Patents by Inventor Monica Garcia Lopez

Monica Garcia Lopez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine derivatives having multimodal activity against pain
    Patent number: 9981942
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 29, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • SPIRO-ISOQUINOLINE-1,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20180111935
    Abstract: The present invention relates to spiro-isoquinoline-1,4?-piperidine compounds having dual pharmacological activity towards both the sigma (?) receptor and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 20, 2015
    Publication date: April 26, 2018
    Inventors: Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ, Ana-Maria CAAMANO-MOURE
  • Piperidine compounds having multimodal activity against pain
    Patent number: 9902711
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: February 27, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez, Eva Maria Ayet Galcera, Maria Teresa Serafini Cabanes
  • 1-METHYLPYRAZOLE-PIPERAZINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170362215
    Abstract: The present invention relates to 1-methylpyrazole-piperazine compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 15, 2015
    Publication date: December 21, 2017
    Inventors: Carmen ALMANSA-ROSALES, Monica GARCIA-LOPEZ, Lourdes GARRIGA-SANAHUJA
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Publication number: 20170313723
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 2, 2015
    Publication date: November 2, 2017
    Applicant: Laboratorios del Dr. Esteve, S.A.
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carlos ALEGRET-MOLINA, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ
  • METHYL-1H-PYRAZOLE ALKYLAMINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170305862
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to methyl-1 H-pyrazole alkylamine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 15, 2015
    Publication date: October 26, 2017
    Inventors: Antoni TORRENS-JOVER, Josep MAS-PRIO, Carmen ALMANSA-ROSALES, Monica GARCIA-LOPEZ
  • ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170101420
    Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 2, 2015
    Publication date: April 13, 2017
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carlos ALEGRET-MOLINA, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ
  • PIPERAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170001967
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 19, 2014
    Publication date: January 5, 2017
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ
  • PIPERIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20170001978
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 19, 2014
    Publication date: January 5, 2017
    Inventors: FéIix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ
  • Piperidine compounds having multimodal activity against pain
    Publication number: 20170001979
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: December 19, 2014
    Publication date: January 5, 2017
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES, Monica GARCIA LOPEZ, Eva Maria AYET GALCERA, María Teresa SERAFINI CABANES
  • Sigma receptor inhibitors
    Patent number: 9181195
    Abstract: The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 10, 2015
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Mónica García López, Antoni Torrens Jover, José Luis Díaz Fernández, Ana María Caamaño Moure
  • SIGMA RECEPTOR INHIBITORS
    Publication number: 20130158029
    Abstract: The invention refers to compounds of general formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Application
    Filed: May 26, 2011
    Publication date: June 20, 2013
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia López, Antoni Torrens Jover, José Luis Diaz Fernández, Ana Maria Caamaño Moure
  • HETEROCYCYL-SUBSTITUTED-ALKYLAMINOPHENYL DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20120322842
    Abstract: The present invention relates to heterocyclyl-substituted alkylamino phenyl derivatives (I) to processes for the preparation thereof, to medicaments comprising them as well as to their use for the preparation of a medicament for the treatment of 5HT7 receptor mediated diseases or conditions. In the compounds (I) x-y-z together form —N—N?CR1— or ?C—NR2—N?.
    Type: Application
    Filed: September 22, 2010
    Publication date: December 20, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia-Lopez, Antoni Torrens-Jover, Monica Alonso-Xalma
  • INDANE-AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20120264799
    Abstract: The present invention relates to indane-amine derivatives, to processes for the preparation thereof, to medicaments comprising them as well as to their use for the preparation of a medicament for the treatment of 5HT7 receptor mediated diseases or conditions.
    Type: Application
    Filed: September 29, 2010
    Publication date: October 18, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE ,S.A.
    Inventors: Monica Garcia-Lopez, Anton Torrens-Jover, Monica Alonso-Xalma
  • Heterocyclyl-substituted-tetrahydro-naphthalen-amine derivatives, their preparation and use as medicaments
    Patent number: 8236845
    Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: August 7, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Monica Garcia-Lopez, Antonio Torrens-Jover, Helmut H. Buschmann
  • Indane-amine derivatives, their preparation and use as medicaments
    Patent number: 8232307
    Abstract: The present invention relates to indane-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment of humans or animals.
    Type: Grant
    Filed: July 4, 2008
    Date of Patent: July 31, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Monica Garcia-Lopez, Antonio Torrens-Jover
  • 5-HTreceptor antagonists
    Patent number: 8188115
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: May 29, 2012
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Josep Mas Prio, Susana Yenes Minguez, Mónica Garcia Lopez, Alberto Dordal Zueras, Luz Romero Alonso, Helmut Henrich Buschmann
  • 5-HT7 receptor antagonists
    Patent number: 8148397
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: April 3, 2012
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Josep Mas Prio, Susana Yenes Minguez, Monica Garcia Lopez, Alberto Dordal Zueras, Luz Romero Alonso, Helmut Henrich Buschmann
  • Heterocyclyl substituted tetrahydronaphthalene derivatives as 5-HT7 receptor ligands
    Patent number: 8097641
    Abstract: The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: January 17, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Monica Garcia-Lopez, Antonio Torrens-Jover, Helmut H. Buschmann
  • INDANE-AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20110053980
    Abstract: The present invention relates to indane-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the preparation of a medicament for the treatment of humans or animals.
    Type: Application
    Filed: July 4, 2008
    Publication date: March 3, 2011
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Monica Garcia-Lopez, Antonio Torrens-Jover