: March 21, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Isao Minamida, Masayoshi Yamaoka, Mitsuru Shiraishi, Toshio Miyawaki
-
Patent number: 4068072Abstract: A derivative of 6-aminopenicillanic acid or 7-aminocephalosporanic acid is produced by a process which comprises chlorinating or brominating a 6-thioacylaminopenicillanic acid or 7-thioacylaminocephalosporanic acid compound to obtain a corresponding iminothiohalide compound, and then solvolyzing the iminothiohalide compound. The process is novel and industrially feasible for producing the amino compound, which is not accompanied by "reconversion reaction".Type: GrantFiled: June 30, 1976Date of Patent: January 10, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Susumu Tsushima, Norichika Matsumoto, Mitsuo Numata
-
Patent number: 4068071Abstract: A derivative of 6-aminopenicillanic acid or 7-aminocephalosporanic acid is produced by a process which comprises disulfidizing a 6-thioacylaminopenicillanic acid or 7-thioacylaminocephalosporanic acid compound to obtain a corresponding disulfide compound, and then solvolyzing the disulfide compound. The process is novel and industrially feasible for producing the amino compound, which is not accompanied by "reconversion reaction".Type: GrantFiled: June 23, 1976Date of Patent: January 10, 1978Assignee: Takeda Chemical Industries, Ltd.Inventors: Susumu Tsushima, Norichika Matsumoto, Mitsuo Numata
-
Patent number: 4012379Abstract: Novel compounds of the formula: ##STR1## wherein X is a lower alkanoyloxy group or a substituted thio group, where the substituent is a nitrogen-containing heterocyclic group, or a pharmaceutically acceptable salt or ester thereof, have a broad antimicrobial spectrum, and besides they are readily absorbed into the living body. Thus, the compounds are useful as therapeutic agent for various bacterial infections of animals including human beings.Type: GrantFiled: October 15, 1974Date of Patent: March 15, 1977Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuo Numata, Masayoshi Yamaoka, Yoshio Imashiro, Isao Minamida