Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract: The application provides a method of isolating a eukaryotic cell expressing an antibody of desired specificity, preferably a monoclonal single chain antibody (scFv). The application further provides methods which allow to clone the variable regions of said antibody from that isolated eukaryotic cell and to recombinantly produce antibodies comprising said variable regions as fusion protein with a purification tag, eg. as Fc-fusion, as a Fab fragment, or as whole antibodies, such as IgG, IgE, IgD, IgA and IgM. Said methods also allows to recombinantly produce antibodies with desired specificity in a fully species specific form, preferably as fully human antibodies.

Abstract: The invention relates to a display cell, comprising two transparent, equidistant plates, wherein the gap between the plates is filled with a liquid-crystal material-containing layer, characterized in that the liquid-crystal material-containing layer is inhomogeneous and anisotropic, wherein it has a first region made up of compartments, which comprise entirely, substantially or mainly liquid-crystal material, and a second, coherent region which comprises entirely, substantially or mainly an organic polymer material and surrounds the compartments made of liquid-crystal material. In addition, the invention relates to a liquid-crystal material-containing mixture which can be used to produce the layer between the plates, and to a method for producing the display cell.

Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract: The use of a substrate supported polymer film as a surface coating for fiber/plastics composite structures produced by the crushed core method from composite structures having a core and at least one prepreg layer, wherein the polymer film is applied to a prepreg surface with its resin side facing the surface before the composite structure is cured and optionally before it is placed in the mold, and curing is effected under applied pressure and at an elevated temperature. The substrate supported polymer film comprises a resin matrix which has a degree of crosslinking that is below its gel point, and which is produced from at least one difunctional or polyfunctional aromatic organic cyanate and at least one difunctional or polyfunctional aromatic alcohol in proportions giving a molar ratio of OCN groups to OH groups in the starting materials used for the production of the prepolymer of from 95:5 to 70:30, and which also contains at least one filler.

Abstract: Novel hybrid monomers containing both the aryltrifluorovyinyloxyether-group (TFVE-group) and the cyanato-group, their synthesis, and the synthesis of polymers made from these new hybrid monomers are disclosed.

Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract: The present invention concerns a polycyanurate foam with a structural element A and either terminal amino groups and/or at least one of the following structural elements B, C, or D: wherein the foam has closed pores that contain carbon dioxide. This foam can be produced in that a substance is worked into the starting material for the polycyanurate that releases water or alcohol approximately at the start of polymerization either spontaneously or thermally or catalytically induced. The water/alcohol reacts with free cyanate groups under cleavage of CO2. The resulting amino groups can react further in the polymerization.

Abstract: A prepolymer is prepared from a starting material a) of one or more bifunctional or polyfunctional organic cyanates; and a starting material b) of one or more bifunctional or polyfunctional aromatic alcohols and/or one or more bifunctional or polyfunctional aliphatic alcohols substituted in the aliphatic group with at least one fluorine atom, wherein the starting materials a) and b) are present in a weight ratio ensuring a molar ratio of the OCN groups to the OH groups between 95:5 and 70:30 in the starting materials a) and b). The prepolymer has a degree of crosslinking that is below the gel point of the prepolymer.

Abstract: A textile web material impregnated with a mixture that contains at least a prepolymer prepolymerized from a starting material of one or more bifunctional or polyfunctional organic cyanates and from a starting material of one or more bifunctional or polyfunctional aromatic alcohols, wherein the one or more bifunctional or polyfunctional organic cyanates and the one or more bifunctional or polyfunctional aromatic alcohols are present in weight ratios ensuring a molar ratio of the OCN groups to the OH groups between 95:5 and 70:30 prior to prepolymerization. The mixture further contains one or more fillers.

Abstract: A structural member (100), particularly for lightweight construction, is described, comprising a two-dimensional extent, and a plurality of adjacent arranged hollow shaped elements (11, 11A) extending across the two-dimensional extent of the structural member, wherein the hollow shaped elements (11, 11A) each have a continuous peripheral side wall (12) and the adjacent hollow shaped elements are connected to each other at their side walls, and wherein two structural spacing parts (15,16), which extend in parallel to the two-dimensional extent of the structural member and form arrangements of the hollow shaped elements (11, 11A), wherein each of the structural spacing parts (15, 16) has a base layer (13, 14) on which the hollow shaped elements (11, 11A) belonging to this structural spacing part (15, 16) are arranged at mutual intervals, and the structural spacing parts (15, 16) are arranged in opposite orientation so that the hollow shaped elements (11, 11A) of the first structural spacing part (15) protrude i

Abstract: Hyperbranchend compounds of triazine rings that contain free OH groups in the outer sphere, are obtainable by copolymerization of (1) at least one di- or higher functional cyanate compound, and (2) at least one compound, selected from mono-, di- and polyvalent aromatic alcohols and mono-, di- and polyfunctional, partly or fully fluorinated alcohols. With one or more (activated) organic acids having formula Q-C(O)Y, wherein Q is an organic residue X having at least one unit which can serve as a crosslinking unit or an organic residue P which cannot undergo a crosslinking reaction, and wherein C(O)Y is either a carboxylic group or is an activated carboxylic residue, derivatives are obtained which can be crosslinked into polymers, via the X residues, and/or which may have specifically tailored properties, via the P residues, and/or by using less than the required amount of acid in order to maintain part of the free hydroxy residues.

Abstract: Novel hybrid monomers contaning both the aryltrifluorovyinyloxyether-group (TFVE-group) and the cyanato-group, their synthesis, and the synthesis of polymers made from these new hybridmonomers are disclosed.

Abstract: The present invention relates to prepolymers produced by reacting resins with phosphororganic compounds obtained from phosphinic acid derivatives, and their use for producing flame resistant polymers, in particular duromers, and the polymers produced therewith. In particular, the present invention relates to a prepolymer for flame resistant polymers, particularly duromers, which is obtained by reacting at least one phosphinic acid derivative of formula I (R1O)(R2)P(O)—R3, wherein R1 and R2 independently of one another represent an optionally substituted alkyl, aryl, arylalkyl, alkylaryl or alkylarylalkyl group with 1 to 20 carbon atoms, R3 represents hydrogen or an optionally substituted alkyl, aryl, arylalkyl, alkylaryl or alkylarylalkyl group with 1 to 20 carbon atoms, with at least one resin preferably selected from the group consisting of an epoxy resin, cyanate resin, an unsaturated polyester, vinyl ester, phenol resin and a bismaleimide.

Abstract: An electric contact coupling for connection of a first group of electric conductors to a second group of electric conductors, and especially for use in the coupling of rail and other vehicles with one another, comprises a first plug contact carrier and a second socket contact carrier which are movable into assembly with one another to bring the plug contact elements of the first contact carrier into electric contact with the socket contact elements of the second contact carrier. The two contact carriers are arranged in respectively associated contact carrier housings. The first contact carrier is movable by a positioning mechanism axially relative to its housing to bring its contacts into engagement with the contacts of the second carrier after the two carrier housings have been brought into engagement with one another. Transversely movable closure members seal the carrier housings against the penetration of dirt and moisture when the carrier housings are uncoupled from one another.

Abstract: The present invention is directed to optical waveguides or waveguide systems, comprising at least (a) a first material which is a poly(perfluorocyclobutane), and in direct contact to this material, (b) a second material which is a polycyanate resin made from at least one aromatic difunctional cyanate of formula (I) wherein R1 to R8 are independently from each other hydrogen, optionally substituted C1-C10 alkyl, C3-C8 cycloalkyl, C1-C10 alkoxy, halogen, phenyl or phenoxy, the alkyl or aryl groups being unfluorinated, partly fluorinated or fully fluorinated with the proviso that (I) carries at least 1 fluorine atom, and Z is a chemical bond, SO2, CF2 CH2, CHF, CH(CH3), isopropylene, hexafluoroisopropylene, n- or iso-C1-C10 alkylene which may be partly or fully fluorinated, O, NR9 whereby R9 is hydrogen or C1-C10 alkyl, N?N, CH?CH, C(O)O, CH?N, CH?N—N?CH, alkyloxyalkylene having 1 to 8 carbon atoms, S, or Si(CH3)2 optionally in mixture with other components.

Abstract: The invention describes a fast curable system for the preparation of amine modified thermosettings containing triazine groups, the system comprising at least one polyfuctional organic monomeric or prepolymerized cyanate and at least one primary or secondary amine, wherein the amount of amine is selected such that the molar ratio of cyanate radicals to amine radicals is from 95:5 to 50:50, and optionally additional additives, characterized in that the amine is present in a form having a blocked or decreased reactivity which can be reactivated without reacting it with a chemical participant of reaction. Further, it is directed to amine modified thermosetting materials containing triazine groups as well as to a method for preparing same.

Abstract: An electrical pressure contact includes a housing sleeve with an end facing the contact and an end facing away from the contact, a contact pin axially slidably supported in the housing sleeve, which pin extends out of the housing sleeve at the side facing the contact, which pin is a pushable into the housing sleeve against the biasing force of the a biasing element arranged in the housing sleeve, and through the conductive body of which pin the electrical contact is made, a terminal piece for fastening to an electrical supply conductor at the end of the housing facing away from the contact, and an axially flexible electrical conductor arranged in the housing sleeve between the terminal piece and the contact pin. The flexible electrical conductor is at its end facing the contact clamped into an axial bore formed in the end of the contact pin facing away from the contact and at its end facing away from the contact is clamped in an axial bore formed in the end of the terminal piece facing the contact.

Abstract: An adhesive system for forming reversible adhesive bonds includes at least one polymeric adhesive component comprising at least one of polyurethanes, polyureas, or epoxy resins and at least one additional component that includes a functional group that can be activated by the introduction of energy, such that a chemical reaction with the adhesive component takes place involving a partial breakdown of the adhesive component. Reversible bonding of articles and controlled parting of an adhesive bond between articles can be achieved with the adhesive system.

Abstract: A device for fixing a heat distribution covering on a printed circuit board includes at least one fixing foot disposed on a placement area next to a plurality of heat-generating electronic components. The fixing foot is attached above a further conductor track plane that extends below a conductor track plane that interconnects the electronic components. The fixing foot carries a fixing element that can be brought into engagement with the heat distribution covering.