Abstract: Provided is a flying apparatus capable of effectively cooling a constituent device. A flying apparatus 10 comprises: an airframe base 14; a power supply unit; an arm 11 which extends from the airframe base 14 toward a periphery; a rotor 12 which is disposed on an end portion side of the arm 11; a motor 17 which rotationally drives the rotor 12; and a power converting unit 19 which converts electric power supplied from the power supply unit to the motor 17. The power converting unit 19 is included inside the arm 11 below a rotation range 24 of the rotor 12.

Abstract: A flight device in which vibrations and anti-torque generated during flight can be effectively reduced includes a first engine, a second engine, a first transmission shaft rotated by the first engine, a second transmission shaft rotated by the second engine, a first rotor rotated by the first transmission shaft, and a second rotor rotated by the second transmission shaft. The first transmission shaft has a hollow structure, and the second transmission shaft is located inside the first transmission shaft.

Abstract: Provided is a flight device that includes multiple drive sources and that can continuously fly even when one of the drive sources stops in flight, by using the other drive source. The flight device 10 includes a first drive system 11 and a second drive system 12. The first drive system 11 includes a battery 27, rotor 151 and the like configured to be rotated by energy supplied from the battery 27, and a first control unit 20 configured to control the numbers of revolutions of the rotor 151 and the like depending on a flight condition. The second drive system includes the battery 27, rotor 181 and the like configured to be rotated by energy supplied from the battery 27, and a second control unit 21 configured to control the numbers of revolutions of the rotor 181 and the like depending on the flight condition.

Abstract: An engine-carrying flight device capable of stably hovering is provided. The engine-carrying flight device 10 can fly in a hovering state in which an altitude is maintained and in an ascending/descending state in which the altitude is changed. The engine-carrying flight device 10 includes main rotors 14, sub-rotors 15, an engine 26; motors 21; and an arithmetic control unit 25. The main rotors 14 are rotated by drive force received from the engine 26, the sub-rotors 15 are rotated by drive force received from the motors 21, and the arithmetic control unit 25 causes a thrust generated by rotation of the main rotors 14 to be smaller than a thrust necessary for keeping the altitude constant, in the hovering state.

Abstract: A flight device that can accurately perform attitude control with a sub-rotor is provided. The flight device 10 includes an airframe 19, an engine 30, motors 21, main rotors 14, and sub-rotors 15. The engine 30 rotates the main rotors 14. The motors 21 rotate the sub-rotors 15. The main rotors 14 are arranged below the sub-rotors 15. In the flight device 10, arranging the main rotors 14 below the sub-rotors 15 prevents the sub-rotors 15 from being affected by an air flow generated by rotation of the main rotors 14. Accordingly, the sub-rotors 15 can provide thrusts as designed by being rotated, and the position and the attitude of the airframe 19 can be accurately adjusted.

Abstract: A flight device in which a mechanism for transmitting power is simplified is provided. The flight device 10 includes an airframe 19, main rotors 14, an engine 30, and power transmission shafts 25. The main rotors 14 are rotated to generate drive force that causes the airframe 19 to lift. The engine 30 includes crankshafts. The power transmission shafts 25 are connected to the crankshafts. Moreover, the engine 30 rotates the main rotors 14 via the power transmission shafts 25. The power transmission shafts 25 are tilted with respect to a second direction D2.

Abstract: A culture method includes culturing a spheroid of a human neural cell-like cell in the presence of a tau protein aggregate and culturing a culture product in a culture medium containing 5 ?g/mL or greater of a lipid, in which the lipid is one or more selected from the group consisting of a glycerolipid, a glycerophospholipid, and a sphingolipid. The culture method includes culturing a spheroid of a human neural cell-like cell in the presence of a tau protein aggregate and culturing a culture product in a culture medium containing a neurotrophic factor.

Abstract: Provided is a flight device that can surely perform transformation operations of legs supporting a fuselage base in landing. A flight device 10 includes: a fuselage base 14; a first leg 26 provided on the fuselage base 14 and transformable between a flight state and a landing state; a second leg 27 provided on the fuselage base 14 as a separate body from the first leg 26 and transformable between the flight state and the landing state; a first drive unit 281 and a second drive unit 282 configured to drive transformation operations of the first leg 26 and the second leg 27; and an operation interconnecting mechanism 16 configured to interconnect the first leg 26 and the second leg 27 in terms of operation.

Abstract: A method of culturing human induced pluripotent stem cells includes inoculating human induced pluripotent stem cells in a culture medium at an inoculation density of 1.0×104 to 1.0×106 cells/cm2 in a culture vessel and subjecting the human induced pluripotent stem cells to two-dimensional culturing. A method of producing cerebral organoids includes culturing a culture of the human induced pluripotent stem cells obtained by the method of culturing human induced pluripotent stem cells in a culture medium containing a BMP inhibitor and a transforming growth factor ? (TGF?) inhibitor to form cell aggregates, culturing the cell aggregates in a culture medium containing a Wnt signal transduction pathway potentiator and an extracellular matrix, and subjecting the culturing obtained in the culturing the cell aggregates to spinner culturing.

Abstract: The present invention provides a flying apparatus that can accurately measure a weight of a transported objected in a simple configuration. The flying apparatus 10 includes rotors 11, motors 12, a flight sensor 13, an electric power conversion unit 14, and a computation control unit 15. The flight sensor 13 measures physical quantities acting on a fuselage base portion 16. The computation control unit 15 generates instruction signals based on the physical quantities to cause the fuselage base portion 16 to be at a predetermined position in a predetermined attitude. The electric power conversion unit 14 adjusts amounts of electric power supplied to the motors 121 and the like based on the received instruction signals. Moreover, the computation control unit 15 calculates an estimated weight that is an estimation value of a weight of the transported object, based on magnitudes of the instruction signals.

Abstract: A method is provided for producing oligodendrocyte-like cells, including (A) increasing abundances of oligodendrocyte transcription factor 2 (OLIG2) mutant and SRY-box transcription factor 10 (SOX10) in human pluripotent stein cells and (B) culturing the human pluripotent stem cells in which the abundances of the OLIG2 mutant and the SOX10 are increased and consequently differentiating the human pluripotent stem cells into oligodendrocyte-like cells, in which the OLIG2 mutant lacks a serine residue of wild-type OLIG2 at position 147, or the serine residue of the wild-type OLIG2 at position 147 is substituted with an amino acid other than serine.

Abstract: A method is provided for producing astrocyte-like cells, including (A) upregulating transcription factors including SRY-box transcription factor 9 (SOX9), nuclear factor IA (NFIA), and nuclear factor IB (NFIB) in human pluripotent stein cells and (B) culturing the human pluripotent stem cells, in which the transcription factors are upregulated, and consequently differentiating the human pluripotent stern cells into astrocyte-like cells.

Abstract: An autonomous flying device achieving a large payload and a long continuous flight time and also accurately adjust position and orientation while flying. The device includes: a main rotor and the like that provide main thrust; a sub rotor and the like that controls the orientation; an engine that generates energy for rotating the main rotor and the like and the sub rotor and the like; and an arithmetic control device that controls rotation of the sub rotor and the like. Also, the main rotor and the like are rotated by being drivingly connected to the engine, whereas the sub rotor and the like are rotated by motors driven by electric power generated from generator and the like operated by the engine. Further, when orientation control to tilt the fuselage is performed, the arithmetic control device increases the output distribution ratio of the sub rotor to above the output distribution ratio of the sub rotor when hovering is performed.

Abstract: Provided is a flight device that can surely perform transformation operations of legs supporting a fuselage base in landing. A flight device 10 includes: a fuselage base 14; a first leg 26 provided on the fuselage base 14 and transformable between a flight state and a landing state; a second leg 27 provided on the fuselage base 14 as a separate body from the first leg 26 and transformable between the flight state and the landing state; a first drive unit 281 and a second drive unit 282 configured to drive transformation operations of the first leg 26 and the second leg 27; and an operation interconnecting mechanism 16 configured to interconnect the first leg 26 and the second leg 27 in terms of operation.

Abstract: According to a production method for a brain organoid, comprising a step 1 of carrying out suspension culture of human pluripotent stem cells having a mutation in at least one or more base sequences in an exon selected from the group consisting of an exon 9, an exon 10, an exon 11, an exon 12, and an exon 13 of a microtubule-associated protein tau (MAPT) gene, and having a mutation in at least one or more base sequences in an intron 10 of the MAPT gene, it is possible to produce a brain organoid having a phosphorylated 3-repeat tau protein and a phosphorylated 4-repeat tau protein.

Abstract: A production method for parvalbumin-positive nerve cells includes: an expression induction step of inducing expression of Ascl1 gene, Dlx2 gene, and MEF2C gene in a cell, and a differentiation step of culturing the cell after the expression induction to differentiate the cells into parvalbumin-positive nerve cell; a cell into which Ascl1 gene, Dlx2 gene, and MEF2C gene are introduced in an expressible manner; and a differentiation inducer for inducing differentiation of a cell into a parvalbumin-positive nerve cell, including Ascl1 gene, Dlx2 gene, and MEF2C gene, or gene products thereof, as an active ingredient.

Abstract: A method for producing a brain organoid is provided, including a step of culturing a neuroectoderm marker-positive cell aggregate in a medium containing an extracellular matrix with a concentration of more than 10% by volume.

Abstract: An autonomous flying device achieving a large payload and a long continuous flight tune and also accurately adjust position and orientation while flying. The device includes: a main rotor and the like that provide main thrust; a sub rotor and the like that controls the orientation; an engine that generates energy for rotating the main rotor and the like and the sub rotor and the like; and an arithmetic control device that controls rotation of the sub rotor and the like. Also, the main rotor and the like are rotated by being drivingly connected to the engine, whereas the sub rotor and the like are rotated by motors driven by electric power generated from generator and the like operated by the engine. Further, when orientation control to tilt the fuselage is performed, the arithmetic control device increases the output distribution ratio of the sub rotor to above the output distribution ratio of the sub rotor when hovering is performed.

Abstract: The present technology relates to a solid-state imaging element that is capable of suppressing occurrence of flares, ghosts, and color-mixing, and is capable of suppressing occurrence of stains caused by moisture and a method for manufacturing the same, and an electronic device. The solid-state imaging element includes a pixel in which a single-layered anti-reflective film is formed on a surface of a microlens and a pixel in which a double-layered anti-reflective film is formed on the surface of the microlens. For example, the present technology is applicable to a rear surface irradiation-type solid-state imaging element.

Abstract: The present technology relates to a solid-state imaging element that is capable of suppressing occurrence of flares, ghosts, and color-mixing, and is capable of suppressing occurrence of stains caused by moisture and a method for manufacturing the same, and an electronic device. The solid-state imaging element includes a pixel in which a single-layered anti-reflective film is formed on a surface of a microlens and a pixel in which a double-layered anti-reflective film is formed on the surface of the microlens. For example, the present technology is applicable to a rear surface irradiation-type solid-state imaging element.