Patents by Inventor Murali Gopalakrishnan

Murali Gopalakrishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20090163470
    Abstract: The invention relates to novel thiazolylidine urea and amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 25, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Ramin Faghih, Gregory A. Gfesser, Kathleen H. Mortell, Murali Gopalakrishnan
  • CHOLINERGIC/SEROTONINERGIC RECEPTOR AND USES THEREOF
    Publication number: 20090123945
    Abstract: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of ?7 nicotinic acetylcholine receptors.
    Type: Application
    Filed: June 25, 2008
    Publication date: May 14, 2009
    Applicant: ABBOTT LABORATORIES
    Inventors: Murali Gopalakrishnan, Jinhe Li, Steven C. Cassar, John Malysz, David J. Anderson, Earl J. Gubbins, Daniel C. Bertrand
  • Novel 1,2,4 Oxadiazole Compounds and Methods of Use Thereof
    Publication number: 20080269236
    Abstract: The invention relates to 1,2,4 oxadiazole compounds and analogs thereof, represented by formula (II), and compositions and methods of use thereof.
    Type: Application
    Filed: June 6, 2008
    Publication date: October 30, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Jianguo Ji, Chih-Lung Lee, Kevin B. Sippy, Tao Li, Murali Gopalakrishnan
  • HETEROCYCLIC COMPOUNDS AND THEIR METHODS OF USE
    Publication number: 20080255203
    Abstract: The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.
    Type: Application
    Filed: December 10, 2007
    Publication date: October 16, 2008
    Applicant: Abbott Laboratories
    Inventors: Chih-Hung Lee, Jianguo Ji, Tao Li, Michael R. Schrimpf, Kevin B. Sippy, Murali Gopalakrishnan
  • IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-beta PEPTIDES
    Publication number: 20080234311
    Abstract: The present invention provides a method for the detection and quantification of A?1-40 produced in native cell types and tissues. Also provided are assays and kits to determine the effect of compounds on the production of amyloid ? peptides.
    Type: Application
    Filed: November 19, 2007
    Publication date: September 25, 2008
    Inventors: Jinhe Li, Murali Gopalakrishnan
  • Pharmaceutical compositions and their methods of use
    Publication number: 20080167286
    Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an ?4?2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
    Type: Application
    Filed: December 10, 2007
    Publication date: July 10, 2008
    Applicant: Abbott Laboratories
    Inventors: Murali Gopalakrishnan, Marie P. Honore, Chih-Hung Lee, John Malysz, Jianguo Ji, Tao Li, Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson
  • THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE
    Publication number: 20080070929
    Abstract: The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
    Type: Application
    Filed: June 27, 2007
    Publication date: March 20, 2008
    Inventors: Ramin Faghih, Gregory Gfesser, Christopher Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl Gubbins, Rachid Kouhen, Jinhe Li, Kathy Sarris, Melissa Michmerhuizen, Ying Wang
  • PYRROLE DERIVATIVES AND THEIR METHODS OF USE
    Publication number: 20080064695
    Abstract: The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: June 27, 2007
    Publication date: March 13, 2008
    Inventors: Ramin Faghih, Gregory Gfesser, Christopher Lynch, Murali Gopalakrishnan, Sujatha Gopalakrishnan, John Malysz, Earl Gubbins, Rachid El Kouhen, Jinhe Li
  • FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES
    Publication number: 20080045539
    Abstract: The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: May 15, 2007
    Publication date: February 21, 2008
    Inventors: Jianguo Ji, Tao Li, Christopher Lynch, Murali Gopalakrishnan
  • Variant human ?7 acetylcholine receptor subunit, and methods of production and use thereof
    Patent number: 7229779
    Abstract: A variant human ?7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human ?7 nAChR. Nucleic acid molecules encoding the variant human ?7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 12, 2007
    Assignee: Abbott Laboratories
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. Mc Kenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Variant human alpha7 acetylcholine receptor subunit, and methods of production and use thereof
    Publication number: 20040203033
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Application
    Filed: December 30, 2003
    Publication date: October 14, 2004
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. Mc Kenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Variant human &agr;7 acetylcholine receptor subunit, and methods of production and use thereof
    Patent number: 6683157
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: January 27, 2004
    Assignee: Abbott Laboratories
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. Mc Kenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Potassium channel openers
    Patent number: 6645968
    Abstract: Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: November 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Hao Bai, Jorge D. Brioni, William A. Carroll, Murali Gopalakrishnan, Robert J. Gregg, Mark W. Holladay, Peggy P. Huang, John F. Kincaid, Michael E. Kort, Philip R. Kym, John K. Lynch, Arturo Perez-Medrano, Henry Q. Zhang
  • Radioligands and their use for identifying potassium channel modulators
    Patent number: 6632418
    Abstract: The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: October 14, 2003
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Gary A. Rotert, William A. Carroll, Murali Gopalakrishnan, Eduardo Jose Vicente Molinari, Rachel A. Davis-Taber, Victoria Eleanor Sarah Scott
  • Variant human alpha7 acetylcholine receptor subunit, and methods of production and use thereof
    Publication number: 20030073161
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Application
    Filed: September 18, 2001
    Publication date: April 17, 2003
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. McKenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Novel radioligands and their use for identifying potassium channel modulators
    Publication number: 20030065182
    Abstract: The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.
    Type: Application
    Filed: July 30, 2002
    Publication date: April 3, 2003
    Inventors: Robert J. Altenbach, Gary A. Rotert, William A. Carroll, Murali Gopalakrishnan, Eduardo Jose Vicente Molinari, Rachel A. Davis-Taber, Victoria Eleanor Sarah Scott
  • Potassium channel openers
    Publication number: 20020028836
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: February 5, 2001
    Publication date: March 7, 2002
    Inventors: Robert J. Altenbach, Hao Bai, Jorge D. Brioni, William A. Carroll, Murali Gopalakrishnan, Robert J. Gregg, Mark W. Holladay, Peggy P. Huang, John F. Kincaid, Michael E. Kort, Philip R. Kym, John K. Lynch, Arturo Perez-Medrano, Henry Q. Zhang
  • Variant human &agr;7 acetylcholine receptor subunit, and methods of production and uses thereof
    Patent number: 6323000
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: November 27, 2001
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. McKenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • VARIANT HUMAN ALPHA7 ACETYLCHOLINE RECEPTOR SUBNIT, AND METHODS OF PROD0U0CTION AND USES THEREOF
    Publication number: 20010006796
    Abstract: A variant human U7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Application
    Filed: December 20, 1996
    Publication date: July 5, 2001
    Inventors: CLARK A. BRIGGS, MURALI GOPALAKRISHNAN, DAVID G. MC KENNA, LISA M. MONTEGGIA, JEAN-MARC ROCH, JAMES P. SULLIVAN, EDWARD TOUMA