Patents by Inventor Moon Hae Sunwoo
Moon Hae Sunwoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11786637Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: March 1, 2021Date of Patent: October 17, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Publication number: 20210178022Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: ApplicationFiled: March 1, 2021Publication date: June 17, 2021Inventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10973953Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: August 17, 2017Date of Patent: April 13, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 9138509Abstract: The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5-7.5.Type: GrantFiled: September 14, 2007Date of Patent: September 22, 2015Assignee: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Moon Hae Sunwoo, Victor A. Lizano, Arthur A. Gertzman
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Publication number: 20140058527Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.Type: ApplicationFiled: October 31, 2013Publication date: February 27, 2014Applicant: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Patent number: 8562613Abstract: The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.Type: GrantFiled: April 5, 2010Date of Patent: October 22, 2013Assignees: Spineology Inc., Musculoskeletal Transplant FoundationInventors: James W. Ahern, Arthur Gertzman, Karen Roche, Moon Hae Sunwoo, Steven Wolfe, John E. Kuslich
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Patent number: 8292968Abstract: A construct for repairing articular cartilage defects includes a cap member and a base member. The cap member has an upper section and a stem depending from a central region thereof. The upper section includes a peripheral region. The stem includes a cavity. The base member has first and second ends, the first end including an annular recess dimensioned such that the stem is receivable therein. The first end also includes an annular edge positioned laterally outwardly from the annular recess, for abutting and supporting the peripheral region of the upper section when the stem is received in the annular recess. The base member further includes an island which is surrounded by the annular recess and receivable in the cavity of the stem, such that the island is abuttable with and may thereby support the central region of the upper section when the stem is received in the annular recess.Type: GrantFiled: February 1, 2011Date of Patent: October 23, 2012Assignee: Musculoskeletal Transplant FoundationInventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich
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Publication number: 20120251609Abstract: A demineralized cancellous bone matrix comprising a cancellous bone matrix that has been demineralized is described herein. The demineralized cancellous bone matrix is rigid and has certain dimensions, including a certain length. Implants comprising at least one demineralized cancellous bone matrix are also described. Also disclosed are methods for treating bone having a void or defect in a patient using at least one demineralized cancellous bone matrix. In addition, methods of making a demineralized cancellous bone matrix are disclosed.Type: ApplicationFiled: March 29, 2011Publication date: October 4, 2012Inventors: Yen-Chen Huang, Moon Hae Sunwoo, Arthur A. Gertzman
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Publication number: 20120205274Abstract: The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexibleType: ApplicationFiled: April 26, 2012Publication date: August 16, 2012Inventors: Moon Hae Sunwoo, Arthur A. Gertzman, Barbara L. Merboth
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Patent number: 8231930Abstract: An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.Type: GrantFiled: August 4, 2009Date of Patent: July 31, 2012Assignee: Maquet Cardiovascular, LLCInventors: Dan Castro, Al Kuehn, Moon Hae Sunwoo
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Patent number: 8221500Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: GrantFiled: July 24, 2008Date of Patent: July 17, 2012Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W Tomford
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Publication number: 20110196508Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.5×105 to 2.5×107.Type: ApplicationFiled: February 11, 2011Publication date: August 11, 2011Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Publication number: 20110166669Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.Type: ApplicationFiled: February 1, 2011Publication date: July 7, 2011Inventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich
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Publication number: 20110070271Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.Type: ApplicationFiled: September 21, 2010Publication date: March 24, 2011Inventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford
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Patent number: 7901457Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: GrantFiled: May 16, 2003Date of Patent: March 8, 2011Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Publication number: 20100286702Abstract: The present invention is a kit and a method of using a kit for treating bone including a fill material mixture made of osteoconductive material, osteoinductive material and a lubricating carrier, a porous container to receive the fill material mixture and a tool that flowably introduces the fill material mixture into the porous container.Type: ApplicationFiled: April 5, 2010Publication date: November 11, 2010Inventors: James W. Ahern, Arthur Gertzman, Karen Roche, Moon Hae Sunwoo, Steven Wolfe, Stephen D. Kuslich, John E. Kuslich
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Publication number: 20100274362Abstract: Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the ?8-?9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the ?8-?9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.Type: ApplicationFiled: January 14, 2010Publication date: October 28, 2010Inventors: Avner Yayon, Katherine G. Truncale, Hilla Barkay-Olami, Alex B. Callahan, Arthur A. Gertzman, Yen-Chen Huang, Morris L. Jacobs, John C. Munson, Eric J. Semler, Roman Shikhanovich, Baruch Stern, Moon Hae Sunwoo, William W. Tomford, Judith I. Yannariello-Brown
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Publication number: 20100112543Abstract: In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor, including a living human donor, and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In other embodiments, the present invention relates to a process for treating a decellularized soft tissue by freezing the same at a plurality of decreasing temperatures at atmosphere or higher such that there is formation of ice crystals having a size greater than 2.0 and lyophilizing the soft tissue under vacuum to remove the water to less than 6% forming a porous matrix.Type: ApplicationFiled: August 3, 2009Publication date: May 6, 2010Inventors: Manh-Dan NGO, Arthur Gertzman, Michael Kawas, Katherine G. Truncale, Moon Hae Sunwoo, Alison Lee, Richard Seeman, Carl Alexander DePaula, Jeffrey S. Cartmell, David J. Gocke, Carina Syring, Rudiger von Versen
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Patent number: RE42208Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.Type: GrantFiled: June 26, 2008Date of Patent: March 8, 2011Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Patent number: RE43258Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.Type: GrantFiled: December 13, 2010Date of Patent: March 20, 2012Assignee: Musculoskeletal Transplant FoundationInventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford