Abstract: The invention relates to surface modified extracellular vesicles, wherein the extracellular vesicles comprise an exogenous polypeptide tag that is covalently linked to a membrane protein of the extracellular vesicles. In a particular embodiment, the tag is covalently linked to the membrane protein of microvesicles by sortase-mediated ligation. Methods of preparing said extracellular vesicles and methods of using said extracellular vesicles loaded with therapeutic molecules for treating a disease are also disclosed herein.

Abstract: Techniques for an application interaction platform are described. In at least some implementations, an instance of a first application can initiate a launch of an instance of a second application. In a scenario where the second application is a multiuser application, the second application can be launched as either a multiuser instance or a single user instance depending on a launch context. Implementations also enable communication among applications, such as to enable applications to exchange state information and modify their execution based on the information.

Abstract: Systems, methods, and non-transitory computer-readable media can receive a context comprising attributes associated with an agent. The attributes associated with the agent can be determined based at least in part on sensor data captured by at least one vehicle. A plurality of trajectory prediction algorithms to be applied to the agent can be evaluated to generate a plurality of performance metrics associated with the plurality of trajectory prediction algorithms. A particular trajectory prediction algorithm of the plurality of trajectory prediction algorithms that is to be applied to the agent can be determined based on evaluating the context against the plurality of performance metrics. The context can be associated with a particular cluster of a plurality of clusters of contexts such that the particular trajectory prediction algorithm is associated with the particular cluster.

Abstract: A device for analyzing body composition provides improved accuracy in measuring body fat, lean body mass and body water using bio-electrical impedance (BIA) measurement. The includes a ring sized to fit a human finger, and including components for passing current. Electrodes are provided for contacting the ring finger of one hand (on an interior portion of the ring), and for making contact with fingers of the opposing hand (on an exterior portion of the ring), so that BIA of the human body can be measured across the human body between the left and right hands, as the result current and voltage applied by the ring. The ring may include components for performing the BIA analysis, or for communicating data to another device for performing the BIA analysis. Results of the analysis may be displayed at the other device, or via a display supported on the ring.

Abstract: Methods, systems, and computer-readable media for record-by-record live migration using segmentation are disclosed. Migration of a data set comprises, for a record in a segment being migrated, storing a first status indicating that the record is offline in a source data store. An instance of the record is stored in the destination data store, and a second status is stored to indicate that the record is online in the destination. The record is deleted from the source after the second status is stored. During the migration, a read request for the record is received and determined to be associated with the segment being migrated. A response to the read request is generated that comprises an authoritative instance of the record. The instance of the record in the destination is determined to represent the authoritative instance based (at least in part) on the first status and the second status.

Abstract: This disclosure relates to quantum computer arrays. In particular, a quantum processor comprises an array of source lines, drain lines and gate lines intersecting each other to define processor cells. Each of the processor cells comprise a first qubit, a second qubit and an electron confinement region disposed between the first qubit and the second qubit. A control circuit controls loading and unloading of an electron into the electron confinement region. The loading of the electron into the confinement region enables exchange interaction between electrons of the first qubit and the second qubit, and the unloading of the electron out of the electron confinement region suppresses exchange interaction between the electrons of the first qubit and the second qubit.

Abstract: Methods, systems, and computer-readable media for augmenting storage functionality using emulation of storage characteristics are disclosed. An access request for a data set is received. The access request is formatted according to a first protocol associated with a first data store, and the first data store is associated with first storage characteristics. The access request is translated into a translated access request. The translated access request is formatted according to a second protocol associated with a second data store, and the second data store is associated with second storage characteristics differing at least in part from the first storage characteristics. The translated access request is sent to the second data store. The translated access request is performed by the second data store on the data set using emulation of one or more of the first storage characteristics not included in the second storage characteristics.

Abstract: An extracellular vesicle loaded with a nucleic acid cargo and method for preparing the loaded vesicle is disclosed.

Abstract: A hybrid zeolitic imidazolate framework having an isolated purity of at least 95 wt. %, which is a coordination product formed between zinc(II) ions, a linker of formula (I), and a linker of formula (II); wherein each linker of formulae (I) and (II) links together adjacent zinc(II) ions, R1 and R2 are independently a hydrogen, an optionally substituted alkyl, an optionally substituted aryl, a halo, a nitro, or a cyano, and R3 and R4 are independently hydrogen, an optionally substituted alkyl, an optionally substituted aryl, or an optionally substituted arylalkyl. A method of making the hybrid zeolitic imidazolate framework and a method of capturing CO2 from a gas mixture with the hybrid zeolitic imidazolate framework.

Abstract: Methods, systems, apparatuses, and computer program products are provided that enable the automated deployment of microservices to a network-accessible server set. The automated deployment may be based on constraint(s) that are specified by a declarative deployment model that is associated with the microservice to be deployed. For example, a centralized deployment orchestrator may receive microservice(s) and their associated declarative deployment model(s). The deployment orchestrator analyzes the declarative deployment model(s) and determines which microservice(s) are to be deployed based on the constraint(s) specified by the declarative deployment model(s). The foregoing techniques advantageously determine when to deploy microservice(s), while also minimizing human intervention typically required to deploy microservice(s).

Abstract: A zirconium metal-organic framework, which is a coordination product formed between zirconium ion clusters and a linker that links together adjacent zirconium ion clusters, wherein the linker is of formula (I) wherein R1 is hydrogen or an optionally substituted alkyl, and R2 to R4 are independently hydrogen, an optionally substituted alkyl, an optionally substituted aryl, or an optionally substituted arylalkyl. A method of capturing CO2 from a gas mixture with the zirconium metal-organic framework.

Abstract: Methods, systems, and computer-readable media for segmentation of maintenance on distributed systems are disclosed. A data set is partitioned according to a hash function into a plurality of segments. A maintenance activity is initiated on a first segment. During the maintenance activity, a first request to perform a first action on the data set is received. Based at least in part on determining that the first request is associated with the first segment using the hash function, the first action is performed using additional processing associated with the maintenance activity. During the maintenance activity, a second request to perform a second action on the data set is received. Based at least in part on determining that the second request is associated with a second segment using the hash function, the second action is performed without the additional processing associated with the maintenance activity.

Abstract: In one aspect, molecular sensors and methods of making molecular sensors are described herein. In some embodiments, such a sensor comprises a first layer having a dual nanohole structure and a second layer having at least one nanopore. In some embodiments, the first and second layer define a chip of the sensor. In another aspect, methods of sensing are described herein, which in some embodiments comprise (i) providing a test sample comprising complexed and/or non-complexed biomolecules; (ii) contacting the test sample with the first layer of the molecular sensor; (iii) irradiating the dual nanohole structure of the sensor with a beam of electromagnetic radiation; (iv) optically trapping the biomolecules in the dual nanohole structure and measuring a surface plasmon resonance; (v) applying an electric field across the nanopore of the sensor; and (vi) measuring change in current across the nanopore during one or more translocation events of the biomolecules.

Abstract: This disclosure describes a transportation matching system that utilizes one or more balancer models to generate an electronic communication distribution strategy based on relative impacts of provider-specific and requester-specific levers over a target time horizon. The disclosed systems utilize the balancer models to generate predictive functions for providers and requesters to determine lever content to distribute (e.g., within electronic communications) to providers and/or requesters to efficiently and/or effectively produce acquisition and/or engagement for a target time horizon. Based on the predictive functions, the disclosed systems generate an electronic communication distribution strategy to provide (or cause to be provided) electronic communications to providers and requesters to efficiently and effectively increase or decrease acquisition and/or engagement.

Abstract: A porous membrane which has a sponge-like morphology. The porous membrane contains imidazole- and benzimidazole-based metal-organic framework fillers embedded in a polymer matrix. Methods of fabricating the porous membrane via steps including solvent casting and coagulating are described. Methods of separating gases using the porous membrane are also provided.

Abstract: Methods, systems, and apparatuses manage rolling out of updates in a network-accessible server infrastructure which operates a plurality of instances of a supporting service. The supporting service is comprised by a plurality of service portions. The instances of the supporting service each include of the service portions. The instances of the supporting service are partitioned into a plurality of slices. Each instance is partitioned to include one or more of the slices, and each slice of an instance includes one or more of the service portions. A software update is deployed to the instances by applying the software update to the slices in a sequence such that the software update is applied to a same slice in parallel across the instances containing that same slice before being applied to a next slice, and waiting a wait time before applying the software domain to a next slice in the sequencing.

Abstract: Techniques for multiuser application platform are described. Generally, a multiuser application allow interaction by multiple different users with a single executing instance of the application. Implementations include a multiuser operating system and a multiuser application programming interface that enable interaction by multiple users with an executing instance of a multiuser application.

Abstract: Techniques are disclosed relating to channel sounding. In some embodiments a transmitter transmits a periodic CAZAC sequence beginning at a point in time that corresponds to a timing signal (e.g., a pulse-per-second signal). In some embodiments, a receiver waits to begin processing received sequences for a time interval corresponding to the length of the CAZAC sequence, where the time interval begins at the same time as the timing signal. This may avoid a need for timing synchronization prior to processing, reduce processing and latency in receiver implementations, and may allow determination of a TOA as well as a channel impulse response estimate by correlating a received cyclically-shifted CAZAC sequence with a local version of the transmitted CAZAC sequence.

Abstract: A method for flushing a fuel cell system during a power-down cycle includes conveying air by an air conveying device through a cathode space of a fuel cell and releasing the conveyed air through an exhaust air line. An outlet valve is cyclically closed and opened during the power-down cycle, where an opening duration depends on an amount of air that is conveyed and the outlet valve connects an anode discharge line to the exhaust air line. The conveyed air is guided from a delivery side of the air conveying device directly to the exhaust air line at least in part through a system bypass.

Abstract: A membrane including a polymer substrate having pore channels and a metal-organic framework disposed on the polymer substrate. Methods of producing the membrane are described. Methods of separating gases using the membrane are also provided.