Patents by Inventor Murali Gopalakrishnan

Murali Gopalakrishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiazolylidine urea and amide derivatives and methods of use thereof
    Patent number: 8383657
    Abstract: The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: February 26, 2013
    Assignee: Abbott Laboratories
    Inventors: Ramin Faghih, Gregory A. Gfesser, Kathleen H. Mortell, Murali Gopalakrishnan
  • CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF
    Publication number: 20120219967
    Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of ?7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: February 6, 2012
    Publication date: August 30, 2012
    Inventors: Murali Gopalakrishnan, Jinhe Li, Steven C. Cassar, John Malysz, David J. Anderson, Earl J. Gubbins, Daniel C. Bertrand
  • PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE
    Publication number: 20110190314
    Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an ?4?2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
    Type: Application
    Filed: April 5, 2011
    Publication date: August 4, 2011
    Applicant: Abbott Laboratories
    Inventors: Murali Gopalakrishnan, Marie P. Honore, Chih-Hung Lee, John Malysz, Jianguo Ji, Tao Li, Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson
  • BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES
    Publication number: 20110124676
    Abstract: The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: January 27, 2011
    Publication date: May 26, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Jianguo Ji, Tao Li, Kevin B. Sippy, Chih-Hung Lee, Murali Gopalakrishnan
  • Biaryl substituted azabicyclic alkane derivatives
    Patent number: 7902222
    Abstract: The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: November 20, 2008
    Date of Patent: March 8, 2011
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, Tao Li, Kevin B. Sippy, Chih-Hung Lee, Murali Gopalakrishnan
  • Fused bicycloheterocycle substituted azabicyclic alkane derivatives
    Patent number: 7872017
    Abstract: The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: January 18, 2011
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, Tao Li, Christopher L. Lynch, Murali Gopalakrishnan
  • Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives
    Publication number: 20100305089
    Abstract: The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: August 3, 2010
    Publication date: December 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Jianguo Ji, Tao Li, Christopher L. Lynch, Murali Gopalakrishnan
  • Pharmaceutical Compositions for the Treatment of Pain
    Publication number: 20100305086
    Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype ?4?2 allosteric modulator. The present application also relates to compositions comprising such compounds for use in treating pain and related disorders mediated by controlling neurotransmitter release in a subject.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 2, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Murali Gopalakrishnan, Chih-Hung Lee, Jianguo Ji, Tao Li, Kevin B. Sippy
  • INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100249105
    Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 30, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Chih-Hung Lee, Tao Li, Gregory A. Gfesser, Kathleen H. Mortell, Ramin Faghih, Diana L. Nersesian, Kevin B. Sippy, William H. Bunnelle, Marc Scanio, Lei Shi, Murali Gopalakrishnan, Diana L. Donnelly-Roberts, Min Hu
  • Pyrrole Derivatives and Their Methods of Use
    Publication number: 20100216748
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: May 7, 2010
    Publication date: August 26, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li
  • Thiazoline and Oxazoline Derivatives and Their Methods of Use
    Publication number: 20100190776
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Application
    Filed: January 28, 2010
    Publication date: July 29, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li, Kathy A. Sarris, Melissa J. Michmerhuizen, Ying Wang
  • Pyrrole derivatives and their methods of use
    Patent number: 7741364
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: June 22, 2010
    Assignee: Abbott Laboratories
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li
  • INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100087471
    Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
    Type: Application
    Filed: September 28, 2009
    Publication date: April 8, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Michael R. Schrimpf, Chih-Hung Lee, Tao Li, Gregory A. Gfesser, Kathleen H. Mortell, Ramin Faghih, Diana L. Nersesian, Kevin B. Sippy, William H. Bunnelle, Marc Scanio, Lei Shi, Murali Gopalakrishnan, Diana L. Donnelly-Roberts, Min Hu
  • Thiazoline and oxazoline derivatives and their methods of use
    Patent number: 7683084
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 23, 2010
    Assignee: Abbott Laboratories
    Inventors: Ramin Faghih, Gregory A. Gfesser, Christopher L. Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl J. Gubbins, Rachid El Kouhen, Jinhe Li, Kathy A. Sarris, Melissa J. Michmerhuizen, Ying Wang
  • NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF
    Publication number: 20100035862
    Abstract: The invention relates to aza-cyclic-indole-2-carboxamide derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: June 24, 2009
    Publication date: February 11, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Murali Gopalakrishnan, Jianguo Ji, Chih-Hung Lee, Tao Li, Kevin B. Sippy
  • Novel Isoxazoles and Methods of Use Thereof
    Publication number: 20090306096
    Abstract: The invention relates to isoxazole derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: June 3, 2009
    Publication date: December 10, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Murali Gopalakrishnan, Jianguo Ji, Chih-Hung Lee, Tao Li, Kevin B. Sippy
  • AMIDE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20090270408
    Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Application
    Filed: February 6, 2009
    Publication date: October 29, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Kathleen H. Mortell, Diana L. Nersesian, Michael R. Schrimpf, Chih-Hung Lee, Murali Gopalakrishnan
  • COMPOSITIONS FOR TREATMENT OF COGNITIVE DISORDERS
    Publication number: 20090221648
    Abstract: The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either ?4?2 subtype or ?7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 3, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Lynne E. Rueter, Gerald B. Fox, Kaitlin E. Browman, James P. Sullivan, Jorge D. Brioni, Marlon D. Cowart, Ramin Faghih, Gregory A. Gfesser, Kathleen H. Mortell, Murali Gopalakrishnan
  • BIARYL SUBSTITUTED DIAZABICYCLOALKANE DERIVATIVES
    Publication number: 20090197860
    Abstract: The invention relates biaryl substituted diazabicycloalkanes, and more particularly bicycloheteroaryl substituted fused diazabicycloalkane derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: November 20, 2008
    Publication date: August 6, 2009
    Applicant: Abbott Laboratories
    Inventors: Jianguo Ji, Tao Li, Kevin B. Sippy, Chih-Hung Lee, Murali Gopalakrishnan
  • BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES
    Publication number: 20090192186
    Abstract: The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: November 20, 2008
    Publication date: July 30, 2009
    Applicant: Abbott Laboratories
    Inventors: Jianguo Ji, Tao Li, Kevin B. Sippy, Chih-Hung Lee, Murali Gopalakrishnan