Patents by Inventor Moon Hae Sunwoo
Moon Hae Sunwoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090319045Abstract: Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member.Type: ApplicationFiled: March 5, 2009Publication date: December 24, 2009Inventors: Katherine G. Truncale, Eric J. Semler, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Roman Shikhanovich, Alex B. Callahan, Judith I. Yannariello-Brown, Morris L. Jacobs, John C. Munson, Yen-Chen Huang
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Publication number: 20090297692Abstract: An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.Type: ApplicationFiled: August 4, 2009Publication date: December 3, 2009Applicant: Maquet Cardiovascular, LLCInventors: Dan Castro, Al Kuehn, Moon Hae Sunwoo
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Publication number: 20090291112Abstract: An allograft osteochondral plug is combined with a mixture that includes freeze-milled cartilage particles, and such combination is used to repair defects in articular cartilage. The plug includes an subchondral bone portion and an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans. At least a portion of the plug has a lateral dimension selected to form an interference fit against a tissue layer exposed as a result of a bore formed in a defect area in articular cartilage of a host. The cartilage particle mixture is placed adjacent at least a portion of the plug for promoting cartilage cell migration into (i.e., from the adjacent host cartilage) and proliferation in the bore, and for enhancing tissue integration between the plug and patient (i.e., host) tissue when the plug is inserted into the bore. Methods for surgical implantation of the plug into a patient are also disclosed.Type: ApplicationFiled: February 9, 2009Publication date: November 26, 2009Inventors: Katherine G. Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Judith I. Yannariello-Brown, Yen-Chen Huang
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Publication number: 20090269388Abstract: The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexibleType: ApplicationFiled: June 4, 2009Publication date: October 29, 2009Inventors: Moon Hae Sunwoo, Arthur A. Gertzman, Barbara L. Merboth
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Patent number: 7585319Abstract: An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.Type: GrantFiled: September 27, 2004Date of Patent: September 8, 2009Assignee: Maquet Cardiovascular, LLCInventors: Dan Castro, Al Kuehn, Moon Hae Sunwoo
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Publication number: 20090074871Abstract: The invention is directed toward an improved formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles ranging from about 100 to 850 microns. The bone particles are mixed in an excipient carrier combination containing carboxymethylcellulose, sodium hyaluronate, and a sodium phosphate saline buffer, the carboxymethylcellulose component of the carrier ranging from about 5.0 to about 11.0% of the composition and the sodium hyaluronate component of the carrier ranging from about 0.3 to about 0.7% of the composition, the composition having a pH between 6.5-7.5.Type: ApplicationFiled: September 14, 2007Publication date: March 19, 2009Inventors: Moon Hae Sunwoo, Victor A. Lizano, Arthur A. Gertzman
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Publication number: 20090069901Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: ApplicationFiled: July 24, 2008Publication date: March 12, 2009Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
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Publication number: 20090043389Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.Type: ApplicationFiled: August 14, 2008Publication date: February 12, 2009Inventors: GORDANA VUNJAK-NOVAKOVIC, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford, Katherine G. Truncale
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Patent number: 7488348Abstract: The invention is directed toward a cartilage repair assembly comprising a cylindrically shaped allograft structure of subchondral bone with an integral overlying smaller diameter cartilage cap which is treated to remove cellular debris and proteoglycans. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the subchondral bone of the structure engages the side wall of the bone portion of the drilled bore in an interference fit while the cartilage cap is spaced from cartilage portion of the side wall of the drilled bore forming a gap in which a milled cartilage and biocompatible carrier mixture is placed allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: GrantFiled: June 14, 2005Date of Patent: February 10, 2009Assignee: Musculoskeletal Transplant FoundationInventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford, Judith I. Yannariello-Brown
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Publication number: 20080274157Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore and is positioned from the side wall of the bone a distance ranging from 10 microns to 1000 microns and is surrounded by milled cartilage and a fibrin thrombin glue. A method for inserting the assembly into a cartilage defect area is disclosed.Type: ApplicationFiled: March 26, 2008Publication date: November 6, 2008Inventors: Gordana Vunjak-Novakovic, Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman
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Publication number: 20080188939Abstract: A method for producing a cleaned bone graft with osteoinductivity above 2.0 suitable for transplantation into a human. The first step is sonicating a bone graft in a nonionic detergent in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. and for a time period ranging from 15 minutes to 2 hours effective to produce a cleaned bone graft essentially free from bone marrow. The bone graft is sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. a plurality of times to remove the detergent producing a cleaned bone graft. The bone graft is then sonicated in hydrogen peroxide in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. for a time period ranging from 10 minutes to about 2 hours effective to retain osteoinductivity of the bone graft and again sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C.Type: ApplicationFiled: February 25, 2008Publication date: August 7, 2008Inventors: Carl Alexander DePaula, Devin Joshua Mahony, Moon Hae Sunwoo, Arthur A. Gertzman
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Patent number: 7241309Abstract: There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain the protein suspended in the slurry.Type: GrantFiled: June 8, 2001Date of Patent: July 10, 2007Assignee: Scimed Life Systems, Inc.Inventors: Dan Castro, Al Kuehn, Moon Hae Sunwoo
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Publication number: 20060204544Abstract: The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition crosslinks the gelatin to form a solid structure and when rehydrated is flexibleType: ApplicationFiled: May 15, 2006Publication date: September 14, 2006Inventors: Moon Hae Sunwoo, Arthur Gertzman, Barbara Merboth
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Patent number: 7067123Abstract: The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.Type: GrantFiled: April 29, 2003Date of Patent: June 27, 2006Assignee: Musculoskeletal Transplant FoundationInventors: Katherine A. Gomes, Moon Hae Sunwoo, Arthur A. Gertzman
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Patent number: 7045141Abstract: The invention is directed toward an osteoimplant for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing composition of demineralized allograft bone material mixed with an aqueous phosphate buffered gelatin which when lyophilized to remove water from the composition cross links the gelatin to form a solid structure.Type: GrantFiled: May 20, 2002Date of Patent: May 16, 2006Assignee: Musculoskeletal Transplant FoundationInventors: Barbara L. Merboth, Moon Hae Sunwoo, Arthur A. Gertzman
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Patent number: 7019192Abstract: The invention is directed toward a formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone particles. The particle size ranges from about 0.1 mm to about 1.0 cm and is mixed in a hydrogel carrier containing a sodium phosphate saline buffer, the hydrogel component of the carrier ranging from about 1.0 to 5.0% of the composition and a pH between 6.8–7.4 with one or more additives of a cellular material, growth factor, demineralized bone chips or mineralized bone chips.Type: GrantFiled: August 19, 2002Date of Patent: March 28, 2006Assignee: Musculoskeletal Transplant FoundationInventors: Arthur A. Gertzman, Moon Hae Sunwoo
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Patent number: 6998135Abstract: A flexible, demineralized unitary bone sheet comprised of cortical cancellous bone having a residual calcium weight of 3.0% to 8.0% with a hyaluronic acid component having a molecular weight of 700,000 to 1,500,000 with the weight of the same ranging from 1% to about 5% of the total sheet weight. The bone sheet is adapted for use during the in vivo repair of a mammalian or animal skeletal system with the thickness of the cortical cancellous sheet ranging from 2.0 mm to about 8.0 mm. The bone sheet has sufficient flexibility to allow the sheet to be shaped to conform to the configuration of a skeletal region to be repaired and sufficient tensile strength to allow the sheet to be so shaped without damage to the sheet.Type: GrantFiled: May 14, 2001Date of Patent: February 14, 2006Assignee: Musculoskeletal Transplant FoundationInventors: Moon Hae Sunwoo, Arthur A. Gertzman, Bruce W. Stroever
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Publication number: 20050222687Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that said shaped bone and cartilage cap when centered in the bore does not engage the side wall of the bore in an interference fit and is surrounded by milled cartilage and carrier. A method for inserting the assembly into a cartilage defect area is disclosed.Type: ApplicationFiled: April 2, 2004Publication date: October 6, 2005Inventors: Gordana Vunjak-Novakovic, Katherine Truncale, Moon Hae Sunwoo, Arthur Gertzman, William Tomford
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Publication number: 20040230303Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.Type: ApplicationFiled: May 16, 2003Publication date: November 18, 2004Inventors: Katherine A. Gomes, Moon Hae Sunwoo, Arthur A. Gertzman
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Patent number: RE39587Abstract: The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier, the hydrogel component of the carrier ranging from about 0.3 to 3.0% of the composition and having a molecular weight of about at least 10,000 Daltons. The composition contains about 25% to about 40% bone powder and can be additionally provided with BMP's and a sodium phosphate buffer.Type: GrantFiled: May 12, 2004Date of Patent: April 24, 2007Assignee: Musculoskeletal Transplant FoundationInventors: Arthur A. Gertzman, Moon Hae Sunwoo